Universitätsklinikum Schleswig-Holstein Campus Lübeck Klinik für Dermatologie, Allergologie und Venerologie

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1 Universitätsklinikum Schleswig-Holstein Campus Lübeck Klinik für Dermatologie, Allergologie und Venerologie Address Ratzeburger Allee Lübeck Deutschland Telephone Fax Website Homepage Projects Research Grants

2 Contribution of T cells to immune complex-induced tissue damage (Applicant Ludwig, Ralf Joachim ) Dual contribution of the spleen tyrosine kinase (SYK) to epidermolysis bullosa acquisita pathogenesis (Applicants Ludwig, Ralf Joachim ; Samavedam, Ph.D., Unni Krishna ) Genetic basis of autoimmune pancreatitis (Applicants Ibrahim, Saleh M. ; Jaster, Robert ) The role of leukotriene B4 and its receptor BLT1 in the pathogenesis of the prototypical organ-specific autoimmune disease epidermolysis bullosa acquisita (Applicant Sadik, Christian David ) The role of mast cells in tumor development and progression (Applicant Hartmann, Karin )

3 Autoimmunität gegen Typ VII Kollagen: Rolle des Komplementsystems für die Induktions- und Effektor-Phase der Autoimmunantwort (Applicant Zillikens, Detlef ) Die Rolle von Toll like receptor 4 in der Pathogenese der Kollagen-induzierten Arthritis (Applicants Ibrahim, Saleh M. ; Pierer, Matthias ) Ein neuartiger IgE-abhängiger Mechanismus der Aktivierung FceRI-positiver Zellen mit Freisetzung von Th2-Zytokinen durch Produkte parasitärer Würmer (Applicant Haas, Helmut ) Identification of susceptibility gene(s) controlling autoantibody production in collagen induced arthritis (Applicant Ibrahim, Saleh M. ) Influence of collagen modifying enzymes on cross-linking (Applicant Brinckmann, Jürgen ) Kontrolle von Mastzellfunktionen bei entzündlichen Prozessen (Applicant Roers, Axel ) Optische Kohärenztomographie (OCT) der Haut (Applicant Welzel, Julia ) Pathogenesis of blister formation in bullous pemphigoid: studies on signal transduction through the 180kDa auto-antigen (BP180/type XVII collagen) (Applicant Zillikens, Detlef ) Plasmazelldepletion über Aktivierung der unfolded protein response: Rolle von Hitzeschockprotein 90-Inhibitoren im Mausmodell der Autoantikörper-vermittelten Epidermolysis bullosa acquisita (Applicant Kasperkiewicz, Michael ) Regulation der Entzündung bei der durch Antikörper gegen die dermo-epidermale Junktionszone induzierten Blasenbildung (Applicant Zillikens, Detlef ) The role of Fas (CD95) in the pathogenesis of collagen induced arthritis (Applicant Ibrahim, Saleh M. )

4 Research Fellowships Interleukin 9 (IL-9) in anticancer immune responses against melanoma in mice and human (Applicant Prüßmann, Wiebke ) Leukotrien B4 als Regulator chemotaktisch-aktiver Substanzen in der Pathogenese chronischer Arthritiden (Applicant Sadik, Christian David ) Longitudinal cloning and genetic characterization of human pemphigus autoantibodies in active disease, remission, and relapse (Applicant Hammers, Matthias Christoph )

5 Clinical Research Units Administrative unit (Applicant Sadik, Christian David ) Biostatistics and systems - Medicine core unit (Applicants Erdmann, Jeanette ; König, Inke Regina ) Central clinical infrastructure (Applicants van Beek, Nina ; Schmidt, Enno ) Genetics of Pemphigoid Diseases in human (Applicant Ibrahim, Saleh M. ) HCA2 activation in Pemphigoid Diseases - therapeutic effec and model of action (Applicants Schwaninger, Markus ; Zillikens, Detlef ) KFO 303: Pemphigoid Diseases - Molecular Pathways and their Therapeutic Potential (Spokesperson Zillikens, Detlef ) LTB4/BLT1 gatekeeping effector cell recruitment in Pemphigoid Diseases (Applicants König, Peter ; Sadik, Christian David ) Therapeutic potential of sialylated Pemphigoid Disease autoantibodies (Applicants Ehlers, Marc ; Hirose, Ph.D., Misa ) The skin microbiome modulating Pemphigoid Diseases (Applicants Baines, John ; Schmidt, Enno ) Collaborative Research Centres Quervernetzungsmuster im Kollagen sklerosierender Hauterkrankungen (Project leaders Brinckmann, Jürgen ; Tronnier, Michael ) The role of mast cells in the tumor microenvironment (Project leader Hartmann, Karin ) Clinical Trials Efficacy and safety of adjuvant immunoadsorption in pemphigus (Applicants Eming, Rüdiger ; Schmidt, Enno )

6 CRC/Transregios Ein neuartiger Mechanismus der Aktivierung FceRi-positiver Zellen mit Freisetzung von Th2-Zytokinen durch monovalente Immunglobulin-bindende Faktoren (Project leaders Gibbs, Bernhard Frederick ; Haas, Helmut ) Research Training Groups GRK 1727: Modulation of Autoimmunity (Spokesperson Zillikens, Detlef ) GRK 1743: Genes, Environment and Inflammation (Spokesperson Franke, Andre ) Graduate Schools GSC 235: Graduate School for Computing in Medicine and Life Sciences (Spokesperson Schweikard, Achim ) Clusters of Excellence EXC 306: Inflammation at Interfaces (Spokesperson Schreiber, Stefan ) GEPRIS is a project of the Deutsche Forschungsgemeinschaft (DFG) Contact GEPRIS at (c) Deutsche Forschungsgemeinschaft (