How does HIV-1 cause AIDS - Comments

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1 Oct 2018, Version (JK), translated from German Due to technical difficulties the complete document is now to be found under: Comments Comments on the "one big question" HOW DOES HIV-1 CAUSE AIDS?, Coffin und Swanstrom (2013) Comments on the state of research on HIV with special consideration of the PCR method Contents 1. Introduction 3 2. Summary 4 3. Comments on the current situation 5 4. Current HIV therapy approaches and their consequences Physicians and basic biochemical research SMON (Japan ) Zoonosis Missing animal model - apes do not get AIDS AIDS vaccination Diagnosis: cross reactions and manufacturer s statements Cross reactions of HIV Ag / Ab tests Other problem factors Antibody tests - manufacturer's statements 51

2 10.4. PCR confirmatory tests - manufacturer s statements False positives in PCR and the diagnosis of retroviral activity Stimulation of reverse transcriptase activity in vitro CD4 cell count - therapy control in the last 25 years HIV / AIDS statistics Inflation of HERV Bystander cell enigma Risk groups: co-infections and drugs Immunosuppressive effects of drugs Nitrites and cancer especially Kaposi Sarkoma Transfer rates in heterosexual couples LTNP Long Term Non Progressors AIDS and Africa (How) Does HIV-1 cause AIDS? Formation of a theory Concluding remarks Further references Annex I: Calculation of the PPV for HIV self-tests in non-risk groups Calculation steps for the PPV of HIV self-tests HIV self-tests in women Evaluation of the results Annex II: Further PCR problem cases or what DNA = DNA means for the methodology Annex III: Information on the correlation of MSM with coinfections and drug abuse Drug abuse Coinfections 124

3 1. Introduction This is about the "one big question", how the HI virus causes AIDS, starting from HOW DOES HIV-1 CAUSE AIDS? As is apparent from this article and the rest of the collection, in the 25+ years since its discovery, we have learned an enormous amount about HIV, but we still cannot answer the one big question: How does HIV-1 cause AIDS? From Coffin und Swanstrom in HIV Pathogenesis: Dynamics and Genetics of Viral Populations and Infected Cells, Cold Spring Harb Perspect Med Jan; 3(1), To begin the discourse, yes, there was the Holocaust. The videos of the Eichmann trial in Jerusalem in 1961 are authentic, see for example There are no aliens. There are viruses. There are successful vaccinations. I myself was vaccinated against polio, tetanus, diphtheria, TB and multiple times against flu, I had measles and chickenpox, and my immune system was successfully trained against tree pollen and grass allergy with a dehyperallergisation therapy. Einstein's Special Theory of Relativity has been confirmed in all (!) experiments. Only people who have witnessed the AIDS hysteria of the 1980s and 1990s can understand the current situation and the astonishment given the still rudimentary understanding of the foundations of HIV / AIDS. And this in view of the catastrophic treatment results. To understand the situation, the following video from 1992 is recommended, Both sides have their say 1. This text brings together information from around 300 scientific publications on the subject of HIV / AIDS. When reading these publications, it should be noted that they were (almost) all written under the dogma that the HI virus is the cause of AIDS. Any other statement would have led to the immediate rejection of the publication, or the scientific integrity would have been attacked directly, regardless of any argument. Two examples for this follow later. 1 I am only concerned with the film by Fritz Poppenberg from Unfortunately, health topics are increasingly being occupied by interest groups of all kinds. Not always in the interest of the patient. Profiteering does not only exist in the pharmaceutical group.

4 2. Summary It is very doubtful that between 1910 and 1950 HIV passed by zoonosis at least twice as a new pathogen in Africa from apes (SIV) to humans (HIV), after it had passed more than 5x non-pathogenically in the millenniums before. The SI virus (SIV) in monkeys has existed for at least 32,000 years. There is still no animal model for AIDS (monkeys do not get AIDS). HIV antigen (Ag) and antibody (Ab) tests show a variety of cross-reactions, especially in coinfections. This is not only relevant for developing countries. In addition, it is difficult to distinguish between endogenous (HERV) and exogenous (HIV) retroviral components. The diagnostic problem of the antigen (Ag) / antibody (Ab) tests continues with PCR. There are considerable doubts about the specificity of the PCR method. Manufacturers strictly reject the use of PCR for HIV diagnosis. And for a good reason. The CD4 cell count has proven to be an unusable measure of therapy control. Even 35 years after the discovery, it is completely unclear how the HI virus can destroy uninfected CD4 cells. Only about 5% of the CD4 cells are infected and CD4 cells are produced in large numbers each day (bystander cell enigma). There are significant adverse effects of HAART therapy. In particular, severe liver damage is expected. HAART patients age prematurely. As a long-term consequence cancer is a thread. The majority of AIDS dead do not die from AIDS-defining diseases. The AIDS numbers from Africa are greatly exaggerated and contributions from malnutrition, parasites or classic infections such as tuberculosis or malaria are included without testing (tuberculosis is AIDS-defining). Many people are unaware of the chaos that the premature use of diagnostic biomedical techniques has caused, without realizing the downsides and analyzing all risks. Ultimately, there is a lot that science just does not know for sure. HIV research depends on unproven, sometimes not even plausible assumptions. That did not prevent a whole HIV / AIDS industry from developing. Much of it has been developed on the living object, i.e. human beings.