Preliminary. Targeted Therapies in Hepatology. Falk Workshop. January 24 25, 2013 Medizinische Hochschule Hannover Germany

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1 Falk Workshop Targeted Therapies in Hepatology January 24 25, 2013 Medizinische Hochschule Hannover Preliminary ProgramApplication for CME credits submitted

2 Preface... 4 Scientific Program Posters... 8 List of Speakers... 9 Information CME credits for the Falk Workshop have been applied for at the European Union of Medical Specialists (UEMS) European Board of Gastroenterology (EBG). The number of credits awarded will be printed in the final program. 3

3 Preface The future has already begun for targeted therapies namely in cancer. This is closely linked to the concept of personalized medicine. However, for several of the targeted therapies associated with a personalized approach analysis of tumor tissue is a prerequisite. Therefore we have to discuss the role of targeted therapies in liver cancer in the context of a decline in liver biopsy for the diagnosis of chronic hepatitis, namely viral hepatitis and also liver tumors. Targeted therapies are just at the beginning. We still have to invest tremendously in basic research in order to identify suitable targets for the development of either small molecules or antibodies facilitating a targeted approach to treatment. In liver diseases the advent of sorafenib has opened the doors for targeted therapies in liver cancer. More drugs will and need to follow since the success of sorafenib certainly is limited. Targeted therapies also have to be developed for non HCC liver tumors like bile duct cancer. After decades of rather unspecific approaches with interferons and ribavirin small molecules specifically targeting different steps of the HCV life cycle are either already approved or in various stages of clinical development. Autoimmune liver diseases are still treated with non specific immunosuppression like prednisone plus minus azathioprine. Specific immune intervention is still in its infancy for autoimmune liver diseases as well as for tolerance induction in organ transplantation. Autoimmune liver diseases and liver transplantation are certainly suitable fields to develop targeted therapies leading to a more personalized medicine. Nevertheless, we are still missing optimal targets for a disease specific immune intervention in autoimmune liver diseases like autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. We still have to invest in basic research bringing light in the aetiology and pathogenesis of diseases like primary sclerosing cholangitis where little is known. Since the discovery of the genes encoding the mitochondrial autoantigens in PBC no significant progress has been achieved in primary biliary cirrhosis that would allow more specific targeted therapies. In cholestatic liver diseases, however, improvements are at hand due to specific intervention with nuclear bile acid receptors like FXR or the use of further modified bile acids, namely NOR-UDCA So far targeted therapies are not available for the most prevalent liver disease which is non alcoholic steatohepatitis (NASH). However, such therapies are urgently needed. Furthermore it would be most welcome if we could have therapies available specifically intervening with specific pathways of fibrogenesis. Antifibrotic therapies are urgently needed for chronic liver diseases where specific aetiology oriented therapies like in viral hepatitis C are not available. Such therapies would also need to have an acceptable safety profile. For patients with end stage cholestatic liver diseases pruritus often is the leading symptom. In contrast to pain effective medical therapies are not available yet. However, recent focus on basic research has lead to the identification of specific pathways for fibrogenesis and pruritus that might lead to future targeted therapies. You are welcome to attend the Falk Workshop on Targeted Therapies in Hepatology on occasion of the 29th annual meeting of the German Association for the Study of the Liver (GASL). We are looking forward to lively discussions following presentations of an outstanding international faculty. Michael P. Manns, Hannover 4

4 Falk Workshop Targeted Therapies in Hepatology January 24 25, 2013 Medizinische Hochschule Hannover The 29 th Annual Meeting of the German Association for the Study of the Liver will follow the Falk Workshop: January 25, h January 26, h Scientific Organization: Michael P. Manns, Hannover Nisar P. Malek, Tübingen Christian P. Strassburg, Bonn Christian Trautwein, Aachen Congress Venue: Medizinische Hochschule Hannover Lecture Hall D (Building J2) Information: Prof. Dr. Michael P. Manns Klinik für Gastroenterologie, Hepatologie und Endokrinologie Phone: +49 (0) 511 / Fax: +49 (0) 511 / Official Language: English Call for Posters: A poster session will take place. For details see page 8 Publication date of final program: January 2013 The final program will be available on the homepage one week before the event. 5

5 Thursday, January 24, Welcome lunch and poster session Welcome M. P. Manns, Hannover Session I Principles of targeted therapies Chair: C. Trautwein, Aachen; A. Vogel, Hannover The role of liver tissue analysis for targeted therapies P. Schirmacher, in cancer What can we learn for liver diseases? Heidelberg Chances and limitations of personalized medicine H. K. Kroemer, Göttingen Macrophages and targeted therapies F. Tacke, Aachen Cell cycle structures as targets for anticancer treatment N. P. Malek, Tübingen Is targeted therapy a future option for antifibrotic therapy? D. Mann, Newcastle Coffee break and poster session Session II Targeted therapies in liver cancer and metabolic liver disease Chair: P. R. Galle, Mainz; J. Nattermann, Bonn Inflammatory signal pathways in HCC development T. Lüdde, Aachen HCC gene profiling - Role for future targeted therapies S. S. Thorgeirsson, in liver cancer Bethesda Targeted therapies for liver cancer Today and tomorrow T. F. Greten, Bethesda Targeted therapies in non-alcoholic steatohepatitis (NASH) H. Tilg, Hall Molecular pathogenesis of pruritus New targets for U. Beuers, interventional therapies Amsterdam 6

6 Friday, January 25, 2013 Session III Targeted therapy in cholestatic and autoimmune liver diseases Chair: G. Gerken, Essen; C. P. Strassburg, Bonn 9.00 Specific immune intervention in autoimmune liver E. Jäckel, diseases utopia or the future? Hannover 9.30 Etiopathogenesis of primary biliary cirrhosis and resulting E. Gershwin, targets for interventional immunotherapies Davis Targeted therapies in cholestatic liver diseases M. Trauner, The role of bile acids and bile acid receptors Vienna Coffee break and poster session Session IV Viral hepatitis and liver transplantation Chair: J. Klempnauer, Hannover; H. Wedemeyer, Hannover Viral life cycle analysis for the identification of antiviral T. Pietschmann, therapies HCV as a model Hannover Personalized therapies for hepatitis C The end is at hand? S. Zeuzem, Frankfurt Strategies for individualized organ tolerance H. J. Schlitt, Regensburg Farewell Farewell lunch Opening of the annual meeting of the GASL 7

7 Poster Session Posters will be exhibited on January 24 25, 2013 at the Medizinische Hochschule Hannover. The authors will be in attendance during coffee and lunch breaks on both days. Call for posters Please submit your poster abstract before October 31, Only one-page abstracts not exceeding 300 words, written in English and saved in Microsoft Word format will be accepted. Abstracts must be submitted via our Internet Abstract Submission System (http://www.falkfoundation.com/poster) where further information regarding the submission format and the submission process is available. The abstracts will be selected by the scientific organizers, preference being given to those thematically related to one of the sessions of the program. The accepted abstracts will be printed and distributed to the participants of the congress together with the documents of the meeting. The authors will receive notification about acceptance and further instructions in November Contact address for further information on the poster session: Falk Foundation e.v. Leinenweberstr Freiburg Telephone: +49 (0)761/ Telefax: +49 (0)761/ Web address for submitting poster abstracts: The first author of an accepted poster will receive travel refunding up to 200 (expense vouchers obligatory). 8

8 List of Speakers, Moderators and Scientific Organizers Prof. Dr. Ulrich Beuers Univ. van Amsterdam, Tytgat Inst. for Liver & Intestinal Research Department of Gastroenterology Meibergdreef AZ Amsterdam The Netherlands Prof. Dr. Peter R. Galle Innere Medizin I Universitätsmedizin der Johannes Gutenberg-Universität Langenbeckstr Mainz Prof. Dr. Guido Gerken Gastroenterologie / Hepatologie Universitätsklinikum Essen Hufelandstr Essen Eric Gershwin, M.D. Professor of Medicine University of California School of Medicine Rheumatology & Allergy One Shields Ave., Tupper Hall Davis, CA, USA Tim F. Greten, M.D. Professor of Medicine National Cancer Institute, NIH Gastrointestinal Cancer Section Med. Oncology, Bldg. 10 / Rm 12N Rockville Pike Bethesda MD USA PD Dr. Elmar Jäckel Klinik für Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover Prof. Dr. Jürgen Klempnauer Transplantationschirurgie Medizinische Hochschule Hannover Prof. Dr. Heyo K. Kroemer Ressort Forschung und Lehre Universitätsklinikum Göttingen Robert-Koch-Str Göttingen PD Dr. Tom Lüdde Medizinische Klinik III Universitätsklinikum Aachen Pauwelsstr Aachen Prof. Dr. Nisar P. Malek Innere Medizin I Universitätsklinikum Tübingen Otfried-Müller-Str Tübingen 9

9 Prof. Derek Mann, Ph.D. Fibrosis Research Laboratories Institute of Cellular Medicine 4th Floor, Catherine Cookson Building Medical School Newcastle University NE2 4HH Great Britain Prof. Dr. Michael P. Manns Klinik für Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover Prof. Dr. Jacob Nattermann Medizinische Klinik I Universitätsklinikum Bonn Sigmund-Freud-Str Bonn Prof. Dr. Thomas Pietschmann Institut für Experimentelle Virologie TWINCORE Zentrum für Experimentelle und Klinische Infektionsforschung GmbH Feodor-Lynen-Str. 7 Prof. Dr. Peter Schirmacher Pathologie Universitätsklinikum Heidelberg Im Neuenheimer Feld 220/ Heidelberg Prof. Dr. Hans Jürgen Schlitt Chirurgie Universitätsklinikum Regensburg Franz-Josef-Strauß-Allee Regensburg Prof. Dr. Christian P. Strassburg Medizinische Klinik I Universitätsklinikum Bonn Sigmund-Freud-Str Bonn PD Dr. Frank Tacke Medizinische Klinik III Universitätsklinikum Aachen Pauwelsstr Aachen Dr. Snorri S. Thorgeirsson Lab. of Experimental Carcinogenesis National Institute of Health Bldg. 37, Room 4146A1 37 Convent Drive Bethesda, MD USA Prof. Dr. Herbert Tilg Innere Medizin Krankenhaus Hall in Tirol Milser Str Hall in Tirol Austria Prof. Dr. Michael Trauner Abteilung für Gastroenterologie und Hepatologie Universitätsklinik für Innere Medizin III AKH Universitätscampus Wien Währinger Gürtel Wien Austria Prof. Dr. Christian Trautwein Medizinische Klinik III Universitätsklinikum Aachen Pauwelsstr Aachen 10

10 Prof. Dr. Arndt Vogel Klinik für Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover Prof. Dr. Stefan Zeuzem Innere Medizin I Klinikum der Johann Wolfgang Goethe-Universität Frankfurt Theodor-Stern-Kai Frankfurt Prof. Dr. Heiner Wedemeyer Klinik für Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover 11

11 General Information Prior to the opening of the Falk Workshop in Hannover Falk Foundation e. V. Telephone: +49 (0)761/ Congress Division Telefax: +49 (0)761/ Leinenweberstr Freiburg () Congress Office During the Falk Workshop Telephone: +49 (0)175/ Medizinische Hochschule Hannover Opening Hours: Thursday, January 24, 2013 Friday, January 25, h h Congress Fees The participation at the Falk Workshop is free of charge, however registration is mandatory. Refreshments during coffee breaks on January 24 and 25, lunches on January 24 and 25, dinner on January 24 and a copy of the abstract volume of the Falk Workshop are also free of charge. 12

12 Registration Congress registrations must reach the Falk Foundation e.v. by December 31, 2012 at the latest. After receipt of registration form, each participant will be provided with confirmation of his registration. On presentation of this confirmation at the congress office in Hannover participants will receive the congress folder containing name badges, admission tickets and the abstract volume. All participants will receive a written confirmation of attendance and CME credits at the end of the meeting. Admission to Scientific Events For admission to scientific events your name badge should be clearly visible. Hotel Accommodation or Airport International Airport Hannover-Langenhagen GmbH The 29th Annual Meeting of the German Association for the Study of the Liver will take place immediately following the Falk Workshop (January 25 and 26, 2013). 13

13 Hannover Medical School

14 General Information: FALK FOUNDATION e.v. Leinenweberstr Freiburg Congress Division Telephone: +49 (0) 761/ Telefax: +49 (0) 761/ VP WS-Hannover 1-9/2012/7.000 Stü

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