Dr. Hasso Seibert Institut für Toxikologie und Pharmakologie für Naturwissenschaftler Universitätsklinikum S-H Brunswiker Str. 10 D Kiel GERMANY

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1 Dr. Hasso Seibert Institut für Toxikologie und Pharmakologie für Naturwissenschaftler Universitätsklinikum S-H Brunswiker Str. 10 D Kiel GERMANY BIBLIOGRAPHY SEIBERT, H. (1978) Der Einfluß des Nervus vagus auf die Herzfrequenz bei der Temperaturadaption des Aales (Anguilla anguilla L.) Verh. Dtsch. Zool. Ges., 201 JANKOWSKY, H.-D. & SEIBERT, H. (1978) Die Wirkung der Temperatur auf die Glykogenolyse isolierter Leberzellen von Fischen. Verh. Dtsch. Zool. Ges., 208 SEIBERT, H. (1979) Thermal adaptation of heart rate and its parasympathethic control in the european eel Anguilla anguilla L. Comp. Biochem. Physiol. 64 C, SEIBERT, H. (1980) Effect of temperature on glycogen metabolism in isolated liver cells of rainbow trout. European Soc. of Comp. Biochem. Physiol., Southhampton, England HOTOPP, W., JANKOWSKY, H-D. & SEIBERT, H. (1980) Criteria of viability - succinate stimulation of respiration and adenine nucleotide content - in isolated liver cells of rainbow trout. Europ. Soc. of Comp. Biochem. Physiol., Southhampton, England JANKOWSKY, H-D. & SEIBERT, H. (1981) Effect of temperature on carbohydrate metabolism in liver cells of rainbow trout. Soc. Exp. Biol., Durham, England JANKOWSKY, H-D., HOTOPP, W. & SEIBERT, H. (1984) Influence of thermal acclimation on glucose production and ketogenesis in isolated eel hepatocytes, Am. J. Physiol. 247, R 471-R 478 SEIBERT, H. (1985) Viability control and oxygen consumption of isolated hepatocytes from thermally acclimated rainbow trout (Salmo gairdnerii). Comp. Biochem. Physiol. 80 B, SEIBERT, H. (1985) Effects of temperature on glucose release and glycogen metabolism in isolated hepatocytes from rainbow trout. Comp. Biochem. Physiol. 81 B, SEIBERT, H., KOLOSSA, M. & WRANGEL, R. (1986) Mammalian spermatozoa as in vitro model for studies on acute cytotoxicity of chemicals. Naunyn-Schmiedeberg's Arch. Pharmacol. 332, R 19 SEIBERT, H. & KOLOSSA, M. (1987) Quantitative structure-toxicity relationships of substituted phenols determined in vitro with a sperm motility assay. in: Alternatives to animal experiments in risk assessment, Proceedings, 135 PAGE 12

2 SEIBERT, H. (1987) Messung der Bewegungsaktivität von Bullenspermien mit Hilfe von Videomikrographie und Computer Bildanalyse I und II. 35. Internationale Fachtagung für Fortpflanzung und Besamung, Wels, Österreich. SEIBERT, H. (1988) Messung der Bewegungsaktivität der Spermatozoen von Mensch und Rind mit Hilfe von Videomikrographie und Computerbildanalyse. Fertilität 4, WRANGEL, R. & SEIBERT, H. (1988) Anwendung der Computer - Videomikrographie zur Charakerisierung menschlicher Ejakulate. Physiologie und Pathologie der Fortpflanzung, Hannover; Zuchthyg. 23, 102 SEIBERT, H., GOSCH, U., REIMER, M. & VIEHMANN, K. (1988) Analysis of the cytotoxic action of chemicals by means of bovine spermatozoa in vitro. Naunyn-Schmiedeberg's Arch. Pharmacol. 337, R 24 KOLOSSA, M., MÖLLER, G. & SEIBERT, H. (1989) Objektive Beurteilung der Bewegungsaktivität von Rindertiefgefriersperma mit Hilfe von Videomikrographie und Computer - Bildanalyse. Dtsch. Tierärztl. Wschr. 96, SEIBERT, H., KOLOSSA, M. WASSERMANN, O. (1989) Bovine spermatozoa as an in vitro model for studies on the cytotoxicity of chemicals: effects of chlorophenols. Cell Biol. Toxicol. 5, DE BEER, C., ALSEN-HINRICHS, C., KRUSE, H., NOACK, G. & SEIBERT, H. (1989) Bestimmung von Blei, Cadmium, Selen und Zink in Humansperma. CAS, 5. Colloqu. Atomspektrom. Spurenanal. (WELZ, B., Ed.), ARMBRUST, B. & SEIBERT, H. (1989) Der Einfluß umweltrelevanter Schwermetalle auf die Spermatogenese in vivo und auf Spermatozoen in vitro - eine Literaturübersicht - Schriftenr. Abt. Toxikol., Univ. Kiel; 15, 1-54 ASCHMANN, C., GÜLDEN, M., SEIBERT, H. & WASSERMANN (1989) Anwendung tierischer Zellkulturen als Ergänzung zum Tierversuch. Abschlußbericht zum BMFT-Projekt A - Teilprojekt 1 NOACK, G., DE BEER, C. & SEIBERT, H. (1990) Blei Cadmium, Selen and Zink im Sperma beruflich nicht exponierter Männer. Fortschritte der Fertilitätsforschung 18, 248 HANSEN, I, KRUSE, H., & SEIBERT, H. (1990) Persistente Organochlorverbindungen im menschlichem Blut und Sperma. Fortschritte der Fertilitätsforschung 18, 250 SEIBERT, H. & GOSCH, U. (1990) A short-term bovine sperm cell assay for the evaluation of the in vitro cytotoxicity of chemicals. ATLA 17, SEIBERT, H. (1990) Alternativmethoden in der Toxikologie. - Sind Tierversuche ersetzbar? Therapiewoche 40, PAGE 11

3 KOLOSSA, M. & SEIBERT, H. (1990) A chemically "defined" diluent for cryopreservation of bovine spermatozoa. Andrologia 22, VOSS, J.-U., MÖRCHEL, S., SEIBERT, H. (1990) Primary cultures of rat hepatocytes on microcarriers as a xenobiotic metabolising system in cocultures. VIIIth. Scand. Workshop on In Vitro Toxicol., Kongsvoll, Norwegen WIENCKE, T. & SEIBERT, H. (1990) Organische Umweltchemikalien und männliche Fertilität. Schriftenr. Abt. Toxikol., Univ. Kiel; 17: 1-73 VOSS, J.-U. & SEIBERT, H. (1991) Metabolism mediated cytotoxicity detected by cocultures of microcarrier-attached rat hepatocytes and BALB/c 3T3 cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 343 (Suppl.) R17 KOLOSSA, M. & SEIBERT, H. (1991) Toxicity testing by means of cryopreserved bovine spermatozoa. ATLA 19, EKWALL, B., BARILE, F.A., BJERREGARD, H., CLOTHIER, R.H., DIERICKX, P.J., FISKESJÖ, G., GARZA-OCANAS, L., GOMEZ-LECHON, M.J., HELLBERG, S., NORDIN, M., SEIBERT, H., SHRIVASTAVA, R., TINGLEFFSKAANILD, M., TYSON, C., VALONE, S., ZUCCO, F., WALUM, E. (1991) Prediction of acute human toxicity for the first 10 MEIC chemicals by altogether 50 cytotoxicity assays. World Congress on Cell and Tissue Culture, Anaheim, CA, USA KOLOSSA, M. & SEIBERT, H. (1991) Cryopreservation of mammalian spermatozoa by means of "chemically" defined media. Cryobiology - Meeting, Kopenhagen, Dänemark VOSS, J.-U. & SEIBERT, H. (1991) Microcarrier-attached rat hepatocytes as a xenobioticmetabolizing system in cocultures. Cell Biol. Toxicol. 7, SEIBERT, H., GÜLDEN, M., KOLOSSA, M. & SCHEPERS, G. (1992) Evaluation of the relevance of selected in vitro toxicity test system for acute systemic toxicity. ATLA 20, VOSS, J.-U. & SEIBERT, H. (1991) Toxicity of glycols and allyl alcohol evaluated by means of cocultures of microcarrier - attached rat hepatocytes and BALB/c 3T3 cells. ATLA 20, EKWALL, B., BARILE, F., BJERREGARD, H., CHESNE, C., CLOTHIER, R., DIERICKX, P., FISKESJÖ, G., GARCA-OCANAS, L., GOMEZ-LECHON, M.J., GÜLDEN, M., KRISTEN, U., KÄRENLAMPI, S., LEWAN, L., NORDIN, M., PERSOONE; G., SEIBERT, H., SHRIVASTAVA, R., STADTLÄNDER, K., TINGLEFF-SKAANILD, M., TRIGLIA, D., TYSON, C., ZUCCO, F. & WALUM, E. (1991) The first ten MEIC chemicals tested in 70 cytotoxicity assays - the influence of cell type and toxicity criteria on cytotoxicity. IXth Scandinavia Workshop on In Vitro Toxicology, Nagu, Finland KOLOSSA, M., GÜLDEN, M. & SEIBERT, H. (1991) Einfluß des experimentellen Aufbaus auf die Ergebnisse von in vitro Zytotoxizitäts - Tests mit proliferierenden Zellen. In: Schöffl, H., Schulte-Herrmann, R. & Tritthart, H.A. (Eds.) Möglichkeiten und Grenzen der Reduktion von Tierversuchen; , Springer-Verlag Wien PAGE 12

4 SCHEPERS, G., ASCHMANN, C., GÜLDEN, M. & SEIBERT, H. (1991) Primär kultivierte Rattenhepatozyten als in vitro Modell zur Erfassung der Wirkung von Chemikalien auf basale Zellfunktionen und Biotransformationsreaktionen. In: Schöffl, H., Schulte-Herrmann, R. & Tritthart, H.A. (Eds.) Möglichkeiten und Grenzen der Reduktion von Tierversuchen; , Springer-Verlag Wien VOSS, J.-U. & SEIBERT, H. (1992) Primärkulturen von Rattenhepatozyten auf Microcarriern als metabolisierendes System in Toxizitätsprüfungen and Zellkulturen. ALTEX 16, GÜLDEN, M., KOLOSSA, M. & SEIBERT, H. (1992) Influence of the experimental design on the outcome of in vitro cytotoxicity tests with proliferating cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 345, 144 VOSS, J.-U., GÜLDEN, M. & SEIBERT, H. (1992) On the role of hepatocyte cultures in in vitro toxicity testing. Xth Scandinavian Workshop on In Vitro Toxicology, Visby, Sweden EKWALL, B., BARILE, F., BJERREGARD, H., CHESNE, C., CLOTHIER, R., DIERICKX, P., FERRO, M., FISKESJÖ, G., GARCA-OCANAS, L., GOMEZ-LECHON, M.J., GÜLDEN, M., ISOMAA, B., JACOBSEN, U., KUNIMOTO, M., KRISTEN, U., KÄRENLAMPI, S., LEWAN, L., NORDIN, M., PERSOONE, G., SAWYER, T., SEIBERT, H., SHERIVASTAVA, R., STADTLÄNDER, K., TINGLEFF-SKAANILD, M., TRIGLIA, D., TYSON, C., ZUCCO, F. & WALUM, E. (1992) Comparison of the results from 100 different cytotoxicity assays of the first ten MEIC chemicals. World Congress on Cell & Tissue Culture, Washington, USA VOSS, J.-U., GÜLDEN, M. & SEIBERT, H. (1992) Cocultures of BALB/c 3T3 cells with microcarrier-attached rat hepatocytes as an in vitro system for studies on metabolism mediated cytotoxicity. INVITOX, De Haan, Belgium EKWALL, B., BARILE, F., CHESNE, C., CLOTHIER, R., CURREN, P., DIERICKX, P., EKWALL, O., FERRO, M., FISKESJÖ, G., GARCA-OCANAS, L., GAY, R., GOMEZ- LECHON, M.J., GÜLDEN, M., HELLBERG, S., IMAI, K., ISOMAA, B., KUNIMOTO,M., KRISTEN, U., KÄRENLAMPI, S., LEWAN, L., MALMSTEN, G., PERSOONE, G., ROMERT, L., SANDBERG, M., SAWYER, T., SEIBERT, H., SHERVASTAVA, R., STAMMATI, A., TANAKA, N., TRIGLIA, D. & WALUM, E. (1992) Further MEIC evaluation: Acute lethal toxicity in man of reference chemicals nos predicted by 60 in vitro toxicity assays and by oral LD50 in rodents. INVITOX, De HAAN, Belgium EKWALL, B., BARILE, F., BONDESSON, I., CLEMEDSON, C., CLOTHIER, R., CURREN, P., DIERICKX, P., FISKESJÖ, G., GARCA-OCANAS, L., GOMEZ-LECHON, M.J., GÜLDEN, M., IMAI, K., JANUS, J., KRISTEN, U., KUNIMOTO, M., KÄRENLAMPI, S., LAVRIJSEN, K., LEWAN, L., MALMSTEN, G., MIURA, T., NAKAMURA, M., OHNO, T., ONO, H., PERSOONE, G., ROMERT, L., ROUGET, R.L., SANDBERG, M., SAWYER, T., SEIBERT, H., SHRIVASTAVA, R., STAMMATI, A., TANAKA, N., WALUM, E., WANG, X. & ZUCCO, F. (1992) Acute lethal toxicity in man predicted by cytotoxicity in 52 cellular assays and by oral LD50 tests in rodents for the first 30 MEIC chemicals. 6th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments, Tokyo, Japan PAGE 11

5 GÜLDEN, M., SEIBERT, H., VOSS, J.-U. & WASSERMANN, O. (1992) Animal cells in vitro as supplement or alternative to animals in acute toxicity testing. Schriftenr. Inst. f. Toxikol. Univ. Kiel; 21, FENTEM, J., FRY, J., GARLE, M., GÜLDEN, M., SEIBERT, H., VOSS, J.-U., WASSERMANN, O., PERCHERMEIER, M. & WIEBEL, F. (1993) An International Evaluation of Selected In Vitro Toxicity Test Systems For Predicting Acute Systemic Toxicity. Report prepared for the Commission of the European Communities, DGXI (Contract No. B92/B4-3063/14086), 143 pp. NOACK-FÜLLER, G., DE BEER, C. & SEIBERT, H. (1993) Cadmium, lead, selenium and zinc in semen of occupationally unexposed men. ANDROLOGIA 25, 7-12 EKWALL, B., CLEMEDSON, C., BARTILE, F., CALLEJA, M.C., CASTELL, J., CHESNE, C., CLOTHIER, R., CURREN, R., DIERICKX, P., MCFARLANE-ABDULLA, E., FERRO, M., FISKESJÖ, G., GARZA-OCANAS, L., GÖMEZ-LECHON, M.J., GÜLDEN, M., ISOMAA, B., JANUS, J., KERSZMAN, G., KRISTEN, U., KUNIMOTO, M., KÄRENLAMPI, S., LAVRIJSEN, K., LEWAN, L., OHNO, T., PERSOONE, G., ROQUET, R., ROMERT, L., SAWYER, T., SEIBERT, H., SHRIVASTAVA, R., STADTLANDER, K., STAMMATI, A., TANAKA, N., TRIGLIA, D., VALENTINO, M., WALUM, E., WANG, X., ZUCCO, F., HARVELL, J.D., MAIBACH, H. (1993) Comparison between human skin irritancy and in vitro cytotoxicity from 77 systems for the first 12 MEIC chemicals. International Symposium "Current trends: In Vitro Skin Toxicology and Eye Irritancy Testing. April EKWALL, B., CLEMEDSON, C., BARTILE, F., CALLEJA, M.C., CASTEL, J., CHESNE, C., CLOTHIER, R.,CURREN, R., DIERICKX, P., MCFARLANE-ABDULLA, E., FERRO, M., FISKESJÖ, G., GARZA-OCANAS, L., GÖMEZ-LECHON, M.J., GÜLDEN, M., ISOMAA, B., JANUS, J., KERSZMAN, G., KRISTEN, U., KUNIMOTO, M., KÄRENLAMPI, S., LAVRIJSEN, K., LEWAN, L., OHNO, T., PERSOONE, G., ROGUET, R., ROMERT, L., SAWYER, T., SEIBERT, H., SHRIVASTAVA, R., STADTLANDER, K., STAMMATI, A., TANAKA, N., TRIGLIA, D., VALENTINO, M., WALUM, X., WANG, X., ZUCCO, F., HARVELL, J.D., MAIBACH, H.(1993) Human dose-response skin irritancy data for the first 12 MEIC chemicals used to evaluate skin toxicity prediction by 77 cytotoxicity assays. International Symposium "Current trends: In Vitro Skin Toxicity and Eye Irritancy Testing" Ottawa, Canada, April WALUM, E., MCFARLANE-ABDULLA, E., BARILE, F., BONDESSON, I., CALLEJA, M.C., CLOTHIER, R., CURREN, R., DIERICKX, P., FISKESJÖ, G., GARZA-OCANAS, L., GÖMEZ-LECHON, M.J., GÜLDEN, M., IMAI, K., JANUS, J., KRISTEN, U., KUNIMOTO, M., KÄRENLAMPI, S., LAVRIJSEN, K., LEWAN, L., OHNO, T., PERSOONE, G., ROGUET, R., ROMERT, L., SANDBERG, M., SAWYER, T., SEIBERT, H., SHIVASTAVA, R., STAMMATI, A., TANAKA, N., ZUCCO, F., CLEMEDSON, C., EKWALL, B. (1993) Prediction of human acute toxicity by 55 cytotoxicity assays for 30 MEIC chemicals: are the human systems performing better than systems with animal cells? Submitted to a FRAME conference on "The use of Human Tissues in In Vitro Toxicology and Testing", April 28-29, Stirling, UK GÜLDEN, M., SEIBERT, H., & VOSS, J.U. (1994) In vitro toxicity screening using cultured rat skeletal muscle cells. II. Agents affecting excitable membranes. Toxicology in Vitro 8, PAGE 12

6 GÜLDEN, M., SEIBERT, H., & VOSS, J.U. (1994) Inclusion of physicochemical data in quantitative comparisons of in vitro and in vivo toxic potencies. ATLA 22, GÜLDEN, M., SEIBERT, H. & VOSS, J.U. (1994) The use of cultured skeletal muscle cells in testing for acute systemic toxicity. Toxicology in vitro 8, SEIBERT, H., GÜLDEN, M., & VOSS, J.U. (1994) An in vitro toxicity testing strategy for the classification and labelling of chemicals according to their potential acute lethal potency. Toxicology in Vitro 8, SEIBERT, H., GÜLDEN, M., & VOSS, J.U. (1994) Comparative cell toxicology: the basis for in vitro toxicity testing. ATLA 22, CLEMEDSON, C., ABDULLA, E., BARILE, F.A., CHESNE, C., CLOTHIER, R., COTTIN, M., CURREN, R., DIERICKX, P., FERRO, M., FISKESJÖ, G., GARZA-OCANAS, L., GOMEZ-LECHON, M.J., GÜLDEN, M., ISOMAA, B., KAHRU, A., KEMP, R.B., KERSZMAN, G., KRISTEN, U., KUNIMOTO, M., KÄRENLAMPI, S., LAVRIJSEN, K., LEWAN, L., OHNO, T., PERSOONE, G., PETTERSON, R., ROGUET, R., ROMERT, L., SAWYER, T., SEIBERT, H., SHRIVASTAVA, M., SJÖSTRÖM, M., TANAKA, N., ZUCCO, F. & EKWALL, B. (1994) Comparisons of the Toxicity of 30 Chemicals as Measured by 68 Different in Vitro Toxicity Tests. TCA - meeting, June 4-7. GÜLDEN, M., SEIBERT, H., VOSS, J. & WASSERMANN, O. (1994) Tierische Zellen in vitro als Ersatz für Tierversuche: Evaluierung des prognostischen Wertes ausgewählter Testmodelle für die Abschätzung der systemischen Toxizität von Chemikalien. Abschlußbericht zum BMFT-Projekt B SEIBERT, H. (1995) Umweltchemikalien mit östrogener Wirkung - Ein neues Problem? UBA- Texte 65/95, SEIBERT, H. (1996) Umweltchemikalien mit endokriner Wirkung. In : Umweltchemikalien mit hormoneller Wirkung - Eine Standortbestimmung für Österreich. Tagungsberichte des Umweltbundesamtes Österreich Bd. 19, 7-21 SEIBERT, H. (1996) Estrogenic chemicals in the environment - a new problem? UBA-Texte 3/96, GÜLDEN, M. & SEIBERT, H. (1996) Cytotoxic and non-cytotoxic effects of the MEIC reference chemicals on spontaneously contracting primary cultured rat skeletal muscle cells. Toxicol. in Vitro 10, SEIBERT, H. (1996) Endokrin wirksame Chemikalien in der Umwelt: Störungen der Entwicklung und Funktion des männlichen Reproduktionssystems. UWSF 8, GÜLDEN, M. & SEIBERT, H. (1996) Synergistische Wirkung von Xenoöstrogenen. UWSF 8, 274 CLEMEDSON, C., MCFARLANE-ABDULLA, E., ANDERSSON, M., BARILE, F.A., CALLEJA, M.C., CHESNE, C., CLOTHIER, R., COTTIN, M., CURREN, R., DANIEL- PAGE 11

7 SZOLGAY, E., DIERICKX, P., FERRO, M., FISKESJÖ, G., GARZA-OCANAS, L., GOMEZ-LECHON, M.J., GÜLDEN, M., ISOMAA, B., JANUS, J., JUDGE, P., KAHRU, A., KEMP, R.B., KERSZMANN, G., KRISTEN, U., KUNIMOTO, M., KÄRENLAMPI, M., LAVRIJSEN, K., LEWAN, L., LILIUS, H., OHNO, T., PERSOONE, G., ROGUET, R., ROMERT, R., SAWYER, T.W., SEIBERT, H., SHRIVASTAVA, R., STAMMATI, A.-L., TANAKA, N., TORRES-ALANIS, O., VOSS, J.-U., WAKURI, S., WALUM, E., WANG, X., ZUCCO, F. & EKWALL, B. (1996) MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals. ATLA 24, Suppl. I, CLEMEDSON, C., MCFARLANE-ABDULLA, E., ANDERSSON, M., BARILE, F.A., CALLEJA, M.C., CHESNE, C., CLOTHIER, R., COTTIN, M., CURREN, R., DANIEL- SZOLGAY, E., DIERICKX, P., FERRO, M., FISKESJÖ, G., GARZA-OCANAS, L., GOMEZ-LECHON, M.J., GÜLDEN, M., ISOMAA, B., JANUS, J., JUDGE, P., KAHRU, A., KEMP, R.B., KERSZMANN, G., KRISTEN, U., KUNIMOTO, M., KÄRENLAMPI, M., LAVRIJSEN, K., LEWAN, L., LILIUS, H., OHNO, T., PERSOONE, G., ROGUET, R., ROMERT, R., SAWYER, T.W., SEIBERT, H., SHRIVASTAVA, R., STAMMATI, A.-L., TANAKA, N., TORRES-ALANIS, O., VOSS, J.-U., WAKURI, S., WALUM, E., WANG, X., ZUCCO, F. & EKWALL, B. (1996) MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA 24, Suppl. I, SEIBERT, H., BALLS, M., FENTEM, J. H., BIANCHI, V., CLOTHIER, H., DIERICKX, P.J., EKWALL, B., GARLE, M.J., GOMEZ-LECHON, M.J., GRIBALDO, L., GÜLDEN, M., LIEBSCH, M., RASMUSSEN, E., ROGUET, R., SHRIVASTAVA, R., & WALUM E. (1996) Acute Toxicity Testing In Vitro and the Classification and Labelling of Chemicals. The report and recommendations of ECVAM Workshop 16. ATLA 24, SEIBERT, H. (1997) Beeinträchtigung der männlichen Fertilität durch endokrin wirksame Stoffe. In: Niedersächsisches Umweltministerium (Hrsg.) Schadstoffe mit hormoneller Wirkung - Wie sicher ist unsere Zukunft? Internationales Hearing, Hannover, Tagungsband, SEIBERT, H. (1997) Chemikalien mit endokriner Wirkung - Forschungsstand und Forschungsbedarf. Journalistenseminar der Information Umwelt, Berlin; Hrsg.: GSF- Forschungszentrum für Umwelt und Gesundheit, Band 21, GÜLDEN, M. & SEIBERT, H. (1997) Influence of protein binding and lipophilicity on the distribution of chemical compounds in in vitro systems. Toxicology in Vitro 11, GÜLDEN, M., TURAN, A. & SEIBERT, H. (1997) Substanzen mit endokriner Wirkung in Oberflächengewässern. Hrsg.: Umweltbundesamt Berlin, UBA-Texte 46/97, 362 pp GÜLDEN, M., SEIBERT, H. & VOSS, J. (1997) Toxikologische Bewertungen ausgewählter organischer Stoffe für die Klassierung nach Nr TA Luft. Schriftenreihe des Instituts für Toxikologie der Universität Kiel, Heft Nr. 36, 163 S. GÜLDEN, M. & SEIBERT, H. (1997) Nicht reproduzierbar: Versuchsergebnisse zur synergistischen Wirkung von Xenoöstrogenen. UWSF 9, PAGE 12

8 SEIBERT, H. (1998) Pestizide und Industriechemikalien mit unerwünschter hormoneller Wirkung und ihr Vorkommen in Oberflächengewässern. In: Hormonal wirksame Substanzen in Umwelt und Lebensmitteln: Vorkommen, Wirkungen und toxikologische Bewertung. 8. Seminar für Toxikologie, Graz, Proceedings, BRUHN, T., LUDEWIG, S., GÜLDEN, M. & SEIBERT, H. (1999) Einstufung von Schadstoffen als endokrin wirksame Substanzen. Hrsg.: Umweltbundesamt Berlin, UBA-Texte 65/99, 143 S. SEIBERT, H. (1998) Substanzen mit endokriner Wirkung in Oberflächengewässern. In: Chemikalien in der Umwelt mit Wirkung auf das endokrine System. Hrsg.: GSF- Forschungszentrum Neuherberg, SEIBERT, H. (1998) Einstufung von Schadstoffen als endokrin wirksame Substanzen. In: Chemikalien in der Umwelt mit Wirkung auf das endokrine System. Hrsg.: GSF- Forschungszentrum Neuherberg, GÜLDEN, M., TURAN, A. & SEIBERT, H. (1998) Endocrinically active chemicals and their occurrence in surface waters. Hrsg.: Umweltbundesamt Berlin, UBA-Texte 66/98, 362 S. GÜLDEN, M., TURAN, A. & SEIBERT, H. (1999) Substanzen mit endokriner Wirkung in Oberflächengewässern. ATV-Schriftenreihe 15, GÜLDEN, M., MÖRCHEL, S. & SEIBERT, H. (2000) Factors influencing nominal effective concentrations of chemical compounds in vitro: cell concentration. Naunyn-Schmiedeberg s Arch. Pharmacol. Suppl. 361, R 164 RÖHL, C., GÜLDEN, M. & SEIBERT, H. (2000) Effects of trialkyltin compounds on rat astrocytes in primary culture. Naunyn-Schmiedeberg s Arch. Pharmacol. Suppl. 361, R 143 GÜLDEN, M., MÖRCHEL, S. & SEIBERT, H. (2001) Factors influencing nominal effective concentrations of chemical compounds in vitro: cell concentration. Toxicol. in Vitro 15, RÖHL, C., GÜLDEN, M. & SEIBERT, H. (2001) Toxicity of organotin compounds in primary cultures of rat cortical astrocytes. Cell Biol. Toxicol. 17, MURIAS, M., MATLAWSKA, I., BYLKA, W., GÜLDEN, M. & SEIBERT, H. (2001) An in vitro investigation of antioxidant properties of Aquilegia vulgaris preparations using cultured C6 glioma cells. 6. Conference Interactions of Xenobiotics, Kiekrz, Polen SEIBERT, H., MÖRCHEL, S. & GÜLDEN, M. (2002) Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration. Toxicol. in Vitro 16, GÜLDEN, M., MÖRCHEL, S., TAHAN, S. & SEIBERT, H. (2002) Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicology 175, SEIBERT, H. (2002) Wirkmechanismen von Umweltchemikalien mit endokrinem Potenzial. In: BfG (Hrsg.) Neuartige toxische Effekte und ihre Relevanz für die Baggergutbeurteilung. BfG- Veranstaltungen 2/2002 PAGE 11

9 ZIELINSKA, M:, GÜLDEN, M. & SEIBERT, H. (2003) Effects of quercetin and quercetin-3-oglycosides on oxidative damage in rat C6 glioma cells. Environm. Toxicol. Pharmacol. 13, GÜLDEN, M., MÖRCHEL, S., SEIBERT, H. (2003) Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay. Toxicology Letters 137, GÜLDEN, M., SEIBERT, H. (2003) Estimation of human serum concentrations of chemicals equivalent to toxic concentrations in vitro. Naunyn-Schmiedeberg s Arch. Pharmacol. 367 (Suppl. 1) R 162 GÜLDEN, M., SEIBERT, H. (2003) In vitro-in vivo extrapolation: estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro. Toxicology 189, GÜLDEN, M., SEIBERT, H. (2003) Bioverfügbarkeit von Chemikalien in vitro und ihre Bedeutung für toxische Potenzen und In vitro-in vivo-extrapolationen. SETAC Tagung Heidelberg GÜLDEN, M. & SEIBERT, H. (2004) Bioavailability of chemicals in vitro: impact on predictions of toxic potencies in mammals and aquatic test organisms. Naunyn-Schmiedeberg s Arch. Pharmacol. 369 (Suppl. 1) R 556 SEIBERT, H., MÖRCHEL, S., GÜLDEN, M. (2004) Cytotoxic potency of trialkyltins to C6 glioma cells in vitro: impact of exposure conditions. Cell Biology and Toxicology 20, WULF, B., GÜLDEN, M., SEIBERT, H. (2004) Further evaluation of the MEIC in vitro toxicity data base. INVITOX 2004 GÜLDEN, M. SEIBERT, H. (2004) Quantitative in vitro-in vivo extrapolation of cytotoxic potencies determined in vitro. INVITOX 2004 GÜLDEN, M., SEIBERT, H. In vitro testing for acute systemic toxicity assessment: integration of biokinetic parameters. INVITOX 2004 GÜLDEN, M., MÖRCHEL, S. SEIBERT, H. (2005) Comparison of mammalian and fish cell line cytotoxicity: impact of endpoint and exposure duration. Aquatic Toxicology 71, GÜLDEN, M., SEIBERT, H. (2005) Impact of bioavailability on the correlation between in vitro cytotoxic and in vivo acute fish toxic concentrations of chemicals. Aquatic Toxicology 72, SEIBERT, H. (2005) In vitro-tests zur Prüfung potenziell endokriner Wirkungen von chemischen Verbindungen: die Arbeit der Validation Management Group Non-animal Assays bei der OECD. 3. Statusseminar: Chemikalien in der Umwelt mit Wirkung auf das endokrine System, Berlin. Proceedings: SEIBERT, H., GÜLDEN, M. (2005) Assessment of the systemic toxicity of chemicals by means of in vitro assays: toxicodynamic and toxicokinetic aspects. ETS & SSCT joint conference, Toila, Estland PAGE 12

10 SEIBERT, H., WULF, B. GÜLDEN, M. (2005) Comparative toxicity of chemicals in vitro: further evaluation of the data of the MEIC programme. ETS & SSCT joint conference, Toila, Estland GÜLDEN, M., SEIBERT, H. (2005) Improvement of in vitro cytotoxicity testing for assessing acute fish toxicity. ATLA (in press) KUZIW, M., GÜLDEN, M., MASER, E., SEIBERT, H. (2005) Protection of C6 glioma cells by polyphenols against peroxide-induced oxidative stress. ETS & SSCT joint conference, Toila, Estland MÜLLER, A., GÜLDEN, M., MASER, E., SEIBERT, H. (2005) Influence of pre-loading on the cytoprotective activity of F0 61-tocopherol against oxidative stress in C6 glioma cells. ETS & SSCT joint conference, Toila, Estland GÜLDEN, M., SEIBERT, H. (2006) In vitro-in vivo extrapolation of toxic potencies for hazard and risk assessment problems and new developments. 5 th World Congress on Alternatives & Animal Use in the Life Sciences, Berlin; Proceedings, ALTEX 23: GÜLDEN, M., DIERICKX, P., SEIBERT, H. (2006) Validation of a prediction model for estimating serum concentrations of chemicals which are equivalent to toxic concentrations in vitro. Toxicology in Vitro 20, SEIBERT, H., GÜLDEN, M. (2006) Impact of experimental conditions on toxic activities of chemicals in vitro Part I: Experimental studies. 24 th Workshop of the Scandinavian Society of Cell Toxicology; Grinda, Sweden GÜLDEN; M., SEIBERT, H. (2006) Impact of experimental conditions on toxic activities of chemicals in vitro Part II: modelling of distribution and bioavailability. 24 th Workshop of the Scandinavian Society of Cell Toxicology; Grinda, Sweden RÜWELER, M., GÜLDEN, M., MASER, E., MURIAS; M., SEIBERT, H. (2006) Cytotoxicity of resveratrol and analogues and cytoprotection against oxidative stress in C6 astroglioma cells in vitro. 24 th Workshop of the Scandinavian Society of Cell Toxicology, Grinda, Sweden BEKEN, J., JIROVA, D., PÜSSA, T., LARUE, L., LIEBSCH, M., STAMMATI, A., VAN DER VALK, J., MIRCIOIU, C., BREIER, A., CASTANO, A., AMCOFF, P., RICHMOND, J., WESTMORELAND, C., ROGIERS, V., ALEPEE, N., COMBES, R., SEIBERT, H. (2007) ESAC Statement on the validity of in vitro tests for skin irritation. ATLA 35, BEKEN, J., JIROVA, D., PÜSSA, T., LARUE, L., LIEBSCH, M., STAMMATI, A., VAN DER VALK, J., MIRCIOIU, C., BREIER, A., CASTANO, A., AMCOFF, P., RICHMOND, J., WESTMORELAND, C., ROGIERS, V., ALEPEE, N., COMBES, R., SEIBERT, H. (2007) ESAC Statement on the Reduced Local Lymph Node Assay (rllna). ATLA 35, BEKEN, J., JIROVA, D., PÜSSA, T., LARUE, L., LIEBSCH, M., STAMMATI, A., VAN DER VALK, J., MIRCIOIU, C., BREIER, A., CASTANO, A., AMCOFF, P., RICHMOND, J., WESTMORELAND, C., ROGIERS, V., ALEPEE, N., COMBES, R., SEIBERT, H. (2007) ESAC Statement on the conclusions of the ICCVAM retrospective study on organotypic in vitro assays as screening tests to identify potential ocular corrosives and severe irritants as determined by PAGE 11

11 US EPA, EU(R41) and UN GHS classifications in a tiered testing strategy, as part of a weight of evidence approach. SEIBERT, H., HORBACH, S., BLAAUBOER, B. (2007) Fourteenth international workshop on in vitro toxicology, 2-5 October 2006, Toxicology in Vitro21, GÜLDEN, M., SEIBERT, H. (2007) The improvement of in vitro cytotoxicity testing for the assessment of acute toxicity in fish. ATLA 35, BEKEN, S., BREIER, A., DAMBROVA, M., HORVATH, K., JIROVA, D., KOLAR, R., KNUDSEN, E., LIEBSCH, M., LARUE, L., DAL NEGRO, G., NIKOLAIDIS, E., MIRCIOIU, C., PFALLER, W., RICHMOND, J., ROGIERS, V., SEIBERT, H., SLADOWSKI, D., VAN DER VALK, J., WESTMORELAND, C., YLIKOMI, T. (2008) ESAC Statement on the performance Standards (PSs) for the Local Lymph Node Assay (LLNA). LINDEN, A., GÜLDEN, M., MARTIN, H-J., MASER, E., SEIBERT, H. (2008) Peroxideinduced cell death and lipid peroxidation in C6 glioma cells. Toxicology in Vitro 22, RÜWELER, M., ANKER, A., GÜLDEN, M., MASER, E. SEIBERT, H. (2008) Inhibition of peroxide-induced radical generation by plant polyphenols in C6 astroglioma cells. Toxicology in Vitro 22, PFALLER, W., JIROVA, D., KNUDSEN, E., PÜSSA, T., YLIKOMI, T., LIEBSCH, M., NIKOLAIDIS, E., HORVATH, K., STAMMATI, A., DAMBROVA, M., MAURICA, M., VAN DER VALK, J., MIRCIOIU, C., CASTANO, A., AMCOFF, P., WESTMORELAND, C., ROGIERS, V., DAL NEGRO, G., SEIBERT, H., JENNINGS, M., KOLAR, R. (2008) ESAC Statement on the use of FCS and other animal-derived supplements. ATLA 36, SEIBERT, H. (2008) 25 th Workshop of the Scandinavian Society for Cell Toxicology, Salzau, Germany, Toxicology in Vitro 22,1349 RÜWELER, M., GÜLDEN, M., MASER, E., MURIAS, M., SEIBERT, H. (2009) Cytotoxic, cytoprotective and antioxidant activities of resveratrol and analogues in C6 astroglioma cells in vitro. Chemico-Biological Interactions 182, BRENNER, S., GÜLDEN, M., MASER, E., SEIBERT, H. (2010) Lasting effect of preceding culture conditions on the susceptability of C6 cells to peroxide-induced oxidative stress. Toxicology in Vitro 24, CASTANO, A., DAMBROVA, M., GRAY, A., HORVATH, K., JENNINGS, M., JIROVA, D., KOLAR, R., KNUDSEN, E., LIEBSCH, M., DAL NEGRO, G., PFALLER, W., PÜSSA, T., ROGIERS, V., SEIBERT, H., STAMMATI, A., VAN DER VALK, J., WESTMORELAND, C., (2009) ESAC Statement on the scientific validity of an in vitro test method for skin corrosivity testing. CASTANO, A., DAMBROVA, M., GRAY, A., HORVATH, K., JENNINGS, M., JIROVA, D., KOLAR, R., KNUDSEN, E., LIEBSCH, M., DAL NEGRO, G., PFALLER, W., PÜSSA, T., ROGIERS, V., SEIBERT, H., STAMMATI, A., VAN DER VALK, J., WESTMORELAND, C., (2009) Statement on the performance under GHS of three in vitro assays for skin irritation testing PAGE 12

12 and the adaptation of the reference chemicals and defined accuracy values of the ECVAM skin irritation performance standards. GÜLDEN, M., JESS, A., KAMMANN, J., MASER, E., SEIBERT, H. (2010) Cytotoxic potency of H 2 O 2 in cell cultures: impact of cell concentration and exposure time. Free Radical Biology & Medicine 49, GÜLDEN, M., SEIBERT, H. (2010) Concentration or dose: what is the proper measure for quantitative in vitro-in vivo extrapolation of toxic potency? ALTEX 27, KAMMANN, J., GÜLDEN, M., MASER, E., SEIBERT, H (2010) Variability of elimination rate and cytotoxic potency of peroxides in C6 astroglioma cell cultures. ALTEX 27, SEIBERT, H., JESS, A., LINDEN, A., MASER, E., PERLE, M., GÜLDEN, M. (2010) Peroxide-induced oxidative stress and cell death in C6 astroglioma cells. ALTEX 27, 123 SEIBERT, H., MASER, E., SCHWEDA, K., SEIBERT, S., GÜLDEN, M. (2011) Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells. Food and Chemical Toxicology 49, SEIBERT, H. & GÜLDEN, M. (2011) In vitro-in vivo extrapolation of toxic potencies: basic requirements. 28 th Workshop of the Scandinavian Society for Cell Toxicology, Tampere, Finland, Abstracts, 27 KAMMANN, J., GÜLDEN, M., SEIBERT, H. (2012) Erstellung eines Konzeptes zur integrierten Bewertung der Umwelt- und Humandaten der Umweltprobenbank des Bundes. Abschlußbericht zum UBA-Projekt: , Band 1 und 2 (569 Seiten) BlaauboeR, B., J., Boekelheide, K., Clewell, H., J., Daneshian, M., Dingemans, M., M., L., Goldberg, A., M., Heneweer, M., Jaworska, J., Kramer, N., I., Leist, M., Seibert, H., Testai, E., VandebrieL, R., J., Yager, J. D. and Zurlo, J. (2012) The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. Transatlantic think tank for toxicology, t4 Workshop Report, ALTEX 29, Klauser, E., Gülden, M., Maser, E., Seibert, S., Seibert, H. (2013) Effects of genistein and buthionine sulfoximine on arsenic trioxide-induced growth inhibition in C6 astroglioma cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 386, S41 SCHÜLER, W., GÜLDEN, M., MASER, E., SEIBERT, S., SEIBERT, H. (2013) Direct and sustained cytoprotective activity of quercetin in C6 astroglioma cells exposed to continuously generated or bolus applied H 2 O 2. Naunyn-Schmiedeberg's Arch. Pharmacol. 386, S75 GÜLDEN, M., SCHREINER, J., SEIBERT, H. (2013) In vitro toxicity testing with microplate cell cultures: impact of cell binding. Toxicology, doi: /j.tox KLAUSER, E., GÜLDEN, M., MASER, E., SEIBERT, S., SEIBERT, H. (2014) Additivity, antagonism, and synergy in arsenic trioxide-induced growth inhibition of C6 glioma cells: effects of genistein, quercetin and buthionine-sulfoximine. Food and Chemical Toxicology 67, PAGE 11

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