Originalarbeiten. Faehling M, Hetzel M, Anders D, Trischler G, Bachem M (2012) Lung. Jun;190(3): Epub 2012 Feb 5.

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1 Originalarbeiten Lung volume reduction coil treatment for patients with severe emphysema: a European multicentre trial. Deslee G, Klooster K, Hetzel M, Stanzel F, Kessler R, Marquette CH, Witt C, Blaas S, Gesierich W, Herth FJ, Hetzel J, van Rikxoort EM, Slebos DJ. (2014) Thorax 69(11): Faehling M, Hetzel M, Anders D, Trischler G, Bachem M (2012) Lung. Jun;190(3): Epub 2012 Feb 5. Scagliotti GV, Pastorino U, Vansteenkiste JF, Spaggiari L, Facciolo F, Orlowski TM, Maiorino L, Hetzel M, Leschinger M, Visseren-Grul C, Torri V. Randomized phase III study of surgery alone or surgery plus preoperative cisplatin and gemcitabine in stages IB to IIIA non-small-cell lung cancer. J Clin Oncol Jan 10;30(2): Epub 2011 Nov 28 Rupp A, Blank J, Blattner S, Adzemovic E, Hetzel M. Implementing in-patient smoking cessation interventions. Basic characteristics of smoking patients in a lung health department (2012) Pneumologie. Jan;66(1):14-9. Epub 2011 Nov 10 Hetzel J, Eberhardt R, Herth FJ, Petermann C, Reichle G, Freitag L, Dobbertin I, Franke KJ, Stanzel F, Beyer T, Möller P, Fritz P, Ott G, P A Schnabel, Kastendieck H, Lang W, Morresi-Hauf AT, Szyrach MN, Muche R, Shah PL, Babiak A, Hetzel M. (2012). Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial. Eur Respir J. Mar;39(3): Epub 2011 Aug 18. Hautmann H, Eberhardt R, Heine R, Herth F, Hetzel J, Hetzel M, Reichle G, Schmidt B, Stanzel F, Wagner M. (2011). Recommendations for sedation during flexible bronchoscopy. Pneumologie. Nov;65(11): Epub 2011 Nov 14 Schumann C, Hetzel J, Babiak AJ, Merk T, Wibmer T, Möller P, Lepper PM, Hetzel M. (2010) Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions. J Thorac Cardiovasc Surg 140(2): Epub 2010 Mar 11. Franke KJ, Theegarten D, Hann von Weyhern C, Nilius G, Brueckner C, Hetzel J, Hetzel M, Ruhle KH, Enderle MD, Szyrach MN (2010). Prospective controlled animal study on biopsy sampling with new flexible cryoprobes versus forceps: evaluation of biopsy size, histological quality and bleeding risk. Respiration. 80(2): Epub 2010 Feb 17. Hetzel J, Kumpf M, Hetzel M, Hofbeck M, Baden W (2011). Cryorecanalization of an obstructed bronchial stent in a 12-year-old boy. Respiration 82(3): Epub 2011 Jan 8 Pauls S, Gulkin D, Feuerlein S, Muche R, Krüger S, Schmidt SA, Dharaiya E, Brambs HJ, Hetzel M. (2010). Assessment of COPD severity by computed tomography: correlation with lung functional testing. Clin Imaging. 34(3):172-8.

2 Feuerlein S, Stolz J, Muche R, Hetzel M, Klass O, Brambs HJ, Pauls S. (2010). Cisterna chyli in patients with malignancy-influence of cardiovascular disease on the prevalence of the cisterna. Eur J Radiol Aug; 79(2):262-5.Epub 2010 Mar 12. Rupp A, Neudert M, Hetzel M. (2010). Smoking cessation programmes at hospitals with departments for lung diseases. Dtsch Med Wochenschr. 135(11): Epub 2010 Mar 1. Schumann C*, Hetzel M*, Babiak AJ, Hetzel J*, Merk T, Wibmer T, Lepper PM, Krüger S (2010). Endobronchial tumor debulking with a flexible cryoprobe for immediate treatment of malignant stenosis. J Thorac Cardiovasc Surg 139(4): Epub 2009 Aug 27. * Equal contributership Franke KJ, Szyrach M, Nilius G, Hetzel J, Hetzel M, Ruehle KH, Enderle MD (2009). Experimental study on biopsy sampling using new flexible cryoprobes: influence of activation time, probe size, tissue consistency, and contact pressure of the probe on the size of the biopsy specimen. Lung. 187(4): Epub 2009 Jun 23. Babiak A, Hetzel J, Krishna G, Fritz P, Moeller P, Balli T, Hetzel M. (2009). Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration. 78(2): Epub 2009 Feb 21. Hetzel J, Hetzel M, Hasel C, Moeller P, Babiak A. (2008). Old meets modern: the use of traditional cryoprobes in the age of molecular biology. Respiration. 76(2): Epub 2008 Jun 26. Pauls S, Buck AK, Hohl K, Halter G, Hetzel M, Blumstein NM, Mottaghy FM, Glatting G, Krüger S, Sunder-Plassmann L, Möller P, Hombach V, Brambs HJ, Reske SN (2007). Improved non-invasive T-Staging in non-small cell lung cancer by integrated 18F-FDG PET/CT. Nuklearmedizin. 46(1):9-14. Babiak A, Hetzel J, Godde F, König HH, Pietsch M, Hetzel M. Mitomycin C and Vinorelbine for second-line chemotherapy in NSCLC--a phase II trial. Br J Cancer. 96(7): Epub 2007 Mar 13. Hetzel M, Bachem M, Anders D, Trischler G, Faehling M. (2005) Effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung. 183: Hetzel M, Hetzel J, Schumann C, Marx N, Babiak A (2004) Cryorecanalization: a new approach for the immediate management of acute airway obstruction. J Thorac Cardiovasc Surg 127(5): Hetzel M, Walcher D, Grüb M, Bach H, Hombach V, Marx N (2003) PPARg activators inhibit MMP-9 expression in human bronchial epithelial cells Thorax 58(9): Hetzel M, Kochs M, Marx N, Mobarak I, Woehrle H, Hombach V Hetzel J. (2003) Pulmonary Hemodynamics in Obstructive Sleep Apnea: Frequency and causes of pulmonary hypertension. Lung 181:1-10

3 Hetzel M, Arslandemir C, König HH, Buck AK, Nüssle K, Glatting G, Gabelmann A, Hetzel J, Hombach V, Schirrmeister H. (2003) F-18 NaF PET for detection of bone metastases in lung cancer - Accuracy, cost-effectiveness and impact on patient management. J Bone Miner Res 18(12): Hetzel M, Hetzel J, Arslandemir C, Nuessle K, Schirrmeister H. (2003) Bone scan staging in lung cancer: is the symptom-based indication for skeletal scintigraphy sufficiently reliable? A prospective study. Br Med J 328(7447): Hetzel M, Wieshammer S, Barnikel U, Hetzel J, Herb S, Kochs M, Hombach V. (1994) Effects of antianginal therapy with atenolol and slow-release nifedipine on respiratory gas exchange and on the ventilatory requirements for aerobic exercise. Z Kardiol 8.3 Suppl.3:83-7 Halter G, Buck AK, Schirrmeister H, Wurziger I, Liewald F, Glatting G, Neumaier B, Sunder-Plassmann L, Reske SN, Hetzel M. (2004) [18F] 3-deoxy-3'-fluorothymidine positron emission tomography: alternative or diagnostic adjunct to 2-[18f]-fluoro-2-deoxy-D-glucose positron emission tomography in the workup of suspicious central focal lesions? J Thorac Cardiovasc Surg.127(4): Schirrmeister H, Arslandemir C, Glatting G, Mayer-Steinacker R, Bommer M, Dreinhofer K, Buck A, Hetzel M. (2004) Omission of bone scanning according to staging guidelines leads to futile therapy in non-small cell lung cancer. Eur J Nucl Med Mol Imaging 31(7): Halter G, Buck AK, Schirrmeister H, Liewald F, Sunder-Plassmann L, Reske SN, Hetzel M.(2004) FLT-PET alternative or diagnostic adjunct to FDG-PET in the workup of suspicious central focal lesions? J Surg Thorac Endovasc 127(4): Buck AK, Halter G, Schirrmeister H, Kotzerke J, Wurziger I, Glatting G, Mattfeldt T, Neumaier B, Reske SN, Hetzel M. (2003) Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG. J Nucl Med 44(9): Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp. Wellinghausen N, Kern WV, Haase G, Rozdzinski E, Kern P, Marre R, Essig A, Hetzel J, Hetzel M.(2003) Int J Med Microbiol 293(6): Schirrmeister H, Glatting G, Hetzel J, Nuessle K, Arslandemir C, Buck AK, Dziuk K, Gabelmann A, Reske SN, Hetzel M. (2001) Prospective evaluation of the clinical value of planar bone scans, SPECT, and 18F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med. 42(12): Buck AK, Hetzel M, Schirrmeister H, Halter G, Möller P, Kratochwil C, Wahl A, Glatting G, Mottaghy FM, Mattfeldt T, Neumaier B, Reske SN. (2005) Clinical relevance of imaging proliferative activity in lung nodules. Eur J Nucl Med Mol Imaging.32(5): Epub 2004 Dec 14.

4 Halter G, Buck AK, Schirrmeister H, Aksoy E, Liewald F, Glatting G, Neumaier B, Muhling B, Nussle-Kugele K, Hetzel M, Sunder-Plassmann L, Reske SN (2004) Lymph node staging in lung cancer using [18F]FDG-PET Thorac Cardiovasc Surg 52(2): Buck AK, Schirrmeister H, Hetzel M, Von Der Heide M, Halter G, Glatting G, Mattfeldt T, Liewald F, Reske SN, Neumaier B. (2002) 3-deoxy-3- [(18)F]fluorothymidine-positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules.cancer Res 62(12): Haug C, Bachem MG, Woehrle H, Hetzel M, Gruenert A. (2002) Evaluation of two modified cardiac troponin I enzyme immunoassays. Clin Chem Lab Med 40(8): Wieshammer S, Hetzel M, Hetzel J, Henze E, Hombach V.(2001) Effects of chronic nitrate therapy on left-ventricular volume in patients with heart failure secondary to coronary disease already treated with captopril: a withdrawal study.cardiology 95(2):61-5. Lechat P, Escolano S, Golmard JL, Lardoux H, Witchitz S, Henneman JA, Maisch B, Hetzel M, Jaillon P. Boissel JP, Mallet A.(1997) Prognostic value of bisoprololinduced hemodynamic effects in heart failure during the Cardiac Insufficiency Study (CIBIS).Circulation. 96(7): Wieshammer S, Hetzel M, Hetzel J, Henze E, Clausen M, Hombach V.(1996) Reproducibility of left ventricular volume measurements at rest and during bicycle exercise in patients with congestive heart failure: a combined radionuclide and haemodynamic study. Nucl Med Commun. 17(7): Hetzel J, Herb S, Hetzel M, Rusteberg T, Kleiser G, Weber J, Kochs M, Hombach V. (1996) Microbiological studies of a nasal positive pressure respirator with and without a humidifier system.wien Med Wochenschr.;146(13-14):354-6 Pousset F, Copie X, Lechat P, Jaillon P, Boissel JP, Hetzel M, Fillette F, Remme W, Guize L, Le Heuzey JY. (1996) Effects of bisoprolol on heart rate variability in heart failure.am J Cardiol 15;77(8):612-7 Wieshammer S, Hetzel M, Hetzel J, Kochs M, Hombach V.(1993) Lack of effect of nitrates on exercise tolerance in patients with mild to moderate heart failure caused bycoronary disease already treated with captopril. Br Heart J 70(1): Wieshammer S, Hetzel M, Hetzel J, Kochs M, Hombach V.(1992) Short-term reproducibility of gas exchange measurements during bicycle exercise in patients with mild tomoderate congestive heart failure. Z Kardiol. 81(5): Wieshammer S, Hetzel M, Barnikel U, Hoher M, Seibold H, Kochs M, Hombach V. (1991) Effects of atenolol, slow-release nifedipine, and their combination on respiratory gas exchange and exercise tolerance in stable effort angina. Klin Wochenschr. 69(14):

5 Haerer W, Bauer U, Sultan N, Cernoch K, Mouselimis N, Fehske KJ, Hetzel M, Stauch M, Hombach V.(1990) Acute and chronic effects of a diuretic monotherapy with piretanide in congestive heart failure - a placebo-controlled trial.cardiovasc Drugs Ther (2): Kasuistiken, Übersichtsarbeiten, Leserbriefe und Buchbeiträge Hetzel M, Merk T, Veitshans S, Willems P, Philipp A, Muradov A, Bartscher E, Prettner R (2012). Patientenzufriedenheit nach LVRC-Behandlung von Patienten mit schwerem Lungenemphysem. Pneumologie 66:165 Hetzel M, Prettner R, Willems P, Philipp A, Muradov A, Veitshans S, Bartscher E, Merk T (2012). Blutungskomplikationen nach transbronchialer Kryosondenbiopsie. Pneumologie 66:166. Hetzel M, Merk T, Philipp A, Willems P, Veitshans S, Muradov A, Bartscher E, Prettner R (2012). Endoskopische Lungenvolumenreduktion durch Coilimplantation bei Patienten mit schwerem heterogenem Lungenemphysem. Pneumologie 66:426. Hetzel M, Hetzel J, Prettner R, Merk T, Rupp A, Willems P, Philipp A, Hnidek K, Bartscher E, Babiak A (2011). Einfluss der Bronchoskopietechnik auf die Sensitivität von Zangenbiopsie und Kryobiopsie bei endobronchialem Tumorverdacht. Pneumologie 65:400. Hetzel M, Prettner R, Philipp A, Willems P, Merk T, Rupp A (2011).Die CTgesteuerte transbronchiale Kryosondenbiopsie zur Abklärung pulmonaler Herdbefunde. Pneumologie 65 :311. Hetzel M, Merk T, Prettner R, Philipp A, Willems P (2011). Multiple Milzherde und mediastinale Lymphome als Tuberkulosemanifestation. Pneumologie 65 :304. Hetzel M, Hetzel J, Merk T, Philipp A, Willems P, Prettner R, Hnidek K, Bartscher E, Babiak A (2010). Möglichkeiten und Grenzen der Navigationsbronchoskopie. Pneumologie 64:354. Hetzel M, Hetzel J, Prettner R, Philipp A, Willems P, Merk, T, Bartscher E, Berweiler I, Stamatopoulou A, Babiak A (2010). Kryorekanalisation für die Behandlung von Tumorverschlüssen der Lappenbronchien. Pneumologie 64:358. Hetzel M, Hetzel J, Prettner R, Merk T, Philipp A, Willems P; Hnidek K; Berweiler I, Bartscher E, Babiak A. (2010). Die transbronchiale Biopsie mit der Kryosonde. Pneumologie 64:424. Hetzel M, Hetzel J, Merk T, Willems P, Prettner, R, Philipp A, Bartscher E, Muradov A, Babiak A (2010). Endoskopische Behandlung von Karzinoidtumoren mit der flexiblen Kryosonde. Pneumologie 64:356

6 Hetzel M, Hetzel J, Prettner R, Merk T, Rupp A, Willems P, Philipp A, Hnidek K, Bartscher E, Babiak A (2010). Diagnostische Bronchoskopien bei Spontanatmung unter tiefer Sedierung mit Propofol. Pneumologie 64:362. Hetzel M (2010). Endobronchiale Kryosondenbiopsie oder endobronchiale Zangenbiopsie bei endoskopischem Malignitätsverdacht. Pneumologie 64:273. Hetzel M, Hetzel J (2010).Methods of cryorecanalization in flexible bronchoscopy: Cryoextraction with a flexible cryoprobe. Europ Resp J 36 (Suppl 54): Hetzel M, Hetzel J, Topalidis T, Philipp A, Babiak A, Willems P, Bartscher E, Berweiler I, Nguyen T, Miller M, Stamatopoulou A (2009). Kryosondenbiopsien für die Cytopathologie. Pneumologie 63: 223. Hetzel M, Hetzel J, Babiak A, Philipp A, Willems, P, Hofmann B, Bartscher E, Berweiler I, Willkomm F, Stamatopoulou A, Hnidek K. (2009). Therapie von bronchialen Blutungen in flexibler Bronchoskopietechnik. Pneumologie 63:225. Hetzel M.; Hetzel J, Babiak A, Willems, P, Hofmann B, Philipp A, Hnidek K, Miller M, Balli T (2009). Verwendung von Führungskathetern bei der Untersuchung des Alveolarraumes mittels konfokaler Laserscanmikroskopie. Pneumologie 63:221. Hetzel M, Hetzel J, Bartscher E, Berweiler I, Philipp A, Willems P, Babiak A, Stamatopoulou A, Hnidek K, Blattner S, Balli T (2009). Ein Rekanalisationsverfahren für die flexible Bronchoskopie: Die Kryoextraktion mit flexiblen Kältesonden. Pneumologie 63:121. Hetzel M, Hetzel J, Babiak A, Bartscher E, Berweiler I, Stamatopoulou A, Willems P, Philipp A, Balli T (2009). Transbronchiale Biopsie mit der flexiblen Kryosonde. Pneumologie 63:216. Hetzel M, Hetzel J, Balli T, Bartscher E, Berweiler I, Philipp A, Willems P, Stamatopoulou A, Frank W, Alexander B (2008). Die Kryorekanalisation mit flexiblen Kältesonden. Pneumologie 62:245. Hetzel M, Balli T, Bartscher E, Willkomm F, Berweiler I, Stamatopoulou A, Philipp A, Willems P, Babiak A (2008). Transbronchiale Lungenbiopsien mit der flexiblen Kryosonde. Pneumologie 62:249 Hetzel M, Koenig H, Babiak A (2007). Zweitlinientherapie mit Mitomycin / Vinorelbin: Lebensqualität und Pharmaökonomie. Pneumologie 61:248. Hetzel M, Berweiler I, Bartscher E, Babiak A (2007). Elektromagnetische Navigation bei der bronchoskopischen Abklärung peripherer Lungenrundherde. Pneumologie 61:247. Hetzel M, Berweiler I, Bartscher E, Babiak A (2007). Elektromagnetische Navigation bei der bronchoskopischen Abklärung peripherer Lungenrundherde. Pneumologie 61:247.

7 Hetzel M, Babiak A, Balli T, Liewald F. Hetzel J. Thermische Verfahren in der Pneumologie(2009). Pneumologe 6: Hetzel M Alexander B, Busatlic S, Schleier J, Willkomm F, Hetzel J (2006). Kryosonden in der interventionellen Bronchologie. Pneumologie 60:182. Hetzel M, Babiak A, Schumann C, Lepper P, Wöhrle H, Habig T, Hetzel J (2005). Kryorekanalisation Eine neue Methode zur Sofortrekanalisation von Tumorstenosen der Atemwege. Pneumologie 59:164. Hetzel M, Schumann C, Babiak A, Wöhrle H, Lepper P, Habig T, Hetzel J (2005). Mitomycin C/Vinorelbin bei chemotherapeutisch vorbehandelten Patienten mit nichtkleinzelligem Bronchialkarzinom. Pneumologie 59:382. Hetzel M, Arslandemir C, Schirrmeister H (2004) Bone scanning in lung cancer. Authors' reply. BMJ, 329: 231. Schirrmeister H, Hetzel M, Hetzel J, Habig T, Schumann C, Bommer M, Blum P, von Beauvais H, Babiak A. (2004) Challenging manifestations of malignancies. Fibrinous tracheitis: an uncommon manifestation of Hodgkin's lymphoma. J Clin Oncol. 22(17): Hetzel M, Hetzel J, Schumann C, Lepper P, Woehrle H, Habig T, Babiak A (2004). Kryorekanalisation Eine neue Methode zur Sofortrekanalisation von Tumorstenosen der Atemwege. Pneumologie 58:73. Hetzel M, Arslandemir C, Hetzel J, Schirrmeister H (2004). Skelettdiagnostik beim Bronchialkarzinom: Eine prospektive Kohortenstudie zur Evaluation der aktuell gültigen Leitlinien. Pneumologie 58:74. Schirrmeister H, Hetzel M, Buck A. (2003) Staging of non-small-cell lung cancer with integrated PET and CT. N Engl J Med. 349(12): ; author reply Herb S, Hetzel M, Hetzel J, Friedrich J, Weber J. (1998) An unusual case of Hughes- Stovin syndrome.eur Respir J.11(5): Hetzel J, Herb S, Hetzel M, Rusteberg T, Kleiser G, Weber J, Kochs M, Hombach V. (1996) Microbiological studies of a nasal positive pressure respirator with and without a humidifier system.wien Med Wochenschr.;146(13-14):354-6 Essig A, Zucs P, Susa M, Wasenauer G, Mamat U, Hetzel M, Vogel U, Wieshammer S, Brade H, Marre R. (1995) Diagnosis of ornithosis by cell culture and polymerase chain reaction in a patient with chronic pneumonia.clin Infect Dis. 21(6): Hombach V, Wieshammer S, Hetzel M. Chronic pulmonary hypertension--causes, effects, therapy Klin Anasthesiol Intensivther. (1995) 47: Review Hetzel M. In: Pschyrembel Therapeutisches Wörterbuch.(1999) Pneumologischer Teil. Walter De Gruyter. Berlin New York.