Molekulare Regulation der duktalen Zelllinie im Pankreas und im Pankreaskarzinom (Applicant von Burstin, Andreas Johannes )

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1 Technische Universität München Klinikum rechts der Isar Innere Medizin II - Klinik & Poliklinik (Gastroenterologie, Hepatologie, Endokrinologie, Infektiologie) Address Ismaninger Straße München Deutschland Telephone Fax direktion.med2@lrz.tum.de Website Homepage Projects

2 Research Fellowships Current projects Inhibitory receptor repertoire of anti-tumoral NK cells in mouse MHC-I-deficient cancers (Applicant Wiedemann, Gabriela ) Investigation of microbiome-host interactions in intestinal graft-versus-host disease as a clinical relevant condition of microbially triggered immune system modulation. (Applicant Thöringer, Christoph Karl ) Identifikation von Tumorsuppressor-Genen durch induzierbare und gewebsspezifische Transposonmutagenese im murinen Intestinaltrakt (Applicant Rad, Roland ) Immunmodluierende Gentherapie des metastasierten Kolonkarzinoms durch intratumoralen IL-12 Gentransfer und Kostimulation ds 4-1BB Glykoproteins (Applicant Ebert, Oliver ) Molekulare Regulation der duktalen Zelllinie im Pankreas und im Pankreaskarzinom (Applicant von Burstin, Andreas Johannes ) Role of stroma-regulated epithelial mirnas and ZEB2 in pancreatic carcinogenesis (Applicant von Figura, Guido ) Research Grants

3 Current projects Analyzing the impact of the tumor microenvironment on esophageal carcinogenesis (Applicant Quante, Michael ) Deciphering MYC-assoziated Vulnerabilities to develop pancreatic cancer subgroup-specific therapies (Applicant Schneider, Günter ) Dissecting the role of Pdk1 signalling in pancreatic cancer to develop novel therapeutic strategies (Applicant Schönhuber, Nina ) Dual recombinase systems for sequential genetic targeting of pancreatic cancer (Applicant Saur, Dieter ) Exploring the interplay of endocytosis with the methionine cycle in pancreatic ductal adenocarcinoma initiation and progression. (Applicant Lubeseder-Martellato, Clara ) Functional analysis of the relevance of Bcl-3 and its interference with STAT3 in acute pancreatitis as an example of inflammation in the gastrointestinal tract (Applicant Algül, Hana ) Functional characterization of Bcl-3 in pancreatic cancer (Applicant Algül, Hana ) Gender-dependent mechanisms of autophagy in the transition of acute to chronic pancreatitis (Applicants Algül, Hana ; Diakopoulos, Ph.D., Kalliope Nina ) Genome-wide pan-haematopoietic transposon screening for oncogenic network discovery in mice (Applicant Rad, Roland ) Interaction between transcription factors RelA and Stat3 in pancreatic carcinogenesis (Applicants Algül, Hana ; Lesina, Marina )

4 Die Rolle des IEX-1 (immediate early response gene X-1) im Pankreaskarzinom (Applicants Arlt, Alexander ; Schneider, Günter ) Die Rolle des Notch-Signalwegs in der pankreatischen Karzinogenese (Applicant Siveke, Jens T. ) Einfluss von Histon Deacetylasen (HDACs) auf die Tumorbiologie des Pankreaskarzinoms in vitro und in vivo. (Applicant Schneider, Günter ) Molecular und functional analysis of the interstitial cells of Cajal as master regulators of gastrointestinal motility (Applicant Saur, Dieter ) Notch signaling in liver cell plasticity, development, and regeneration (Applicant Geisler, Fabian K. ) Clinical Trials EAGLE: Early goal-directed volume resuscitation in severe acute pancreatitis: A randomised multi-centre study (Applicant Huber, Wolfgang ) Independent Junior Research Groups Current projects Mechanisms of pancreatic carcinogenesis with respect to its cellular origin (Applicant von Figura, Guido )

5 Collaborative Research Centres Current projects CXCR4-imaging in esophageal cancer - diagnosis and prognosis (Project leaders Quante, Michael ; Schottelius, Margret ) Genetic evolution of pre-germinal center B cell lymphomas in transgenic mice with the focus on Mantle Cell Lymphoma (Project leaders Rad, Roland ; Zimber-Strobl, Ursula ) Imaging of mechanism-driven biomarkers to develop and monitor precise therapies for pancreatic cancer (PDAC) subtypes (Project leaders Saur, Dieter ; Schneider, Günter ) Molecular and metabolic imaging and targeting of tumor heterogeneity in pancreatic cancer (Project leaders Siveke, Jens T. ; Walch, Axel ) Preclinical development and multimodal imaging of novel immunovirotherapeutics for cancer (Project leader Altomonte, Jennifer ) Charakterisierung der durch RBP-Jk vermittelten Repression und Rolle von RBP-Jk in der Lympho-Hämatopoese (Project leaders Liptay, Claudia-Susanne ; Schmid, Roland M. ) Einfluß von Smad-4 auf die Tumorgenese im Pankreas (Project leaders Hameister, Horst ; Schmid, Roland M. ) The IKK-NF-KappaB signalpathways as molecular target of the pancreas carcinome (Project leaders Schmid, Roland M. ; Schneider, Günter ) The role of NF-êB/Rel activation during acute pancreatitis and inflammation-associated pulmonary damage (Project leaders Algül, Hana ; Schmid, Roland M. ) Zelluläre und molekulare Mechanismen der NO abhängigen Signaltransduktion im Gastrointestinaltrakt (Project leader Saur, Dieter ) Major Research Instrumentation Kleintier-Ultraschallgerät

6 Research Training Groups GRK 1482: Interface Functions of the Intestine between Luminal Factors and Host Signals (Spokesperson Haller, Dirk ) GEPRIS is a project of the Deutsche Forschungsgemeinschaft (DFG) Contact GEPRIS at (c) Deutsche Forschungsgemeinschaft (