PUBLIKATIONSVERZEICHNIS

Transkript

1 PUBLIKATIONSVERZEICHNIS Priv.-Doz. Dr. med. Rainer Freynhagen, D.E.A.A. Stand: Juli

2 Originalarbeiten referenziert mit IF: Tesfaye S, Wilhelm S, Lledo A, Schacht A, Tölle T, Bouhassira D, Cruccu G, Skljarevski V, Freynhagen R. Duloxetine and pregabalin: High-dose monotherapy or their combination? The "COMBO-DN study" - a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain. Pain May 31. doi:pii: S (13) IF 6,03 Freynhagen R, Geisslinger G, Schug SA. Opioids for chronic non-cancer pain. BMJ May 29; 346:f2937. doi: /bmj.f2937 IF 14,09 Treede RD, Wagner T, Kern KU, Husstedt IW, Arendt G, Birklein F, Cegla T, Freynhagen R, Gockel HH, Heskamp ML, Jager H, Joppich R, Maier C, Leffler A, Nagelein HH, Rolke R, Seddigh S, Sommer C, Stander S, Wasner G, Baron R. Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. Curr Med Res Opin May;29(5): Epub 2013 Mar 21. IF 2.38 Timmerman H, Wolff AP, Schreyer T, Outermans J, Evers AW, Freynhagen R, Wilder-Smith OH, van Zundert J, Vissers KC. Cross-Cultural Adaptation to the Dutch Language of the PainDETECT-Questionnaire. Pain Pract Jul 9. IF 2.21 Koy A, Freynhagen R, Mayatepek E, Tibussek D. Hereditary Sensory and Autonomic Neuropathy With Autonomic Crises: A Turkish Variant of Familial Dysautonomia? J Child Neurol Feb;27(2): IF 1.67 Jana Koroschetz, Stefanie E Rehm, Ulrich Gockel, Mathias Brosz, Rainer Freynhagen, Thomas R Tölle and Ralf Baron. Fibromyalgia and neuropathic pain - differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia. BMC Neurology, 2011 May 25;11:55. IF

3 Friederike Mahn, Phillip Hüllemann, Ulrich Gockel, Mathias Brosz, Rainer Freynhagen, Thomas R. Tölle, Ralf Baron. What makes painful radiculopathy different from other painful neuropathies? A comparison of sensory symptom profiles and co-morbidities. PLoS ONE May 9;6(5):e IF 4.35 Bettina Pollok, Vanessa Krause, Valery Legrain, Markus Ploner, Rainer Freynhagen, Ilka Melchior, Alfons Schnitzler. Differential Effects of Painful and Non-Painful Stimulation on Tactile Processing in Fibromyalgia Syndrome and Subjects with Masochistic Behaviour. PLoS ONE Dec 28;5(12) IF 4.35 Rehm S, Koroschetz J, Gockel U, Brosz M, Freynhagen R, Tölle TR, Baron R. A cross sectional survey in 3035 patients with fibromyalgia: Subgroups of patients with typical co-morbidities and sensory symptom profiles (2010). Rheumatology 2010 Jun;49(6): IF 4,136 Lötsch J, Freynhagen R, von Hentig N, Griessinger N, Zimmermann M, Sittl R, Geisslinger G. Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care. Inflamm Res May 20. [Epub ahead of print] IF 1,457 Baron R, Freynhagen R, Tölle TR, Cloutier C, Leon T, Murphy TK, Phillips K; The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy. Pain May 19. [Epub ahead of print] IF 6,03 Schmidtko A, Lötsch J, Freynhagen R, Geisslinger G. Ziconotide for treatment of severe chronic pain. Lancet May 1;375(9725): IF 28,41 Ziegler D, Hidvégi T, Gurieva I, Bongardt S, Freynhagen R, Sen D, Sommerville K; Efficacy and Safety of Lacosamide in Painful Diabetic Neuropathy. (2010). Diabetes Care 2010 Apr;33(4): IF 7,851 3

4 Doehring A, Freynhagen R, Griessinger N, Zimmermann M, Sittl R, Hentig N, Geisslinger G, Lötsch J. Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care. Clin J Pain Nov-Dec;25(9):781-5 IF 2,889 Baron R, Tölle TR, Gockel U, Brosz M, Freynhagen R. A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms. Pain 2009 Nov;146(1-2):34-40 IF 6,03 Schmidt CO, Schweikert B, Wenig CM, Schmidt U, Gockel U, Freynhagen R, Tölle TR, Baron R, Kohlmann T. Modelling the prevalence and cost of back pain with neuropathic components in the general population. Eur J Pain Nov;13(10): IF 3,80 Freynhagen R, Bennett MI. Diagnosis and management of neuropathic pain. BMJ Aug 12;339 ff. IF 12,87 Muth-Selbach U, Hermanns HU, Stegmann J, Kollosche K, Freynhagen R, Bauer I, Lipfert P. Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system. Eur J Pharmacol Jun 24;613(1-3): Epub 2009 Apr 24. IF 2,787 Lötsch J, von Hentig N, Freynhagen R, Griessinger N, Zimmermann M, Doehring A, Rohrbacher M, Sittl R, Geisslinger G. Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers. Pharmacogenet Genomics Jun;19(6): IF 4,409 4

5 Freynhagen R, Baron R. The evaluation of neuropathic components in low back pain. Curr Pain Headache Rep Jun;13(3): IF 3,52 Muth-Selbach U., Hermanns H., Driehsen C., Lipfert P., Freynhagen R. Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats. Brain Res Bull Apr 6;79(1):63-8. IF 1,95 Freynhagen R., Rolke, R., Baron R., Tölle T.R., Rutjes AK, Schu S., Treede RD. Letter to the Editor of Pain: author reply to the letter by Schiltenwolf and Akbar Pain Sep 15;138(3): IF 4,84 Junker, U.*, Freynhagen, R.*, Längler K, Gockel U, Schmidt U, Tölle TR, Baron R, Kohlmann T. *authors contributed equally Paper versus electronic rating scales for pain assessment: a prospective, randomised, cross-over validation study with 200 chronic pain patients Curr Med Res Opin Jun;24(6): IF 3,06 Freynhagen R., Rolke, R., Baron R., Tölle T.R., Rutjes AK, Schu S., Treede RD. Letter to the Editor of Pain: author reply to the letter "Cheese and Chalk? Missing the real anatomy" by Breck McKay. Pain May 14. [Epub ahead of print] IF 4,84 Freynhagen R., Rolke, R., Baron R., Tölle T.R., Rutjes AK, Schu S., Treede RD. Letter to the Editor of Pain: author reply on Pseudoradicular and radicular low-back pain - a disease continuum rather than different entities? Pain Apr;135(3):312-3; IF 4,84 Freynhagen R., Rolke, R., Baron R., Tölle T.R., Rutjes AK, Schu S., Treede RD. Pseudoradicular and radicular low-back pain - A disease continuum rather than different entities? Answers from quantitative sensory testing. Pain Mar;135(1-2): IF 4,84 5

6 Tölle T.R.T., Freynhagen R., Versavel M., Trostmann U., Young J. A randomized, double-blind, placebo-controlled study evaluating twicedaily dosing of pregabalin for relief of neuropathic pain associated with diabetic peripheral neuropathy. Eur J Pain Feb;12(2): IF 3,33 Freynhagen R, Grond S, Schüpfer G, Hagebeuker A, Schmelz M, Ziegler D, von Giesen HJ, Junker U, Wagner KJ, Konrad C. Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine. Int J Clin Pract Dec;61(12): IF 1,188 Boehm, O., Zur, B., Koch, A., Tran, N., Freynhagen, R., Hartmann, M., Zacharowski, K. Clinical Chemistry Reference Values in Wistar rats and C57/BL6 mice. Biological Chemistry 2007 May, Vol. 388, pp IF 2,6 Stevens, M., Hermanns, H., Freynhagen, R., Novotny, G., Lipfert, P. Regeneration of baroafferents after implantation into different vessels. Journal of the Peripheral Nervous System 2007 Mar;12(1):40-9 IF 1,7 Bennet, MI, Attal, N, Backonja, MM, Baron, R, Bouhassira, D, Freynhagen, R, Scholz, J, Tölle, TR, Wittchen, HU, Jensen, TS. Using screening tools to identify neuropathic pain. PAIN 2007 Feb;127(3): IF 4,84 Werdehausen, R., Braun, S., Hermanns, H., Freynhagen, R., Lipfert, P., Stevens, M.F. Uniform Distribution of Skin Temperature Increase Following Different Regional Anesthesia Techniques of the Lower Extremity. Reg Anesth Pain Med Jan-Feb;32(1):73-8. IF 2,6 Koch, A., Zacharowski, K., Böhm, O., Stevens, M., Lipfert, P., von Giesen, H-J., Wolf, A., Freynhagen, R. NO and pro-inflammatory cytokines in correlation with pain intensity of chronic pain patients. IF 1,21 Inflammation Research 2007 Jan;56(1):32-7. IF 1,46 6

7 Jetzek-Zader, M., Hermanns, H., Freynhagen, R., Lipfert, P., Stevens, M.F. Increase in skin temperature after spinal anesthesia in infants Reg Anesth Pain Med 2006; Nov-Dec;31(6): IF 2,6 Sprenger T., Valet M., Woltmann R., Zimmer C., Freynhagen R., Kochs E., Tölle T., Wagner K. Imaging pain modulation by subanaesthetic S-(+)-ketamine Anaesthesia & Analgesia 2006; Sep;103(3): IF 2,18 Freynhagen R., Baron R., Gockel U., Tölle T.R.T. paindetect: a new screening questionnaire to identify neuropathic components in patients with back pain Curr Med Res Opin 2006; Vol. 22, No. 10, IF 2,92 Lötsch, J., Dudziak, R., Freynhagen, R., Marschner, J., Geisslinger, G. Fatal postoperative morphine intoxication due to delayed onset of respiratory depression after morphine injections. Clinical Pharmacokinetics 2006; 45 (11): IF 5,2 Freynhagen R, Busche P, Konrad C, Balkenohl M. Wirksamkeit und Wirkungsbeginn von Pregabalin bei Patienten mit neuropathischen Schmerzen. [Effectiveness and time to onset of pregabalin in patients with neuropathic pain]. Der Schmerz, 2006; Aug; 20(4): IF 1,8 R. Freynhagen, J. Vogt, P. Lipfert, U. Muth-Selbach Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats. Brain Research Bulletin 2006; Mar 31;69(2): IF 2,43 Freynhagen R., Baron R., Tölle T.R.T, Stemmler E., Gockel U., Stevens MF., Maier C. Screening on neuropathic pain components in patients with chronic back pain: prospective observational pilot study (MIPORT). Curr Med Res Opin 2006; Mar;22(3): IF 2,92 Freynhagen, R., von Giesen, H-J., Busche, P., Sabatowski, R., Konrad, C., Grond,S. Switch from Reservoir to Matrix Systems for Transdermal Fentanyl: A Prospective, Multicenter Study in Chronic Pain Outpatients. Journal of Pain and Symptom Management 2005; Sep;30(3): IF 2,19 7

8 Freynhagen, R., Strojek, K Griesing T., Whalen, E., Balkenohl; M. Efficacy of pregabalin in neuropathic pain evaluated with a novel study design: a 12- week, randomized, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens of pregabalin. Pain 2005;115, IF 4,06 R. Freynhagen, U. Muth-Selbach, P. Lipfert, M. F. Stevens, K. Zacharowski, T. R. Tölle, H-J. von Giesen. The effect of mirtazapine in patients with chronic pain and concomitant depression. Curr Med Res Opin 2005;22(2): IF 2,96 Übersichten, Kasuistiken Neuropathischer Schmerz, auch eine neurologische Erkrankung?! Nervenheilkunde. 2012; 31(3) gelistet in Current Contents, SciSearch, Neuroscience Citation Index, EMBASE, Scopus R, Wirz S, Rolke R., Freynhagen R. Diagnosis of neuropathic pain Ther Umsch Sep;68(9): Review. gelistet in Medline, EMBASE und Scopus Junker, U., Freynhagen, R. Palliativmedizin: Hochdifferenzierte Opioidtherapie Deutsches Ärzteblatt 2008; 105, Heft 8, Steiger, H-J., Horstmann, G., Freynhagen, R. Therapiemöglichkeiten der Trigeminusneuralgie- Fokus chirurgische Verfahren [Current treatment modalities for trigeminal neuralgia- focus surgical intervention] Deutsches Ärzteblatt, 2007, 104, Heft 39,

9 Rehm,S., Koroschetz, J., Freynhagen, R., Baron, R. Pathophysiologie des neuropathischen Schmerzes- Optimale Behandlungsstrategien anhand der pathophysiologischen Mechanismen. Klinikarzt 2007; 36 (5): Beck, L., Janßen, G., Freynhagen, R., Göbel, U. Palliativmedizin: Betreuung, Schmerztherapie und Symptomkontrolle [Palliative medicine: Care, pain therapy and symptom monitoring] Gynäkologe, 2006, 39(6): Freynhagen, R., Junker U.: Chamäleon Neuropathischer Schmerz. [Neuropathic pain] MMW Fortschr Med. 2005; Mai 5;147(18):40-2. Freynhagen R., Tölle T, Gockel U et al. Pain Detect- ein Palmtop-basiertes Verfahren für Versorgungsforschung, Qualitätsmanagement und Screening bei chronischen Schmerzen. Akt Neurol, 2005, 32:273 Freynhagen, R., Busche, P. Schmerz-State of the Art. PharmaFokus ZNS, 2005, 2:18 Freynhagen, R. Mixed-Pain als neue Rationale: Pie in the Sky or Pie on the Plate? Psychoneuro 2005, 31 (2): Freynhagen, R. Nervenschmerzen. Von der Theorie zur Therapie. MedReport 2004, 13:28,1-2 Junker U., Baron R., Freynhagen, R. Chronische Schmerzen: Das mixed pain concept als neue Rationale. Deutsches Ärzteblatt, 2004; 101:20, Freynhagen, R., Zenz, M., Strumpf, M. WHO Stufe II- Klinische Realität oder didaktisches Instrument? [WHO Step II- clinical reality or a didactic instrument?] Schmerz, 1994, Aug;8:

10 Monographien, Buchbeiträge Standl, Schulte am Esch et al. (Herausgeber). Freynhagen, R. Verfasser des Kapitels 12.5.; Schmerzambulanz. Schmerztherapie. Georg Thieme Verlag 2. Auflage, 2010 ISBN Schenk, Michael, Rieger Achim (Herausgeber). Multimodale Tumorschmerztherapie. Freynhagen, R. Verfasser der Kapitel und Uni-Med Verlag. Bremen London Boston, 1. Auflage 2008; ISBN Junker, U., Schmitz, A., Busche P., Freynhagen, R. Schmerz- und Symptomtherapie bei Tumorpatienten [Pain and Symptom Management in Cancer Patients] Klinische Onkologie 2007/2008, S. 1-10, Hrsg: Roth, S.L. et al. Bueno, L., Fink, K., Freynhagen, R. et al for the Pregabalin Review Group. Pregabalin. Pharmacotherapy Monographs, Volume 2. Marius Press, 2007; ISBN-10: ISBN-13: Freynhagen R., Baron, R. Kompendium Neuropathischer Schmerz. Ein praxisorientierter Leitfaden. Aesopus Verlag, 2. Auflage 2005; ISBN Bueno, L., Fink, K., Freynhagen, R. et al for the Pregabalin Review Group. Pregabalin. Pharmacotherapy Monographs, Volume 2. Marius Press, 2007 ISBN-10: ISBN-13:

11 Akzeptierte wissenschaftliche Poster (nur 2012/2013) THE PAIN ASSESSMENT FOR LOWER BACK IMPACTS (PAL-I): QUALITATIVE DEVELOPMENT AND COGNITIVE EVALUATION OF A NEW PATIENT REPORTED OUTCOME INSTRUMENT FOR THE ASSESSMENT OF IMPACTS OF LOW BACK PAIN Abhilasha Ramasamy, Forest Research Institute, Jersey City, NJ, USA Steven I. Blum, Forest Research Institute, Jersey City, NJ, USA Kelly P. McCarrier, Health Research Associates, Mountlake Terrace, WA, USA Manjari Quintanar-Solares, Health Research Associates, Mountlake Terrace, WA, USA Don M. Bushnell, Health Research Associates, Mountlake Terrace, WA, USA Hiltrud Liedgens, Grunenthal GmbH, Aachen, Germany Mona L. Martin, Health Research Associates, Mountlake Terrace, WA, USA Charles Argoff, Albany Medical College, Albany, NY, USA Rainer Freynhagen, Benedictus Krankenhaus Tutzing and Technische Universität München, Germany Donald L. Patrick, University of Washington, Seattle, WA, USA Mark Wallace, UCSD, San Diego, CA, USA QUALITATIVE DEVELOPMENT AND COGNITIVE EVALUATION OF A NEW PATIENT REPORTED OUTCOME INSTRUMENT FOR THE ASSESSMENT OF LOW BACK PAIN Kelly P. McCarrier, Health Research Associates, Mountlake Terrace, WA, USA Mona L. Martin, Health Research Associates, Mountlake Terrace, WA, USA Abhilasha Ramasamy, Forest Research Institute, Jersey City, NJ, USA Manjari Quintanar-Solares, Health Research Associates, Mountlake Terrace, WA, USA Don M. Bushnell, Health Research Associates, Mountlake Terrace, WA, USA Hiltrud Liedgens, Grunenthal GmbH, Aachen, Germany Steven I. Blum, Forest Research Institute, Jersey City, NJ, USA Charles Argoff, Albany Medical College, Albany, NY, USA Rainer Freynhagen, Benedictus Krankenhaus Tutzing and Technische Universität München Germany Donald L. Patrick, University of Washington, Seattle, WA, USA Mark Wallace, UCSD, San Diego, CA, USA Beide akzeptiert für: International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 18th Annual International Meeting, New Orleans, LA, May 18-22, 2013 SPONTANEOUS AND PROBED DISEASE-DEFINING CONCEPTS IDENTIFIED THROUGH CONCEPT ELICITATION INTERVIEWS IN LOW BACK PAIN Kelly P. McCarrier, Health Research Associates, Mountlake Terrace, WA, USA Steven I. Blum, Forest Research Institute, Jersey City, NJ, USA Mona L. Martin, Health Research Associates, Mountlake Terrace, WA, USA Hiltrud Liedgens, Grunenthal GmbH, Aachen, Germany Manjari Quintanar, Health Research Associates, Mountlake Terrace, WA, USA Abhilasha Ramasamy, Forest Research Institute, Jersey City, NJ, USA Charles Argoff, Albany Medical College, Albany, NY, USA Rainer Freynhagen, Benedictus Krankenhaus Tutzing and Technische Universität München Germany 11

12 Donald L. Patrick, University of Washington, Seattle, WA, USA Mark Wallace, UCSD, San Diego, CA, US ASSESSMENT OF THE MOST BOTHERSOME SYMPTOMS AND IMPACTS REPORTED BY PATIENTS WITH LOW BACK PAIN Kelly P. McCarrier, Health Research Associates, Mountlake Terrace, WA, USA Steven I. Blum, Forest Research Institute, Jersey City, NJ, USA Mona L. Martin, Health Research Associates, Mountlake Terrace, WA, USA Hiltrud Liedgens, Grunenthal GmbH, Aachen, Germany Manjari Quintanar, Health Research Associates, Mountlake Terrace, WA, USA Abhilasha Ramasamy, Forest Research Institute, Jersey City, NJ, USA Charles Argoff, Albany Medical College, Albany, NY, USA Rainer Freynhagen, Benedictus Krankenhaus Tutzing and Technische Universität München Germany Donald L. Patrick, University of Washington, Seattle, WA, USA Mark Wallace, UCSD, San Diego, CA, USA Beide akzeptiert für: International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 15th Annual European Congress, Berlin, Germany, Nov 3-7, 2012 NEW INSIGHTS INTO DISEASE-SPECIFIC PATTERNS OF NEUROPATHIC PAIN SYMPTOMS USING THE paindetect-questionnaire (PD-Q) WITH A SIMPLE STANDARDIZATION PROCEDURE T. Keller b, R. Baron a, R. Freynhagen c, U. Gockel d, T. Kohlmann e, E. Stemmler f and T.R. Tölle g a Sektion Neurologische Schmerzforschung und Therapie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany b StatConsult GmbH, Magdeburg, Germany c Zentrum für Anästhesiologie, Intensivmedizin, Schmerztherapie & Palliativmedizin, Benedictus-Krankenhaus, Tutzing, Germany d Grünenthal GmbH, Aachen, Germany e Institute for Community Medicine, Universität Greifswald, Germany f Pfizer Pharma GmbH, Berlin, Germany g Technische Universität München, Klinik für Neurologie, Munich, Germany TEST AND RE-TEST OF THE paindetect-questionnaire (PD-Q) R. Baron a, R. Freynhagen c, U. Gockel d, T. Kohlmann e, T. Keller b, E. Stemmler f and T.R. Tölle g a Sektion Neurologische Schmerzforschung und Therapie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany b StatConsult GmbH, Magdeburg, Germany c Zentrum für Anästhesiologie, Intensivmedizin, Schmerztherapie & Palliativmedizin, Benedictus-Krankenhaus, Tutzing, Germany d Grünenthal GmbH, Aachen, Germany e Institute for Community Medicine, Universität Greifswald, Germany f Pfizer Pharma GmbH, Berlin, Germany g Technische Universität München, Klinik für Neurologie, Munich, Germany 12

13 Beide akzeptiert für: Fourth International Congress on Neuropathic Pain, Meeting of The Special Interest Group on Neuropathic Pain (NeuPSIG) of the International Association for the Study of Pain (IASP). Toronto, Canada, May 23-26,