Global Emerging Fungal Infection Registry. Initiated in Report June Working group of the. Under the auspices of

Transkript

1 Global Emerging Fungal Infection Registry Initiated in 2003 Report June 2014 Working group of the Under the auspices of Supported by unrestricted grants from Astellas Pharma, Gilead Sciences, Merck and Pfizer

2 Table of Contents Table of Contents... 2 Introduction... 3 Current Results... 7 Public Relation Activities FungiQuest Activity Achievements and Goals Presentations Publications Awards Recent Accomplishments Goals for Contact Information Study Co-ordinators Contributors Members Report June

3 Introduction The incidence of invasive fungal infections (IFI) is increasing in all parts of the world. The etiology for this ongoing epidemiological development is not completely understood. However, major contributing factors are the increasing number of transplantation procedures undertaken around the world (estimated at 500,000 per year), a widening of the indications for intensive chemotherapy, and the growing number of other clinical conditions requiring immunosuppressive treatment. Therapeutic standards have been developed for the most frequent IFI, i.e. candidiasis, aspergillosis and cryptococcosis. However, the so called emerging fungi are also a reason for the increased number of IFIs. Thus, clinicians are now facing infections due to a variety of different fungi without any reliable treatment recommendations and therapeutic decision making is not evidence-based. Prevalence of emerging fungi is virtually unknown and there is an additional knowledge gap in pathogen biology, since isolates have not been collected systematically. These shortcomings have been described in detail in the recent Clinical Practice Guidelines of the European Fungal Infection Study Group (ESCMID- EFISG) and the European Confederation of Medical Mycology (ECMM). In order to help alleviate the lack of knowledge on epidemiology, clinical course, biology and pathomechanisms, and finally to aid in facilitating an evidence based diagnostic-therapeutic integrated approach of IFI caused by emerging fungi, FungiScope - A Global Emerging Fungal Infection Registry was created in FungiScope uses a web-based electronic case form accessible via For inclusion in the registry, cultural, histopathological, serological or molecular evidence of IFI and associated clinical symptoms and signs are required. The clinical data on underlying disorder and IFI are entered through a web-based interface. Ideally, the pathogen isolated and samples of infected tissue are collected, examined and stored in a bio-bank called Fungithek. The clinical and biological data are subsequently evaluated and analysed. Figure 1a and b present the data / sample flow and overall project structure. The clinical database and the bio-bank are connected and anonymized data are easily accessable via a web-based search engine FungiQuest (Figure 2). In the following report we introduce the most current results and achievements. We also discuss future goals and ongoing developments of the project. Report June

4 Figure 1a: Project structure Report June

5 Sequencing Isolate FungiThek Morphological reference Biopsy FungiThek Sequencing and Ribosomal RNA FISH Figure 1b: Material flow Report June

6 Found a fungus you know nothing about? FungiQuest. go to Type the name of the fungus into the search box Browse through FungiScope cases with the same kind of fungal infection Figure 2: FungiQuest database search engine Report June

7 Current Results To date, 373 cases have been documented and considered valid. The most frequently registered pathogens were Mucorales (previously Zygomycetes) (n=164; 57.9%), Fusarium spp. (n=61; 16,4%), yeasts (n=51; 13.7%), and Dematiaceae (n=36; 9.7%) followed by Penicillium spp. / Paecilomyces spp. (n=17; 4.6%) and Scedosporium spp. (n=14; 3.8%) (Figure 3). The majority of patients were Caucasian followed by Asian and North/South American Indian origins (Figure 4). The contribution of cases by country is shown in Figure 5. Sites of infection differed among pathogens (Figure 6). In patients with invasive mucormycosis, the lungs were the most commonly involved organs with an incidence of 70.7%. Other involved sites were the paranasal sinuses (23.2%), deep soft tissues (14.6%) and the central nervous system (13.4%). Fusarium spp. infections most frequently presented as blood stream infections or skin infections (49.2% each). Other commonly affected sites were lungs (37.6%) and deep soft tissues (21.3%). Infections with Dematiaceae mostly involved the eyes, paranasal sinuses, deep soft tissues, and skin (range from 11.1% to 30.6%). By contrast, yeasts were most often diagnosed from blood cultures (66.7%) followed by pulmonary infections (27.5%). The evaluation of risk factors for the development of IFI revealed differences between individual pathogens shown in Figure 7. The most common risk factors for developing an infection with Mucorales or Fusarium spp. were chemotherapy (57.9% and 60.7%, respectively) or haematopoetic stem cell transplantation (HSCT) (31.1% for both) followed by ICU stay and diabetes mellitus with rates ranging from 14.8% to 28%. Furthermore, chemotherapy was the most common risk factor in patients presenting with yeast infections (51%). In addition, 35.5% of patients were treated in intensive care units. Other risk factors were diabetes mellitus and chronic pulmonary disease (13.7% each), haematopoetic stem cell transplantation (15.7%) and solid organ transplantation (11.8%). By contrast, patients with a Dematiaceae infection presented most frequently with diabetes mellitus (44.4%) and/or chronic renal disease (16.7%). All-cause-mortality, mortality due to fungal infection and response to treatment differed among individual pathogens (Figure 8). The highest all-cause-mortality was observed in patients with mucormycosis (59.8%), followed by patients with yeast (54.9%) and Fusarium spp. infections (52.5%). Mortality due to fungal infection was highest in patients with Mucorales (45.7%) followed by yeast (41.2%) and Fusarium spp (41.0%). By contrast, the lowest all-cause-mortality was observed in patients with Dematiaceae (8%). None of these deaths were due to the Report June

8 fungal infection. The highest rates of complete and partial remission were observed in patients with IFI caused by Dematiaceae and Penicillium/Paecilomyces spp (73.5% and 70.6%, respectively). Patients with a Mucorales infection displayed the lowest rate of response to treatment (39.4%). In conclusion, the clinical relevance of invasive fungal infections by emerging fungi is increasing. Over the past 10 years a large number of cases from numerous countries around the globe could be documented and showed a broad spectrum of pathogens. Further investigators and coordinators are encouraged to contribute to the significant success of FungiScope. Report June

9 Mucorales (previously Zygomycetes) Fusarium Yeast Dematiaceae Penicillium/Paecilomyces Scedosporium Other Figure 3: Distribution of 373 pathogens by major groups Report June

10 number of cases Caucasian (White) 260 Asian North/South American Indian or Alaska Native Sub-Saharan African/Afro-American Hispanic/Latino North African Unkown Figure 4: Ethnicities Figure 5: Contributing countries Report June

11 Mucorales (previously Zygomycetes) (n=164) Fusarium spp (n=61) Lungs 71% Blood 49% Paranasal Sinus 23% Skin 49% Soft tissue Central nervous system Bones 15% 13% 12% Lungs Soft tissue 21% 38% GI-Tract 12% Paranasal Sinus 16% Skin 10% Eyes 13% 0% 20% 40% 60% 80% 0% 20% 40% 60% Blood Yeasts (n=51) 67% Dematiaceae (n=36) Lungs 28% Eyes 31% Liver 14% Paranasal Sinus 25% Kidney Central nervous system Soft tissue 14% 12% 8% Soft tissue Skin 11% 23% 0% 20% 40% 60% 80% 0% 10% 20% 30% 40% Figure 6: Sites of infection for major groups Report June

12 Mucorales (previously Zygomycetes) (n=164) Fusarium spp (n=61) Fusarium spp (n=58) Chemotherapy 58% Chemotherapy 57% 61% HSCT 31% HSCT HSCT 31% 31% ICU stay 28% ICU stay ICU stay 22% 21% Diabetes mellitus 17% Diabetes Diabetes mellitus mellitus 14% 15% 0% 20% 40% 60% 80% 0% 20% 40% 60% 0% 20% 40% 60% 80% Yeasts (n=51) Dematiaceae (n=36) Chemotherapy 51% ICU stay HSCT 16% 36% Diabetes Yeasts (n=51) 44% Diabetes mellitus 14% Chronic pulmonary disease 14% Solid organ transplant 12% Chronic renal disease 12% Major surgery 10% 0% 10% 20% 30% 40% 50% 60% 70% ICU stay Chronic pulmonary disease Chronic renal 17% HSCT disease Chronic renal disease 0% 10% 20% 30% 40% 50% 60% 0% 20% 40% 60% Figure 7: Most important risk factors for major groups Report June

13 80% 74% 70% 60% 50% 40% 60% 55% 53% 46% 41% 41% 39% 51% 49% 30% 20% 10% 0% 8% Mortality Mortality due to IFI Favourable outcome 3% Mucorales Fusarium spp. Yeasts Dematiaceae Figure 8: Outcomes for major groups Report June

14 Public Relation Activities We were pleased to present FungiScope at ICAAC 2013 in Denver at a booth in the exhibition hall. There we offered information about the project in pamphlets as well as reminders of the activity (FungiScope pens and post-it pads). During the three days of the convention, an estimated 100 conversations, either brief or more in-depth, were held about the project with interested booth visitors. The majority of visitors, who were mainly clinicians or microbiologists, had never heard of FungiScope before. Many commented that there is a definite need for this registry and were happy to realize that it exists and could be a receptacle for cases from their institution. Approximately 250 flyers were taken, along with 500 pens and 250 post-it pads. Karen Pankraz, TA from our team, was at the booth fulltime to welcome inquiries and distribute information. Additionally, Dr. Wahlers, Dr. Vehreschild and Prof. Cornely were often present to answer specific and in-depth questions about the project. Where appropriate, contact information was collected for future collaboration. Overall, this was a positive experience for our team many inquiries, much positive feedback. FungiQuest Activity The usage of FungiQuest has been monitored continuously over the last 3 years. Figure 9 gives an overview of the number of enquiries on the website ( whereas Figure 10 provides an overview of the countries from which the enquiries came from. Of note, the usage has increased considerably since May 2013 i.e. after our ECCMID appreance. Report June

15 Figure 9: Number of enquiries of FungiQuest per month (trendline in blue) Report June

16 Figure 10: Country of origin of FungiQuest-Users Report June

17 Achievements and Goals Presentations June 25 28, 2014 June 15 16, 2014 May 10 13, 2014 January 10 12, 2014 October 11 14, 2013 September 22 25, 2013 September 9 13, 2013 September 5 7, 2013 April 27 30, 2013 October 19-23, 2012 September 9-12, 2012 June 23-26, 2012 April 25-28, 2012 March 31-April 3, 2012 January 24-25, 2012 Kongress für Infektionskrankheiten und Tropenmedizin (KIT), Köln, Germany Symposium on Infections in the immunocompromised hosts, International Immunocompromised Host Society (ICHS), Berlin, Germany 24 th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain 10 th National Conference of the Society for Indian Human and Animal Mycologists (SIHAM), Coimbatore, Tamil Nadu, India 6 th Trends in Medical Mycology (TIMM), Copenhagen, Denmark Joint Annual Meeting of the German Society for Hygiene and Microbiology and the German Society for Infectious Diseases (DGI), Rostock, Germany 53 rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Denver, CO, USA 47 th Congress of the German Society for Mycology (DMykG e.v.), Tübingen, Germany 23 rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Berlin, Germany Annual Congress of the German Society for Hematology and Oncology (DGHO), Stuttgart, Germany 52 nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, USA 18 th Congress of the International Society for Human and Animal Mycology, Berlin, Germany 11 th Congress of Infectious Diseases and Tropical Medicine, Cologne, Germany 22 nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), London, UK 3 rd WATL-Congress, Berlin, Germany Report June

18 Publications October 2013 Nucci M, Marr K, Vehreschild M, de Souza C, Velasco E, Cappelano P, Carlesse F, Queiroz-Telles F, Sheppard D, Kindo A, Cesaro S, Hamerschlak N, Solza C, Heinz W, Schaller M, Atalla A, Arikan- Akdagli S, Bertz H, Castro Jr C, Herbrecht R, Hoenigl M, Härter G, Hermansen NE, Josting A, Pagano L, Salles M, Mossad SB, Ogunc D, Pasqualotto A, Araujo V, Troke P, Lortholary O, Cornely O, Anaissie E. Improvement in the outcome of invasive fusariosis in the last decade. Accepted for publication in Clinical Microbiology and Infection May 2013 Pagano L, Cornely O, Caira M, Cesaro S, Gasbarrino C, Girmenia C, Heinz WJ, Herbrecht R, Lass-Flörl C, Nosari A, Potenza L, Racil Z, Rickerts V, Sheppard DC, Simon A, Ullmann AJ, Valentini CG, Vehreschild JJ, Candoni A, Vehreschild MJ. Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematological diseases: a report from the SEIFEM and FUNGISCOPE registries. Haematologica 2013 May 28, Epub ahead of print January 2013 Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ, Bialek R, Schmoll HJ. Right flank pain and high fever in a neutropenic patient with acute lymphoblastic leukaemia. Mycoses 2013, Jan; 56(1):90-92 October 2011 de Hoog GS, Robert V, Lackner M, Vehreschild MJ, Vehreschild JJ, Symoens F, Göttlich-Fligg E, Garcia- Hermoso D, Harun A, Meyer W, Chen SC, Hamprecht A, Fischer G, Buzina W, Cornely OA, Guarro J, Cano J, Horré R. Making moulds meet. Information retrieval as a basis for understanding Pseudallescheria and Scedosporium. Mycoses 2011 Oct;54 Suppl 3:1-4 December 2009 M.J.G.T. Rüping, W.J. Heinz, A.J. Kindo, V. Rickerts, C. Lass-Flörl, C. Beisel, R. Herbrecht, Y. Roth, G. Silling, A.J. Ullmann, K. Borchert, G. Egerer, J. Maertens, G. Maschmeyer, A. Simon, M. Wattad, G. Fischer, J.J. Vehreschild, O.A.Cornely. Report June

19 Forty-one Recent Cases of Invasive Zygomycosis from a Global Clinical Registry. J Antimicrob Chemother 2010 Feb;65(2): July 2008 Rüping MJGT, Albermann N, Ebinger F, Burckhard I, Beisel C, Müller C, Vehreschild JJ, Kochanek M, Fätkenheuer G, Bangard C, Ullmann AJ, Herr W, Kolbe K, Hallek M, Cornely OA. Posaconazole concentrations in the central nervous system. J Antimicrob Chemother 2008 Dec;62 (6): Awards Young Investigator Award 2010 (Nachwuchsförderpreis) of the German Society for Mycology (DMykG e.v.) awarded to Dr. M.J.G.T. Vehreschild for her work on FungiScope Recent Accomplishments Booth in exhibit hall of 53 rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Denver, CO, USA (September 9 13, 2013) Database restructuring including: o Harmonizing different wording used for documentation o Structural adjustments facilitating data export and analysis o Incorporation of FungiThek into the database Goals for 2014 Launch of improved database and new CRF Publication of a subset analysis on rare yeasts, including resistance patterns Publication of a comparison between sequencing and morphological results for the first 100 FungiScope isolates Extending the FungiQuest platform (online since April 2010): o Faster inclusion of new cases o Inclusion of FungiThek / isolate information o Improved search-engine Report June

20 Contact Information Chair Oliver A. Cornely, MD, FIDSA, FACP Project manager Danila Seidel, PhD Coordinating physicians Maria J.G.T. Vehreschild (née Rüping), MD Kerstin Wahlers, MD Reviewing physicians Philipp Köhler, MD Hilmar Wisplinghoff, MD Technical advisor, site operator clinicalsurveys.net Jörg J. Vehreschild, MD University Hospital of Cologne Department I for Internal Medicine Infectious Diseases Clinical Trials Unit II Herderstr Cologne Germany T F Report June

21 Study Coordinators Clinical ID Microbiology Molecular Biology Pharmacology Pathology Austria Elisabeth Presterl, MD Allgemeines Krankenhaus - Universitätskliniken Wien Währinger Gürtel Wien T F elisabeth.presterl@meduniwien. ac.at Brazil Cornelia Lass-Flörl, MD Institute of Hygiene, Microbiology and Social Medicine Universität Innsbruck Fritz-Pregl-Str Innsbruck T F cornelia.lass-floerl@uibk.ac.at Walter Buzina, MD Institut für Hygiene Medizinische Universität Universitätsplatz Graz T F walter.buzina@meduni-graz.at Ulrich Strasser. MD Institut für Pathologie Medizinische Universität Innsbruck Müllerstr. 44 A-6020 Innsbruck T F ulrich.strasser@i-med.ac.at Marcio Nucci, MD Hospital Universitário Universidade Federal do Rio de Janeiro Av. Brigadeiro Trompovsky S/N Rio de Janeiro T F mnucci@hucff.ufrj.br Czech Republic Zdeněk Ráčil, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska Brno T /3642 F zracil@fnbrno.cz Iva Kocmanova, MD Dept. of Microbiology University Hospital Brno, Jihlavska Brno T ikocmanova@fnbrno.cz Martina Lengerova, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska Brno T mlengerova@nbrno.cz Mojmir Moulis, MD Dept. of Pathology University Hospital Brno Jihlavska Brno T mmoulis@fnbrno.cz Ludmila Malaskova, MD Dept. of Biochemistery University Hospital Brno Jihlavska Brno T lmalas@fnbrno.cz Report June

22 Clinical ID Microbiology Molecular Biology Pharmacology Pathology Germany Oliver A. Cornely, MD, FIDSA, FACP Klinikum der Universität Klinik I für Innere Medizin Köln T F oliver.cornely@ctuc.de Axel Hamprecht, MD Klinikum der Universität Institut f. Mikrobiologie, Immunologie u. Hygiene Goldenfelsstr Köln T F +49-(0) axel.hamprecht@uk-koeln.de Ralf Bialek, MD MVZ Labor Dr. Krause Steenbeker Weg Kiel T bialek@labor-krause.de Fedja Farowski, Biochemist Klinikum der Universität Institut für Pharmakologie Köln T F fedja.farowski@ctuc.de Birgid Markiefka Klinikum der Universität Institut für Pathologie Köln birgid.markiefka@ukkoeln.de Volker Rickerts, MD Robert Koch Institute Postbox: Berlin T rickertsv@rki.de India Anupma Jyoti Kindo, MD Dept. of Microbiology Sri Ramachandra Medical College/Research Institute No.1, Ramachandra Nagar Porur, Chennai, T F anupmalakra@yahoo.com Anuradha Chowdary Department of Medical Mycology Vallabhbhai Patel Chest Institute University of Delhi Delhi T F dranuradha@hotmail.com Report June

23 Clinical ID Microbiology Molecular Biology Pharmacology Pathology Israel Morad Wattad, MD Rabin Medical Center Infectious Diseases Unit 39 Jabotinski St Petah Tikva T F Moradv@clalit.org.il Italy Livio Pagano, MD Dipartimento di Ematologia Universita Cattolica del Sacro Cuore (Roma) Largo Francesco Vito Roma T F lpagano@rm.unicatt.it Turkey Maurizio Sanguinetti, MD Istituto di Microbiologia (Roma) Università Cattolica del Sacro Cuore Largo Francesco Vito Roma T F msanguinetti@rm.unicatt.it Annamaria Tortorano, MD Dip. Sanità Pubblica- Microbiologia-Virologia Milano Università di Milano Via Pascal, 36/ Milano T F annamaria.tortorano@unimi.it Andrea Novelli, MD Dipartimento di Farmacologia Università degli Studi di Firenze Viale Pieraccini, Firenze T F andrea.novelli@unifi.it Gianluigi Vago, MD Department of Clinical Sciences Luigi Sacco Hospital University of Milan Via Pascal, 36/ Milano T F gianluca.vago@unimi.it Sevtap Arikan-Akdagli, MD Mycology Laboratory (Ankara) Hacettepe University Ankara F +90 (312) sevtap.arikan@gmail.com Report June

24 Contributors Australia Melbourne Royal Melbourne Hospital, Infectious Diseases Royal Melbourne Hospital, 1 Clinical Centre of Excellence in Infectious Diseases Austria Graz Medical University of Graz, Department of Internal Medicine, Joint Facilities, Division of Pulmonology Innsbruck Innsbruck Medical University, Division of Hygiene und Medical Microbiology (HMM) Belgium Leuven University Hospitals Leuven Laboratory of Clinical Bacteriology and Mycology Department of Haematology Department of Pharmaceutical and Pharmacological Science Brazil Porto Alegre Universidade Federal do Rio Grande do Sul (UFRGS), Department of Paediatrics Universidade Federal do Rio Grande do Sul (UFRGS), Department Molecular Diagnostic Laboratory Canada Montreal Université de Montréal, CHU Sainte-Justine, Pédiatres infectiologues McGill University, Department Microbiology and Immunology Nenad Macesic Monica Slavin Martin Hoenigl Cornelia Lass- Flörl Edith Vermeulen Johan Maertens Isabel Spriet Denise Pereira Alessandro Pasqualotto Philipe Ovetchkine Don Sheppard China Report June

25 Zhejiang Zhejiang University, Pulmonary Department Cuba Habana Instituto de Hematologia e Imunologia Czech Republic Brno University Hospital Brno, Department of Internal Medicine Hemato-Oncology Denmark Copenhagen Copenhagen University Hospital Rigshospitalet, Department of Haematology France Strasbourg University Hospital of Strasbourg, Hôpital de Hautepierre, Department of Oncology and Hematology Germany Aachen Uniklinik RWTH Aachen, Medizinische Klinik IV, Klinik für Onkologie, Hämatologie und Stammzelltransplantation Berlin Robert Koch Institut, Abteilung für Infektionskrankheiten Charité - Universitätsmedizin Berlin, Universitätsklinik für Allgemein-, Viszeral-, Gefäß- und Thoraxchirurgie Charité - Universitätsmedizin Berlin Dortmund Klinikum Dortmund Nord, Abteilung Pneumologie und Infektiologie Erlangen Universitätsklinikum Erlangen, Medizinische Klinik 5 Hämatologie und Internistische Onkologie Zhang Jin Alberto Arencibia Núñez Zdenek Racil Emil Hermansen Raoul Herbrecht Carolin Becker Volker Rickerts Sebastian Friese Barbara Korinth Stefanie Später Stefan Kallert Lisa Meintker Report June

26 Essen Universitätsklinikum Essen, Institut für Medizinische Mikrobiologie Frankfurt am Main Universitätsklinikum Frankfurt, Abteilung Infektiologie Frankfurt a.d. Oder Klinikum Frankfurt Oder, Abteilung Unfallchirurgie Freiburg Universitätsklinikum Freiburg, Klinik für Innere Medizin I, Abteilung Hämatologie, Onkologie und Stammzelltransplantation Göttingen Georg-August-Universität, Abteilung Hämatologie und Onkologie Greifswald Ernst-Moritz-Arndt-Universität Greifswald, Friedrich Loeffler Institut für Medizinische Mikrobiologie Halle- Wittenberg Martin-Luther-Universität Halle-Wittenberg, Klinik für Innere Medizin IV, Onkologie und Hämatologie Heidelberg Ruprecht-Karls-Universität Heidelberg, Medizinische Klinik V, Abt. Hämatologie, Onkologie und Rheumatologie Homburg/Saar Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Klinik für Pädiatrische Onkologie und Hämatologie Jena Universitätsklinikum Jena, Klinik für Kinder- und Jugendmedizin, Sektion Hämatologie, Onkologie, Stammzelltransplantation Universitätsklinikum Jena, Klinik, Zentrum für Infektionsmedizin und Krankenhaushygiene Karlsruhe Städtisches Klinikum Karlsruhe, Medizinische Klinik III Köln Uniklinik Köln, Klinik I für Innere Medizin Jörg Steinmann Johanna Kessel Dirk Kunzmann Hartmut Bertz Silke Neumann Katrin Schulz Hans-Joachim Schmoll, Maximillian Christopeit Martina Gronkowski Gerlinde Egerer Arne Simon Bernd Gruhn Stephanie Beier Mathias Pletz Jean-Charles Moulin Oliver Cornely, Fedja Farowski, Report June

27 Magdeburg Städtisches Klinikum Magdeburg, Hämatologie/ Onkologie München Klinikum der Universität München (LMU), Medizinische Klinik und Poliklinik IV, Klinische Infektiologie Klinikum München, Krankenhaushygiene Münster Universitätsklinikum Münster, Klinik für Kinder- und Jugendmedizin- Pädiatrische Hämatologie und Onkologie Postdam Ernst von Bergmann Klinikum, Klinik für Hämatologie, Onkologie und Palliativmedizin Ulm Uniklinik Ulm, Klinik III für Innere Medizin, Sektion Infektiologie und Klinische Immunologie Würzburg Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik II, Abtl. Leber- und Infektionsambulanz Greece Athens Attikon University Hospital, Department of Emergency and Critical Care Hungary Budapest Semmelweis University, First Department of Medicine Szeged University of Szeged, Faculty of Science, Department of Microbiology University of Szeged, Albert Szent-Györgyi Clinical Centre, Department of Clinical Microbiology Maria Vehreschild, J.Janne Vehreschild, Kerstin Wahlers Kersten Borchert Johannes Bogner Elisabeth Meyer Andreas Groll Gerda Silling Georg Maschmeyer Georg Härter Werner Heinz Andrew Ullmann Anna Kuhn Carolin Spielau- Gleidies Elisabeth Paramythiotou Judit Demeter Lorant Hatvani László Bereczki Report June

28 India Ahmedabad Infectious Diseases Clinic, "VEDANTA" Institute of Medical Sciences Navarangpura Chandigarh Government Medical College Hospital (GMCH), Department of Microbiology Porur Sri Ramachandra University Medical College, Department of Microbiology Israel Holon Edith Wolfson Medical Center, Department of Otolaryngology Head & Neck Surgery Jerusalem Hadassah University Medical Center, Department of Internal Medicine, Infectious Diseases Shaare Zedek Medical Center, Infectious Disease Unit Petah Tikva Rabin Medical Center, Infectious Diseases Unit Italy Bari University of Bari Aldo Modo, Department of Biomedical Science and Human Oncology Atul Patel Jagdish Chander Anupma Jyoti Kindo Yehudah Roth Maya Korem Eli Ben-Chetrit Morad Wattad Maria Teresa Montagna Brescia Spedali Civili, Department of Hematology Padova Policlinico G.B. Rossi, Oncoematologia Pediatrica Rome Universita Cattolica del Sacro Cuore, Istituto di Microbiologia Chiara Cattaneo Simone Cesaro Maurizio Sanguinetti Netherlands Nijmegen Report June

29 Canisius-Wilhelmina Ziekenhuis Hospital, Department of Medical Microbiology Romania Iași Universitatea Petre Andrei, Department of Mycology- Mycotoxicology Russia Moscow Federal research center of pediatric hematology, oncology and immunology named after Dmitry Rogachev, Infection Control Department St. Petersburg St. Petersburg Medical Academy of Postgraduate Education, Department of Clinical mycology allergology and immunology Slovakia Bratislava National Cancer Institute Thailand Khon Kaen Khon Kaen University, Division of Infectious Diseases and Tropical Medicine Tunisia Sousse CHU Farhat Hached of Sousse and the Faculty of Medicine of Sousse Turkey Ankara Hacettepe University Medical School, Department of Medicine, Section of Infectious Diseases and Clinical Microbiology Antalya Akdeniz University Medical Faculty, Department of Clinical Microbiology Jacques Meis Mihai Mares Galina Solopova Nikolay Klimko Sofya Khostelidi Lubos Drgona Ploenchan Chetchotisakd Akila Fathallah Sevtap Arikan Dilara Ogunc Report June

30 USA Cleveland Cleveland Clinic Lerner College of Medicine of Case Western University, Department of Infectious Diseases, Section of Transplant Infectious Diseases, Medicine Institute and Transplant Center Sherif Beniameen Mossad Members Angola Luanda University of Luanda, Department of Microbiology Argentina Buenos Aires El Centro de Internacion de FUNDALEU, Departamento Medico, REMIIN (Registro de Micosis Invasoras) Instituto Nacional de Enfermedades Infecciosas Dr. C.G. Malbran Rosario Universidad Nacional de Rosario, Centro de Referencia de Micologia Facultad de Ciencias Bioquimicas University Hospital Rosario, Centro de Transplante de Medula Osea de Rosario (CETRAMOR) Australia Perth Royal Perth Hospital, Department of Microbiology and Infectious Diseases Austria Baden Landesklinikum Baden- Mödling, Anästhesiologie und Intensivmedizin Feldbach LKH Feldbach, Abteilung für Innere Medizin - Fürstenfeld, Hämato-Onkologie Feldkirch Moises Francisco Maria Cecilia Dignani Susana Cordoba Maria Biasoli Jose Anibal Cozzi Christopher Heath Franz Schwameis Christina Leitner Report June

31 Landeskrankenhaus Feldkirch, Abteilung für Innere Medizin Graz Medizinische Universität Graz, Institut für Hygiene, Mikrobiologie und Umweltmedizin Innsbruck Medizinische Universität Innsbruck, Institut für Hygiene, Mikrobiologie und Sozialmedizin Medizinische Universität Innsbruck, Institut für Pathologie Klagenfurt Landeskrankenhaus Klagenfurt, Krankenhaushygiene Linz Allgemeines Krankenhaus Linz, Kinder- Herzzentrum Linz Wagner-Jauregg Nervenklinik, Klinik für Anästhesiologie Salzburg Salzburger Universitätsklinikum, Zentrum für Krankenhaushygiene und Infektionskontrolle St. Pölten Landesklinikum St. Pölten, 1. Medizinische Abteilung Steyr Landeskrankenhaus Steyr, Institut für Anästhesie und Intensivmedizin Wien Hanusch-Krankenhaus der Wiener Gebietskrankenkasse, Institut für Pathologie und Mikrobiologie Hanusch-Krankenhaus der Wiener Gebietskrankenkasse, 3. Medizinische Abteilung, Hämatologisch-Onkologisches Zentrum Medizinische Universität Wien, Universitätsklinik I für Innere Medizin, Infektionen und Tropenmedizin Medizinische Universität Wien, Klinik für Dermatologie, Abteilung für Immundermatologie und Infektiöse Hauterkrankungen Wilhelminenspital Wien, Abteilung für Anästhesie, Bernd-Lorenz Hartmann Walter Buzina Anna Huppert, Isabella Schalk Ulrich Strasser Ulrich Zerlauth Werner Moosbauer Udo Illievich Markus Hell Petra Pichler Achim von Goedecke Uwe König Michael Pfeilstöcker Christina Forstner (nee Kratzer) Wolfgang Pöppl Peter Starzengruber Christoph Steininger Katharina Grabmeier- Pfistershammer Report June

32 Intensiv- und Schmerzmedizin Universitätsklinik für Krankenhaushygiene und Infektionskontrolle Belarus (Republic of) Minsk Republic Research Center for Pediatric Oncology, Hematology and Immunolog Belgium Leuven KU Leuven, Faculty of Medicine, Department of Microbiology and Immunology, Laboratory of Clinical Bacteriology and Mycology Mons CHU Ambroise Paré, Unité d hémato-oncologie Peter Wimmer Elisabeth Presterl Sviatlana Kandaurava Katrien Lagrou Marc Antoine Brazil Salvador da Bahia Hospital Universitario Professor Edgard Santos UFBA, Serviço de Oncohematologia / TMO Curitiba Hospital das Clinicas- Universidada Federal do Paraná, Laboratory of Mycology Rio de Janeiro Hospital Universitário Clementino Fraga (UFRJ), Hematology and Mycology Laboratory Canada Calgary Peter Lougheed Center, Department of Medicine, Section of Infectiuos Diseases Montreal Jewish General Hospital, Department of Microbiology and Infectious Diseases Quebec Laboratoire de santé publique du Quebec, Secteur Mycologie Marco Aurélio Salvino, Monica Botura Flávio de Queiroz Telles Marcio Nucci Andrew Johnson Mark Miller Philippe Dufresne Report June

33 Hamilton/Ontario McMaster University, Department of Medicine, Division of Infectious Diseases Hamilton General Hospital, Department of Medicine, Division of Medical Microbiology Vancouver Vancouver General Hospital, Microbiology Laboratory Chile Santiago de Chile Clínica Alemana, Unidad de Infectología Valparaíso Universidad de Valparaíso, Facultad de Medicina China Beijing Peking University People's Hospital, Institute of Hematology Guangdong Guangdong General Hospital, Department of Hematology Guangzhou GuangZhou NanFang hospital, Respiratory and critical care medicine Department Hangzhou Zhejiang University School of Medicine, The First Affiliated Hospital, Bone Marrow Transplant Center Shanghai Changhai Hospital, Department of Hematology Columbia Medellin Conjunto Residencial Montevideo Croatia Zagreb Zagreb University Hospital Centre, Division of Internal Medicine Shariq Haider Tracy Reed Debbie Yamamura Diane Roscoe Luis Thompson Moya Thomas Weitzel Feng-Rong Wang Xin Du Su Jin He Huang Jian-Min Yang Angela Restrepo, Angela Tobón Nemet Damir, Radovan Vrohvac Report June

34 Czech Republic Olomouc Palacky University, Faculty of Medicine, Department of Microbiology Denmark Copenhagen Copenhagen University Hospital, Deptartment of Hematology Rigshospitalet, Department of Hematology-Granulocyte Research Lab. France Montpellier Service de soins intensifs en hématologie Paris Hospital Saint-Louis, Département d'hématologie Germany Aachen Medizinisches Zentrum Städteregion Aachen, Klinik für Orthopädie Augsburg Klinikum Augsburg, II. Medizinische Klinik, Einheit für Stammzelltransplantation Bad Kreuznach Sana Rheumazentrum Rheinland-Pfalz AG, Rheumatologische Ambulanz Berlin Vivantes Krankenhaus, Klinik für Hämatologie und Onkologie DRK Kliniken Berlin Charité-Universitätsmedizin Berlin, Medizinische Klinik und Poliklinik II Charité-Universitätsmedizin Berlin, Center für Muskuloskeletale Chirurgie Robert Koch Institut, Abteilung für Infektionskrankheiten Petr Hamal Jannik Helweg-Larsen Andreas Birkedal Glenthøj Patrice Ceballos Emmanuel Raffoux, Patricia Ribaud Rolf Sobottke Christoph Schmid Eckhard Weber Jörg Beyer Markus Müller Olaf Süss Markus Ruhnke Andrej Trampuz Michael Seibold Report June

35 Helios-Klinikum Berlin-Buch, Klinik für Neurologie Bielefeld Städtische Kliniken Bielefeld gem.gmbh, Klinik für Hämatologie, Onkologie & Palliativmedizin Bochum Klinikum der Ruhr-Universität Bochum, St. Josef Hospital, Gastroenterologie und Infektiologie Bonn Universitätsklinikum zu Bonn, Klinik für Neonatologie Universitätsklinikum zu Bonn, Medizinische Klinik und Poliklinik III Borstel Medical Clinic, Research Center Borstel, Division of Clinical Infectious Diseases Bremen Klinikum Bremen-Mitte, Medizinische Klinik I Dortmund Klinikum Dortmund-Nord, Abteilung Pneumologie/Infektiologie Dresden Uniklinik Dresden, Medizinische Klinik und Poliklinik I Krankenhaus Dresden-Friedrichstadt, Dermatologie Krankenhaus Dresden-Friedrichstadt, Mykologisches Labor Düsseldorf Universitätsklinikum Düsseldorf, HNO-Klinik Universitätsklinikum Düsseldorf, Klinik für Hämatologie, Onkologie und klinische Immunologie Erlangen Uniklinik Erlangen, Medizinische Klinik 5 Hämatologie und Internistische Onkologie Essen Universitätsklinikum Essen, Klinik für Knochenmarktransplantation Universitätsklinikum Essen, Klinik für Nephrologie Kliniken Essen Süd, Klinik für Hämatologie/ Internistische Onkologie und Franz- Josef Dieste Martin Görner Renate Schlottmann Cornelia Graef Axel Kaeferstein Dominik Wolf Christoph Lange Henrike Thomssen Bernhard Schaaf, Greta Ullrich Ulrich Schuler Gesina Hansel Irina Vennewald Katrin Gollner, Kathrin Scheckenbach Thomas Schröder Stefan Krause Wolf Rösler Rudolf Trenschel Oliver Witzke Mohammed Wattad Report June

36 Stammzelltransplantation Frankfurt am Main Infektiologikum Frankfurt Onkologikum Frankfurt Klinikum der Johann Wolfgang Goethe-Universität, Zentrum für Kinder- und Jugendmedizin, Klinik III Klinikum der Johann Wolfgang Goethe-Universität, Zentrum für Innere Medizin, Medizinische Klinik II Hämatologie, Onkologie, Rheumatologie, Infektiologie AGAPLESION Markus-Krankenhaus Klinik für Palliativmedizin Frankfurt/Oder Klinikum Frankfurt Oder, Abteilung für Innere Medizin, Hämatologie und Onkologie Freiburg Universitätsklinikum Freiburg, Hämatologie und Onkologie Universitätsklinikum Freiburg Universitätsklinikum Freiburg, Zentrum für Infektiologie und Reisemedizin Geesthacht Medizinischen Versorgungszentrum Dr. Kramer und Kollegen, LADR GmbH Göttingen Universitätskliniken Göttingen, Institut für Medizinische Mikrobiologie Greifswald Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Klinik und Poliklinik für Innere Medizin C, Hämatologie und Onkologie- Transplantationszentrum Halle (Saale) Universitätsklinikum Halle (Saale) Halle- Wittenberg Martin-Luther-Universität Halle- Wittenberg, Klinik für Innere Medizin IV, Onkologie und Hämatologie Hamburg Asklepios Klinik St. Georg, Institut für Infektiologie Heidelberg Universitätsklinikum Heidelberg, Medizinische Klinik V, Gaby Knecht Angelika Böhme Thomas Lehrnbecher Anjali Dubey Sabine Mousset Michael Kiehl Werner Neubauer Helmut Lang Dirk Wagner Ralf Bialek Uwe Groß William Krüger Claudia Wickenhauser Hans- Heinrich Wolf M. Sabranski Johann-Wilhelm Report June

37 Abt. Hämatologie, Onkologie und Rheumatologie Universitätsklinikum Heidelberg, ThoraxKlinik Universität Heidelberg, Abteilung für Infektiologie, Sektion Krankenhaushygiene Zelluläre Immuntherapie, Medizinische Universitätsklinik V Karlsruhe Städtisches Klinikum Karlsruhe, Medizinische Klinik III Kiel Universitätsklinikum Schleswig-Holstein, Medizinische Klinik und Poliklinik II Köln Kliniken der Stadt Köln, Krankenhaus Merheim, Institut für Hygiene Konstanz Klinikum Konstanz, Klinik für Anästhesiologie und Operative Intensivmedizin Leverkusen Klinikum Leverkusen, Medizinische Klinik IV Allgemeine Innere Medizin, Infektiologie, Pneumologie, Osteologie Lübeck Universität Lübeck, Institut für Medizinische Mikrobiologie und Hygiene Mainz Johannes-Gutenberg-Universität, III. Medizinische Klinik und Poliklinik, Hämatologie, internistische Onkologie, Pneumologie Mannheim Universitätsklinikum Mannheim, III. Medizinische Klinik Mönchengladbach MVZ Stein und Kollegen, Laboratoriumsmedizin, Mikrobiologie, Infektionsepidemiologie München Ludwig- Maximilians-Universität München, Medizinische Klinik und Poliklinik IV, Abteilung für Infektions- und Tropenmedizin Klinikum Harlaching, Städtisches Klinikum München Schmier Gerlinde Egerer Nicola Lehners Maren Schuhmann Alexandra Heininger Michal Schmitt Jean-Charles Moulin Heinz-A. Horst Frauke Mattner Wolfgang Krüger Stefan Reuter Jan Rupp Ralf Georg Meyer Anne Dietz Roman Schwarz Thomas Löscher Meinolf Karthaus, Report June

38 GmbH, Klinik für Hämato-Onkologie Klinikum der Universität München-Großhadern, Kinderkardiologie und Pädiatrische Intensivmedizin Klinikum der Universität München-Großhadern, Klinik für Hals-, Nasen- und Ohrenheilkunde Klinikum der Universität München-Großhadern, Medizinische Klinik III Münster Uniklinik Münster, Medizinische Klinik A Mutlangen Klinikum Schwäbisch Gmünd, Stauferklinik, Hämatologie/Onkologie/Immunologie/Rheumatologie Rostock Universitätsklinikum Rostock, Klinik und Poliklinik für Innere Medizin, Abteilung für Hämatologie, Onkologie, Palliativmedizin Sindelfingen Kliniken Sindelfingen, Medizinische Klinik I, Hämatologie und Onkologie, Tübingen Universität Tübingen, Klinik für Dermatologie Universität Tübingen, Institut für Medizinische Mikrobiologie und Hygiene Witten Marienhospital Witten, Abteilung für Kinder- und Jugendmedizin Universität Witten/Herdecke, Medizinische Klinik 5- Hämatologie und Internistische Onkologie Würzburg Universität Würzburg, Medizinische Klinik und Poliklinik für Innere Medizin II Universität Würzburg, Institut für Hygiene und Mikrobiologie Greece Athens Athens University, 1st Department of Propaedeutic Medicine Aghia Sophia Children s Hospital, Cystic Fibrosis Department Xaver Schiel Markus Loeff Robert Guerkov Helmut Ostermann, Lisa Peterson Felix Rosenow Holger Hebart Brigitte Kragl Stefan Neuburger Sybille Schmidt Matthias Willmann Bahman Gharavi Stefan Sauerland Jürgen Löffler, Hartwig Klinker Bhanu Sinha Anna Skiada Stavros Doudounakis Report June

39 Athens University, Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory Attikon University General Hospital, Laboratory for Clinical Microbiology General University Hospital ATTIKON Hungary Budapest Military Hospital, Budapest Szeged University of Szeged, Dep. Of Microbiology India Bangalore Narayana Health, Bangalor Ramaiah Curie Centre of Oncology Apollo Hospitals Mazumdar Shaw Hospital Center, Narayana Health Chandigarh Postgraduate Institute of Medical Education & Research, Department of Medical Microbiology Postgraduate Institute of Medical Education & Research, Department of Pulmonary Medicine Chennai Global Hospital and Health City, Dep. of Infectious Diseases Kolkata Tata Medical Center Manipal Manipal University, Kasturba Medical College, Department of Microbiology Mumbai Grant Medical College and Sir J.J. Group of Hospitals, Department of Microbiology Jaslok Hospital, Department of Infectious Diseases Global Hospitals Hinduja Hospital New Delhi George L. Petrikkos Joseph Meletiadis Maria Stamouli Laszlo Rokusz Laszlo Kredics Anil Kumar Purnima Parthasarathy Sunil Bhat Arunaloke Chakrabarti Ritesh Agarwal Subramanian Swaminathan Mammen Chandy Prakash Yegneswaran Sarala Menon Om Shrivastav Dhanashree Kelkar- Galwankar Sangmesh Chavanda Report June

40 Institute Rotary Cancer Hospital Deen Dayal Upadhyayaa Hospital University of Delhi, Department of Medical Mycology Vallabhbhai Patel Chest Institute Tiruchirapalli Institute of Ophthalmology Indonesia Jakarta Mangunkusumo Hospital, University of Indonesia, Department of Internal Medicine Ireland Dublin Dublin Saint James Hospital, Trinity College, Department of Microbiology Israel Haifa Rambam medical Center, Infection Disease Unit Petah Tikva Rabin Medical Center, Dep. of Infectious Disease Tel Aviv Sheba Medical Center Israel, Department of Clinical Microbiology Tel Aviv Sourasky Medical Center, Infectious Diseases Unit Italy Firenze Università degli Studi di Firenze, Dipartimento di Farmacologia Genova Ospedale San Martino, Divisione di Ematologia e Trapianto di Midollo Osseo Milan University of Milan, Laboratorio di Micologia Medica, Sezione Sanità Pubblica University of Milan, Luigi Sacco Hospital, Pathology Sameer Bakhshi Lalit Kumar Neelam Sood Anuradha Chowdhary Philip A. Thomas Erni Juwita Nelwan Thomas Rogers Anat Shteren Jihad Bishara Nathan Keller Ronen Ben-Ami Michal Dekel Andrea Novelli Andrea Bacigalupo Anna Maria Tortorano Gianluigi Vago Report June

41 Unit Humanitas Clinical Institute Rome Universita Cattolica del Sacro Cuore, Dipartimento di Ematologia San Camillo-Forlanini Hospital, Hematology Unit Palermo Policlinico Gemelli, Dep. of Infectious Diseases Japan Chiba Chiba University Hospital, Medical Mycology Research Center (MMRC), Division of Clinical Research Nagasaki Nagasaki University Hospital, Department of Molecular Microbiology and Immunology Shizuoka Shizuoka Cancer Center, Division of Infectious Diseases Korea Seoul Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Hematology- Oncology Clinic, Hematopoietic Stem Cell Transplantation Center The Catholic University of Korea, Department of Internal Medicine, Division of Infectious Diseases Suwon Ajou University School of Medicine, Department of Hematology-Oncology Kuwait Kuwait City Kuweit University, Faculty of Medicine, Department of Microbiology Concetta De Luca Livio Pagano Mariagrazia Garzia Enrico Maria Trecarichi Katsuhiko Kamei, Akira Watanabe Shigeru Kohno Shinichiro Morioka Hyeon Seok Eom Dong-Gun Lee Joon Seong Park Eiman Mokaddas Lebanon Beirut Report June

42 American University of Beirut Medical Center, Department of Medicine, Division of Infectious Disease Lithuania Vilnius Vilnius University Hospital, Santariskiu Klinikos, Nephrology Centre, Department of Nephrology, Kidney Transplantation and Dialysis Vilnius University Hospital, Santariskiu Klinikos, Department of Hematology Macedonia Skopje University Sts Cyril and Methodius, Medical Faculty, Institute for Microbiology and Parasitology Mexico Guadalajara Hospital Civil de Guadalajara, Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental Mexico City Ixtlamatia Clinical Research S.A. de C.V Sinaloa Hospital General de Culiacán Netherlands Groningen University Medical Center Groningen New Zealand Wellington Aotea Pathology, Microbiology Department North Ireland Belfast Belfast City Hospital, Department of Bacteriology Souha Kanj-Sharara Marius Miglinas Indre Klimiene Gordana Mirchevska Eduardo Rodriguez- Noriega Miguel Ángel Reséndiz Ramón Rivas Llamas Jan P. Arends Hongtao Liu John E. Moore Norway Trondheim Report June

43 Medisinsk Klinikk - St. Olav Hospital HF, Department of Infection Peru Lima Hospital Nacional Edgardo Rebagliati Martins, Hematology/ BMT Department Poland Lodz Medical University of Lodz, Department of Pediatrics, Oncology, Hematology and Diabetics Wroclaw Wroclaw Medical UniversityOncology, Hematology and Diabetics Portugal Coimbra Coimbra University Hospital Porto University of Porto, Institute of Molecular Pathology and Immunology Hospital São João Hospital São João, Laboratorio de Microbiologia Russia Krasnodar City Regional Children Hospital Moscow Russian Cancer Research Centre Vishnevsky Institute of Surgery Federal research center of pediatric hematology, oncology and immunology named after Dmitry Rogachev, Infection Control Department St. Petersburg I Pavlov State Medical University, Raisa Hannula Eduardo Fernandez-Vertiz Filip Pierlejewski Jaroslaw Dybko Rui Tome Rita Caramalho Ana Carneiro Maria Dolores Pinheiro Tatiana Askretova Anton Ivanov Andrey Chizhov Galina Solopova Vladimir Vavilov Saudi Arabia Riyadh Report June

44 King Fahad Medical City, Department of Medicine King Faisal Specialist Hospital and Research Center, Section of Infectious Diseases Serbia Belgrade University of Belgrade, Department of Microbiology and Immunology, Serbian Society of Medical Mycology (SSMM), National Medical Mycology Reference Laboratory (NMMRL) Clinic of hematology, Clinical Centre of Serbia Novi Sad Clinical center of Vojvodina Singapore Mount Elizabeth Medical Centre, Infectious Diseases Care University Medicine Center, National University Health System (NUHS), Division of Infectious Diseases National University Hospital, Department of Pediatrics Infectious Diseases South Africa Cape Town Groote Schuur Hospital, University of Cape Town, Department of Orthopaedic Surgery Durban University of KwaZulu-Natal, Nelson R. Mandela School of Medicine, Department of Infection Prevention and Control Johannesburg Hospital and University of Witwatersrand, Department of Medicine Spain Cadiz Puerta del Mar University Hospital, Clinical Microbiology Laboratory Huelva Hospital Juan Ramon Jimenez-Huelva, Grupo Andaluz de Leucemias Agudas GALA Musa Garbati Hail Al-Abdely Valentina Arsic Arsenijevic Ava Vidovic Ivanka Savic-Tatic Asok Kurup Chai Louis Yi Ann Si Min Chan Robert Dunn Teke Apalata Mervyn Mer Manuel Rodriguez- Iglesias Eusebio Martín Chacón Report June

45 Madrid Hospital de la Princesa, Servicio de Hematología de la Unidad de Consejo y Cuidado Oncológico de Sanitas Hospital la Paz, Department of Hematology Murcia Hospital Morales Meseguer, Hematology and Medical Oncology Service Palma de Mallorca University Hospital Son Espases Santander Hospital Universitario Marqués De Valdecilla, Department of Hematology Sevilla University Hospital Virgen des Rocio/CSIC/University of Seville, Clinical Unit of Infectious Disease, Microbiology and Preventative Medicine Valencia Hospital Universitario La Fe, Servicio de Microbiología, University Hospital La Fe, Department of Hematology Schweden Luleå Sunderby Hospital, Clinical Microbiological Laboratory Switzerland Basel Universitätsspital Basel, Abteilung für Infektiologie und Spitalhygiene Universitätsspital Basel, Medizin I Abteilung für Hämatologie Bern Inselspital, Universitätsklinik für Infektiologie Inselspital, Klinik für Pneumologie Taiwan Taipeh Far Eastern Memorial Hospital, Department of Internal Medicine, Division of Infectious Diseases Rafael de la Cámara Pilar Gomez Pietro Pastora Iniesta Lopez-Matencio Antonia Sampol Lucrecia Yanez San Segundo Martin-Pena Almudena Javier Peman Rebeca Rodriguez- Veiga Peter Cettner Andreas Widmer Ursula Flueckiger Alois Gratwohl Stefan Zimmerli Sebastian Ott Chia- Ying Liu Report June

46 National Taiwan University, Tai-Chen Stem Cell Therapy Center National Taiwan University Hospital, Department of Internal Medicine, Division of Infectious Diseases Turkey Ankara Hacettepe University Medical School, Department of Medicine, Section of Infectious Diseases Baskent University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology Istanbul Beyoglu Eye Training and Research Hospital Izmir Dokuz Eylül University, Faculty of Medicine, Division of Hematology Kayseri Erciyes University, Faculty of Medicine, Department of Pediatrics Division of Pediatric Hematology and Oncology Ukraine Kiev National Cancer Institute Ukranian National Children Hospital, Centre of pediatric hematology and BMT Jih-Luh Tang Yee-Chun Chen Murat Akova, Ömrün Uzun Can Boga Serhat Imamoglu Fatih Demirkan, Ömür Gökmen Sevindik Ekrem Unal Kateryna Filonenko Iulia Bazaluk United Kingdom Glasgow Southern General Hospital, Department of Microbiology Nitish Khanna Kilmarnock University Hospital Crosshouse, Department of Microbiology Kingsgate ID Consultancy London St Guys and St. Thomas NHS Trust Orpington Abhijit Bal Peter F. Troke Jon Lambourne Report June

47 South London Healthcare NHS Trust, Princess Royal University Hospital Swansea Singleton Hospital, Department of Microbiology USA Ann Arbor Taubman Center, Department of Internal Medicine, Division of Infectious Diseases Baltimore Johns Hopkins University School of Medicine, Department of Pathology, Division of Microbiology Denver University of Colorado, Department of Pathology Duarte City of Hope National Medical Center, Division of Infectious Diseases Indianapolis MiraVista Diagnostics and MiraBella Technologies Iowa City University of Iowa, College of Medicine, Department of Pathology, Medical Microbiology Division, Park Ridge St. James School of Medicine Washington University of Washington, Division of Infectious Diseases M. Mansour Ceesay Nidhika Berry Marisa Miceli Sean Zhang Diane Hutchinson Sanjeet Singh Dadwal Patricia Connolly Linda Boyken Harish Gugnani Philip Coffin Report June