Breeding progress through data acquisition and data analysis. Schweizer SennenhundVerein für Deutschland e.v. Dr. Norbert Bachmann

Transkript

1 Breeding progress through data acquisition and data analysis Schweizer SennenhundVerein für Deutschland e.v.

2 Execution of breeding in the SSV according to phase program: Phase I In case problems occur increasingly within the population, data will becollected. Problems can be aberration of health as well as deviations in the exterior.

3 Execution of breeding in the SSV according to phase program: Phase II Evaluation of the data collected in phase I. Creation of a breeding program involving the club members as well as scientific support.

4 Execution of breeding in the SSV according to phase program: Phase III Verification of the breeding success (population analysis) continue the breeding program modificate the breeding program stop the breeding program.

5 Breeding goals-priority list health / high life span FCI standard for Bernese Mountain Dogs movement (functional properties) behavior (functional properties) exterior

6 Breeding goals-priority list health / high life span increase the average life span -> 9-10 years fighting cancer fighting hip dysplasia fighting elbow dysplasia

7 Breeding goals-priority list FCI standard for Bernese Mountain Dogs: Movement (functional properties) GAIT / MOVEMENT : Sound and balanced movement in all gaits covering a lot of ground; free stride reaching well out in front, with good drive from behind; at the trot, coming and going, legs moving forward in a straight line. important for quality of life!

8 Breeding goals-priority list FCI standard for Bernese Mountain Dogs: BEHAVIOUR / TEMPERAMENT: Self-confident, attentive, vigilant, fearless in every day situations; good-naturedand devoted to his own people, self-assured and placid towards strangers ; of medium ; of medium temperament, docile. important for quality of life! important for quality of life!!!

9 Breeding strategies since 1978 until 2012 Data capturing Data storage Data maintenance Transparency of data (understandable for every breeder) Data capturing Data storage Data maintenance Blood sample collection Blood sample processing Blood sample warehousing DNA-extraction Since 1996 Blood sample collection Blood sample processing Blood sample warehousing DNA-extraction until 2012 Breeding with phenotypic information from 2012 on Breeding with genomic breeding values Breeding with phenotypic information

10 Promotion of data density / data transparency Voluntary measures (examples) questionnaire activities reward of transparency annual publication of the reporting rates of live and death Non Voluntary Breeding regulations (examples) responsibility to genome testing from the third litter..." "10 out of 14 ancestors must have death or life reports publication of data in database

11 Phase III - Breeding success review (population analysis) Example: life span average life expancy of Bernese Mountain dogs, in months, SSV /617 Meld. 102,62 102,98 103,53 101,7 1990/196 Meld. 1991/230 Meld. 1992/222 Meld. 97, /268 Meld. 93, /316 Meld. 100,4 1995/306 Meld. 98, /351 Meld. 92, /483 Meld. 92, /388 Meld. 91, /372 Meld. 96, /319 Meld. Year of birth Bernes Mountain dogs,ssv 2001/438 Meld. 91,14 91,05 90, /492 Meld. 2003/401 Meld. 2004/335 Meld. 97,51 97, /289 Meld.

12 Phase III - Breeding success review (population analysis) Example: life span Blutabnahme bei Zuchthunden für eine "Blutbank" Dr. Terill Eckart referiert zum Malignen Histiozytose bei dem SSV-Zuchtin Hohenroda Lebenserwartung beim Berner Sennenhund wird zum zentralen Thema Formulare Totmeldungen internationales Gesundheitssymposium in der Gesundheitssymposium Schweiz, der SSV stellt zum erstmalig seine Hohenroda Zuchtplan Berner Sennenhunde: Fragebögen "Tod-/Lebendmeldung" Zuchtstrategien zu Langlebigkeit und Gesundheit "Lebenserwartung Berner Deckrüdenbeschränkung/- Meldeverpflichtung Lebend-/Todmeldung C.Fechler/ Dr. N. Bachmann Sennenhunde" zentrales Thema umverteilung Altersfrischewettbewerbe Einführung SSV-Kurier als neues Medium Informationsartikel zum Lebensalter durch Höhere Lebenserwartung in SSV- Chronik als Zuchtziel durch Arbeitskreis Berner formuliert "10 von 14 Regel, Lebend- /Todmeldung" Arbeitskreis Berner Anerkennung der Frühsterblichkeit Randomisierung 1. internationales Gesundheitssymposium in der Schweiz, als "genetisches Problem" Röntgenkandidaten ca. 550 Todmeldungen K.Klaiber Präsident C. Fechler Zuchtleiter u. Zuchtbuchführer Dr. N. Bachmann, Präsident C. Fechler Zuchtleitung Satzungsreform: Zuchtentscheidung: Zuchtausschuss u. Mitgliederversammlung

13 Phase III - Breeding success review (population analysis) Example: life expectancy and genomic breeding values Introduction of the genome test on a voluntary basis: dogs tested genomically 917 registered in Dogbase 364 are dead Publication of results for life expectancy, hip dysplasia and elbow dysplasia SSV pretest (histiocytic sarcoma, MH)

14 Phase III - Breeding success review (population analysis) Example: life expectancy and genomic breeding values Life ecpectancy corelating with the genomic breeding value for longevity dogs 74 dogs 85 dogs 79 dogs 76 dogs Gr. 1: > 143 Mo Gr. 2: Mo Gr. 3: Mo Gr. 4: Mo Gr. 5:< 72 Mo genomically tested dogs, reported dead (07/2018) mittlere averagelebenserwartung life expectancies in in months Monaten ,4 132, ,8 102,3 82,5 89,7 54,3 80,1 mittlerer average genomic genomischer breeding Zuchtwert value "Langlebigkeit" longevity Lineair Linear (mittlerer (average genomic genomischer Zuchtwert breeding value "Langlebigkeit") longevity ) mittlere average life Lebenserwartung expectancies in months in Monaten ,3 107,8 82,5 54,3 mittlerer average genomic genomischer breeding Zuchtwert value longevity "Langlebigkeit" 121, ,3 89,7 80,1

15 Phase III - Breeding success review (population analysis) Example: life expectancy and genomic breeding values We can draw the following conclusions: A high age means a high genomic life value. In case the curve runs similarly linear in the next 3 to 5 years when a majority of the test candidates will be dead, we can for sure claim the genomic breeding value for age a suitable breeding instrument to increase the life expectancy.

16 Phase III - Breeding success review (population analysis) Example: life expectancy and genomic breeding values Life expectancy in relation to to the genomic breeding value for "Histiocytic sarcoma" (07/2018) dogs 74 dogs 85 dogs 79 dogs 76 dogs Gr. 1: > 143 Mo 152 Gr. 2: Mo 132,3 90,6 91,4 Gr. 3: Mo 107,8 101,7 Gr. 4:72-95 Mo 82,5 117,7 Gr. 5:< 72 Mo 54,3 107, mittlere averagelebenserwartung life expectancies in months in Monaten ,3 107,8 82,5 54,3 mittlerer average genomic genomischer breeding Zuchtwert value "Histiozytäres Histiocytic sarcoma Sarkom" 90,6 91,4 101,7 117,7 107,6 mittlere averagelebenserwartung life expectancies in months in Monaten mittlerer average genomischer genomic breeding Zuchtwert value Histiocytic "Histiozytäres sarcoma Sarkom"

17 Phase III - Breeding success review (population analysis) Example: life expectancy and genomic breeding values Conclusio: For reaching a very high age > 10 years the SSV-pretest alone is not meaningful The results of the SSV-pretest within the group 10 years and older (reached age) as well as within the group died under the age of 8 are on a similar level. Therefore a simultaneous consideration of the genomic breeding value for age is essential for the breeding progress.

18 Phase III - Breeding success review (population analysis) Example: X-ray rate %

19 Phase III - Breeding success review (population analysis) Example: hip-dysplasie BERNER SENNENHUND 100% 80% 60% 40% 20% 0% Geburtsjahrgang HD-frei HD-Verdacht HD-leicht HD-mittel HD-schwer

20 Phase III - Breeding success review (population analysis) Example: ellbow-dysplasie 100% 80% 60% 40% 20% 0% Geburtsjahrgang ED-frei ED-Grad I ED-Grad II ED-Grad III

21 The long way to healthy, suitable and standard-conformant dogs Collection and record of data Data density Data quality Blood sample collection Constant evaluation and verification of the development of breeding progress

22 Thank you for your attention!