Reproductive Medicine

Transkript

1 Volume 10 (2013) // Special Issue 2 // ISSN Journal of Reproductive Medicine Special Issue and Endocrinology Journal für Reproduktionsmedizin und Endokrinologie Andrology Embryology & Molecular Biology Endocrinology Ethics & Law Genetics Gynaecology Contraception Psychosomatic Medicine Reproductive Medicine Urology Member of the Official Organ: AGRBM, BRZ, DVR, DGA, DGGEF, DGRM, DIR, EFA, OEGRM, SRBM/DGE Vertriebskennzeichen der Deutschen Post: Y Preis: EUR 85, Indexed in EMBASE/Excerpta Medica/Scopus Krause & Pachernegg GmbH, Verlag für Medizin und Wirtschaft, A-3003 Gablitz

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3 D I R Annual 2012

4 Table of Contents Preface 6 Authors 8 General Survey of Medically Assisted Reproduction Treatments (ART) in Germany Outcome of ART Registry Participants Total Number of Treatment Cycles Number of Ovum Pick-ups (OPU) Number of Treatment Cycles Summary of Statistics in Brief 2012 CoD Nov D I R Statistics in Brief 2012 CoD Nov D I R Statistics in Brief 2011 CoD Nov Clinical Pregnancies (CP), Miscarriages (MISC), Ectopic Pregnancies (EP), and Still Births (SB) Multiple Births Births as a Function of Number of Embryos Transferred and Age Groups Births as a Function of Number of Embryos Transferred Fertilisation Rate Distribution of Indications Outcome for IVF, ICSI and Cryo Transfers IVF and ICSI Results TESE and Cryo Transfer Results J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

5 Outcome as a Function of Female Age 2012 IVF 22 Outcome as a Function of Female Age 2012 ICSI 23 Clinical Pregnancies (CP)/ET as a Function of the Number of Embryos Transferred and Age Groups Clinical Pregnancies (CP)/Fresh Transfer as a Function of Embryo Quality Clinical Pregnancies (CP)/Frozen Transfer as a Function of Embryo Quality Miscarriage (MISC) Rates as a Function of Female Age and Number of Embryos Transferred Clinical Pregnancy Rate (CPR) as a Function of the Stimulation Protocol Mean Age for Women and Men Duration of Unwanted Childlessness Prior to First Treatment Number of Treatment Cycles per Woman Children Born Children Born Children as a Function of Week of Gestation (WoG) and Birth Weight (BW) Ovarian Hyperstimulation Syndrome and Complications Complications as a Function of Ovum Pick-up (OPU) Ovarian Hyperstimulation Syndrome (OHSS) as a Function of the Stimulation Protocol List of D I R Registry Participants Sponsors 43 Editorial Board 44 Imprint 45 J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 5

6 D I R Annual 2012 K Bühler*, U Czeromin, JS Krüssel, V Blumenauer, K Fiedler, C Gnoth, L Happel, M Kupka, A Tandler-Schneider Starting with the 2009-Annual, the German IVF Registry has published its yearbook also in English. It is our great pleasure to now present the 2012-Annual as a modified reprint of the German D I R Yearbook that was published already in December The preparation of the 2012 English edition had to tackle major challenges. After the long-standing cooperation had been terminated by the Regional Medical Chamber of Schleswig Holstein, the registry, under great time pressure, managed to establish the alternative data management with Weise & Associates consulting & technology GmbH, Düsseldorf. Due to the cancellation by the Medical Chamber, participation in the registry is no longer mandatory. Yet, of the 128 German IVF centers (2012) 120 had exported their data, cycle by cycle, into the D I R registry: 80,467 cycles were documented, i.e. an average of 671 cycles per center. In 2011, the centers had documented an average of 632 cycles per center. Because of major changes in the reimbursement regulations in 2004, compared with 2003 a decrease of 45% occurred. Since then, the numbers have increased steadily again by a total of 23% within the past 9 years. Over all the years, an increase in the pregnancy rate (PR) has been achieved. In 2012, the PR/ET after the IVF treatments was 30.4%, 29.0% after ICSI, and after " Cryo transfer" (frozen-thawed transfer, mostly in the 2-PN stage ) 21.1%. These data demonstrate the high quality of reproductive medicine in Germany, arriving at impressive results despite the restrictive legislation: in accordance with the Embryo Protection Act of 1990, embryo selection and thus the elective single embryo transfer (eset) are forbidden in Germany. Egg donation is prohibited as well. Cryopreservation is allowed but usually only of 2-PN stage oozytes. Yet the regulation that only a maximum of three embryos may be transferred has certainly led to positive effects. Due to the increasing quality of stimulation, improved oozyte treatment and changes in transfer technology, the number of transferred embryos has decreased 20% in fresh cycles since In 2012, an average of 1.84 to 1.86 embryos were transferred in fresh cycles. This responsible approach of both patients and doctors for reproductive medicine has led to a 80% reduction of the proportion of triplets and the total number of children born after ART during this time. Certainly, this development is among the Registry s many merits and it will continue to vigoroulsy pursue and support quality assurance of reproductive medicine in Germany. Although data export to the German IVF Registry is no longer mandatory, the registry will continue to provide each center with a wealth of data, thus enabling each center to evaluate its position among the registry participants as a whole. Thus, each center is encouraged to examine its data self-critically and evaluate its results. Every new beginning also bears a special charm and offers the opportunity for change: the yearbook s layout was significantly modernized and its graphical appearance implemented by state-of-the art possibilities. The great advantage of the German IVF Registry is the electronic data collection for each initiated treatment cycle since Meanwhile, more than 1.2 million ART cycles have been documented in the D I R database. The prospective documentation as well as the cycle by cycle data collection are of particular value. We gratefully acknowledge that the changed situation has not kept the vast majority of German centers from continuing their participation in this world-wide recognized registry, has not kept them from supplying their predominantly prospective data at their own expense: since 1997 they have spent more than 2.1 million Euros for THEIR project, the German IVF Registry. *On March , Dr. Klaus Bühler resigned from the his position as President of the Board. We are grateful for the many years of hard work and emotional concern for the IVF-Registry. He is followed by Dr. Ute Czeromin as President. Dr. med. Andreas Tandler-Schneider accepted the call to fill the vacant board position. 1) D I R Jahrbuch 2012 J Reproduktionsmed Endokrinol (Special Issue 2) 6 J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

7 Acknowledgements Our thanks go to all the physicians, embryologists and other members of the medical staff for their diligence in collecting the data since the very beginning in They provide the foundation for the success and the world-wide high acclaim of this registry. Our gratitude also goes to the team of Weise & Associates and Markus Kimmel for rebuilding the new data base and performing the statistical evaluation of all the data in such a short period of time. We sincerely thank all of those assisting us in publishing the English version of the yearbook again, especially Monika Uszkoreit and Dipl. Des. Soo-Hee Kim. Dr. med. Ute Czeromin Dr. med. K. Bühler Prof. Dr. med. Jan Krüssel J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 7

8 Responsible for this Edition Deutsches IVF-Register e. V. German IVF Registry President (until March ) Dr. med. K. Bühler Members of the Board Dr. med. K. Bühler Dr. med. U. Czeromin Prof. Dr. med. J.-S. Krüssel Curators Dipl.-Biol. V. Blumenauer Dr. med. K. Fiedler PD Dr. med. C. Gnoth Prof. Dr. med. M. Kupka Dr. med. A. Tandler-Schneider Co-opted Member: Dr. med. L. Happel Past Presidents Prof. Dr. med. R. Felberbaum ( ) Prof. Dr. med. H.-K. Rjosk ( ) Prof. Dr. med. F. Lehmann ( ) D I R-Data Management W&A Weise & Associates consulting & technology GmbH Fon Fax info@weise-associates.de Web: Contact: Stefan Fitzthum, Manager Customer Care and Markus Kimmel, Kimmelnet Mobile: mmk@kimmelnet.de Web: Design and Layout a.umi design etc. Dipl.-Des. Soo-Hee Kim Fon mail@a-umi.com D I R Office Monika Uszkoreit MRU-Consulting GbR Torstraße Berlin Fon d.i.r.geschaeftsstelle@mru-consulting.de Copyright D I R Deutsches IVF-Register J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

9 Outcome of ART 2012 Centers for IVF-, ICSI-, and Cryo Transfer Treatments Members of the German IVF-Registry 2012 n = 128 Registry Participants 2012 n = 120 Data Received by Deadline Nov n = 80,467 ( %) Plausible n = 77,378 (96.16 %) Prospective (all Cycles) n = 65,363 (84.47 %) Prospective (IVF, ICSI, IVF/ICSI) n = 41,528 (81.48 %) Number of Women Treated* n = 47,807 Mean Number of Treatment Cycles per Woman 1.68 Registry Participants IVF-, ICSI- and Cryo Transfer Treatments [... ] IVF For values from ICSI to 2011 see Cryo Total ** *) Base quantity: Total number of women, including implausible treatment cycles **) 8 Members did not export their 2012 data J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 9

10 Total Number of Treatment Cycles 2012 IVF, ICSI, IVF/ICSI, Cryo Transfer Prospective Data IVF ICSI IVF/ICSI Cryo Transfer No Treatment Total n 9,237 31, ,527 6,309 65,363 % Number of Ovum Pick-ups Cycles (OPU) IVF, ICSI* Prospective and Retrospective Data IVF ICSI 55,000 50,000 45,000 40,000 35,000 30,000 25,000 20,000 15,000 10,000 5, [... ] *** IVF 742 3,806 7,343 For values from 1991 to 2011 see 23,936 28,058 11,848 11,410 11,082 11,362 11,264 11,585 11,346 11,341 11,512 ICSI 37,692 51,389 25,339 26,370 28,015 31,452 34,333 36,712 38,463 40,641 38,462 Total** 742 3,806 7,343 62,306 80,434 37,633 38,382 39,769 43,612 46,431 49,170 50,798 53,076 50,968 *) OPUs leading to an IVF- and/or ICSI oocyte treatment **) In each case, "Total also contains values for IVF/ICSI. For 2012 e.g. 994 OPUs ***) Based upon the 120 participating centers 10 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

11 Number of Treatment IVF, ICSI, IVF/ICSI, Cryo Transfer Plausible Data [... ] *** IVF 742 3,806 7,343 For values from 1991 to ,936 28,058 11,848 11,098 11,082 11,362 11,264 11,585 11,346 11,341 11,512 ICSI see www. 37,692 51,389 25,339 25,532 28,015 31,452 34,333 36,712 38,463 40,641 38,462 IVF/ICSI deutsches-ivfregister.de , Cryo 14,923 14,265 16,883 14,471 14,926 16,566 17,646 17,866 17,969 19,228 19,074 None* 9,802 11,133 4,928 4,539 4,600 5,137 5,825 5,946 6,289 6,618 7,335 Total** 742 4,201 8,653 87, ,854 59,448 56,232 59,295 65,316 69,902 72,984 76,072 78,922 77,378 From 1999 on each initiated cycle is documented. *) No treatment: treatments aborted prior to oocyte culture **) "Total" may contain GIFT cases. Documentation has been neglected since 2005 due to lack of statistical relevance ***) Based upon the 120 participating centers Summary of Statistics in Brief 2012 CoD Nov IVF, ICSI and IVF/ICSI Prospective and Retrospective Data J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 11

12 D I R Statistics in Brief CoD Nov German IVF Registry 12 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

13 D I R Statistics in Brief 2011 CoD Nov German IVF Registry (Based upon Registry Participants 2012) J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 13

14 Clinical Pregnancies (CP), Miscarriages (MISC), Ectopic Pregnancies (EP), and Still Births (SB) 2011 Prospective and Retrospective Data (Based upon Registry Participants 2012) Birth Rate/Transfer for patients with 2 embryos transferred and a surplus of at least 2 PN-stage embryos: IVF 23.97%, ICSI 22.58%, IVF/ICSI 25.26% IVF ICSI IVF/ICSI Cryo Transfer n % n % n % n % Treatment Cycles 10,190 38,498 1,052 18,483 Clinical Pregnancies 2, , , No Information , Births 1, , , Miscarriages , Induced Abort. + Fetal Reduc.* 38 (45) (168) (4) (26) 0.71 Ectopic Pregnancies Children 2,267 8, ,659 Still Births** Malformations Baby-Take-Home-Rate*** *) Number of cycles in which an induced abortion was documented. A more detailed differeniation cannot be supplied at this time. The brackets contain the number of embryos **) Number of still births in relation to the number of children born ***) Percentage of births per number of treatments 1 ) Total cycles reduced by the number of cycles with unknown pregnancy outcome 2 ) For cycles with unknown pregnancy outcome, the probable birth rate (births/pregnancy) was calculated and added to the number of known births 14 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

15 Multiple Births 2011 Prospective and Retrospective Data (Based upon Registry Participants 2012) % Singletons Twins Triplets IVF ICSI IVF/ICSI Cryo IVF ICSI IVF/ICSI Cryo Transfer n % % n % % n % % n % % CP/ET 2, ,00 10, , Births 1, , , Singletons 1, , , Twins , Triplets Quadruplets No Information , Miscarriages , EPs J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 15

16 Births as a Function of Number of Embryos Transferred and Age Groups IVF, ICSI, IVF/ICSI, Cryo Transfer Prospective and Retrospective Data (Based upon Registry Participants 2012) Woman s Age in Years Singletons Twins Triplets Quadruplets Total n % n % n % n % < = 24 1 Embryo Embryos 1, ,031 3 Embryos Total 1, , Embryo 1, ,377 2 Embryos 14, , ,335 3 Embryos 2, ,783 Total 18, , , Embryo 3, ,326 2 Embryos 29, , ,539 3 Embryos 7, , ,385 Total 40, , , Embryo 3, ,502 2 Embryos 21, , ,118 3 Embryos 9, , ,867 Total 35, , ,487 > = 40 1 Embryo Embryos 2, ,781 3 Embryos 2, ,758 Total 5, ,273 Total number of births : 128, J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

17 Births as a Function of Number of Embryos Transferred Prospective and Retrospective Data IVF Singletons Twins Triplets Quadruplets Total n % n % n % n % 1 Embryo 1, ,896 2 Embryos 17, , ,882 3 Embryos 5, , ,134 Total 25, , ,912 ICSI Singletons Twins Triplets Quadruplets Total n % n % n % n % 1 Embryo 3, ,754 2 Embryos 41, , ,952 3 Embryos 11,957 74,75 3, ,997 Total 56, , ,703 Cryo Transfer Singletons Twins Triplets Quadruplets Total n % n % n % n % 1 Embryo 1, ,880 2 Embryos 11, , ,397 3 Embryos 4, , ,631 Total 17, , ,908 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 17

18 Fertilisation Rate 2012 IVF and ICSI Prospective Data Embryos per Transfer 3 and Children After IVF, ICSI Prospective and non-prospective Data * IVF Embryos Transf Children/Transf Children/Deliv ICSI Embryos Transf Cryo- Transfer Children/Transf Children/Deliv Embryos Transf Children/Transf Children/Deliv ) In 182 cases no IVF- or ICSI treatment was performed. 74 are cases in which oocytes were recovered but nevertheless a cryo transfer was performed 2) Reason: e.g. immature oocytes or no sperm available 3) Mean *) Based on the 120 participating centers 18 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

19 Distribution of Indications 2012 IVF and ICSI Prospective Data IVF Male Factor Normal Reduced Semen Quality Other** Total Female Factor n % n % n % n % Normal 1, , Tubal Pathology 1, , Endometriosis , Hyperandrog./PCO Ovulatory Dysf Psychogen. Factors Other* , No Information Total 4, , , , ICSI Male Factor Normal Reduced Semen Qual. Azoospermia Other** Total Female Factor n % n % n % n % n % Normal , , , Tubal Pathology , , Endometriosis , Hyperandrog./PCO , Ovulatory Dysf , , Psychogen. Factors Other* , , , No Information , , Total 2, , , , , *) The indications "sperm antibodies and "cervical factor are included here **) The indication "pathological function test is included here J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 19

20 IVF and ICSI Results 2012 Prospective Data IVF 2012 n % Fertilisation % Embryo % Transfer % Clin. Preg. % IVF 9, Successful Fertilis.* 8, Minimum 1 Embryo 8, ET Performed 8, Clin. Pregnancy 2, Birth 1, Miscarriage Ectopic Pregnancy No Information ICSI 2012 Total n % Fertilisation % Embryo % Transfer % Clin. Preg. % ICSI 31, Successful Fertilis.* 29, Minimum 1 Embryo 29, ET Performed 28, Clin. Pregnancy 8, Birth 4, Miscarriage 1, Ectopic Pregnancy No Information 2, *) Successful fertilisation of at least one oocyte per cycle 20 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

21 TESE and Cryo Transfer Results 2012 Prospective Data ICSI 2012 Sperm Retrieval by TESE or Cryo TESE n % Fertilisation % Embryo % Transfer % Clin. Preg. % ICSI 1, Successful Fertilis.* 1, Minimum 1 Embryo 1, ET Performed 1, Clin. Pregnancy Birth Miscarriage Ectopic Pregnancy No Information Cryo Transfer Results 2012 Prospective Data Cryo Transfer 2012 n % PN % Transfer % Clin. Preg. % Cryo Transfer Cycles 17, Thawed PN 15, ET Performed 15, Clin. Pregnancy 3, Birth 1, Miscarriage Ectopic Pregnancy No Information *) Successful fertilisation of at least one oocyte per cycle J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 21

22 Outcome (Clinical Pregnancy (CP)) as a Function of Female Age 2012 Prospective Data IVF 2012 % Clin. Preg./ET Miscarriages/Clin. Preg. % <= >=44 Years n ET % CP/ET Age in Years OPU Oocytes 1 Insemin. 1 ET ET/OPU % Trans. CP CP/OPU Embr. 1 % CP/ET % CP/ET: 2 Embr. transf. + min. 2 PN surplus < = 29 1, , , , , > = 40 1, , Total 9, , , ) Mean 22 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

23 Outcome (Clinical Pregnancy (CP)) as a Function of Female Age 2012 Prospective Data ICSI 2012 % Clin. Preg./ET Miscarriages/Clin. Preg. % <= >=44 0 Years n ET % CP/ET Age in Years OPU Oocytes 1 Insemin. 1 ET ET/OPU % Trans. CP CP/OPU Embr. 1 % CP/ET % CP/ET: 2 Embr. transf. + min. 2 PN surplus < = 29 3, , , , , , , , , > = 40 6, , Total 31, , , ) Mean J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 23

24 Clinical Pregnancies (CP)/ET as a Function of the Number of Embryos Transferred and Age Groups 2012 IVF, ICSI, Cryo Transfer Prospective Data IVF 1 Embryo 2 Embryos 3 Embryos Total Age in Years ET CP/ET % ET CP/ET % ET CP/ET % ET CP/ET % < = , , , , , > = Total 1, , , , ICSI 1 Embryo 2 Embryos 3 Embryos Total Age in Years ET CP/ET % ET CP/ET % ET CP/ET % ET CP/ET % < = , , , , , , , , , , , , , > = Total 4, , , , Cryo Transfer 1 Embryo 2 Embryos 3 Embryos Total Age in Years ET CP/ET % ET CP/ET % ET CP/ET % ET CP/ET % < = , , , , , , , , , , , > = Total 2, , , , J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

25 Clinical Pregnancies (CP)/Fresh Transfer as a Function of Embryo Quality 2012 IVF, ICSI, IVF/ICSI Prospective Data Quality < = 29 Years Years Years > = 40 Years Total Ideal Not Ideal ET CP/ET % ET CP/ET % ET CP/ET % ET CP/ET % ET CP/ET % , , , , , , , , , , , , , , , , , Total 4, , , , , Clinical Pregnancies (CP)/Frozen Transfer as a Function of Embryo Quality 2012 Cryo Transfer Prospective Data Quality IVF ICSI Ideal Not Ideal ET CP/ET % ET CP/ET % , , , , , , Total* 3, , *) In 15 cases there is no information on the quality J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 25

26 Miscarriage (MISC) Rates as a Function of Female Age and Number of Embryos Transferred 2012 Prospective Data IVF, ICSI, IVF/ICSI 1 Embryo 2 Embryos 3 Embryos Total Age in Years CP MISC/CP % CP MISC/CP % CP MISC/CP % CP MISC/CP % < = , , , , , , , > = Total 1, , , , Cryo Transfer 1 Embryo 2 Embryos 3 Embryos Total Age in Years CP MISC/CP % CP MISC/CP % CP MISC/CP % CP MISC/CP % < = , , > = Total , , J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

27 Clinical Pregnancy Rate (CPR) as a Function of the Stimulation Protocol 2012 Prospective Data IVF u-fsh rec-fsh hmg reclh u. recfsh reclh u. hmg Other* No Info. Total Short GnRHa Transfer Rate (%) CP/ET (%) Long GnRHa 47 1, ,164 Transfer Rate (%) CP/ET (%) No GnRHa-Analoga Transfer Rate (%) CP/ET (%) GnRHa-Antagonists 64 2, ,474 Transfer Rate (%) CP/ET (%) Total 137 5,018 2, , ,237 ICSI u-fsh rec-fsh hmg reclh u. recfsh reclh u. hmg Other* No Info. Total Short GnRHa ,279 Transfer Rate (%) CP/ET (%) Long GnRHa 141 5,753 2, , ,818 Transfer Rate (%) CP/ET (%) No GnRHa-Analoga 46 1, ,165 Transfer Rate (%) CP/ET (%) GnRHa-Antagonists 161 8,180 2,820 1,096 1, ,168 Transfer Rate (%) CP/ET (%) Total ,410 6, , ,430 *) e.g. u-fsh and hmg, Clomifen/rec-FSH, Clominfen/hMG etc. J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 27

28 Mean Age for Women and Men IVF, ICSI, IVF/ICSI Prospective and Retrospective Data (Based on Registry Participants 2012) n = 697,841 Treatment Cycles with Plausible Age Documentation Age in Years 38.6 Man 38.4 Woman Mean % Confidence Interval (CI) (e.g. with a probability of 95 %, the mean women s age is between and years in 1997) Man 2012: Woman 2012: J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) Year

29 Duration of Unwanted Childlessness Prior to First Treatment IVF, ICSI, IVF/ICSI Prospective and Retrospective Data (Based on Registry Participants 2012) Duration of Unwanted Childlessness Prior to First Treatment in Years n = 345,956 First Treatments with Known Duration of Unwanted Childlessness Year Number of Treatment Cycles per Woman IVF, ICSI, IVF/ET, Cryo ET Prospective and Retrospective Data (Based on Registry Participants 2012) n Treatments per Woman n = 422,259 Women % [Proportion of Women with n Treatments] J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 29

30 Children Born Prospective and Retrospective Data IVF, ICSI, IVF/ICSI Singletons Twins Triplets Quadruplets Total n % n % n % n % n , , ,165 * (6,774) (61.04) (3,919) (35.31) (405) (3.65) (0) - (11,098) , , ,376 * (7,724) (62.78) (4,210) (34.22) (362) (2.94) (7) (0.06) (12,303) , , ,259 * (10,688) (62.78) (5,866) (34.22) (533) (2.94) (24) (0.14) (17,111) , , ,428 * (5,352) (62.46) (2,801) (34.28) (223) (3.11) (0) - (8,376) , , ,658 * (5,515) (63.90) (2,906) (33.44) (179) (2.66) (11) (0.13) (8,611) , , ,017 * (5,894) (64.05) (2,890) (33.75) (174) (2.08) (0) - (8,958) , , ,231 * (6,628) (64.69) (3,471) (33.88) (143) (1.40) (4) (0.04) (10,246) , , ,448 * (6,672) (64.34) (3,481) (33.57) (209) (2.02) (8) (0.08) (10,370) , , ,007 * (7,217) (66.02) (3,523) (32.23) (183) (1.67) (8) (0.07) (10,931) , , ,504 * (6,724) (64.62) (3,507) (33.70) (175) (1.68) (0) - (10,406) , , ,015 * (6,880) (63.95) (3,832) (35.06) (216) (1.97) (0) - (10,928) , , ,734 * (5,428) (62.65) (3,082) (35.28) (153) (1.75) (0) - (8,663) *) The values in brackets indicate live births. Totalling : 100,059 (96,611) singletons, 54,716 (54,094) twins, 5,275 (5,025) triplets, 88 (85) quadruplets. In total: 160,138 (155,815) NOTE: Including the year 2010, values are taken from the 2011 annual. From 2011 on they are based on the 2012 registry participants. 30 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

31 Children Born Prospective and Retrospective Data Total (IVF, ICSI, IVF/ICSI, Cryo Transfer) Singletons Twins Triplets Quadruplets Total n % n % n % n % n , , ,533 * (7,764) (62.33) (4,248) (34.10) (444) (3.56) (0) - (12,456) , , ,987 * (8,902) (64.02) (4,615) (33.19) (382) (2.75) (7) (0.05) (13,906) , , ,877 * (11,887) (63.48) (6,237) (33.31) (578) (3.09) (24) (0.13) (18,726) , , ,500 * (6,869) (65.81) (3,306) (31.68) (262) (2.51) (0) - (10,437) , , ,703 * (7,020) (65.93) (3,408) (32.01) (209) (1.96) (11) (0.10) (10,648) , , ,095 * (7,402) (67.14) (3,417) (30.99) (202) (1.83) (4) (0.04) (11,025) , , ,670 * (8,364) (66.45) (4,043) (32.12) (176) (1.40) (4) (0.03) (12,587) , , ,834 * (8,416) (66.07) (4,084) (32.06) (230) (1.81) (8) (0.06) (12,738) , , ,392 * (8,969) (67.42) (4,114) (30.92) (213) (1.60) (8) (0.06) (13,304) , , ,024 * (8,566) (66.35) (4,105) (31.80) (239) (1.85) (0) - (12,910) , , ,693 * (8,767) (64.03) (4,526) (33.05) (294) (2.15) (0) - (13,587) , , ,909 * (6,968) (65.07) (3,660) (34.18) (201) (1.88) (0) - (10,829) *) The values in brackets indicate live births. Totalling : 120,730 (120,584) singletons, 61,755 (61,098) twins, 5,752 (5,588) triplets, 92 (89) quadruplets. In total: 188,329 (187,359) NOTE: Including the year 2010, values are taken from the 2011 annual. From 2011 on they are based on the 2012 registry participants. J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 31

32 Children as a Function of Week of Gestation (WoG) and Birth Weight (BW) 2011* Singletons 2011 WoG < > 41 Total n ,778 2,153 1, ,221 BW Q ,380 1,440 1,590 1,990 2,030 2,340 2,600 2,840 3,010 3,150 3,276 3,340 3,150 2,990 BW Median , ,265 1,475 1,678 1,890 2,209 2,365 2,643 2,940 3,100 3,300 3,420 3,550 3,640 3,500 3,330 BW Q ,245 1,234 1,300 1,490 1,670 1,880 2,114 2,400 2,600 2,880 3,180 3,400 3,600 3,710 3,840 3,920 3,850 3,660 Percentiles 2011: p25 = 38th WoG, p50 = 39th WoG, p75 = 40th WoG; Percentiles : p25 = 38th WoG, p50 = 39th WoG, p75 = 40th WoG Proportion of children born before the completion of the 37th WoG: 12.74% Twins 2011 WoG < Total** n ,928 BW Q ,120 1,340 1,490 1,650 1,840 1,980 2,190 2,345 2,480 2,600 2,540 2,590 2,000 BW Median ,115 1,318 1,484 1,700 1,860 2,010 2,200 2,410 2,590 2,710 2,830 2,935 3,190 2,400 BW Q ,120 1,240 1,460 1,600 1,850 2,050 2,210 2,410 2,630 2,840 2,904 3,040 3,200 3,640 2,740 Percentiles 2011: p25 = 34th WoG, p50 = 36th WoG, p75 =37th WoG; Percentiles : p25 = 34th WoG, p50 = 36th WoG, p75 = 37th WoG Proportion of children born before the completion of the 37th WoG: 71.28% **) The total contains 10 cases with a WoG > 40 Triplets 2011 WoG Total*** n BW Q ,035 1,190 1,370 1,550 1,580 1,740 1,850 1,740 1,280 BW Median ,140 1,320 1,480 1,730 1,765 1,950 1,978 2,090 1,660 BW Q ,115 1,280 1,420 1,730 1,843 1,870 2,190 1,990 2,200 1,920 Percentiles 2011: p25 = 29th WoG, p50 = 32th WoG, p75 =33th WoG; Percentiles : p25 = 30th WoG, p50 = 32th WoG, p75 = 33th WoG Proportion of children born before the completion of the 37th WoG: 98.50% ***) The total contains 4 cases with a WoG >35 *) Children with plausible birth weight and week of gestation, using prospective and retrospective data 32 J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

33 Children as a Function of Week of Gestation (WoG) and Birth Weight (BW) 2011* Singletons 2011 g BW 25th, 50th, 75th Percentile WoG 4,000 3,750 3,500 3,250 3,000 2,750 2,500 2,250 2,000 1,750 1,500 1,250 1, < >41 WoG n 2,200 2,100 2,000 1,900 1,800 1,700 1,600 1,500 1,400 1,300 1,200 1,100 1, < >41 WoG Twins 2011 g BW 25th, 50th, 75th Percentile WoG 3,750 3,500 3,250 3,000 2,750 2,500 2,250 2,000 1,750 1,500 1,250 1, < >41 WoG n < >41 WoG Triplets 2011 g BW 25th, 50th, 75th Percentile WoG 2,250 2,000 1,750 1,500 1,250 1, < >41 WoG n < >41 WoG *) Children with plausible birth weight and week of gestation, using prospective and retrospective data J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 33

34 Complications as a Function of Ovum Pick-up (OPU) 2012 Prospective Data Total OPU s 42, % No Information % No Complications 42, % Complications % Complications n % Vaginal Bleeding Intraabdom. Bleeding Intestinal Tract Injury Peritonitis Hospitalisation Surgery Other Total J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2)

35 Ovarian Hyperstimulation Syndrome (OHSS) as a Function of the Stimulation Protocol IVF, ICSI, IVF/ICSI Prospective Data Stimulation % Oocytes Retrieved n OHSS III OHSS III/Stim % Short GnRH 3, FSH only 1, hmg only 1, FSH + hmg Other No Information Long GnRH 15, ,46 FSH only 8, hmg only 3, FSH + hmg 3, Other No Information No Analoga 6, FSH only 3, hmg only 1, FSH + hmg 1, Other No Information GnRH-Antagonists 20, FSH only 11, hmg only 4, FSH + hmg 2, Other No Information 1, Total 45, J Reproduktionsmed Endokrinol 2013; 10 (Sonderheft 2) 35

36 List of Registry Members Contributing to the 2012 D I R Annual Kinderwunschzentrum Dresden Praxisklinik Dr. med. H.-J. Held Dr. med. Hans-Jürgen Held Prager Straße 8 a Dresden T: , F: info@ivf-dresden.de Gynäkologische Endokrinologie und Reproduktionsmedizin der Universitätsfrauenklinik Dresden Dr. med. Constanze Reisenbüchler, Dr. med. Katja Keller, Dr. med. Jennifer-Lucia Wacker, Prof. Dr. med. Wolfgang Distler, Dr. rer. nat. Gudrun Keck Fetscherstraße Dresden T: , F: wolfgang.distler@uniklinikum-dresden.de Kinderwunschzentrum Leipzig-Chemnitz Dr. med. Fayez Abu Hmeidan, Dr. med. Petra Jogschies, Dörte Geistert, Laila Shugair Goldschmidtstraße Leipzig T: , F: info@ivf-leipzig.de Kinderwunschzentrum Praxisklinik City Leipzig Dr. med. Astrid Gabert, Dr. med. Katharina Bauer, Dr. med. Isabel Schwandt, FÄ Jana Sonneck, Dr. med. Doreen Marx, Prof. Dr. med. Henry Alexander, Dr. rer. nat. Stefanie Breuer Petersstraße Leipzig T: , F: info@ivf-city-leipzig.de Universitätsklinikum Halle (Saale) Zentrum für Reproduktionsmedizin und Andrologie Univ.-Prof. Dr. med. Hermann M. Behre, Dr. med. Petra Kaltwaßer, Dr. med. Solveig Köller, Dr. rer. nat. Ewald Seliger, Dr. rer. nat. Thomas Greither Ernst-Grube-Straße Halle (Saale) T: , F: zra@uk-halle.de Zentrum für Reproduktionsmedizin Jena & Erfurt PD Dr. med. habil. Heidi Fritzsche, Dipl. med. Jens-Peter Reiher, Dr. med. Angela Hoffmann, Dr. med. Andreas Fritzsche Markt Jena T: , F: Dr.H.Fritzsche@t-online.de Kinderwunschzentrum Leipzig-Chemnitz Dr. med. Fayez Abu Hmeidan, Dr. med. Petra Jogschies, Dörte Geistert, Laila Shugair Jakobikirchplatz Chemnitz T: , F: info@ivf-chemnitz.de Kinderwunschzentrum Praxisklinik City Leipzig Standort Chemnitz Dr. med. Astrid Gabert, Dr. med. Katharina Bauer, Dr. med. Isabel Schwandt, FÄ Jana Sonneck, Dr. med. Doreen Marx, Dr. rer. nat. Stefanie Breuer Flemmingstraße 2 a Chemnitz T: , F: info@kinderwunschzentrum-chemnitz.de Kinderwunschzentrum am Potsdamer Platz Dr. med. Anja Mutz, Dr. med. Hanadi Awwadeh Leipziger Platz Berlin T: , F: info@kinderwunsch-potsdamerplatz.de Praxis für Fertilität Kinderwunsch- und Endometriose-Zentrum Berlin Dr. med. Gülden Halis, Dr. med. David J. Peet, Dipl.-Biol. Sonja Zeitler Friedrichstraße Berlin T: , F: info@fertilitaet.de MVZ Praxisklinik Sydow am Gendarmenmarkt GmbH Dr. med. Peter Sydow, Dr. med. Carmen Sydow, Dr. med. Ulrike Bergmann-Hensel, Dr. med. Birgit Bestvater, Dr. med. Wibke Wilkening Kronenstraße Berlin T: , F: info@praxisklinik-sydow.de Gynäkologikum Berlin PD Dr. med. Bernd Krause, Dr. med. Björn Horstkamp, Dipl. med. Gili Pajenson, Dr. med. Alexandra von Palombini, Dr. med. Petra Rudolph Uhlandstraße Berlin T: , F: info@gynaekologikum-berlin.de Kinderwunschzentrum Berlin Dr. med. Reinhard Hannen, Dr. med. Christian Friedrich Stoll Landgrafenstraße Berlin T: , F: info@kinderwunschzentrum.de Kinderwunsch am Wittenbergplatz Praxis Dr. med. Rolf Metzger in Praxisgemeinschaft mit Berliner Kinderwunschzentrum Dr. med. Rolf Metzger, Dr. med. Christiane Peters, Rainer Mogalle Tauentzienstraße Berlin T: , F: mail@berlin-ivf-praxis.de Kinderwunschzentrum an der Gedächtniskirche Dr. med. Matthias Bloechle, Dr. med. Silke Marr Rankestraße Berlin T: , F: info@kinderwunsch-berlin.de Kinderwunschzentrum FERA im Wenckebach-Klinikum Dr. med. Andreas Jantke, Dr. med. Anna Stegelmann, Dipl.-Biol. Cornelia Meyer Wenckebachstraße Berlin T: , F: kinderwunsch@fera-berlin.de Kinderwunschzentrum am Innsbrucker Platz Berlin Babette Remberg, Dr. med. Susanne Tewordt-Thyselius, Dr. rer. nat. Thomas Jeziorowski Hauptstraße Berlin T: , F: praxis@kinderwunschpraxis-berlin.de Praxis für Kinderwunschtherapie Berlin Helle-Mitte Dr. med. Muna Zaghloul-Abu Dakah, Dr. med. Swetlana Hoffmann Stendaler Straße Berlin T: , F: info@berliner-kinderwunsch.de 36 J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

37 Fertility Center Berlin Auf dem Gelände der DRK Kliniken Westend Prof. Dr. med. Heribert Kentenich, Dr. med. Gabriele Stief, Dr. med. Andreas Tandler-Schneider, Dr. med. Anette Siemann, Dr. med. Marina Werling, Dr. rer. nat. Ulrike Montag, Dr. rer. nat. Claus Sibold, Bipl.-Biopharmak. Jacqueline Ulrich Spandauer Damm Berlin T: , F: Kinderwunschzentrum Potsdam Dr. med. Kay-Thomas Moeller, Dr. med. Kathleen Linca, Dr. Manzoor Nowshari Babelsberger Straße Potsdam T: , F: info@kinderwunsch-potsdam.de Praxiszentrum Frauenheilkunde Rostock PD Dr. med. Heiner Müller, Annette Busecke, Anja Bossow Südring Rostock T: , F: info@ivf-rostock.de MVZ Fertility Center Hamburg GmbH Prof. Dr. med. Klaus Rudolf, Dr. med. (IL) Robert Fischer, Dr. med. Olaf G. J. Naether, Dr. med. Kay Christian Löbbecke Speersort Hamburg T: , F: fch@kinderwunsch-hamburg.de Kinderwunschzentrum Altonaer Straße im Gynaekologicum Hamburg Dr. med. Annick Horn, Dr. med. Wolf Michel, Dr. med. Tim Cordes, Prof. Dr. med. Markus S. Kupka Altonaer Straße Hamburg T: , F: info@ivf-hamburg.de Kinderwunsch Praxisklinik Fleetinsel Hamburg Tip/Dr. univ. Ist. Semsettin E. Koçak, Dr. med. Peter List, Cemile Ballnus, Dr. rer. nat. Uwe Weidner Admiralitätsstraße Hamburg T: , F: kocak@kinderwunschzentrum-hamburg.de MVZ Endokrinologikum Hamburg Zentrum für Hormon- und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin Prof. Dr. med. Christoph Keck, PD Dr. med. Michael Graf, PD Dr. med. Ulrich A. Knuth, Dr. med. Mandana Motamedi, Dr. med. Tina Osterholz-Zaleski, Dr. med. Raquel Pozo Ugarte, PD. Dr. med. Sabine Segerer, Dr. med. Nina Wegmann, Dr. rer. nat. Birthe Nitz, Nicole Becker Lornsenstraße Hamburg T: , F: gyninfo@endokrinologikum.com Universitäres Kinderwunschzentrum Lübeck Ambulanzzentrum des UKSH ggmbh Prof. Dr. med. Georg Griesinger M. Sc., PD Dr. med. Askan Schultze-Mosgau Ratzeburger Allee Lübeck T: , F: kinderwunsch@uk-sh.de fertilitycenterkiel Dr. med. Martin Völckers, Dr. med. Julia Schlütter Prüner Gang Kiel T: , F: info@fertilitycenter.de Kinderwunschzentrum im Universitäts- Klinikum Schleswig-Holstein Campus Kiel Prof. Dr. med. Liselotte Mettler, Dr. med. Andreas Schmutzler Arnold-Heller-Straße 3 Haus Kiel T: , F: repromed@ .uni-kiel.de KinderwunschKiel Dr. med. Kurt Brandenburg, Dr. med. Angela Carstensen Im Brauereiviertel Kiel T: , F: info@kinderwunschkiel.de Tagesklinik Oldenburg Zentrum für Kinderwunschbehandlung Dr. med. Jörg Hennefründ, Dr. med. Heike Boppert, Dr. med. Michael Heeder Achternstraße Oldenburg T: , F: info@tagesklinik-oldenburg.de Team Kinderwunsch Oldenburg Dr. med. Saif Jibril, Dr. med. Gerhard Pohlig Leo-Trepp-Straße Oldenburg T: , F: tko@telemed.de Kinderwunschzentrum Ostfriesland Dr. med. Grita Hasselbach, Dr. rer. nat. Isabell Motsch Hafenstraße 6 d Leer (Ostfriesland) T: , F: info@kinderwunschostfriesland.de Kinderwunsch Bremen Dr. med. Achim von Stutterheim, Tanja Finger, Dr. med. Anjarasoa Jung Emmastraße Bremen T: , F: info@kinderwunschbremen.de BZF-Bremer Zentrum für Fortpflanzungsmedizin Dr. med. Olaf Drost, Prof. Dr. med. Ernst Heinrich Schmidt, Dr. sc. hum. Martin Pinteric Gröpelinger Heerstraße Bremen T: , F: info@icsi.de Team Kinderwunsch Hannover Dr. med. Nabil Saymé, Dipl.-Biol.T. Krebs Brühlstraße Hannover T: , F: info@team-kinderwunsch-hannover.de Medizinische Hochschule Hannover Bereich Gynäkologische Endokrinologie und Reproduktionsmedizin, OE 6410 OÄ Dr. med. Cordula Schippert, OA Dr. med. Guillermo-José Garcia-Rocha, FÄ PD Dr. Frauke von Versen-Höynck Carl-Neuberg-Straße Hannover T: , F: Schippert.Cordula@mh-hannover.de Kinderwunschzentrum Langenhagen & Wolfsburg MVZ Ärztlicher Leiter: Dr. med. Thilo Schill Ostpassage Langenhagen Sauerbruchstraße Wolfsburg T: , F: praxis@kinderwunsch-langenhagen.de J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 37

38 Zentrum für Reproduktionsmedizin und Humangenetik Dr. med. Franz-J. Algermissen, Dr. med. Peter F. Justus, Dr. med. Georg Wilke, Dr. med. Notker Graf Gartenstraße Hildesheim T: , F: Zentrum für Kinderwunschbehandlung und pränatale Medizin Dr. med. Dipl.-Biochem. Onno Buurman, Dr. med. Michael Dumschat, Dr. med. Ralf Menkhaus Simeonsplatz Minden T: , F: Praxisklinik Prof. Volz Prof. Dr. med. Joachim Volz, PD Dr. med. Stefanie Volz-Köster Adenauer Platz Bielefeld T: , F: kinderwunsch@frog.de.com Bielefeld Fertility-Center Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie Paul A. Ebert, Dr. med. Karl Völklein, Beata Szypajlo, Dr. med. Wiebke Rübberdt, Dr. med. Beate Harms Werther Straße Bielefeld T: , F: praxis@kinderwunsch-bielefeld.de MVZ für Reproduktionsmedizin am Klinikum Kassel Dr. med. Marc Janos Willi, Dr. med. Oswald Schmidt, Prof. Dr. (UBsAs) Miguel J. Hinrichsen Mönchebergstraße Kassel T: , F: info@kinderwunsch-kassel.de RepKo - Reproduktionsmedizinisches Kompetenzzentrum am Universitätsklinikum Gießen & Marburg GmbH Prof. Dr. med. Peyman Hadji, Dr. med. Volker Ziller, Dr. med. Berna Seker-Pektas, Dr. med. Cennet Dalmis, Dr. med. Yasemin Üsküdar Baldingerstraße Marburg T: , F: Klinikstraße Gießen T: , F: Kinderwunschzentrum Mittelhessen Dr. med. Amir Hajimohammad, Berthold Oels Sportparkstraße Wetzlar T: , F: info@ivf-mh.de gyn-medicum Göttingen Dr. med. Monica Tobler, Jana Rostek Waldweg Göttingen T: , F: info@kinderwunsch-praxis-goettingen.de Kinderwunschzentrum Göttingen Dr. med. Rüdiger Moltrecht, Dr. med. Sabine Hübner, Dr. med. Thomas Welcker, Dr. rer. nat. Stephanie Mittmann, Dr. med. Peter Schulzeck, Dr. med. Filiz Sakin-Kaindl Kasseler Landstraße 25 a Göttingen T: , F: info@kiwu-goettingen.de Kinderwunschzentrum Magdeburg Dr. med. Ingrid Nickel, Dr. med. Evelyn Richter, Dipl. Biol. Katrin Pribbernow Ulrichplatz Magdeburg T: , F: info@kiwumed.de Otto-von Guericke-Universität Magdeburg Klinik für Reproduktionsmedizin Prof. Dr. med. Jürgen Kleinstein, Dr. med. Anke Britta Brössner Gerhart-Hauptmann-Straße Magdeburg T: , F: juergen.kleinstein@med.ovgu.de Kinderwunsch-Kö Dr. med. Martina Behler, Tanja Emde Königsallee Düsseldorf T: , F: info@kinderwunsch-koe.de Interdisziplinäres Kinderwunschzentrum Düsseldorf MVZ GmbH Dr. med. M.C.W. Scholtes, Dipl. med. Kersten Marx, PD Dr. med. Stefan Kißler, Dr. med. Petra Hubert, Dr. med. Selma Yildirim-Assaf Völklinger Straße Düsseldorf T: , F: info@ivf-duesseldorf.de UniKiD Universitäres interdisziplinäres Kinderwunschzentrum Düsseldorf Prof. Dr. med. Jan-Steffen Krüssel, Dr. med. Nina Bachmann, Dr. med. Daniel Fehr, M.Sc., Dr. med. Tanja Freundl-Schütt, PD Dr. med. Alexandra Hess, Dr. med. Barbara Mikat-Drozdzynski, Dr. med. Andrea Schanz, Sonja Schu, Dr. rer. nat. Jens Hirchenhain, Dr. rer. nat. Dunja M. Baston-Büst Moorenstraße Düsseldorf T: , F: info@unikid.de pro-kindwunsch Kinderwunschzentrum Niederrhein Dr. med. Georg M. Döhmen, Dr. med. Thomas Schalk Von-Groote-Straße Mönchengladbach T: , F: info@pro-kindwunsch.de green-ivf Grevenbroicher Endokrinologikum & IVF-Zentrum Dr. med. Jürgen Tigges, Dr. med. Kerstin Friol, PD Dr. med. Christian Gnoth Rheydter Straße Grevenbroich T: , F: praxis@green-ivf.de Bergisches Kinderwunschzentrum Remscheid Dr. med. Johannes Luckhaus, Dr. med. Anke Beerkotte Elberfelder Straße Remscheid T: , F: mail@kinderwunsch-remscheid.de Überörtliche Berufsausübungsgemeinschaft der Kinderwunschzentren Dortmund, Siegen, Dorsten GbR Prof. Dr. med. Stefan Dieterle, Dr. med. Andreas Neuer, Prof. Dr. med. Robert Greb, Dr. med. Katharina Möller-Morlang, Dr. med. Thomas von Ostrowski Olpe Dortmund T: , F: Hermelsbacher Weg Siegen T: , F: Südwall Dorsten T: , F: info@kinderwunschzentrum.org 38 J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

39 novum Zentrum für Reproduktionsmedizin Essen - Duisburg Prof. Dr. med. Thomas Katzorke, Dr. med. Susanne Wohlers, Najib N. R. Nassar, Dr. med. Sylvia Bartnitzki, Prof. Dr. med. Peter Bielfeld Akazienallee Essen T: , F: Ärzteforum in der Tonhallenpassage Friedrich-Wilhelm-Straße Duisburg T: , F: info@ivfzentrum.de REProVita - Kinderwunschzentrum Recklinghausen Dr. med. Cordula Pitone Hertener Straße Recklinghausen T: , F: info@reprovita.de Kinderwunschpraxis Gelsenkirchen Dr. med. Ute Czeromin, Dr. med. Ina Walter-Göbel, Dr. med. Kathrin Fißeler Munscheidstraße Gelsenkirchen T: , F: info@kinderwunsch-gelsenkirchen.de FCM Fertility Center Münsterland Dr. med. Ulrich Hilland Crispinusstraße 12 (am Europaplatz) Bocholt T: , F: praxis@fcm-net.de MVZ Kinderwunsch- und Hormonzentrum Münster GmbH Dr. med. Dr. rer. nat. Lutz Belkien, Dr. med. Caroline Niehoff, Prof. Dr. med. Axel Kamischke Hötteweg Münster T: , F: info@ivf-muenster.de Kinderwunschpraxis an der Promenade Mempel & Stratmann Dr. med. Andrea Mempel, Susanne Stratmann, Dr. rer. nat. Melanie Rickert-Föhring Von-Vincke-Straße Münster T: , F: willkommen@kinderwunsch-promenade.de UKM Kinderwunschzentrum Universitätsklinikum Münster PD Dr. med. Andreas Schüring, Leiter Kinderwunschzentrum, Gynäkologische Endokrinologie und Reproduktionsmedizin, Klinik für Frauenheilkunde und Geburtshilfe; Prof. Dr. med. Sabine Kliesch, Chefärztin Klinische Andrologie; Urologie, Andrologie; Centrum für Reproduktionsmedizin Albert-Schweitzer-Campus 1, Gebäude D Münster T: , F: info-kinderwunsch@ukmuenster.de Zentrum für Kinderwunschbehandlung Osnabrück Irene Coordes, Dr. med. Manfred Schneider Rheiner Landstraße Osnabrück T: , F: info@kinderwunsch123.de GMP Frauenheilkunde & Reproduktionsmedizin Dr. med. Dieter Struller, Dr. med. Christof Etien Graf-Salm-Straße Bedburg, Erft T: , F: info@kinderwunsch-erft.de MVZ PAN Institut für Endokrinologie und Reproduktionsmedizin Dr. med. Stefan Palm, Dr. med. Irene Pütz, Dr. med. Mirko Dannhof, PD Dr. med. Dolores Foth, Dipl. Psych. Anika Sauer, Dipl. Psych. Andrea Giles, Dr. med. Georg Mansmann, PD Dr. med. Torsten Schmidt, Prof. Dr. med. Martina Breidenbach, Dr. med. Sigrid Gerards, Dr. med. Jürgen Laser, Dipl.-Biol. Claudia Grewenig, Dr. rer. nat. Maike Warnstedt, Dr. rer. nat. Bastian Schäferhoff Zeppelinstraße 1 Neumarkt Galerie Köln T: , F: repro@pan-klinik.de Kinderwunschzentrum Köln Dr. med. Markus Merzenich Schönhauser Straße Köln T: , F: info@kinderwunschzentrum-koeln.de und Kinderwunschzentrum Eva Schwahn Schönhauser Straße Köln T: , F: info@wunschkind-koeln.de Frauenarztpraxis mit Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin Dr. med. Klaus Grunwald Kasernenstraße Aachen T: , F: kinderwunsch-aachen@t-online.de Universitäts-Frauenklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin Medizinische Fakultät der RWTH Aachen Prof. Dr. med. Joseph Neulen, Dr. med. Benjamin Rösing Pauwelsstraße Aachen T: , F: gyn-endokrinologie@ukaachen.de Universitätsklinikum Bonn Gynäkologische Endokrinologie und Reproduktionsmedizin Prof. Dr. med. Hans H. van der Ven, Prof. Dr. med. Katrin van der Ven, Dr. med. Ulrike Bohlen, Dr. med. vet. Maria Köster Sigmund-Freud-Straße Bonn T: , F: officerepro@ukb.uni-bonn.de Praxisklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin PD Dr. Dr. med. Gernot Paul Prietl, Dr. med. Monika Prietl, Dr. med. Peter Henschen Theaterplatz Bonn-Bad Godesberg T: , F: ivf@careme.de Kinderwunsch Praxisklinik Trier Dr. med. Mohsen Satari, Prof. Dr. med. Jürgen P. Hanker Wissenschaftspark (WIP) Max-Planck-Straße Trier T: , F: info@kinderwunsch-trier.de Kinderwunsch Zentrum Mainz Dr. med. Robert Emig, Dr. med. Silke Mettlin, Prof. Dr. med. Thomas Steck Fort Malakoff Park Rheinstraße Mainz T: , F: dr.emig@kwz-mz.de Kinderwunschzentrum der Universitätsmedizin Mainz Univ.-Prof. Dr. Rudolf Seufert M. Sc., Dr. Ruth Gomez, Dr. Ch. Haidner Langenbeckstraße Mainz T: , F: kinderwunsch@frauen.klinik.uni-mainz.de J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 39

40 Kinderwunschzentrum Mittelrhein Dr. med. Josef Beran, Dr. med. Birgit Müller, Dr. med. Sebastian Hagelauer Marktstraße Neuwied Neustadt Koblenz T: , F: info@kinderwunsch-mittelrhein.de Zentrum für Reproduktionsmedizin Prof. Dr. med. Dr. med. habil. Ernst Siebzehnrübl, Dr. med. Anja Weidner Hanauer Landstraße Frankfurt am Main T: , F: anmeldung@ivf-ffm.de Kinderwunschzentrum Frankfurt Prof. Dr. med. Prof. h. c. Eberhard Merz, Dr. med. Christine Molitor, Dr. med. Marie-Theres Swayzer, Ines Böhnisch, Dr. Claas Mehnert Steinbacher Hohl Frankfurt am Main T: , F: info@kinderwunschzentrum-frankfurt.de Fertilitätszentrum und Gynäkologische Endokrinologie Klinik für Frauenheilkunde und Geburtshilfe Goethe-Universität Dr. med. Nicole Sänger, Dr. med. Annette Bachmann, Dr. Anna Michaelis Theodor-Stern-Kai Frankfurt am Main T: , F: info.ivf@kgu.de Kinderwunsch- und Endometriosezentrum am Büsing Park Dr. med. Konstantin Manolopoulos, Dr. med. Birgit Lühr, L. Fökel, L. Tsiflika Herrnstraße Offenbach T: , F: info@offenbach-kinderwunsch.de Kinderwunschzentrum Darmstadt Prof. Dr. med. Gerhard Leyendecker, Dr. med. Aysen Bilgicyildirim, Dr. med. Matthias Inacker Bratustraße Darmstadt T: , F: info@kwz-da.de MVZ Kinderwunschzentrum Wiesbaden GmbH Dr. med. Martin Schorsch, Dr. med. Thomas Hahn, Dr. med. Geza Adasz, Karin Schilberz, Dr. med. Michael Amrani Mainzer Straße Wiesbaden T: , F: info@kinderwunschzentrum-wiesbaden.de Kinderwunsch-Praxis IVF-Saar Saarbrücken- Kaiserslautern Dr. med. Lars Happel, Andreas Giebel, Dr. med. Sascha Tauchert, Dr. med. Anette Russu, Dr. med. Marika Otte, Dr. rer. medic. Martin Greuner Europaallee Saarbrücken T: , F: Maxstraße Kaiserslautern T: , F: zentrum@ivf-saar.de Klinik für Frauenheilkunde, Geburtshilfe und Reproduktionsmedizin Universitätskliniken des Saarlandes Prof. Dr. med. E.-F. Solomayer, OA P. Rosenbaum, Prof. Dr. Dr. ME Hammadeh, Dr. med. Kathrin Abel, Dr. med. Daniel Benndorf, Dr. med. Peter Jankowski, Dr. med. Simona Moga Kirrbergstraße Homburg T: , F: ivf@uks.eu kliniken_institute/frauenklinik/ Kinderwunschzentrum Ludwigshafen Dr. med. Tobias Schmidt, Dr. med. Elena Hartschuh, Dr. med. Claudia Schmidt, Dr. rer. nat. Nicole Hirschmann Ludwigstraße 54 b Ludwigshafen T: , F: kontakt@kinderwunsch-lu.de Kinderwunschzentrum der Universitätsmedizin Mannheim Prof. Dr. med. Marc Sütterlin, Dr. med. Regine Schaffelder, Dr. med. Julia Rehnitz, Dr. med. Jade Mayer, Dr. sc. hum. Monika Gentili Theodor-Kutzer-Ufer Mannheim T: , F: ivflabor@umm.de Viernheimer Institut für Fertilität PD Dr. med. S. Volz-Köster, Dr. med. C. Nell Walter-Gropius-Allee Viernheim T: , F: info@vif-kinderwunsch.de Kinderwunschzentrum Heidelberg Dr. med. Waltraud Parta-Kehry, Dr. sc. hum. Suat Parta, Friederike Tesarz, Dr. med. Daniela Seehaus, Dr. med. Christina Thöne, Dr. B. Hauff Römerstraße Heidelberg T: , F: info@kwz-hd.de Abt. für Gynäkologische Endokrinologie und Fertilitätsstörungen Universitätsklinikum Heidelberg Prof. Dr. med. Thomas Strowitzki, Prof. Dr. Bettina Toth, PD Dr. med. Ariane Germeyer, Dr. med. Sabine Rösner, Dr. med. Julia Rehnitz, Dr. med. Verena Holschbach, Dr. rer.nat. Inge Eberhardt, Dr. rer. nat. Jens Dietrich Im Neuenheimer Feld Heidelberg T: , F: thomas.strowitzki@med.uni-heidelberg.de Kinderwunschambulanz html Kinderwunsch-Zentrum Stuttgart Prof. Dr. med. Dieter H. A. Maas, Dr. med. Friedrich Gagsteiger, Dr, med. Klaus Bühler, Dr. med. Nina Kircher, Dr. med. Lisa Beiglböck, Dr. med. Gerhild Weiß Friedrichstraße Stuttgart T: , F: info@kwz-stuttgart.de Kinderwunsch-Zentrum-Stuttgart, Praxis Villa Haag Dr. med. Dieter B. Mayer-Eichberger Herdweg Stuttgart T: , F: info@kinderwunschpraxis.de Frauenarztpraxis mit Tagesklinik Reproduktionsmedizin Univ.-Prof. Dr. med. Ute Fuchs, Dr. rer. nat. Silvia Harrer Kornbergstraße Stuttgart T: , F: Prof.UteFuchs@t-online.de Kinderwunschzentrum Ludwigsburg Dr. med. Andreas Ott, Dr. med. Annette Schmid, Dr. med. Katja Becker Pflugfelder Straße Ludwigsburg T: , F: info@kiwu-lb.de 40 J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

41 KinderwunschPraxis Dres. Göhring Dr. med. Ulrich Göhring, Dr. med. Inés Göhring Hagellocher Weg Tübingen T: , F: IVF-Zentrum der Universitäts-Frauenklinik Tübingen Dr. med. Melanie Henes, Dr. Philippe Cledon Calwerstraße Tübingen T: , F: melanie.henes@med.uni-tuebingen.de Kinderwunschzentrum Aalen Dr. med. Rainer Rau, Dr. med. Birgit Schröppel, Dr. rer. nat. Roland Eid Weidenfelder Straße Aalen T: , F: info@kinderwunsch-aalen.de IVF-Zentrum Esslingen Praxis Dr. J. E. Costea Dr. med. Johann Emil Costea, Dipl.-Ing. Luminitza Costea, Dr. rer. nat. Michael Troge Martinstraße Esslingen T: , F: info@ivf-praxis.com Centrum für Kinderwunsch Pforzheim Verena Peuten Zerrenner Straße Pforzheim T: , F: info@kinderwunsch-pforzheim.de Kinderwunschzentrum Karlsruhe Karlsruher IVF-Programm Arbeitsgemeinschaft für Fortpflanzungsmedizin Hans-Jürgen Gräber, Dr. med. Daniela Plathow, Dr. Frank Tetens, Laborärzte Dr. Ehrfeld + Kollegen, Humangenetik Dr. Schlüter Waldstraße Karlsruhe T: , F: info@ivf-programm.de Kinderwunsch Bodensee Dr. med. Andreas Heine, Dr. med. Antje Hiemer, Dr. Angela Panhans Maggistraße Singen T: , F: info@endlichnachwuchs.de Centrum für gynäkologische Endokrinologie und Reproduktionsmedizin Freiburg (CERF) Dr. med. Rudolf Weitzell, Dr. med. Maria Thiemann, PD Dr. med. Birgit Wetzka, Prof. Dr. med. Franz Geisthövel Bismarckallee 7 f Freiburg T: , F: info@kinderwunsch-hormone.de Universitätsklinikum Freiburg Klinik für Endokrinologie und Reproduktionsmedizin Dr. med. Stephanie Friebel, Dr. med. Aida Hanjalic-Beck, Dr. Bengi Acar-Perk Hugstetter Straße Freiburg T: , F: stephanie.friebel@uniklinik-freiburg.de endokrinologie.html Zentrum für Reproduktionsmedizin München Gemeinschaftspraxis für Frauenheilkunde und Geburtshilfe Dr. med. Walter Bollmann, Dr. med. Thomas Brückner, Dr. med. Ulrich Noss Tal München T: , F: info@ivf-bbn.de Zentrum für Gynäkologische Endokrinologie und Reproduktionsmedizin Klinikum der LMU München Innenstadt Prof. Dr. med. Christian J. Thaler, Prof. Dr. med. Klaus Friese Maistraße München T: , F: Kinderwunsch Zentrum an der Oper Dr. med. Helmut Lacher, Dr. med. Jörg Puchta, PD Dr. med. Hans-Ulrich Pauer, Dr. med. Silke Michna Maximilianstraße 2 a München T: , F: info@hormonzentrum.de Kinderwunsch Centrum München-Pasing Dr. med. Klaus Fiedler, Dr. med. Irene von Hertwig, Dr. med. Gottfried Krüsmann, Prof. Dr. Dr. med. habil. Wolfgang Würfel, Ina Laubert, Dr. med. Claudia Santjohanser, Sabine Völker, Osama Meri, Dr. med. Jan Krüsmann Lortzingstraße München T: , F: info@ivf-muenchen.de Hormon- und Kinderwunschzentrum Klinikum der LMU München Grosshadern Prof. Dr. med. Christian J. Thaler, Dr. rer. nat. Viktoria von Schönfeldt, Prof. Dr. med. Klaus Friese Marchioninistraße München T: , F: Kinderwunsch Centrum Chiemsee Dr. med. Susann Böhm, Dr. med. Matthias Lehnert, Johannes Wagner Hochriesstraße Prien am Chiemsee T: , F: info@kinderwunsch-chiemsee.de IVF-Zentrum Augsburg GMP Dres. Hiller, Bauer, Kraus, Steinfeld-Birg Dr. med. Klaus-Friedrich Hiller, Dr. med. Thomas Bauer, Dr. med. Harald Kraus, Dr. med. Dieter Steinfeld-Birg Prinzregentenstraße Augsburg T: , F: info@ivf-augsburg.de Zentrum für Reproduktionsmedizin am Klinikum Kempten-Oberallgäu Prof. Dr. med. Ricardo Felberbaum, Gerhard Allgayer, Dr. med. Claudia Daufratshofer, Dipl. Biol. Mohammad Kousehlar Robert-Weixler-Straße Kempten T: , F: ricardo.felberbaum@klinikum-kempten.de Universitätsfrauenklinik und Poliklinik Ulm Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie PD Dr. med. Katharina Hancke Prittwitzstraße Ulm T: , F: repromed.ufk@uniklinik-ulm.de Kinderwunsch-Zentrum Ulm Dr. med. Friedrich Gagsteiger, Dr. med. Natalie Reeka, Dr. med. Kerstin Eibner, Dr. med. Nilofar Huzurudin, Dr. med. Verena Domschat, Julia Koglin Einsteinstraße Ulm T: , F: info@kwz-ulm.de J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 41

42 Kinderwunsch und Frauen-Hormon Centrum Nürnberg Dr. med. Joachim Neuwinger, Dr. med. Barbara Munzer-Neuwinger, Prof. Dr. med. Peter Licht Agnesgasse Nürnberg T: , F: GMP Dres. Hamori, Behrens, Hammel Dr. med. Miklos Hamori, Dr. med. Rolf Behrens, Dr. med. Andreas Hammel Nürnberger Straße Erlangen T: , F: Kinderwunschzentrum Erlangen Dr. med. Jan van Uem, Dr. med. Madeleine Haas Michael-Vogel-Straße 1 e Erlangen T: , F: info@vanuem.com Universitäts-Fortpflanzungszentrum Franken (UFF) Prof. Dr. med. Matthias W. Beckmann, PD Dr. med. Patricia Oppelt, Prof. Dr. rer. nat. Ralf Dittrich Universitätsstraße Erlangen T: , F: fk-uff@uk-erlangen.de Klinik am Hofgarten Kinderwunsch-Zentrum Bayreuth Dr. med. Dr. phil. Stefan Todorow, Dr. med. Erika Schwarz Richard-Wagner-Straße Bayreuth T: , F: info@ivf-bayreuth.de Zentrum für Reproduktionsmedizin, Medizinische Genetik, Pränataldiagnostik Dr. med. Reinhard Mai, Dr. med. Wolfgang Schmitt, Dr. med. Lore Mulfinger Juliuspromenade Würzburg T: , F: kontakt@drs-mai-schmitt-mulfinger.de Universitätsklinikum Würzburg Frauenklinik und Hebammenschule Zentrum für gynäkologische Endokrinologie und Reproduktionsmedizin Prof. Dr. med. Ursula Zollner, Dr. med. Michael Schwab, Dr. rer. nat. Claudia Staib Josef-Schneider-Straße Würzburg T: , F: kinderwunsch@klinik.uni-wuerzburg.de Kinderwunschzentrum Amberg Am Klinikum St. Marien Amberg Dr. med. Jürgen Krieg Mariahilfbergweg Amberg T: , F: info@dr-krieg.de KITZ Regensburg - KinderwunschTherapie im Zentrum Prof. Dr. med. Bernd Seifert, Dr. med. Claudia Gaßner Hemauerstraße Regensburg T: , F: info@kitz-regensburg.de Kinderwunschzentrum Niederbayern Dr. med. Hans-Joachim Kroiss, Dr. med. Samuel Dadze, Dr. IM Tem. Elfriede Bernhardt Stadtfeldstraße Deggendorf T: , F: praxis@ivf-bayern.de dr.kroiss@ivf-bayern.de kinderwunsch-niederbayern.de 42 J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

43 Without generous support publishing this Annual would not have been possible. Our gratitude goes to FERRING Arzneimittel GmbH, Kiel 4,500 EUR Merck Serono GmbH, Darmstadt 4,500 EUR MSD Sharp & Dohme GmbH, Haar bei München 4,500 EUR J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 43

44 Journal of Reproductive Medicine and Endocrinology Publisher Krause & Pachernegg GmbH Verlag für Medizin und Wirtschaft Postfach 21, Mozartgasse 10 A-3003 Gablitz, Austria phone +43/2231/ fax +43/2231/ Chief Editor Prof. Dr. med. Hermann M. Behre Zentrum für Reproduktionsmedizin und Andrologie Universitätsklinikum Halle Martin-Luther-Universität Halle-Wittenberg Ernst-Grube-Str. 40 D Halle, Germany phone +49/345/ fax +49/345/ Official Organ of the Following Scientific Societies Arbeitsgemeinschaft Reproduktionsbiologie des Menschen (AGRBM) Bundesverband Reproduktionsmedizinischer Zentren Deutschlands (BRZ) Dachverband Reproduktionsbiologie und -medizin (DVR) Deutsche Gesellschaft für Andrologie (DGA) Deutsche Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin (DGGEF) Deutsche Gesellschaft für Reproduktionsmedizin (DGRM) Deutsches IVF-Register (D I R) Embryologenforum Austria (EFA) Österreichische Gesellschaft für Reproduktionsmedizin und Endokrinologie (OEGRM) Sektion Reproduktionsbiologie und -medizin der Deutschen Gesellschaft für Endokrinologie (SRBM/DGE) Editors Andrology Prof. Dr. med. Hans-Christian Schuppe Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie Universitätsklinikum Gießen u. Marburg GmbH D Gießen, Germany hans-christian.schuppe@derma.med.uni-giessen.de CME/DFP Dipl. Med. Jens W. Jacobeit ENDOKRINOLOGIKUM Hamburg, Zentrum für Hormon- und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin D Hamburg, Germany jens.jacobeit@endokrinologikum.com Univ.-Doz. Dr. Dietmar Spitzer IVF-Zentren Prof. Zech A-5020 Salzburg, Austria d.spitzer@salzburg.ivf.at Embryology and Molecular Biology Prof. em. Dr. med. Dr. rer. nat. Henning M. Beier Direktor des Instituts für Anatomie und Reproduktionsbiologie a.d. Institut für Molekulare und Zelluläre Anatomie RWTH Aachen D Aachen, Germany hmbeier@ukaachen.de Univ.-Prof. Dr. Gottfried Dohr Institut für Zellbiologie, Histologie und Embryologie Medizinische Universität Graz A-8010 Graz, Austria gottfried.dohr@medunigraz.at Endocrinology Prof. Dr. med. Dr. h. c. mult. Thomas Rabe Universitäts-Frauenklinik D Heidelberg, Germany thomas_rabe@med.uni-heidelberg.de Prof. Dr. med. Ludwig Wildt Klinische Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin Universitäts-Frauenklinik Innsbruck A-6020 Innsbruck, Austria ludwig.wildt@i-med.ac.at Ethics and Law Prof. Dr. med. Franz Geisthövel Centrum für Gynäkologische Endokrinologie und Reproduktionsmedizin Freiburg (CERF) D Freiburg i. Br., Germany geisthoevel@t-online.de Dr. med. Ulrich Hilland Fertility Center Münsterland D Bocholt, Germany praxis@fcm-net.de Prof. Dr. med. Herbert Zech Institut für Reproduktionsmedizin und Endokrinologie A-6900 Bregenz, Austria zech@ivf.at Genetics PD Dr. med. Tina Buchholz Zentrum für Polkörperdiagnostik, Praxis für Gynäkologie und Genetik, Labor für Reproduktionsgenetik D München, Germany info@gyn-gen-lehel.de Univ.-Prof. Mag. Dr. Markus Hengstschläger Vorstand des Instituts für Medizinische Genetik Medizinische Universität Wien A-1090 Wien, Austria markus.hengstschlaeger@meduniwien.ac.at Gynaecology Prim. Univ.-Prof. Dr. med. Joerg Keckstein Abteilung für Gynäkologie und Geburtshilfe Landeskrankenhaus Villach A-9500 Villach, Austria joerg.keckstein@lkh-vil.or.at Prof. Dr. med. Michael Ludwig Facharzt für frauenheilkunde und Geburtshilfe Gynäkologische Endokrinologie und Reproduktionsmedizin amedes Zentrum für Endokrinologie Kinderwunsch Pränatale Medizin im Barkhof D Hamburg, Germany michael.ludwig@amedes-group.com Prof. Dr. med. Hans Heinrich van der Ven Abt. für Gynäkologische Endokrinologie und Reproduktionsmedizin Zentrum für Geburtshilfe und Frauenheilkunde Rheinische Friedrich-Wilhelm-Universität D Bonn-Venusberg, Germany hans.van_der_ven@ukb.uni-bonn.de Contraception Prim. Dr. Hans Concin Abteilung für Frauenheilkunde und Geburtshilfe Landeskrankenhaus Bregenz A-6900 Bregenz, Austria hans.concin@lkhb.at Prof. Dr. med. Dr. h. c. mult. Thomas Rabe Universitäts-Frauenklinik D Heidelberg, Germany thomas_rabe@med.uni-heidelberg.de Psychosomatic Medicine Prof. Dr. med. Heribert Kentenich Fertility Center Berlin D Berlin, Germany kentenich@fertilitycenterberlin.de PD Dipl.-Psych. Dr. sc. hum. Tewes Wischmann Universitätsklinikum Heidelberg D Heidelberg, Germany tewes.wischmann@med.uni-heidelberg.de Reproductive Medicine Dr. Klaus Bühler Vorsitzender Deutsches IVF-Register e.v. D I R Kinderwunsch-Zentrum Ulm & Stuttgart D Stuttgart, Germany buehler@ivf-zentrum.de buehler.kf@t-online.de Prof. Dr. med. Wolfgang Urdl Universitätsklinik für Frauenheilkunde Graz A-8010 Graz, Austria wolfgang.urdl@ivf-institut.at Prof. Dr. Dr. med. Wolfgang Würfel Kinderwunsch Centrum München (KCM) D München, Germany info@ivf-muenchen.de Urology Prof. Dr. med. Sabine Kliesch Centrum für Reproduktionsmedizin und Andrologie, Klinische Andrologie Universitätsklinikum Münster D Münster, Germany sabine.kliesch@ukmuenster.de 44 J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2)

45 Imprint Official Organ of Following Scientific Societies: Arbeitsgemeinschaft Reproduktionsbiologie des Menschen (AGRBM) Bundesverband Reproduktionsmedizinischer Zentren Deutschlands (BRZ) Dachverband Reproduktionsbiologie und -medizin (DVR) Deutsche Gesellschaft für Andrologie (DGA) Deutsche Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin (DGGEF) Deutsche Gesellschaft für Reproduktionsmedizin (DGRM) Deutsches IVF-Register (D I R) Embryologenforum Austria (EFA) Österreichische Gesellschaft für Reproduktionsmedizin und Endokrinologie (OEGRM) Sektion Reproduktionsbiologie und -medizin der DeutschenGesellschaft für Endokrinologie (SRBM/DGE) Chief Editor: Prof. Dr. med. Hermann M. Behre Zentrum für Reproduktionsmedizin und Andrologie Universitätsklinikum Halle Martin-Luther-Universität Halle-Wittenberg Ernst-Grube-Str. 40, D Halle, Germany phone +49/345/ , fax +49/345/ hermann.behre@medizin.uni-halle.de Publisher s Office: Krause & Pachernegg GmbH Verlag für Medizin und Wirtschaft Mozartgasse 10, A-3003 Gablitz, Austria phone +43/2231/61 258, fax +43/2231/ Layout: a.umi design etc. Soo-Hee Kim Printers: Druckerei Bunter Hund Berlin Saarbrücker Straße 24C Deutsche Post: Vertriebskennzeichen Y Place of Publication: A-3003 Gablitz, Austria Policy: The Journal of Reproductive Medicine and Endocrinology welcomes submission of clinically and research oriented reviews in the fields of andrology, embryology, molecular biology, endocrinology, ethics and law, genetics, gynaecology, contraception, psychosomatic medicine, urology etc. Copyright: All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanic, including photocopy, recording, or any information storage and retrieval system, without written permission from Krause & Pachernegg GmbH Krause & Pachernegg GmbH Authors, editors and publisher do not accept responsibility for any loss or damage arising from actions or decisions based on information contained in this publication: ultimate responsibility for the treatment of patients and interpretation of published material lies with the medical practitioner. Statements and opinions expressed in articles herein are those of the authors and not necessarily those of the editors or publisher. Great care is devoted to the compilation of the articles. Even so, however, errors in data processing cannot always be avoided. In view of this and because developments in medical science advance very quickly, it is recommended that the reader conducts his own independent inquiries and/or research as regards the stated diagnostic methods, measurements of medication dosis etc. The editors and publisher disclaim any responsibility or liability for the correctness of such material and do not guarantee, warrant or endorse any product or service advertised in this publication nor do they guarantee any claim made by the manufacturer of such product or service. Ethical Approval: All original research involving human subjects must be accompanied by evidence of prior ethics committee approval. Authors must supply evidence of informed consent of research participants (patients). The use of general descriptive names, trade names, trademarks etc. in this publication even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. J Reproduktionsmed Endokrinol 2013; 10 (Special Issue 2) 45

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