& SCHLAGANFALL ARTERIOSKLEROSE. 31. Jahrestagung der DGAF. 30 Jahre DGAF

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1 ARTERIOSKLEROSE & SCHLAGANFALL 31. Jahrestagung der DGAF 30 Jahre DGAF Tagungsstätte der Justus-Liebig-Universität Gießen Rauischholzhausen Deutsche Gesellschaft für Arterioskleroseforschung e.v

2 Programm Donnerstag, :00-14:30 Learn to lead - Nachwuchsmodul How to write a paper (Ch. Gleißner, Heidelberg; D. Sedding, Hannover) 15:00-17:30 Freie Vorträge (Vorsitz: P. Libby, Boston; N. Marx, Aachen) 15:00-15:15 Jutta Schütt, Kerstin Troidl, Raghav Oberoi, Ann-Kathrin Koch, Christina Winterbauer, Thomas Schmitz-Rixen, Bernhard Schieffer, Karsten Grote Toll-like receptor 2 stimulation improves peripheral blood flow recovery following experimental hindlimb ischemia injury 15:15-15:30 D. Baumstark, S. Neumann, J. Eiglsperger, S. Norkauer, M. Fuhrmann, M. Mündner, J. Wack, H. Scharnagl, T. Stojakovic, W. März, P. Pagel Lipoprotein Profiling with the AXINON System 15:30-15:45 Ackermann K., Schwarz A., Bonaterra G., Kinscherf R. Effects of GDF-15 on autophagy in human MФ after oxldl- exposition 15:45-16:00 D. Gündüz, C. Liebetrau, C. Troidl, H. Nef, S. Rohrbach, C. W. Hamm, M. Aslam Farnesyl transferase inhibitors protect endothelial barrier function against inflammation-induced endothelial hyperpermeability 16:00-16:15 Milzi, Andrea, Burgmaier, Mathias, Marx, Nikolaus, Reith Sebastian In coronary culprit lesions fibrous cap thickness but not calcification is associated with the presence of diabetes an optical coherence tomography study 16:15-16:30 Michael Torzewski, Amir Ravandi, Calvin Yeang, Andrea Edel, Rahul Bhindi, Stefan Kath, Laura Twardowski, Jens Schmid, Xiaohong Yang, Ulrich F. W. Franke, Joseph L. Witztum, Sotirios Tsimikas Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis 16:30-16:45 Härdtner C, Kornemann J, Jander A, Zou J, Schmidt B, Lubojansky S, Starz C, Dufner B, Hoppe N, Rotta detto Loria J, Bode C, Zirlik A, Hilgendorf I Oral atorvastatin treatment inhibits macrophage proliferation in atherosclerotic lesions 16:45-17:00 Karsten Grote, Raghav Oberoi, Birgit Markus, Sabine Pankuweit, Jutta Schütt, Christian Troidl, Faranak Fassihianifard, Anika Witten, Monika Stoll, Bernhard Schieffer MicroRNA expression profiling in monocyte subpopulations among patients with different stages of coronary artery disease 17:00-17:15 Jasmin Schmitz Open Access and publication of research data Current developments and requirements 17:30-19:30 Moderierte Posterbegehung (Vorsitz: R. Heller, Jena; H. Li, Mainz; H. Langer, Tübingen; K. Schütt, Aachen) 19:30-20:30 Keynote Lecture P. Libby (Boston) New insights into the mechanisms of the acute coronary syndromes 20:30 Kongress Dinner

3 Freitag, :30-10:00 Arteriosklerose und Schlaganfall I Gemeinsame Sitzung DGAF/DSG (Vorsitz: A. Grau, Ludwigshafen; M. Torzewski, Stuttgart) 8:30-8:50 Antikoagulation zur Prävention des Schlaganfalls - NOACs, VKA oder Aspirin? (A.Grau, Ludwigshafen) 8:50-9:10 Asymptomatische Carotisstenose - konservative Therapie, Intervention oder OP? (P. Ringleb, Heidelberg) 9:10-9:30 Vorhofverschluss nach Schlaganfall - für wen? (P. Diehl, Freiburg) 9:30-9:45 Claudia Schoenichen, Franziska Glatzki, Maximilian Mauler, Veronique Ollivier, Nadine Herr, Christopher Starz, Daniela Stallmann, Christoph Bode, Ingo Ahrens, Benoît Ho-Tin-Noé, Ingo Hilgendorf, Daniel Duerschmied Acute phase serotonin mediated neutrophil trafficking is independent of endothelial adhesion molecules 9:45-10:00 Dieter Lütjohann, Oliver Weingärtner, Bodo Cremers, Sarah Seiler-Mußler, Hans-F. Schött, Anja Kerksiek, Silvia Friedrichs, Sven Meyer, Ursula Ulbricht, Adam Zawada, Ulrich Laufs, Bruno Scheller, Danilo Fliser, Michael Böhm, Gunnar H. Heine Markers of cholesterol homeostasis predict future cardiovascular events 10:00-10:20 Pause 10:20-11:30 Arteriosklerose und Schlaganfall II Gemeinsame Sitzung DGAF/DSG (Vorsitz: Ch. Gleißner, Heidelberg; T. Magnus, Hamburg) 10:20-10:40 Poststroke Angiogenese - friende or foe? (P. Harm, Berlin) 10:40-11:00 Inflammation nach Schlaganfall - Therapie durch Nanoantikörper (T. Magnus, Hamburg) 11:00-11:15 Martin Berger, Katie Wraith, Simbarashe Magwenzi, Ahmed Aburima, Robert Law, Jennifer Rossington, Benjamin Spurgeon, Casey Woodward, Maria Febbriao, Nikolaus Marx, Khalid Naseem Hyperlipidaemia associated oxidized LDL and oxidized phospholipids induce platelet hyperactivity through a CD36-dependent activation of PDE3A 11:15-11:30 Nadia Otero, Mareike Hörmann, Sentot Santoso, Ulrich J. Sachs Association of integrin αvβ3 inhibition with endothelial apoptosis in cerebrovascular damage

4 Programm Freitag, :30-13:00 Freie Vorträge (Vorsitz: I. Hilgendorf, Freiburg; R. Koenen, Maastricht) 11:30-11:45 Christopher Starz, Carmen Haerdtner, Maximilian Mauler, Alina Jander, Bi- Lin Schmidt, Sebastian Lubojansky, Bianca Dufner, Natalie Hoppe, Christoph Bode, Andreas Zirlik, Daniel Dürschmied, Ingo Hilgendorf P-selectin dependent platelet-leukocyte complex formation is dispensable for leukocyte recruitment to sites of inflammation 11:45-12:00 Tanja Vajen, Birke J. Benedikter, Alexandra C. A. Heinzmann, Elena M. Vasina, Yvonne Henskens, Martin Parsons, Patricia B. Maguire, Frank R. Stassen, Johan W. M. Heemskerk, Leon J. Schurgers, Rory R. Koenen Induction of pro-inflammatory smooth muscle cell response by platelet extracellular vesicles: an insight into communication of platelets and vascular cells 12:00-12:15 Alexandra.CA. Heinzmann, Tanja Vajen, Johan. WM. Heemskerk, Judith. M. Cosemans, Tilman. M. Hackeng, Rory. R. Koenen Involvement of aiibb3 integrin on the release of extracellular vesicles and the chemokines CXCL4 and CCL5 by platelets 12:15-12:30 Annemiek Dickhout, Marc van Zandvoort, Tilman M. Hackeng, Rory R. Koenen CCL5 and CXCL4 are rapidly internalized in endothelial cells 12:30-12:45 Claudia Ender, Katrin Spengler, Anne Grunau, Regine Heller Endothelial autophagy under basal and inflammatory conditions 14:00-15:30 Young Investigator Award (Vorsitz: R. Kinscherf, Marburg; S. Lorkowski, Jena) 14:00-14:15 Sebastian Diebold, Julia Möllmann, Florian Kahles, Alexander Nickel, Christoph Maack, Nikolaus Marx, Michael Lehrke GLP-1 secretion is increased in a murine model of myocardial infarction leading to improved left ventricular function and mitochondrial respiratory capacity. 14:15-14:30 Alina Jander, Jiadai Zou, Carmen Haerdtner, Jan Kornemann, Christopher Starz, Bi-Lin Schmidt, Sebastian Lubojansky, Natalie Hoppe, Bianca Dufner, Johannes Rotta detto Loria, Christoph Bode, Andreas Zirlik,Ingo Hilgendorf Lipid im- and exporters differentially determine macrophage turnover in the plaque 14:30-14:45 Ben Kappel, Robert Stoehr, Alena Nonnast, Lorenzo De Angelis, Nikolaus Marx, Massimo Federici Disruption of gut microbiota by antibiotics exacerbates atherosclerosis by interfering with intestinal lipid metabolism 14:45-15:00 Maximilian Mauler, Thilo Witsch, Nadine Herr, Claudia Schoenichen, Christoph Koentges, Timotheo Marchini, Carmen Härdtner, Daniela Stallmann, Christoph Bode, Heiko Bugger, Ingo Ahrens, Ingo Hilgendorf, Daniel Duerschmied Platelet serotonin aggravates myocardial reperfusion injury via degranulation

5 Freitag, :00-15:15 J. Merz, A. Heidenreich, S. von Garlen, P. Stachon, S. Geis, B. Dufner, N. Hoppe, N. Anto Michel, M. Idzko, C. Bode, A. Zirlik The role of the purinergic receptor P2X7 in the pathogenesis of atherosclerosis 15:15-15:30 Raghav Oberoi, Ann-Kathrin Koch, Jutta Schuett, Harald Schuett, Karsten Grote, Bernhard Schieffer Chronic administration of tumour necrosis factor alpha blocker aggravates plaque formation in a mouse model of experimental atherosclerosis 17:00-18:00 Keynote Lecture H. Hahmann: 30 Jahre DGAF 18:00-19:00 Verleihung des W.H. Hauss-Preises Claudia Goettsch, Joshua Hutcheson, Sasha Singh, Hiroshi Iwata, Sumihiko Hagita, Peter Libby, Pawel Szulc, Masanori Aikawa, Elena Aikawa Sortilin Promotes Microcalcification and Associates with Cardiovascular Risk 19:00-20:00 Verleihung der Rudolph-Schönheimer-Medaille mit Vortrag 20:00 Gemeinsamer Imbiss Samstag, :00-11:00 Academia meets Practice: der kardiovaskuläre Hochriskopatient Gemeinsame Sitzung DGAF/DGK (Vorsitz: A. Zirlik, Freiburg; B. Schieffer, Marburg) 9:00-9:20 Endpunktstudien und kardiovaskuläre effekte in der modernen Diabetologie (M. Lehrke, Aachen) 9:20-9:40 Herzinsuffizienz Wann Valsartan/Sacubitril, Mitraclip, LVAD, HTX? (S. Grundmann, Freiburg) 9:40-10:00 Modernes Lipidmanagement - Was sagen uns die Guidelines, welche Rolle spielen PCSK9-Inhibitoren (A. Zirlik, Freiburg) 10:00-10:20 Anti-inflammatorische Therapie in der Arteriosklerose - Der Jungbrunnen der Zukunft (B. Schieffer, Marburg) 10:20-10:40 revaskularisierung bei Patienten mit Diabetes - Stent, BVS oder Chirurgie (D. Sedding, Hannover) 10:40-11:00 Antithrombotische Therapie bei Diabetiker mit KHK, Dual, Triple - wie lange? (H. Langer, Tübingen) Freie Vorträge (N. Otero Vasquez, Gießen; D. Sedding, Hannover) 11:20-11:35 Philipp Lang, Solveig Hasselwander, Gisela Reifenberg, Huige Li, Ning Xia Comparison of diets used in mouse model of diet-induced obesity

6 Programm Samstag, :35-11:50 Christine Dawczynski, Anne-Christin Schneider, Jennifer Hartmann, Stefan Lorkowski Modulation of cardiovascular risk factors by the MoKaRi diet 11:50-12:05 Florian Kahles, Ana Libermann, Constantin Halim, Julia Möllmann, Sebastian Diebold, Mathias Burgmaier, Hannes M Findeisen, Corinna Lebherz, Nikolaus Marx, Michael Lehrke Activation of the GIP system reduces vascular infiltration and proinflammatory activation of monocytes in ApoE-/- mice 12:05-12:20 Elisabeth Ullmann, Yuliya Mikhed, Jörg Fahrer, Matthias Oelze, Swenja Kröller-Schön, Sebastian Steven, Philipp Welschof, Elena Zinßius, Paul Stamm, Fatemeh Kashani, Siyer Roohani, Joana Melanie Kress, Lan P. Tran, Eberhard Schulz, Bernd Epe, Bernd Kaina, Thomas Münzel, Andreas Daiber Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance 12:20-12:35 Florian Willecke, Mark Colin Gissler, Nathaly Anto Michel, Katharina Pfeiffer, Carmen Härtner, Ingo Hilgendorf, Dennis Wolf, Peter Stachon, Esther Lutgens, Lesca M. Holdt, Christoph Bode, Norbert Gerdes, Andreas Zirlik Attenuation of Atherosclerosis by CD40 Deficiency in Smooth Muscle Cells in Mice 12:35-12:50 P. Albrecht, J. Merz,P. Stachon,C. Bode The deficiency of the purinergic P2Y2 receptor protects hyperlipidemic mice from suffering metabolic syndrome 13:00 Vergabe des "Young Investigator Awards" und des Posterpreises

7 Kooperationspartner Sponsoringpartner Gold Sponsoren Silber Sponsoren Bronze Sponsoren Prof. Dr. med Winfried März Weitere Sponsoren Gemäß FSA-Kodex und AKG Verhaltenskodex geben wir für folgende Unternehmen die Höhe ihrer Beteiligung für die Einräumung vonwerberchten und Standflächen bekannt: Novartis 7.500, Sanofi 5.000, Amgen 2.500, Astra Zeneca 2.500, Bayer Health Care 2.500, Boehringer Ingelheim 2.500, Daiichi-Sankyo 2.500, MSD 2.500, St. Jude Medical 2.500, SYNLAB 2.500, Vifor Pharma 2.500, Privatsponsor: Prof. Dr. med.winfried März 2.500, Abbott