Universitätsklinikum Freiburg Department Innere Medizin Klinik für Innere Medizin II - Gastroenterologie, Hepatologie, Endokrinologie u Infektiologie

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1 Universitätsklinikum Freiburg Department Innere Medizin Klinik für Innere Medizin II - Gastroenterologie, Hepatologie, Endokrinologie u Infektiologie Address Hugstetter Straße Freiburg Deutschland Telephone Fax birke.bausch@uniklinik-freiburg.de Website Homepage Projects Research Grants OX40-mediated immune regulation in viral hepatitis and hepatocellular carcinoma (Applicant Böttler, Tobias ) Gentransfer in Gram-positiven Bakterien: Untersuchungen der Mechanismen am Beispiel eines mobilisierbaren Streptokokkenplasmids mit breitem Wirtbereich (pmv158) (Applicant Grohmann, Elisabeth )

2 Cytokin vermittelte Mechanismen zur Kontrolle der hepadnaviralen Replikation (Applicant Schultz, Ursula ) Chaperon-Abhängigkeit der Hepatitis B Virus Replikation Biochemische Charakterisierung der Interaktion zwischen Reverser Transkriptase (P-Protein) und RNA-Verpackungssignal aviärer Hepatitis-B-Viren CD4+ T cell failure in chronic HCV infection (Applicant Semmo, Nasser ) Transgenes Mausmodell mit ß-Zell-spezifischer Überexpression des Proteins p8 zur Analyse der p8-vermittelten Expansion, Protektion und Regeneration differenzierter ß-Zellen des endokrinen Pankreas in vivo (Applicant Päth, Günter ) Gerok Stelle, Innere Medizin, Gastroenterologie (Applicant Blum, Hubert E. ) Protein-Protein-Interaktionen im Hepatitis C Virus Replikationskomplex: Bedeutung für die Virusreplikation und antivirale Strategien (Applicant Brass, Volker ) Hochauflösende Protein-Strukturanalyse durch Elektronen-Kryomikroskopie von chimären Hepatitis B Virus Corepartikeln Hochauflösende Protein-Strukturanalyse durch Elektronen-Kryomikroskopie von chimären Hepatitis B Virus Corepartikeln (Applicant Böttcher, Bettina ) Hepatitis C Virus-induzierbare Zellinien: Charakterisierung viraler Genprodukte und Interaktionen mit zellulären Funktionen (Applicant Moradpour, Darius ) Analysis of alpha-fetoprotein immune responses in patient with hepatocellular carcinoma (Applicant Geißler, Michael ) Structural dynamics of the nucleocapsid of hepatitis B viruses

3 Bedeutung der TRAIL (tumor necrosis factor-related apoptosis inducing ligand)-induzierten Apoptose für die Ausheilung der Hepatitis C Virusinfektion (Applicant Fischer, Richard ) Vector-targeting CLP-vaccines against tick-transmitted infections (Applicant Nassal, Michael ; Simon, Markus Michael ; Wallich, Reinhard ) Infection Biology and Epidemiology of Staphylococci and Staphylococcal Diseases in South and Central Afrika (Applicant von Briesen, Hagen ; Herrmann, Mathias ; Kern, Winfried V. ; Mellmann, Alexander ; Peters, Georg ) Environmental dissemination and accumulation of antibiotic pharmazeuticals, pathogens, and resistance determinants as caused by wastewater irrigation (Applicant Grohmann, Elisabeth ; Siemens, Jan ) Priority Programmes Native display of Borrelia antigens on the surface of hepatitis B virus capsids: Improved prophylactic and potential therapeutic vaccines against Lyme disease Independent Junior Research Groups T-cell response to hepatitis B and C (Applicant Thimme, Robert ) Molekulare Voraussetzungen für die Entwicklung immundominanter und protektiver Virus-spezifischer CD8+ T-Zellantworten (Applicant Neumann-Haefelin, Christoph ) Heisenberg Professorships Immunbiologie der Hepatitis B und C Virus-Infektion und des hepatozellulären Karzinoms (Applicant Thimme, Robert )

4 Research Fellowships Beyond checkpoint inhibitors: Natural killer cells limiting antitumor T cell immunity in hepatocellular carcinoma (Applicant Schmidt, Nathalie ) Charakterisierung der IL-10 Antwort bei der akuten und der chonischen LCMV-Infektion in vivo und in vitro und Etablierung einer effizienten antiviralen Therapie basierend auf der IL-10 Rezeptorblockade (Applicant Böttler, Tobias ) Identification and validation of human genes that modulate HCV replication using a whole-genome small interfering RNA (sirna) library (Applicant Jilg, Nikolaus ) Research Units Cellular DNA repair in cccdna formation during hepatitits B virus infection - addressing functionally redundant repair pathways Immunopathogenesis of hepatitis B virus and hepatitis C virus infection (Applicant Thimme, Robert ) Protective CD8+ T cell responses and role of viral escape in HBV infection (Applicant Neumann-Haefelin, Christoph ) Teilprojekt MIKRO: Räumliche Verteilung und Aktivität von mikrobiellen Lebensgemeinschaften in urbanen Böden (Applicant Szewzyk, Ulrich ) Einfluss von Mikroorganismen auf die Beschaffenheit urbaner Böden (Applicant Szewzyk, Ulrich ) Impact of HBV-HCV coinfection on virus-specific cytotoxic T-cell responses and viral persistence (Applicant Brass, Volker )

5 Collaborative Research Centres Impaired virus-specific CD8+ T cells contribute to liver pathology in hepatitis B and hepatitis C virus infection (Project leader Thimme, Robert ) HLA-B*27 in hepatitis C: at the cross-roads between viral control and immunopathology (Project leader Neumann-Haefelin, Christoph ) Alpha-Fetoprotein spezifische Immuntherapie des hepatozellulären Karzinoms (Project leader Blum, Hubert E. ; Geißler, Michael ; Mohr, Leonhard ) Identification and functional analysis of regulatory T cells during chronic HCV infection (Project leader Thimme, Robert ) CRC/Transregios Mechanisms of antiviral therapy-induced virus-specific CD8+ T cell restoration in chronic viral hepatitis (Project leader Hofmann, Maike ; Thimme, Robert ) Viral escape from dominant virus-specific CD8+ T cell responses in hepatitis B virus (HBV) mono-infection and HBV/hepatitis D virus co-infection and strategies to restore antiviral CD8+ T cell response (Project leader Neumann-Haefelin, Christoph ) Characterization of follicular T helper cell responses in viral hepatitis (Project leader Böttler, Tobias ) Unravelling the role of DNA repair in the formation of the hepatitis B virus cccdna persistence reservoir (Project leader Nassal, Michael ; Schreiner, Sabrina ) Immune monitoring and Bioinformatics (Project leader Bauer, Tanja ; Eils, Roland ; Neumann-Haefelin, Christoph ; Schiemann, Matthias ) Major Research Instrumentation Durchflusszytometer mit 5 Lasern

6 Clinical Trials Covered transjugular intrahepatic portosystemic stent shunt versus optimezed medical treatment for the secondary prevention of variceal bleeding in cirrhosis (Applicant Sauerbruch, Tilman ) Research Training Groups GRK 300: Pathogenic Microorganisms: Molecular Mechanisms and Genomic Approaches (Spokesperson Clayton, Christine Elizabeth ) Graduate Schools GSC 4: Molecular Cell Research in Biology and Medicine (MOBILMED) (Spokesperson Borner, Christoph ) GEPRIS is a project of the Deutsche Forschungsgemeinschaft (DFG) Contact GEPRIS at (c) Deutsche Forschungsgemeinschaft (