Radiobiological applications of laser accelerated ion beams and visions for future research infrastructure

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1 EMMI Plasma Physics Workshop May 2011 Radiobiological applications of laser accelerated ion beams and visions for future research infrastructure U. Schramm Laser particle acceleration division Institut for Radiation Physics Ulrich Schramm HZDR

2 EMMI Plasma Physics 5/2011 Demonstrate stable laser accelerated proton pulses (sufficient energy) with a dose rate of some Gy / min in few shots dosimetric protocols (and techniques) for measuring the biological effectiveness, i.e. dose dependent cell damage detected with different methods Ulrich Schramm u.schramm@hzdr.de HZDR

3 J. Pawelke, L. Karsch, W. Enghardt, et al. E. Beyreuther, Y. Dammene, L. Laschinsky, U. Schramm, S. Kraft, K. Zeil, J. Metzkes, D. Naumburger, et al. T. Richter, C. Richter, et al. A. Irman, A. Jochmann, et al. M. Bussmann, A. Debus, T. Kluge, et al. M. Siebold, S. Bock, U. Helbig, F. Röser, M. Löser, et al. T. Cowan, R. Sauerbrey Ulrich Schramm HZDR

4 requirements for cell irradiation experiments with laser plasma accelerated proton pulses LPA (vacuum) online dosimetry Proton energies >5 MeV (no stopping on sub-mm scale) Dose rates of Gy/min between 0.1 and 10 Gy (pulse dose / stability) windows cell-monolayer on 50 micron biofilm Seite Ulrich 4Schramm u.schramm@hzdr.de HZDR

5 requirements for cell irradiation experiments with laser plasma accelerated proton pulses Proton energies >5 MeV (no stopping on sub-mm scale) Dose rates of Gy/min between 0.1 and 10 Gy (pulse dose / stability) Seite Ulrich 5Schramm u.schramm@hzdr.de HZDR

6 energy requirements for cell irradiation experiments Proton energies >5 MeV (no stopping on sub-mm scale) Dose rates of Gy/min between 0.1 and 10 Gy (pulse dose / stability) Draco laser parameters : up to 3J on target in 30fs focused to 3 micron FWHM Seite Ulrich 6Schramm u.schramm@hzdr.de HZDR

7 stability requirements for cell irradiation experiments Proton energies >5 MeV (no stopping on sub-mm scale) Dose rates of Gy/min between 0.1 and 10 Gy (pulse dose / stability) Seite Ulrich 7Schramm u.schramm@hzdr.de HZDR

8 dose requirements for cell irradiation experiments Proton energies >5 MeV Dose rates of Gy/min between 0.1 and 10 Gy (pulse dose / stability) Energy filtering (protection from other radiation) 2µm Ti foil E P > 4.8 MeV > 6.8 MeV > 8.4 MeV E P > 11.4 MeV 1µm Au disk ø 100µm E P > 15.7 MeV Dose [Gy] Seite Ulrich 8Schramm u.schramm@hzdr.de HZDR

9 dose requirements for cell irradiation experiments Proton energies >5 MeV Dose rates of Gy/min between 0.1 and 10 Gy (pulse dose / stability) Energy filtering (protection from other radiation) 2µm Ti foil E P > 4.8 MeV > 6.8 MeV > 8.4 MeV E P > 11.4 MeV 1µm Au disk ø 100µm E P > 15.7 MeV Dose [Gy] Seite Ulrich 9Schramm u.schramm@hzdr.de HZDR

10 further requirements for cell irradiation experiments with laser accelerated proton pulses Proton energies >5 MeV Dose rates of Gy/min between 0.1 and 10 Gy (pulse dose / stability) Dipole filter Transmission ionization chamber integrated Dosimetry and cell irradiation system (Faraday-cup, RCFstacks, cell samples) Energy filtering / transport (radiation protection ) Online and absolute offline dosimetry Homogeneous irradiation Sample size ~cm 2 Cell irradiation in air Seite Ulrich 10 Schramm u.schramm@hzdr.de HZDR

11 online performance control for laser accelerated proton pulses proton beam camera view stacked scintillator layers Seite Ulrich 11 Schramm HZDR

12 online performance control for laser accelerated proton pulses proton beam camera view stacked scintillator layers Seite Ulrich 12 Schramm HZDR

13 energy filtering (and transport) Proton spectrum at cell location accumlated pulses rotated sample Seite Ulrich 15 Schramm HZDR

14 shot-to-shot stability 140 mgy per shot Stable and online monitored pulse-to-pulse operation for controlled irradiation of three samples and reference irradiations Seite Ulrich 16 Schramm HZDR

15 Dose dependent cell irradiation 1.5 Gy 2.7 Gy 4.1 Gy DNA double strand breaks in a cell nucleus, stained Seite Ulrich 17 Schramm u.schramm@hzdr.de HZDR

16 Intra- and inter-day reproducibility of dose Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 Pulse dose [mgy] Clonogenic survival H2AX/BP1 DNA DSB Cell irradiation Curve represents ~ 4180 laser shots (50% for cell irradiations) Seite Ulrich 18 Schramm u.schramm@hzdr.de HZDR

17 Relative dose accuracy D/D=0.194±0.064 Clonogenic survival H2AX/BP1 DNA DSB 0.20 D/D D/D=0.096± Cell irradiation first experiment with reliable dose & dose uncertainties radiobiological data analyzable Seite Ulrich 19 Schramm u.schramm@hzdr.de HZDR

18 Preliminary message Dose [Gy] As expected, no difference between pulsed laser accelerated beam and continuous tandem beam (same result with improved dynamics for DNA double strand break endpoint) Seite Ulrich 20 Schramm HZDR

19 Dose dependent cell irradiation two successfull campaigns so far (about 5000 fully controlled and monitored shots) first step in translational research, animal studies as soon as ~ 30MeV available increase proton energy and stability Increase the laser power up to PW level, diode pumped scaling to be determined (absorption, etc.) Use clever target design (RMTs, cones, etc.) that enhances acceleration fields Exploit radiation pressure regime Seite Ulrich 21 Schramm u.schramm@hzdr.de HZDR

20 TNSA proton energy power scaling 60 MeV limit scaling following J. Schreiber, et al., PRL 97, , 2006 Seite Ulrich 22 Schramm HZDR

21 TNSA proton energy power scaling K. Zeil, et al., New Journal of Physics 12, (2010) Energy scaling??? 2um 5um Ultra-short pulses (Draco) Seite Ulrich 23 Schramm HZDR

22 Upgrade of the Ti:Sapphire laser Draco ELBE SRF e-linac (40 MeV, ps, 13 MHz) SRF photo gun (nc) Dual beam option (50TW / 500TW) installation scheduled for mid 2012 Synchronized to ELBE Ulrich Schramm u.schramm@hzdr.de HZDR

23 Petawatt, Energy-Efficient Laser for Optical Plasma Experiments ELBE SRF e-linac (40 MeV, ps, 13 MHz) SRF photo gun (nc) Crucial points: Active medium (Yb:CaF2) and disc cooling Power amplifier layout (multipass pump and seed) Brightness of diode laser pumps (almost solved) PW area Ulrich Schramm HZDR

24 Plans / Ideas for the next HGF Research Infrastructure (very preliminary) Ulrich Schramm u.schramm@hzdr.de HZDR

25 ARD Test facility - distributed facility for investigating acceleration schemes with high gradients (plasma wakefield, laser plasma of any kind) Helmholtz beamline - high power (rep-rated) laser European XFEL and high energy laser synced to (new or planned) XFEL end station Helmholtz beamline - high power (rep-rated) laser FAIR synced to FAIR beam line(s) Ulrich Schramm u.schramm@hzdr.de HZDR

26 (multiple filamentation of freely propagating 100 TW beam in air) Ulrich Schramm HZDR