In Vitro Biotesting of Nanoparticles on Mammalian Cells

Save this PDF as:
 WORD  PNG  TXT  JPG

Größe: px
Ab Seite anzeigen:

Download "In Vitro Biotesting of Nanoparticles on Mammalian Cells"

Transkript

1 In Vitro Biotesting of Nanoparticles on Mammalian Cells, Franziska Sambale Frank Stahl, Antonina Lavrentieva Leibniz Universität Hannover Callinstraße 3, Hannover

2 Life Cycle of Nanomaterials consumer worker transport storage products fabrication waste transport/diffusion? air Transformation/degradation? water food transport/diffusion? Aitken R., RS Report Nanoscience and nanotechnologie, (2004)

3 Nanopartikuläre Beschichtungen im Innovationsverbund Nanopartikuläre Lackbeschichtung Verbesserung bestehende Rezeptur Herstellung photokatalytisch-aktiver, transparenter Beschichtungen durch Titandioxidpartikel 1,0 61nm Transmission T bei 500nm [-] x 50,3 DT (primär) x 10,3 DT (primär) 0,9 x 90,3 DT (primär) 0,8 0,7 0, Partikelgröße x 50,3 [nm] Nanopartikuläre Kunstharzoberfläche Abriebbeständige Beschichtung mit Easy-to-Clean-Oberfläche

4 Uptake Possibilities of Nanoparticles Inhalation Lungs A549 cells Absorption Skin NIH-3T3 cells Liver HepG2 cells Resorption Gut Caco2 cells Transition blood brain barrier? Nerves PC-12 cells

5 Aim of my Project: Screening System for Nanoparticle Safety Testing All materials Pre Screening: Cell lines: NIH-3T3, HepG2, A549 Viability: MTT/WST-1 assay Morphology: Calcein labeling Significant variation Fine Screening: Cell lines: NIH-3T3, HepG2, A549 Energy metabolism: ATP yield Proliferation: BrdU labeling Gene expression: qpcr, microarray Cell death: Annexin V/PI assay Significant variation material has a toxic effect material has no toxic effect Selected materials Complex Screening: Primary cells Cell systems to imitate in vitro conditions such as blood brain barrier Material is non toxic Significant variation

6 Overview Cells Lung, skin and liver cells (A549 cells, NIH-3T3 cells, HepG2 cells) Stem cells Exposure Suspension Coating Extraction Surface Growth Culture Condition Static Dynamic Static Dynamic Static Dynamic Cell Growth 2D 3D 2D 3D 2D 3D 2D 3D 2D 3D 2D 3D Analytic Pre Screening: Fine Screening: Cell Viability, Cell Proliferation, Cell Morphology Cell Adhesion, Cell Metabolism, ATP level, DNA level, LDH release

7 Stage of Work Comparison of Different Ways of Exposure Suspension I.S. EN ISO (2012): Biological evaluation of medical devices Extraction Coating Surface Growth Cell adhesion and growth Nanoparticle extraction Cell adhesion and growth Cell adhesion and growth, exposure Exposure Exposure Cell analysis Cell analysis Cell analysis

8 Benchmark-System Non-toxic Titanium dioxide nanoparticles (UV 100) Toxic Zinc oxide nanoparticles (0.1 % Ru) 120 TiO2 A549 E ZnO A Vi abilit ät [ %] Vi abilit ät [ %] Konzentration [ppm] Konzentration [ppm]

9 Screening-System Benchmark-System: Lebend-Tod-Färbung (Calcein-AM/Pi-Färbung) Kontrolle ZnO 0,1 % Ru A549-Zellen NIH-3T3-Zellen

10 Prozesskette der nanopartikuläre Beschichtung (Aluminiumoxid Nanopartikel) Ausgangsmaterial Vorstufen Erste Formulierung Aluminiumoxid- Suspension Aluminiumoxid- Beschichtung Aluminiumoxid- Beschichtung (modifiziert) Aluminiumoxid- Beschichtung (Größe) Aluminiumoxid- Schicht Zweite Formulierung Konzentration Partikelgröße Modifikation Konzentration Partikelgröße Dritte Formulierung Aluminiumoxid- Schicht mit TiO 2 - Nanopartikel Indirekte Farbpigmentierung Direkte Farbpigmentierung Nanopartikuläre Kunstharzoberfläche

11 Toxikologische Charakterisierung: Ausgangsmaterials und Vorstufen Ausgangsmaterial Aluminiumoxid-Suspension Aluminiumoxid (11 ± 2 nm (REM)) Wässrige Suspension, ph 7 Vorstufe: Aluminiumoxid-Beschichtung Suspension: Aluminiumoxid (EtOH): 500 nm (DLS) Aluminiumoxid (H 2 O): 130 nm (DLS) Extraktionsbedingungen: 72 h, 37 C, 5 % CO 2 3 cm²/ml DMEM (10 % FKS) 10 % w/w Beschichtung 125 HepG2 Zellen A549 Zellen HepG2 Zellen A549 Zellen Viabilität (%) Viabilität (%) Konzentration (µg/ml) 0 Al 2 O 3 (H 2 O) Al 2 O 3 (EtOH) K AluC H2O AluC EtOH Aluminiumoxid, AluC-Pulver (REM)

12 Toxikologische Charakterisierung: Konzentration und Partikelgröße (zweite Formulierung) Zweite Formulierung Aluminiumoxid-Schichten Vergleich von verschiedenen Konzentrationen in der Schicht Zweite Formulierung Aluminiumoxid-Schichten Vergleich von verschiedenen Partikelgrößen in der Schicht 125 HepG2 Zellen A549 Zellen 100 HepG2 Zellen A549 Zellen Viabilität (%) * * * * * * Viabilität (%) * * * * * K Ref 2% 3% 4% 5% 6% Konzentration (%) 0 K 274* Partikelgröße (nm) Aluminiumoxid mit Silan, 4% in der Schicht (Jutta Hesselbach) Aluminiumoxid, perfluoriert (Alexander Kockmann), 274*

13 Toxikologische Charakterisierung: Al 2 O 3 -Schicht mit Farbpigmente Dritte Formulierung Aluminiumoxid-Schichten Vergleich von verschiedenen Farbpigmentierungen 125 HepG2 Zellen A549 Zellen Ref 1: Gelcoat/Styrol Ref 2: Gelcoat 100 Viabilität (%) * * * * * * * * * 25 * 0 F1-4 F1 Ref 1 F1 Ref 2 F2-4 F2 Ref 1 F2 Ref 2 F3-4 F3 Ref 1 F3 Ref 2 Al 2 O 3 -Styrol Al 2 O 3 -TiO 2 -Styrol Al 2 O 3 -Gelcoat-TiO 2 TiO 2 im Styrol TiO 2 direkt im Gelcoat

14 Stage of Work Coating vs. Suspension: 2D Static Culture (Surface Growth) Lung cells (A549 cells) Skin cells (NIH-3T3 cells Viability [%] ZnO-NP suspension ZnO-NP coating 0 0, ,9 Concentration [µg/cm²] Nanoparticle: ZnO (0,1 % Ru) Suspension: IC 50 = 18 µg/cm² Coating: IC 50 = 35 µg/cm² Nanoparticle: ZnO (0,1 % Ru) Suspension: IC 50 = 3 µg/cm² Coating: IC 50 = 8 µg/cm²

15 Stage of Work Suspension: 2D Dynamic Culture Dynamic culture condition More physiological conditions (comparable with blood stream) Well-defined shear stress Cell viability Cell metabolism ATP level Cell adhesion (ECIS)

16 Stage of Work Static vs. Dynamic Culture Condition Cell Morphologhy of Skin Cells (NIH-3T3 cells) Static Culture Dynamic Culture

17 Stage of Work 2D vs. 3D Cell Culture Animal Zyoxel-Human Tissue Testing Technologies, D static cell culture is unrepresentative model Cell-cell and cell-matrix interactions significant role in cellular response to drugs and toxins

18 Stage of Work Suspension: 3D Cell Culture Modells Cell Adhesion on Scaffolds Cell Aggregation, Spheroid Formation Cell Immobilization in Hydrogel

19 Establishment of 3D Cell Cultures: 3 Models

20 Establishment of 3D Cell Cultures : Microtissues / Cell Spheroids

21 Stage of Work Suspension: 3D Static (Speroid) Skin Cells (NIH-3T3 cells) Cell Morphology =500 µm ZnO-NP Concentration [ppm] 200 µm 200 µm 0 ppm 16 ppm

22 22

23 23

24 Konfokalmikroskopie, nach 4h Inkubation mit QDots Bright field DAPI QDots Qdots+DAPI Magnified spheroid

25 Establishment of 3D Cell Cultures : Hydrogel-based cell cultures

26 26

27 27

28 Stage of Work Suspension: 3D Static (Scaffold) ZnO-NP Concentration [ppm] Viability [%] Viability [%] ZnO-NP 2D A549 ZnO-NP 3D A549 (Scaffold) 20 ZnO-NP 2D NIH-3T3 ZnO-NP 3D NIH-3T3 (Scaffold) Concentration [µg/ml] 0 0,1 0, Concentration [µg/ml] Nanoparticle: ZnO (0,1 % Ru) 2D:IC 50 = 56 µg/ml 3D: IC 50 = 202 µg/ml Nanoparticle: ZnO (0,1 % Ru) 2D:IC 50 = 8 µg/ml 3D: IC 50 = 12 µg/ml

29 Stage of Work 2D vs. 3D Cell Morphology (Hydrogel) Skin Cells (NIH-3t3 cells) 500 µm 500 µm Control 40 ppm ZnO-NP

30 Stage of Work Suspension: 3D Dynamic Culture Dynamic culture conditions Well-defined shear stress 3D cell growth More physiological condition (comparable with blood stream) Cell viability Cell metabolism ATP level

31 Dynamic 3D Cell Culture

32 Summary and Outlook Current in vitro nanotoxicity research needs optimization Nanoparticle coating instead of nanoparticle suspension 2D cells are more sensitive 3D cell culture is a better model (cell-cell interactions) Further experiments Compare different 3D cell models Development of dynamic cultivation Combine both ideas with a 3D dynamic model

33 Thank you for your attention.

34

cellasys GmbH BioChip-based electrochemical platform for the label-free monitoring of living cells 2012/09/08 LINZ 2012 EUSAAT 2012

cellasys GmbH BioChip-based electrochemical platform for the label-free monitoring of living cells 2012/09/08 LINZ 2012 EUSAAT 2012 cellasys GmbH BioChip-based electrochemical platform for the label-free monitoring of living cells 2012/09/08 LINZ 2012 EUSAAT 2012 Dr.-Ing. Joachim Wiest www.cellasys.com Motivation Continuous monitoring

Mehr

Influence of dust layer thickness. on specific dust resistivity

Influence of dust layer thickness. on specific dust resistivity on specific dust resistivity D. Pieloth, M. Majid, H. Wiggers, P. Walzel Chair of Mechanical Process Engineering, TU Dortmund, Dortmund/Germany Outline 2 Motivation Measurement of specific dust resistivity

Mehr

Numerical analysis of the influence of turbulence on the exchange processes between porous-medium and free flow

Numerical analysis of the influence of turbulence on the exchange processes between porous-medium and free flow Numerical analysis of the influence of turbulence on the exchange processes between porous-medium and free flow T. Fetzer Institut für Wasser- und Umweltsystemmodellierung Universität Stuttgart January

Mehr

SAFETY CONSIDERATIONS ON LIQUID HYDROGEN (PART 2)

SAFETY CONSIDERATIONS ON LIQUID HYDROGEN (PART 2) SAFETY CONSIDERATIONS ON LIQUID HYDROGEN (PART 2) Karl Verfondern Research Center Jülich, Germany 2 nd European Summer School on Hydrogen Safety Belfast, July 30 August 8, 2007 Types of Cryogen Release

Mehr

Cluster #4 stellt sich (was) vor...

Cluster #4 stellt sich (was) vor... Cluster #4 stellt sich (was) vor... Ausgangssituation Der Cluster Experimental Therapy & Drug Resistance vertritt ein zentrales Thema Schwerpunkt an der Schnittfläche zwischen experimenteller und klinischer

Mehr

Laser zur Funktionalisierung von Oberflächen Auch in der Textilindustrie?

Laser zur Funktionalisierung von Oberflächen Auch in der Textilindustrie? Laser zur Funktionalisierung von Oberflächen Auch in der Textilindustrie? Nanoworkshop Hohenems 11.12.2014 Johannes Edlinger 2014-12-11 Oberflächenmodifikation mit Lasern? Was kann man tun Anhand von zwei

Mehr

Cloud und Big Data als Sprungbrett in die vernetzte Zukunft am Beispiel Viessmann

Cloud und Big Data als Sprungbrett in die vernetzte Zukunft am Beispiel Viessmann Cloud und Big Data als Sprungbrett in die vernetzte Zukunft am Beispiel Viessmann Adam Stambulski Project Manager Viessmann R&D Center Wroclaw Dr. Moritz Gomm Business Development Manager Zühlke Engineering

Mehr

Junction of a Blended Wing Body Aircraft

Junction of a Blended Wing Body Aircraft Topology Optimization of the Wing-Cabin Junction of a Blended Wing Body Aircraft Bin Wei M.Sc. Ögmundur Petersson M.Sc. 26.11.2010 Challenge of wing root design Compare to conventional aircraft: Improved

Mehr

Simulation of a Battery Electric Vehicle

Simulation of a Battery Electric Vehicle Simulation of a Battery Electric Vehicle M. Auer, T. Kuthada, N. Widdecke, J. Wiedemann IVK/FKFS University of Stuttgart 1 2.1.214 Markus Auer Agenda Motivation Thermal Management for BEV Simulation Model

Mehr

OpEx at Nycomed Austria Linz

OpEx at Nycomed Austria Linz OpEx at Nycomed Austria Linz OpEx KPIs People (current status): 221 Yellow Belts (Target 2011: 291) 3 Green Belts 3 Black Belts Projects OPEX Activities Pipeline 2 About to be started 1 Ongoing 16 Completed

Mehr

Mobile JENCOLOR Evaluation Kits with Windows 8 Smart PC for Color Measurement Applications

Mobile JENCOLOR Evaluation Kits with Windows 8 Smart PC for Color Measurement Applications Mobile JENCOLOR Evaluation Kits with Windows 8 Smart PC for Color Measurement Applications Paul-Gerald Dittrich, Fred Grunert, Dietrich Hofmann MAZeT GmbH Firmenpräsentation Version xx 1 Content 1. Mobile

Mehr

EPICAL EPICAL. The Non-Coated Bioactive Calcium-Rich Surface* * Developed in cooperation with the Federal Institute for Material Research and Testing

EPICAL EPICAL. The Non-Coated Bioactive Calcium-Rich Surface* * Developed in cooperation with the Federal Institute for Material Research and Testing EPICAL The Non-Coated Bioactive Calcium-Rich Surface* An Awarded Procedure! EPICAL An Awarded Procedure! * Developed in cooperation with the Federal Institute for Material Research and Testing EPICAL -

Mehr

Making quality visible. National Quality Certificate for Old Age and Nursing Homes in Austria (NQC)

Making quality visible. National Quality Certificate for Old Age and Nursing Homes in Austria (NQC) Making quality visible. National Quality Certificate for Old Age and Nursing Homes in Austria (NQC) Human Rights Council Genf, 15 September 2015 The Austrian System of Long Term Care System: 2 main components:

Mehr

Dispersion and Retention of Dusts Consisting of Ultrafine Primary Particles in Lungs

Dispersion and Retention of Dusts Consisting of Ultrafine Primary Particles in Lungs Dispersion and Retention of Dusts Consisting of Ultrafine Primary Particles in Lungs D. Schaudien, J. W. Knebel, I. Mangelsdorf, J.-U. Voss, W. Koch, O. Creutzenberg Research Project F 2133 D. Schaudien

Mehr

Cleanroom Fog Generators Volcano VP 12 + VP 18

Cleanroom Fog Generators Volcano VP 12 + VP 18 Cleanroom Fog Generators Volcano VP 12 + VP 18 Description & Functional Principle (Piezo Technology) Cleanrooms are dynamic systems. People and goods are constantly in motion. Further installations, production

Mehr

MODELLING AND CONTROLLING THE STEERING FORCE FEEDBACK USING SIMULINK AND xpc TARGET

MODELLING AND CONTROLLING THE STEERING FORCE FEEDBACK USING SIMULINK AND xpc TARGET MODELLING AND CONTROLLING THE STEERING FORCE FEEDBACK USING SIMULINK AND xpc TARGET Dipl.-Ing. M. Brünger-Koch, 05/06/09 Model-Based Design Conference 2005 1 Agenda 1. Introduction Company and institute

Mehr

Modelling CO 2 and trace gas exchange between landsurface

Modelling CO 2 and trace gas exchange between landsurface Modelling CO 2 and trace gas exchange between landsurface and atmosphere Rüdiger Grote (Ruediger.Grote@kit.edu) Institut für Meteorologie und Klimaforschung, Atmosphärische Umweltforschung, Garmisch-Partenkirchen,

Mehr

Ultrasound as an effective method to isolate intact mitochondria from CHO cells for physiological studies

Ultrasound as an effective method to isolate intact mitochondria from CHO cells for physiological studies Ultrasound as an effective method to isolate intact mitochondria from CHO cells for physiological studies J. Bahnemann, S. Kayo, A-P. Zeng Institute of Bioprocess and Biosystems Engineering, Hamburg University

Mehr

EXPLORING SERVICE DESIGN DIVE STRETCH JUMP AND WIN!! Freitag, 13. Dezember 13

EXPLORING SERVICE DESIGN DIVE STRETCH JUMP AND WIN!! Freitag, 13. Dezember 13 EXPLORING SERVICE DESIGN DIVE STRETCH JUMP AND WIN!! SERVICE DESIGN DEFINITION Use Design Thinking and Design Methods for creating services that are USEFUL, USEABLE, DESIRABLE & VALUABLE AND DIFFERENT.

Mehr

Präsentation Cluster 4 Experimental Therapy & Drug Resistance

Präsentation Cluster 4 Experimental Therapy & Drug Resistance Präsentation Cluster 4 Experimental Therapy & Drug Resistance CCC Netzwerktreffen am 16. Jänner 2014 Coordination: R. Mader & W. Berger W. Berger Kurzportrait Cluster 4: Ziele, Mission Hauptziel: Entwicklung

Mehr

technische universität dortmund Fakultät Bio- & Chemieingenieurwesen Mechanische Verfahrenstechnik

technische universität dortmund Fakultät Bio- & Chemieingenieurwesen Mechanische Verfahrenstechnik , thermal equilibrium and the measurement of dust resistivity D. Pieloth, P.Walzel PiKo Workshop MPI for Polymer Research / 30th September 2011 Fakultät Bio- & Chemieingenieurwesen Mechanische Verfahrenstechnik

Mehr

New X-ray optics for biomedical diagnostics

New X-ray optics for biomedical diagnostics New X-ray optics for biomedical diagnostics Franz Pfeiffer, Julia Herzen Technical University Munich, Physics-Department, Chair for Biomedical Physics (E17) Jürgen Mohr, Johannes Kenntner Karlsruhe Institute

Mehr

A central repository for gridded data in the MeteoSwiss Data Warehouse

A central repository for gridded data in the MeteoSwiss Data Warehouse A central repository for gridded data in the MeteoSwiss Data Warehouse, Zürich M2: Data Rescue management, quality and homogenization September 16th, 2010 Data Coordination, MeteoSwiss 1 Agenda Short introduction

Mehr

European Qualification Strategies in Information and Communications Technology (ICT)

European Qualification Strategies in Information and Communications Technology (ICT) European Qualification Strategies in Information and Communications Technology (ICT) Towards a European (reference) ICT Skills and Qualification Framework Results and Recommendations from the Leornardo-da-Vinci-II

Mehr

HIR Method & Tools for Fit Gap analysis

HIR Method & Tools for Fit Gap analysis HIR Method & Tools for Fit Gap analysis Based on a Powermax APML example 1 Base for all: The Processes HIR-Method for Template Checks, Fit Gap-Analysis, Change-, Quality- & Risk- Management etc. Main processes

Mehr

Quality Management is Ongoing Social Innovation Hans-Werner Franz

Quality Management is Ongoing Social Innovation Hans-Werner Franz Quality Management is Ongoing Social Innovation Hans-Werner Franz ICICI Conference, Prague 1-2 October 2009 What I am going to tell you social innovation the EFQM Excellence model the development of quality

Mehr

Possible Contributions to Subtask B Quality Procedure

Possible Contributions to Subtask B Quality Procedure Possible Contributions to Subtask B Quality Procedure aeteba - Energy Systems, Germany Elmar Sporer zafh.net Stuttgart, Germany Dr. Dirk Pietruschka 1/14 aeteba - Consortium of different companies - Turnkey

Mehr

Support Technologies based on Bi-Modal Network Analysis. H. Ulrich Hoppe. Virtuelles Arbeiten und Lernen in projektartigen Netzwerken

Support Technologies based on Bi-Modal Network Analysis. H. Ulrich Hoppe. Virtuelles Arbeiten und Lernen in projektartigen Netzwerken Support Technologies based on Bi-Modal Network Analysis H. Agenda 1. Network analysis short introduction 2. Supporting the development of virtual organizations 3. Supporting the development of compentences

Mehr

Milenia Hybridetect. Detection of DNA and Protein

Milenia Hybridetect. Detection of DNA and Protein Milenia Hybridetect Detection of DNA and Protein Firmenprofil und Produkte Milenia Biotec GmbH ist im Jahr 2000 gegründet worden. Die Firma entwickelt, produziert, vermarktet und verkauft diagnostische

Mehr

Chemical heat storage using Na-leach

Chemical heat storage using Na-leach Hilfe2 Materials Science & Technology Chemical heat storage using Na-leach Robert Weber Empa, Material Science and Technology Building Technologies Laboratory CH 8600 Dübendorf Folie 1 Hilfe2 Diese Folie

Mehr

Model-based Development of Hybrid-specific ECU Software for a Hybrid Vehicle with Compressed- Natural-Gas Engine

Model-based Development of Hybrid-specific ECU Software for a Hybrid Vehicle with Compressed- Natural-Gas Engine Model-based Development of Hybrid-specific ECU Software for a Hybrid Vehicle with Compressed- Natural-Gas Engine 5. Braunschweiger Symposium 20./21. Februar 2008 Dipl.-Ing. T. Mauk Dr. phil. nat. D. Kraft

Mehr

Aspekte der Energieeffizienz beim Einsatz von Nanotechnologien

Aspekte der Energieeffizienz beim Einsatz von Nanotechnologien BmU Treffen Nanokommission 20. 2. 2008, Berlin Aspekte der Energieeffizienz beim Einsatz von Nanotechnologien Dr. Karl-Heinz Haas Sprecher des Fraunhofer- Verbundes Nanotechnologie 97082 Würzburg haas@isc.fhg.de

Mehr

Smart Import for supplier projects

Smart Import for supplier projects Release July 2014 Smart Import for supplier Wizard for receiving supplier in the versiondog system Tool for automated import, versioning and Check-In of files edited externally Enhanced user New-look overview

Mehr

Role of CXCR4 and Gab1 in the development of muscle precursor cells

Role of CXCR4 and Gab1 in the development of muscle precursor cells Role of CXCR4 and Gab1 in the development of muscle precursor cells Dissertation zur Erlangung des akademischen Grades des Doktors der Naturwissenschaften (Dr. rer. nat.) eingereicht im Fachbereich Biologie,

Mehr

Highlights versiondog 3.1

Highlights versiondog 3.1 Highlights versiondog 3.1 Release June 2014 Smart Import for supplier Wizard for receiving supplier in the versiondog system Tool for automated import, versioning and Check-In of files edited externally

Mehr

Integration of a CO 2 separation process in a coal fired power plant

Integration of a CO 2 separation process in a coal fired power plant Integration of a CO 2 separation process in a coal fired power plant, Hans Fahlenkamp, Bernhard Epp Technische Universität Dortmund *AiF 15234 N: CO 2 Druckgaswäsche mit Membrankontaktoren Forschungsstellen:

Mehr

nanoximet (Oxidant generating capacity as a metric to allow grouping of nanomaterials and prediction of human health effects)

nanoximet (Oxidant generating capacity as a metric to allow grouping of nanomaterials and prediction of human health effects) nanoximet Oxidantien-Bildungspotential als Maß für die Gruppierung von Nanomaterialien und Voraussage von gesundheitlichen Auswirkungen auf den Menschen (Oxidant generating capacity as a metric to allow

Mehr

Software development with continuous integration

Software development with continuous integration Software development with continuous integration (FESG/MPIfR) ettl@fs.wettzell.de (FESG) neidhardt@fs.wettzell.de 1 A critical view on scientific software Tendency to become complex and unstructured Highly

Mehr

glass made for the sun

glass made for the sun glass made for the sun AR-coated 2 mm thin solar glass for Glass-Glass-PV-Modules structure Share Products 51% 50,01% 49,99% company facts Start float glass production in Sept. 2009 Capacity float line

Mehr

Eingebettete Taktübertragung auf Speicherbussen

Eingebettete Taktübertragung auf Speicherbussen Eingebettete Taktübertragung auf Speicherbussen Johannes Reichart Workshop Hochgeschwindigkeitsschnittstellen Stuttgart, 07.11.2008 Unterstützt durch: Qimonda AG, München Institut für Prof. Elektrische

Mehr

Franke & Bornberg award AachenMünchener private annuity insurance schemes top grades

Franke & Bornberg award AachenMünchener private annuity insurance schemes top grades Franke & Bornberg award private annuity insurance schemes top grades Press Release, December 22, 2009 WUNSCHPOLICE STRATEGIE No. 1 gets best possible grade FFF ( Excellent ) WUNSCHPOLICE conventional annuity

Mehr

Solar Air Conditioning -

Solar Air Conditioning - Bavarian Center of Applied Energy Research Solar Air Conditioning - Research and Development Activities at the ZAE Bayern Astrid Hublitz ZAE Bayern, Munich, Germany Division: Technology for Energy Systems

Mehr

Hazards and measures against hazards by implementation of safe pneumatic circuits

Hazards and measures against hazards by implementation of safe pneumatic circuits Application of EN ISO 13849-1 in electro-pneumatic control systems Hazards and measures against hazards by implementation of safe pneumatic circuits These examples of switching circuits are offered free

Mehr

AS Path-Prepending in the Internet And Its Impact on Routing Decisions

AS Path-Prepending in the Internet And Its Impact on Routing Decisions (SEP) Its Impact on Routing Decisions Zhi Qi ytqz@mytum.de Advisor: Wolfgang Mühlbauer Lehrstuhl für Netzwerkarchitekturen Background Motivation BGP -> core routing protocol BGP relies on policy routing

Mehr

Publikationsliste: J. Falduti, F. Gudermann, J. Uhlenküken (2004) On-line IgG Quantification for Bioprocessing Genetic Engineering News 24 (19): 46 47

Publikationsliste: J. Falduti, F. Gudermann, J. Uhlenküken (2004) On-line IgG Quantification for Bioprocessing Genetic Engineering News 24 (19): 46 47 Publikationsliste: F. Gudermann (2006) Instrumentation and Concepts for Automated Cell Culture Analysis Vortrag zum Amgen BioProcessors Symposium on High Throughput Biopharmaceutical Development, Los Angeles,

Mehr

Prof. Dr. Margit Scholl, Mr. RD Guldner Mr. Coskun, Mr. Yigitbas. Mr. Niemczik, Mr. Koppatz (SuDiLe GbR)

Prof. Dr. Margit Scholl, Mr. RD Guldner Mr. Coskun, Mr. Yigitbas. Mr. Niemczik, Mr. Koppatz (SuDiLe GbR) Prof. Dr. Margit Scholl, Mr. RD Guldner Mr. Coskun, Mr. Yigitbas in cooperation with Mr. Niemczik, Mr. Koppatz (SuDiLe GbR) Our idea: Fachbereich Wirtschaft, Verwaltung und Recht Simple strategies of lifelong

Mehr

DISS. ETH NO. 20201 BONE REMODELING IN THE VICINITY OF IMPALNT SURFACES. A dissertation submitted to ETH ZURICH. for the degree of. Doctor of Sciences

DISS. ETH NO. 20201 BONE REMODELING IN THE VICINITY OF IMPALNT SURFACES. A dissertation submitted to ETH ZURICH. for the degree of. Doctor of Sciences DISS. ETH NO. 20201 BONE REMODELING IN THE VICINITY OF IMPALNT SURFACES A dissertation submitted to ETH ZURICH for the degree of Doctor of Sciences presented by THOMAS JOHANNES PETER HEFTI Dipl. Werkstoffing.

Mehr

Einführung: Präparationsmethoden für zuverlässige Größenmessungen mit AFM und TSEM

Einführung: Präparationsmethoden für zuverlässige Größenmessungen mit AFM und TSEM Einführung: Präparationsmethoden für zuverlässige Größenmessungen mit AFM und TSEM PD Dr.-Ing. habil. Michael Stintz DIN-Workshop Präparationsmethoden für zuverlässige Größenmessungen mit AFM und TSEM

Mehr

Nanomaterialien. Chancen, Risiken, Freisetzung Perspektiven. Thomas A. J. Kuhlbusch. Institut für Energieund Umwelttechnik e.v.

Nanomaterialien. Chancen, Risiken, Freisetzung Perspektiven. Thomas A. J. Kuhlbusch. Institut für Energieund Umwelttechnik e.v. Nanomaterialien Lagerung Produkt Chancen, Risiken, Freisetzung Perspektiven Freisetzung Arbeiter Produktion Lab./nd. Freisetzung Transport Freisetzung Thomas A. J. Kuhlbusch Transport/Diffusion? Transformation/Abbau?

Mehr

From a Qualification Project to the Foundation of a Logistics Network Thuringia. Logistik Netzwerk Thüringen e.v.

From a Qualification Project to the Foundation of a Logistics Network Thuringia. Logistik Netzwerk Thüringen e.v. From a Qualification Project to the Foundation of a Logistics Network Thuringia Strengthening the role of Logistics through Corporate Competence Development a pilot project by Bildungswerk der Thüringer

Mehr

Numerical Modelling of CO 2 Storage in Geological Formations with MUFTE-UG

Numerical Modelling of CO 2 Storage in Geological Formations with MUFTE-UG Numerical Modelling of CO 2 Storage in Geological Formations with MUFTE-UG Anozie Ebigbo, Andreas Kopp, Holger Class, Rainer Helmig Wednesday, 14th March 2007 Outline Motivation Physical/mathematical and

Mehr

Presentation of a diagnostic tool for hybrid and module testing

Presentation of a diagnostic tool for hybrid and module testing Presentation of a diagnostic tool for hybrid and module testing RWTH Aachen III. Physikalisches Institut B M.Axer, F.Beißel, C.Camps, V.Commichau, G.Flügge, K.Hangarter, J.Mnich, P.Schorn, R.Schulte, W.

Mehr

NIALM for Smart Buildings LoReMA Load Recognition Monitoring and Acting

NIALM for Smart Buildings LoReMA Load Recognition Monitoring and Acting NIALM for Smart Buildings LoReMA Load Recognition Monitoring and Acting 1st International Workshop on Non-Intrusive Load Monitoring Carnegie Mellon University, Pittsburgh, PA May 7th, 2012 Stephan Tomek

Mehr

Realtime Security for Enterprise Networks based upon the Correlation of Metadata

Realtime Security for Enterprise Networks based upon the Correlation of Metadata Realtime Security for Enterprise Networks based upon the Correlation of Metadata Josef von Helden (University of Applied Sciences and Arts, Hanover) 15.06.2011, München Introduction 2011/06/15 ESUKOM 2

Mehr

Meteorological measurements at the Offshore Platform FINO 2 - new insights -

Meteorological measurements at the Offshore Platform FINO 2 - new insights - FINO 2011 Conference May 11 th 2011, Hamburg, Germany Meteorological measurements at the Offshore Platform FINO 2 - new insights - Dipl.-Geoök. Stefan Müller, Dipl.-Ing Joachim Schwabe Content 1. FINO

Mehr

Aktuelles zu Neuartigen Therapien (ATMPs)

Aktuelles zu Neuartigen Therapien (ATMPs) Aktuelles zu Neuartigen Therapien (ATMPs) I. Reischl, PhD Institut Überwachung AGES/MEA Traisengasse 5, 1200 Wien Österreichische Agentur für Gesundheit und Ernährungssicherheit GmbH Themen Klassifizierung

Mehr

PRO SCAN WASSERANALYSE PER SMARTPHONE WATER ANALYSIS BY SMARTPHONE ANALYSE DE L EAU PAR SMARTPHONE

PRO SCAN WASSERANALYSE PER SMARTPHONE WATER ANALYSIS BY SMARTPHONE ANALYSE DE L EAU PAR SMARTPHONE N02 WASSERANALYSE PER SMARTPHONE WATER ANALYSIS BY SMARTPHONE ANALYSE DE L EAU PAR SMARTPHONE NO 2 NO 3 ph Cl 2 CO 2 ANALYSE DIAGNOSE LÖSUNG ANALYSIS DIAGNOSIS SOLUTION THE NEW GENERATION ph KH GH N03

Mehr

slides alcohol prk.wmv

slides alcohol prk.wmv Pain and functioning post Alcohol PRK vs. -PRK: A prospective Intra-individual Comparison Toam Katz, Gisbert Richard, S. J. Linke Subjektive Entwicklung der Schmerzsymptomatik und Funktion nach Alcohol

Mehr

TPI NEXT applied for medical. AQSF Fachgruppe Medizintechnik

TPI NEXT applied for medical. AQSF Fachgruppe Medizintechnik TPI NEXT applied for medical AQSF Fachgruppe Medizintechnik About b-quality 2 Ziele und Anforderungen von Testprozessen Testprozesse (sollen) - Fehler finden - Schwachstellen aufdecken Anforderungen an

Mehr

GIS-based Mapping Tool for Urban Energy Demand

GIS-based Mapping Tool for Urban Energy Demand GIS-based Mapping Tool for Urban Energy Demand Building Services, Mechanical and Building Industry Days Conference Johannes Dorfner Debrecen, 14 October 2011 Outline 1. Motivation 2. Method 3. Result 4.

Mehr

FLOXCOM - WP 7 Modelling and Optimisation of Wall Cooling - Wall Temperature and Stress Analysis

FLOXCOM - WP 7 Modelling and Optimisation of Wall Cooling - Wall Temperature and Stress Analysis FLOXCOM - WP 7 Modelling and Optimisation of Wall Cooling - Wall Temperature and Stress Analysis B&B-AGEMA Dr.-Ing. K. Kusterer 1. Status report 2. 3-D simulation of final combustor geometry 3. Publications

Mehr

Zusammenfassung, Aussenwirkung und Nutzen. Assessment

Zusammenfassung, Aussenwirkung und Nutzen. Assessment Zusammenfassung, Aussenwirkung und Nutzen der Ergebnisse für das Risk Assessment Berlin 2009 2 www.nanopartikel.info www.nanotox.de www.nano-tracer.de Berlin 2009 3 www.nanopartikel.info Berlin 2009 4

Mehr

Bedarfsadäquater Robotereinsatz in stationären Pflegeeinrichtungen

Bedarfsadäquater Robotereinsatz in stationären Pflegeeinrichtungen Bedarfsadäquater Robotereinsatz in stationären Pflegeeinrichtungen IMEW Institut Mensch, Ethik und Wissenschaft ggmbh Technikgestaltung - Die Perspektive Behinderung im Kontext der Innovations- und Technikentwicklung

Mehr

Organic plant breeding: EU legal framework and legislative challenges Öko-Pflanzenzüchtung: EUrechtlicher. Herausforderungen.

Organic plant breeding: EU legal framework and legislative challenges Öko-Pflanzenzüchtung: EUrechtlicher. Herausforderungen. Organic plant breeding: EU legal framework and legislative challenges Öko-Pflanzenzüchtung: EUrechtlicher Rahmen und Herausforderungen Antje Kölling IFOAM EU Policy Manager EkoSeedForum 20-22 March 2014

Mehr

In situ SEM as a tool for investigating micro and nanoscale processes in materials research

In situ SEM as a tool for investigating micro and nanoscale processes in materials research In situ SEM as a tool for investigating micro and nanoscale processes in materials research Reiner Mönig Institut for Materials Research II Electrical Mechanical Heating Electrochemical Experiments Projektbüro

Mehr

Von$Siebel$zu$Fusion$als$evolu0onärer$Weg$$$$$$$$$$$$$$$$$$$$$$$ Alexander$Doubek$ Senior$Manager$ $

Von$Siebel$zu$Fusion$als$evolu0onärer$Weg$$$$$$$$$$$$$$$$$$$$$$$ Alexander$Doubek$ Senior$Manager$ $ Von$Siebel$zu$Fusion$als$evolu0onärer$Weg$$$$$$$$$$$$$$$$$$$$$$$ Alexander$Doubek$ Senior$Manager$ $ Riverland$at$a$glance$ Partner for High Quality System Integrations Commited to deliver premium business

Mehr

DEMMIN. Durable Environmental Multidisciplinary Monitoring Information Network

DEMMIN. Durable Environmental Multidisciplinary Monitoring Information Network DEMMIN Durable Environmental Multidisciplinary Monitoring Information Network German Aerospace Center (DLR) German Remote Sensing Data Center (DFD) Department of Ground Segment (BN) Folie 1 Neustrelitz

Mehr

Risk-Managements for Installation, Maintenance and Reprocessing of Medical Devices

Risk-Managements for Installation, Maintenance and Reprocessing of Medical Devices Risk-Managements for Installation, Maintenance and Reprocessing of Medical Devices Laws, Guidelines and Standards Medizinproduktegesetz (MPG) Medizinprodukte-Betreiberverordnung (MBetreibV) Sicherheitsplanverordnung

Mehr

new possibilities for the worldwide market

new possibilities for the worldwide market new possibilities for the worldwide market GIS for everyday life EMEA 2008-10- 28-30 London und Geoinformation 1 Modeling our world Objects to be modeled Formats LOD Clearing: Platform & Tools Interaction

Mehr

SARA 1. Project Meeting

SARA 1. Project Meeting SARA 1. Project Meeting Energy Concepts, BMS and Monitoring Integration of Simulation Assisted Control Systems for Innovative Energy Devices Prof. Dr. Ursula Eicker Dr. Jürgen Schumacher Dirk Pietruschka,

Mehr

Context-adaptation based on Ontologies and Spreading Activation

Context-adaptation based on Ontologies and Spreading Activation -1- Context-adaptation based on Ontologies and Spreading Activation ABIS 2007, Halle, 24.09.07 {hussein,westheide,ziegler}@interactivesystems.info -2- Context Adaptation in Spreadr Pubs near my location

Mehr

Studienkomitee A2 Transformers. Martin A. Stössl Siemens AG Österreich Transformers Weiz

Studienkomitee A2 Transformers. Martin A. Stössl Siemens AG Österreich Transformers Weiz Studienkomitee A2 Transformers Martin A. Stössl Siemens AG Österreich Transformers Weiz A2 Working Groups - Themenschwerpunkte 1. Zuverlässigkeit A2.37 Tx reliability survey A2.40 Copper sulphide long-term

Mehr

Symbio system requirements. Version 5.1

Symbio system requirements. Version 5.1 Symbio system requirements Version 5.1 From: January 2016 2016 Ploetz + Zeller GmbH Symbio system requirements 2 Content 1 Symbio Web... 3 1.1 Overview... 3 1.1.1 Single server installation... 3 1.1.2

Mehr

UV-MASTER. Härtung von Foliendekoroberflächen mit UV-Strahlung UV-Curing of film decorated mold parts (IMD/IML)

UV-MASTER. Härtung von Foliendekoroberflächen mit UV-Strahlung UV-Curing of film decorated mold parts (IMD/IML) UV-MASTER Härtung von Foliendekoroberflächen mit UV-Strahlung UV-Curing of film decorated mold parts (IMD/IML) OBERFLÄCHEN-REINIGUNGS-SYSTEME SURFACE-CLEANING-SYSTEMS UV-MASTER UV-HÄRTUNG von Design-Folien

Mehr

Medizinische Klinik II Medizinische Klinik IV

Medizinische Klinik II Medizinische Klinik IV CAMPUS GROSSHADERN CAMPUS INNENSTADT LOREM IPSUM SETUR ALARME Medizinische Klinik II Medizinische Klinik IV Effect of Mipomersen on LDL-Cholesterol levels in Patients with Severe LDL-Hypercholesterolemia

Mehr

Eliminating waste in software projects: Effective knowledge management by using web based collaboration technology Diplom.de

Eliminating waste in software projects: Effective knowledge management by using web based collaboration technology Diplom.de Frederik Dahlke Eliminating waste in software projects: Effective knowledge management by using web based collaboration technology The enterprise 2.0 concept applied to lean software development Diplom.de

Mehr

Concepts and Strategies for personalized telemedical Biofeedback-Therapies

Concepts and Strategies for personalized telemedical Biofeedback-Therapies Concepts and Strategies for personalized telemedical Biofeedback-Therapies Med-e-Tel 18.04.07 in Luxembourg Telemetric Personal Health Monitoring Platform for medical sensors and devices Combination of

Mehr

Potential der Nanotechnologien in der Pharma Industrie. Andreas Schreiner, Novartis

Potential der Nanotechnologien in der Pharma Industrie. Andreas Schreiner, Novartis Potential der Nanotechnologien in der Pharma Industrie Andreas Schreiner, Novartis Hightech Zentrum Aargau Brugg, 21. November 2016 Disclaimer This presentation is based on publicly available information;

Mehr

PACKAGING FOR LIFE MULTIFLEX TUBEN MULTIFLEX TUBES

PACKAGING FOR LIFE MULTIFLEX TUBEN MULTIFLEX TUBES PACKAGING FOR LIFE MULTIFLEX TUBEN MULTIFLEX TUBES Decor-Layer Barrier-Layer Function-Layer LINHARDT MULTIFLEX TUBE SCHICHT FÜR SCHICHT EIN MULTITALENT. Das Neue: Der Tubenmantel aus einem mehrschichtigen

Mehr

Challenges for the future between extern and intern evaluation

Challenges for the future between extern and intern evaluation Evaluation of schools in switzerland Challenges for the future between extern and intern evaluation Michael Frais Schulentwicklung in the Kanton Zürich between internal evaluation and external evaluation

Mehr

Customer-specific software for autonomous driving and driver assistance (ADAS)

Customer-specific software for autonomous driving and driver assistance (ADAS) This press release is approved for publication. Press Release Chemnitz, February 6 th, 2014 Customer-specific software for autonomous driving and driver assistance (ADAS) With the new product line Baselabs

Mehr

Prediction Market, 28th July 2012 Information and Instructions. Prognosemärkte Lehrstuhl für Betriebswirtschaftslehre insbes.

Prediction Market, 28th July 2012 Information and Instructions. Prognosemärkte Lehrstuhl für Betriebswirtschaftslehre insbes. Prediction Market, 28th July 2012 Information and Instructions S. 1 Welcome, and thanks for your participation Sensational prices are waiting for you 1000 Euro in amazon vouchers: The winner has the chance

Mehr

CMMI, BOOTSTRAP, SPICE, AutomotiveSPICE... was wollen die wirklich? - Werkzeuge richtig eingesetzt! Bernd.Hindel@methodpark.de

CMMI, BOOTSTRAP, SPICE, AutomotiveSPICE... was wollen die wirklich? - Werkzeuge richtig eingesetzt! Bernd.Hindel@methodpark.de CMMI, BOOTSTRAP, SPICE, AutomotiveSPICE... was wollen die wirklich? - Werkzeuge richtig eingesetzt! Bernd.Hindel@methodpark.de Agenda Ausgangssituation und Problem Nachweis der Lernenden Organisation Ausblick

Mehr

Nano und Umwelt. Harald F. Krug Empa. Materials Science and Technology. Bundesrat EDI. ETH-Rat. und Überblick. Einführung. Empa.

Nano und Umwelt. Harald F. Krug Empa. Materials Science and Technology. Bundesrat EDI. ETH-Rat. und Überblick. Einführung. Empa. Nano und Umwelt Einführung und Überblick Harald F. Krug Empa Empa Materials Science and Technology ETH Bereich Bundesrat EDI ETH-Rat ETH Zurich EPF Lausanne Forschungsinstitute PSI EMPA WSL EAWAG Materials

Mehr

Scenario Building Workshop - Interplay of problem framings

Scenario Building Workshop - Interplay of problem framings Transdiciplinary Conference Inter- and Transdisciplinary Problem Framing, ETH Zürich, 27-28 November 2008 Scenario Building Workshop - Interplay of problem framings PD Dr. Rolf Meyer*, Dr. Martin Knapp*,

Mehr

Which data and when?

Which data and when? PRO-data for market access in Germany where and when? Frank-Ulrich Fricke PRO-data for market access in Germany where and when? AMNOG the German assessment Which data and when? Requirements to be met Seite

Mehr

a new line of steam sterilizers

a new line of steam sterilizers a new line of steam sterilizers ticheeasy to use and high consumption savings multifunction display controlled by micro-processor double and patented motor-operated closure stainless steel chamber without

Mehr

New observation strategies with e-control

New observation strategies with e-control New observation strategies with e-control (FESG) neidhardt@fs.wettzell.de Martin Ettl (FESG), Helge Rottmann (MPIfR), Christian Plötz (BKG), Matthias Mühlbauer (BKG), Hayo Hase (BKG), Walter Alef (MPIfR),

Mehr

From HiL to Test Vehicle:

From HiL to Test Vehicle: From HiL to Test Vehicle: Reuse of test cases with same test automation Agenda: Trailer Presentation Agenda: Movie about Tool Questions After presentation Live Demo Vehicle Meeting point: ETAS Stand 1642

Mehr

Pilot area B: Zeeland (B + NL) Pilot area C: Terschelling and Northern Fryslan (NL) Pilot area D: Borkum (D)

Pilot area B: Zeeland (B + NL) Pilot area C: Terschelling and Northern Fryslan (NL) Pilot area D: Borkum (D) Pilot area A: Belgische Middenkust, (B) Pilot area B: Zeeland (B + NL) Pilot area C: Terschelling and Northern Fryslan (NL) Pilot area D: Borkum (D) Pilot area E: Schleswig and Sdr. Jylland (D + DK) Pilot

Mehr

Design-to-Target: Optimierte Innovationsvorhaben im Oberflächenbereich.! Your specialist for surface modifications and characterization!

Design-to-Target: Optimierte Innovationsvorhaben im Oberflächenbereich.! Your specialist for surface modifications and characterization! Design-to-Target: Optimierte Innovationsvorhaben im Oberflächenbereich.! Your specialist for surface modifications and characterization! Agenda! Vorstellung Referenten! Vorstellung SuSoS und Xirrus! Innovationsvorhaben!

Mehr

EXPERT SURVEY OF THE NEWS MEDIA

EXPERT SURVEY OF THE NEWS MEDIA EXPERT SURVEY OF THE NEWS MEDIA THE SHORENSTEIN CENTER ON THE PRESS, POLITICS & PUBLIC POLICY JOHN F. KENNEDY SCHOOL OF GOVERNMENT, HARVARD UNIVERSITY, CAMBRIDGE, MA 0238 PIPPA_NORRIS@HARVARD.EDU. FAX:

Mehr

INTERREG IIIa Project R&D - Ready for Research and Development Project results and ongoing activities

INTERREG IIIa Project R&D - Ready for Research and Development Project results and ongoing activities INTERREG IIIa Project R&D - Ready for Research and Development Project results and ongoing activities Györ, 5th December 2007 Key regions + perifary for surveys Background objectives CENTROPE needs a strategy

Mehr

Biologische Funktion von Organometallverbindungen

Biologische Funktion von Organometallverbindungen FOR 630 Treffen in Berlin Eggersdorf 30. Mai bis 1. Juni 2007 Biologische Funktion von Organometallverbindungen Programm Mittwoch 30.05. 2007 14:00 Begrüßung (Prof. Dr. R. Gust, Prof. Dr. N. Metzler-Nolte)

Mehr

Steca Electronics Services and products for an ecological future. 13th of June 2012 Christian Becker

Steca Electronics Services and products for an ecological future. 13th of June 2012 Christian Becker Steca Electronics Services and products for an ecological future. 13th of June 2012 Christian Becker Brief overview over the company 2 This is Steca The philosophy of Steca Steca has long stood for ideas

Mehr

1.9 Dynamic loading: τ ty : torsion yield stress (torsion) τ sy : shear yield stress (shear) In the last lectures only static loadings are considered

1.9 Dynamic loading: τ ty : torsion yield stress (torsion) τ sy : shear yield stress (shear) In the last lectures only static loadings are considered 1.9 Dynaic loading: In the last lectures only static loadings are considered A static loading is: or the load does not change the load change per tie N Unit is 10 /sec 2 Load case Ι: static load (case

Mehr

TRL 3-5 in Horizont 2020: Research & Innovation Actions; FET Anforderungen für Antragsteller in NRW und erfolgreiche Ansätze Begutachtungskriterien

TRL 3-5 in Horizont 2020: Research & Innovation Actions; FET Anforderungen für Antragsteller in NRW und erfolgreiche Ansätze Begutachtungskriterien TRL 3-5 in Horizont 2020: Research & Innovation Actions; FET Anforderungen für Antragsteller in NRW und erfolgreiche Ansätze Begutachtungskriterien Thomas Görgen, Liv Adler, 21. Mai 2015 Agenda Bayer Begutachtungsprozess

Mehr

Rheinische Friedrich-Wilhelms-Universität Bonn Institut für Biochemie und Molekularbiologie

Rheinische Friedrich-Wilhelms-Universität Bonn Institut für Biochemie und Molekularbiologie Rheinische Friedrich-Wilhelms-Universität Bonn Institut für Biochemie und Molekularbiologie Adresse Nußallee 11 53115 Bonn Deutschland Telefon +49 228 73-2412 Telefax +49 228 73-2416 E-Mail sekretariat@ibmb.uni-bonn.de

Mehr

KTI Project: LIDT and Degradation Testing for Industrial Applications

KTI Project: LIDT and Degradation Testing for Industrial Applications KTI Project: LIDT and Degradation Testing for Industrial Applications Total Investment: Industry: Personel Misc./Equipment Research: Personel 1.713 MCHF 989 kchf 330 kchf 649 kchf 734 kchf CSEM EMPA University

Mehr

ZEW-Workshop Financing Entrepreneurship and Innovation in Science-based Industries. Recent Developments in the German Venture Capital Market

ZEW-Workshop Financing Entrepreneurship and Innovation in Science-based Industries. Recent Developments in the German Venture Capital Market ZEW-Workshop Financing Entrepreneurship and Innovation in Science-based Industries Recent Developments in the German January 22, 1999 Dr. Matthias Bank Universität Erlangen-Nürnberg Lehrstuhl für Bank-

Mehr