58. Biometrisches Kolloquium

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1 58. Biometrisches Kolloquium March 13 15, 2012, Berlin, Germany Abstracts of Talks and Posters Editors: Frederike Fuhlbrück Program Committee: Ronja Foraita, Katja Ickstadt, Bernd-Wolfgang Igl, Oliver Kuß, Tina Müller, Stephanie Roll, Joachim Spilke, Richardus Vonk

2 Program Analytische Modelle in der Medizin, Wednesday, March 14, 2:00pm 3:30pm, Haus Bauwesen, lecture hall H1, room D101, 1 st floor Bayessche Verfahren 1, Thursday, March 15, 9:00am 10:30am, Haus Bauwesen, lecture hall H2, room D102, 1 st floor Bayessche Verfahren 2, Thursday, March 15, 11:00am 12:30pm, Haus Bauwesen, lecture hall H2, room D102, 1 st floor Bioinformatik 1, Tuesday, March 13, 2:00pm 3:30pm, Haus Bauwesen, lecture hall H1, room D101, 1 st floor Bioinformatik 2, Tuesday, March 13, 4:00pm 5:30pm, Haus Bauwesen, lecture hall H1, room D101, 1 st floor Clinical Trial Statistics and Beyond: From a Statistician to a Drug Developer, Wednesday, March 14, 11:00am 12:30pm, Haus Grashof, Beuth Saal, room C16, ground floor Cloud Computing, Wednesday, March 14, 11:00am 12:30pm, 58. Biometrisches Kolloquium, March 13 15, 2012, Berlin III

3 Haus Bauwesen, lecture hall H2, room D102, 1 st floor Confounder Kontrolle in Beobachtungsstudien, Tuesday, March 13, 2:00pm 3:30pm, Haus Bauwesen, lecture hall H2, room D102, 1 st floor Didaktik, Tuesday, March 13, 4:00pm 5:30pm, Haus Bauwesen, lecture hall H2, room D102, 1 st floor Fallzahlplanung, Thursday, March 15, 9:00am 10:30am, Haus Bauwesen, lecture hall H5, room D136, 1 st floor Gemischte Modelle in Landwirtschaft und Medizin 1, Thursday, March 15, 9:00pm 10:30pm, Haus Bauwesen, lecture hall H1, room D101, 1 st floor Gemischte Modelle in Landwirtschaft und Medizin 2, Thursday, March 15, 11:00am 12:30pm, Haus Bauwesen, lecture hall H1, room D101, 1 st floor Genetische Statistik, Wednesday, March 14, 2:00pm 3:30pm, Haus Bauwesen, lecture hall H2, room D102, 1 st floor Hochdimensionale Globaltests 1, Wednesday, March 14, 9:00am 10:30am, Haus Bauwe- sen, lecture hall H5, room D136, 1 st floor Hochdimensionale Globaltests 2, Wednesday, March 14, 11:00am 12:30pm, Haus Bauwesen, lecture hall H5, room D136, 1 st floor Meta-analysis and non-randomized clinical trials, Thursday, March 15, 11:00am 12:30pm, Haus Grashof, Beuth Saal, room C16, ground floor Nichtklinik 1, Wednesday, March 14, 9:00am 10:30am, IV 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

4 Haus Bauwesen, lecture hall H3, room D117, 1 st floor Nichtklinik 2, Wednesday, March 14, 11:00am 12:30pm, Haus Bauwesen, lecture hall H3, room D117, 1 st floor Nichtparametrische Statistik 1, Tuesday, March 13, 2:00pm 3:30pm, Haus Bauwesen, lecture hall H3, room D117, 1 st floor Nichtparametrische Statistik 2, Tuesday, March 13, 4:00pm 5:30pm, Haus Bauwesen, lecture hall H3, room D117, 1 st floor Non-Inferiority trials and multiple testing, Thursday, March 15, 9:00am 10:30am, Haus Grashof, Beuth Saal, room C16, ground floor Sample size, Tuesday, March 13, 4:00pm 5:30pm, Haus Grashof, Beuth Saal, room C16, ground floor Statistics in Practice 1, Thursday, March 15, 9:00am 10:30am, Haus Bauwesen, lecture hall H3, room D117, 1 st floor Statistics in Practice 2, Thursday, March 15, 11:00am 12:30pm, Haus Bauwesen, lecture hall H3, room D117, 1 st floor Survival 1, Wednesday, March 14, 9:00am 10:30am, Haus Bauwesen, lecture hall H1, room D101, 1 st floor Survival 2, Wednesday, March 14, 11:00am 12:30pm, Haus Bauwesen, lecture hall H1, room D101, 1 st floor Unbiased estimation and clinical relevance in clinical trials, Tuesday, March 13, 2:00pm 3:30pm, 58. Biometrisches Kolloquium, March 13 15, 2012, Berlin V

5 Haus Grashof, Beuth Saal, room C16, ground floor Validierung 1, Tuesday, March 13, 2:00pm 3:30pm, Haus Bauwesen, lecture hall H5, room D136, 1 st floor Validierung 2, Tuesday, March 13, 4:00pm 5:30pm, Haus Bauwesen, lecture hall H5, room D136, 1 st floor Variable Selection and Regularization, Thursday, March 15, 11:00am 12:30pm, Haus Bauwesen, lecture hall H5, room D136, 1 st floor Young Statisticians, March 14, 9:00am 10:30am, Haus Bauwesen, lecture hall H2, room D102, 1 st floor Zusatznutzen gemäss AMNOG, Wednesday, March 14, 9:00am 10:30pm, Haus Grashof, Beuth Saal, room C16, ground floor VI 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

6 Contents Program III Part I Abstracts for talks Modelling the Mean and Covariance Structure for Continuous Bounded Longitudinal Data Mouna Akacha Counteracting Bias when Analysing Rare Binary Outcome: Experiences from Prospective Cohort Studies of Pregnancy Arthur Allignol, Reinhard Meister Education for Statistics in Practice Per Kragh Andersen Analysis of survival data with the Cox model, and beyond Per Kragh Andersen Elastic SCAD as a novel penalization method for SVM classification and feature selection tasks in high-dimensional data Natalia Becker, Axel Benner Anwendung von Hotelling s T 2 -Statistik zum Vergleich von zwei diagnostischen Tests in Meta-Analysen. Lars Beckmann, Wiebke Sieben, Ralf Bender Biometrisches Kolloquium, March 13 15, 2012, Berlin VII

7 Zwei-Phasen Designs zur Berücksichtigung zusätzlicher Confounder-Information in pharmakoepidemiologischen Datenbankstudien Sigrid Behr, Walter Schill, Iris Pigeot Einfluss von Netzwerkgröße und Inkonsistenz auf die Ergebnisse von Netzwerk Meta-Analysen Ralf Bender, Sibylle Sturtz Predictive biomarkers: Treatment-by-marker interaction in high-dimensional data Wiebke Werft, Martina Fischer, Axel Benner Application of Microarray Analysis on Computer Cluster and Cloud Platforms Christoph Bernau Choice of non-inferiority margin: Current practices and their impact on the risk to accept inferior treatments Primrose Beryl Gladstone, Werner Vach Model-Based Recursive Partitioning in Cox s Proportional Hazards Model with Adjustment for Measurement Error Hanna Birke Validating statistical algorithms on high performance computing clusters Methods Bernd Bischl, Michel Lang, Olaf Mersmann, Jörg Rahnenführer, Claus Weihs Weakly informative priors for pharmaceutical dose-response trials Björn Bornkamp Added predictive value of high-throughput molecular data to clinical data, and its validation Anne-Laure Boulesteix, Willi Sauerbrei High- and Low-Dimensional Global Tests for Repeated Measures Edgar Brunner, David Ellenberger Framing a problem Carl-Fredrik Burman VIII 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

8 Stochastic modeling, simulation and statistical analysis of drug interactions in combination therapies for chronic hepatitis C Tje Lin Chung, Eva Herrmann Cell Lines, Chemotherapy Response, and the Need for Reproducible Research Kevin R. Coombes, Keith A. Baggerly The wild bootstrap for the Aalen-Johansen estimator of the cumulative incidence function of a competing risk Susanna Di Termini, Jan Beyersmann, Markus Pauly Inferring Effects of Dynamic Treatments from Observational Data Vanessa Didelez A DISCUSSION OF ESTIMATORS OF THE ODDS RATIO Christiana Drake, Travis Loux Bayesian nonparametric learning from high-dimensional data David Dunson Konzept und Erfahrungen des Deutschen Krebsforschungszentrums in der Planung von Tierversuchen im Regierungsbezirk Karlsruhe Lutz Edler, Tim Holland-Letz, Annette Kopp-Schneider Spatial P-splines and Mixed Models in Agricultural Trials Paul Eilers, Fred van Eeuwijk High- and Low-Dimensional Repeated Measures: Improved Approximations David Ellenberger Evaluation of sample size adaptation rules in clinical studies aiming at an overall performance optimization Stefan Englert, Meinhard Kieser Reproducible Computational Research: A Perspective Manuel Eugster Biometrisches Kolloquium, March 13 15, 2012, Berlin IX

9 Unsicherheit: Herausforderungen bei der Kommunikation von gesundheitlichen Risiken an den aktuellen Beispielen Dioxin, EHEC und Antibiotika Suzan Fiack Blinded continuous monitoring of nuisance parameters in clinical trials Tim Friede, Frank Miller Joint Bayesian Inference of Condition Specific mirna and Transcription Factor Activities from Combined Gene and microrna Expression Data Benedikt Zacher, Khalid Abnaof, Stephan Gade, Erfan Younesi, Achim Tresch, Holger Fröhlich Explicit calculation of the mean summary statistic s joint null distribution in a toy case gene set test Mathias Fuchs A Bivariate Cumulative Probit Model for the Analysis of Neuronal Data Julia Furche, Thomas Kneib, Jutta Kretzberg Graph based fusion of mirna and mrna expression data Stephan Gade, Christine Porzelius, Maria Fälth, Jan C. Brase, Daniela Wuttig, Ruprecht Kuner, Harald Binder, Holger Sültmann, Tim Beißbarth 37 Ein Plädoyer für kontrollierte nicht-randomisierte Studien Wilhelm Gaus, Muche Rainer Statistische Herleitung einer Responder-Definition für die Reduktion von Hitzewallungen Statistical derivation of a responder definition for the reduction of hot flushes Christoph Gerlinger, Florian Hiemeyer, Thomas Schmelter Die geplante klinische Studie PREVENT-JIA zur Validierung eines Biomarkers bei Juveniler Idiopathischer Arthritis Bayes-Ansätze zur Nutzung von unterschiedlichem Vorwissen bei der Analyse von Überlebenszeiten Joachim Gerß, Nico Wulffraat, Lucy R. Wedderburn, Nicolino Ruperto, Helmut Wittkowski, Michael Frosch, Dirk Föll X 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

10 Graph based fusion of mirna and mrna expression data Helena Margareta Geys Estimation of treatment effects in adaptive clinical trials Ekkehard Glimm Relaxing the null hypothesis of global tests Jelle Goeman Nachweis statistischer Signifikanz und klinischer Relevanz beim Vergleich von Überlebenszeiten Matthias Gondan, Meinhard Kieser Validierung von Diagnosetests zur Anwendung in Tierpopulationen auch hier das Problem des fehlenden Goldstandards! Matthias Greiner Validierung von Diagnosetests zur Anwendung in Tierpopulationen auch hier das Problem des fehlenden Goldstandards! Sonja Greven, Thomas Kneib Adjusting for Multiple Testing by Using Multivariate Meta-Analysis and Closed Testing Procedures Robert Großelfinger, Ralf Bender Der Einsatz von Prädiktionsintervallen bei Meta-Analysen mit zufälligen Effekten Ulrich Grouven, Ralf Bender, Guido Skipka Statistik für Anwender Die Quadratur des Kreises? Mario Hasler Zusatznutzen: Wie wird das Ausmaß bei der Nutzenbewertung quantifiziert? Dieter Hauschke Bayesian Nowcasting during the EHEC/HUS Outbreak in Germany, 2011 Matthias an der Heiden, Michael Höhle The Evolving Role of Statisticians in Drug Development Guenter Heimann Biometrisches Kolloquium, March 13 15, 2012, Berlin XI

11 Auswertung und Fallzahlberechnung in Dosis-Findungs-Studien mit aktiver Kontrolle Hans-Joachim Helms, Norbert Benda, Tim Friede Lohnt sich der Einsatz von aktivierenden Methoden bei der Biometrieausbildung von Studierenden der Molecular Life Science? Ein randomisierter, kontrollierter Vergleich Claudia Hemmelmann, Andreas Ziegler Segmentation of fluorescence microscopy time series Sabrina Herrmann, Katja Ickstadt, Roland Fried, Martin Schäfer, Peter Verveer, Franziska Thorwirth Evaluating componentwise boosting for SNP data from a clinical cohort study Stefanie Hieke, Axel Benner, Richard F. Schlenk, Martin Schumacher, Lars Bullinger, Harald Binder Log-normal frailty models fitted as Poisson generalized linear mixed models Katharina Hirsch, Andreas Wienke, Oliver Kuß Incubation Period and Back Projection for the EHEC O104:H4 Outbreak in Germany, 2011 Michael Höhle, Maria Wadl Monotonicity-Constrained Regression: An Application to Species Distribution Models Benjamin Hofner Auswahl einer Teststatistik für genetische Assoziation in Fall-Kontroll-Studien Theresa Holste Model selection procedures under order restriction- an alternative to related multiple test procedures? Ludwig Hothorn, Rebecca Kuiper Global testing for complex ordinal data Monika Jelizarow, Ulrich Mansmann XII 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

12 Modeling continuous predictors with a spike at zero: Issues in univariate and multivariable model building with procedures based on fractional polynomials Carolin Jenkner, Eva Lorenz, Heiko Becher, Willi Sauerbrei Global testing on incomplete expression profiles from gel-based proteomics experiments Klaus Jung Survival models with preclustered gene groups as covariates Kai Kammers, Michel Lang, Jan G. Hengstler, Marcus Schmidt, Jörg Rahnenführer Adjusting for selection bias in single-blinded randomized controlled clinical trials Lieven Kennes Überblick und Vergleich von Methoden zur Bewertung der klinischen Relevanz von Studienergebnissen Meinhard Kieser Innovative Methoden und Anwendungen zur Fallzahlplanung für klinische Studien Meinhard Kieser Kosten und Nutzen einer Public Cloud für eine Biometrie- Abteilung, illustriert an einem Permutationsansatz Jochen Knaus Variational Bayes Approximations in Geoadditive Quantile Regression Thomas Kneib, Elisabeth Waldmann Validierung in Genetischen Assoziationsstudien Inke R. König Resampling Verfahren für Konfidenzintervalle Frank Konietschke Welche Tierversuche erfordern welche Fallzahlplanung - empirische Erfahrungen der Fallzahlplanung in Niedersachsen Lothar Kreienbrock, Sergej Kudinov Biometrisches Kolloquium, March 13 15, 2012, Berlin XIII

13 Ein Algorithmus zur Bestimmung der Regressionsfunktion in Modellen mit monotoner Regressionsfunktion und ordinalskalierter abhaengiger Variablen Bertram Krumm Using Random Forests for probability estimation Jochen Kruppa Comparing recruitment strategies by discrete event simulation Hermann Kulmann, Harald Siedentop Haribo macht Dozenten froh und Studenten ebenso Cornelia Ursula Kunz, Geraldine Rauch Validating statistical algorithms on high performance computing clusters Applications Michel Lang, Bernd Bischl, Jörg Rahnenführer Regression modeling of the cumulative incidence function with missing causes of failure using pseudo-observations Aurelien Latouche, Margarita Moreno-Betancur Randomisierte Phase II Studien ohne Vergleich? Christine Lautenschläger, Juliane Parsche, Jakob Leicht, Andreas Wienke 85 Bestimmung des Ausmaßes des Zusatznutzen in der frühen Nutzenbewertung- erste Beispiele Friedhelm Leverkus Eine Methode Zur Charakterisierung von Randomisierungsverfahren Carolin Malsch Simulation of high-dimensional categorical data Ulrich Mansmann, Monika Jelizarow Multivariate Tests of Marginal Effects in General Models and Arbitrary Dimension Florian Markowetz Multivariate Tests of Marginal Effects in General Models and Arbitrary Dimension Reinhard Meister XIV 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

14 Grundbegriffe, Verständnis, Methodenanwendung Wieviel Mathematik braucht eine Biometrie für Nichtbiometriker? Hubert Merkel Information Approximations and Experimental Designs in Nonlinear Mixed Effects Models Tobias Mielke Time-to-Event Data: A Different Angle by Population Evolution Charts And New Statistical Tests Joachim Moecks, Walter Koehler Automated Classification of Cell Populations with Multichannel Flow Cytometry Data Challenges in Mapping a Sparsely Populated Data Space Manuel Nietert, Steve Wagner Efficiency of regularized regression methods for genomic selection Joseph O. Ogutu, Torben Schulz-Streeck, Hans-Peter Piepho Comparing biodiversity by simultaneously testing a user-defined selection of diversity indices Philip Pallmann Resampling methods for paired data Markus Pauly, Frank Konietschke Cloud Computing für die Lebenswissenschaften mit cloudnumbers.com Moritz v. Petersdorff-Campen A hitchhiker s guide to mixed models for randomized experiments Hans-Peter Piepho Fitting bivariate event times with the correlated frailty model Diana Pietzner, Andreas Wienke Modified Huynh-Feldt Correction for Unequal Covariance Matrices Marius Placzek, Edgar Brunner Biometrisches Kolloquium, March 13 15, 2012, Berlin XV

15 Parallel computing at the IMBE Erlangen Infrastructure, Solutions and Applications. Sergej Potapov, Werner Adler Generalization of biomedical results from iterative validation to meta-analysis Jörg Rahnenführer Planning and evaluating clinical trials with composite time-to-first-event endpoints in a competing risk framework Geraldine Rauch, Jan Beyersmann Detection of Single Nucleotide Variations in Proteomic Mass Spectrometry Data Sven Giese, Franziska Zickmann, Bernhard Renard Berücksichtigung von räumlichen Kovarianz-Strukturen in landwirtschaftlichen Feldversuchen Untersuchungen zur Einhaltung des nominalen Fehlers 1. Art und zur Power von t- und F-Test Christel Richter, Bärbel Kroschewski Various Approaches for the Comparison of two Diagnostic Tests Regarding Sensitivity and Specificity Daniela Rieck, Antonia Zapf A unified framework for benchmark dose estimation applied to model averaging and mixed models Christian Ritz, Daniel Gerhard, Ludwig A. Hothorn Stability investigations of multivariable regression models derived from low and high dimensional data Willi Sauerbrei, Anne-Laure Boulesteix, Harald Binder Spatial modelling of Ras protein structures on the cellular membrane Martin Schäfer, Peter Verveer, Katja Ickstadt Group sequential designs for three-arm gold-standard non-inferiority trials Patrick Schlömer, Werner Brannath XVI 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

16 Analytic tools for modelling phenotypic variation in agricultural experiments Sabine Schnabel, Paul Eilers, Fred van Eeuwijk Robustheit verschiedener Ansätze zur verblindeten Fallzahlanpassung für klinische Studien mit Zähldaten Simon Schneider, Heinz Schmidli, Tim Friede A modelling strategy to analyse 1-year survival in a cohort of patients with severe cutaneous adverse reactions (SCARs) Peggy Sekula, Martin Schumacher, Maja Mockenhaupt Modellwahl, Bias und Coverage in der bivariaten Meta-Analyse Wiebke Sieben, Lars Beckmann, Ralf Bender Sparse Principal Component Analysis using Stability Selection Martin Sill, Axel Benner Quantitative assessment of interactions between biologically active agents Sven Stanzel, Helene Bayer Tests and sample size calculations for non-inferiority trials with Poisson distributed count data Kathrin Stucke, Meinhard Kieser Hidden Markov Models for the modeling of branching processes: Analysis of single cell fluorescence microscopic time lapse movies Achim Tresch, Henrik Failmezger Correlated infections: quantifying individual heterogeneity in the spread of infectious diseases Steffen Unkel, C. Paddy Farrington, Heather J. Whitaker, Richard Pebody125 The (little) need for and the (large) impact of post hoc application of formal criteria to check clinical relevance in well conducted RCTs Werner Vach, Primrose Beryl Gladstone Multivariable fraktionelle Polynome für korrelierte abhängige Variablen unter der Verwendung von verallgemeinerten Schätzgleichungen Maren Vens, Jördis Stolpmann, Claudia Hemmelmann, Andreas Ziegler Biometrisches Kolloquium, March 13 15, 2012, Berlin XVII

17 bamdit: an R package for Bayesian Meta-Analysis of Diagnostic Test Data Pablo Emilio Verde, Arnold Sykosch Bewertung von Evidenz nach GRADE in der frühen Nutzenbewertung von Medizinprodukten Reinhard Vonthein, Andreas Ziegler Bayesian estimation of a disease transmission model based on ordinary differential equations: Rotavirus in Germany Felix Weidemann, Manuel Dehnert, Judith Koch, Michael Höhle Genetic additive and dominance effects on bovine milk metabolites Dörte Wittenburg, Nina Melzer, Dirk Repsilber, Norbert Reinsch Multiple time scales in modelling the incidence of hospital infections Martin Wolkewitz, Ben Cooper, Adrian Barnett, Susanna Di Termini, Francisco Alvarez-Lerma, Pedro Olaechea, Mercedes Palomar, Martin Schumacher The problem of zero inflated datasets: Comparing test procedures within an application in parasitology Ramona Zeimet, Inga Ruddat, Lothar Kreienbrock Integration of (epi-)genomic and gene expression data in Bayesian variable selection models: investigating the influence of model setup and priors Manuela Zucknick, Stefan Pfister, Axel Benner Part II Abstracts for posters Mapping of dynamic expression QTL Marit Ackermann, Weronika Sikora-Wohlfeld, Andreas Beyer Using Mutual Information and Answer Set Programming to refine Acidithiobacillus ferrooxidans whole genome transcriptional regulation network Andrés Aravena, Carito Guziolowski, Anne Siegel, Alejandro Maass XVIII 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

18 Ein Zweistichprobentest für Split-Plot-Designs mit zufällig fehlenden Werten bei unbekannten Kovarianzmatrizen Benjamin Becker Orthogonal regression an alternative method to ordinary least squares Manfred Berres, Ruth Volland, Irene Beck, Andreas Monsch Mantel-Haenszel Estimation for a General Risk Ratio Dankmar Böhning Identification of gene-based biosignatures for radiation biodosimetry Sonja Boldt, Katja Knops, Ralf Kriehuber, Olaf Wolkenhauer Die Performance von Regression Calibration und SIMEX in einer Ereigniszeitanalyse mit Messfehlern in den Kovariablen unter einem komplexen Fehlermodell Dirk Enders, Walter Schill Efficient computation of ridge-regression BLUP in genomic selection in plant breeding Boubacar Estaghvirou, Hans-Peter Piepho, Joseph O. Ogutu, Torben Schulz-Streeck, Frank Technow Bayesian Analysis of FRAP-Images with Mixed-Effect Priors Martina C. Feilke, Volker J. Schmid Network Analysis with Nonparametric Bayesian Networks Yessica Fermin, Jakob Wieczorek, Katja Ickstadt Display of missing values Surveillance of A(H1N1) vaccination in pregnancy Frederike Fuhlbrück, Simon Rucker, Anna Geinets, Natalja Senkov, Steven Kunde, Lan Wascher, Arthur Allignol, Reinhard Meister Display of complete datasets Surveillance of A(H1N1) vaccination in pregnancy Frederike Fuhlbrück, Simon Rucker, Anna Geinets, Natalja Senkov, Steven Kunde, Lan Wascher, Arthur Allignol, Reinhard Meister Biometrisches Kolloquium, March 13 15, 2012, Berlin XIX

19 Statistische Analysemethoden für linkszensierte Variablen mit Anwendung auf Simulations- und Messdaten Katarzyna Gawrych, Anne Lotz, Benjamin Kendzia, Tobias Weiß, Thomas Brüning, Beate Pesch A nonparametric test for weak stochastic dominance Matthias Gondan, André Scherag A modified partial least squares approach Hayan Hasan A new approach towards simulation of the Rule of Ten for a Cox Regression Pascal Miosga, Tje Lin Chung, Hanns Ackermann, Eva Herrmann, Werner Helm A new statistical strategy to analyze circadian body temperature rhythms in a "hot flush" animal model Bernd-Wolfgang Igl, Dorothee Girbig, Sandra Hischke, Karsten Keller, Katja Prelle, Vladimir Patchev, Richardus Vonk Schätzen der Varianzinflation im Andersen-Gill-Modell Katharina Ingel, Antje Jahn-Eimermacher Refinement of Genetic Associations using Genotype Imputation with Data from 1000 Genomes Project M Kabisch, T Dünnebier, F Melchior, B Pesch, T Brüning, S Rabstein, Y Ko, C Baisch, H-P Fischer, C Justenhoven, H Brauch, V Harth, U Hamann, J Lorenzo Bermejo Comparison of count models regarding their ability to capture the relationship between genomic instability and methylation in human hepatocellular carcinoma Miriam Kesselmeier, Thomas Longerich, Robert Geffers, Justo Lorenzo Bermejo Binary regression: The measures of total gain in positive and negative predictive value in evaluating the usefulness of a risk prediction model Jens Klotsche, Ina Liedmann, Marina Niewerth, Kirsten Minden XX 58. Biometrisches Kolloquium, March 13 14, 2012, Berlin

20 Improvement of a Bayesian model: Combining results from adult and pediatric clinical trials for planning and analyzing a new pediatric trial. Raphael Koch, Joachim Gerß, Wolfgang Köpcke, Andreas Faldum Penalized unimodal spline regression Claudia Köllmann, Björn Bornkamp, Roland Fried, Katja Ickstadt Finding relevant metabolites by Partial Least Squares (PLS) analysis Konrad Neumann, Robert Pieper Comparison of Methods for Treatment Selection in Seamless Phase II/III Trials Incorporating Information on Short-term Endpoints Cornelia Ursula Kunz, Tim Friede, Nicholas Parsons, Susan Todd, Nigel Stallard Schätzung von sekundären Endpunkten in mehrstufigen Phase-II-Studien in der Onkologie Cornelia Ursula Kunz, Meinhard Kieser Analytical dose-response functions for univariate and bivariate distribution classes and application of a modified fractional polynomial procedure. Eva Lorenz, Carolin Jenkner, Willi Sauerbrei, Heiko Becher Die Cluster-Delta-Methode zur Ersetzung fehlender Werte in klinischen Verlaufsstudien Benjamin Mayer, Lisa Hegele Non-parametric two-sample tests: tuning of raw data before ranking Joachim Moecks Efficiency of augmented p-rep designs Jens Möhring, Hans-Peter Piepho Taking advantage of genotype imputation to detect the association between known risk variants and disease subphenotypes in dilated cardiomyopathy Barbara Peil, Benjamin Meder, Monika Stoll, Hugo A. Katus, Justo Lorenzo Bermejo Biometrisches Kolloquium, March 13 15, 2012, Berlin XXI

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