Graduate School of Chemistry and Biochemistry. 5 th April 2005

Größe: px
Ab Seite anzeigen:

Download "Graduate School of Chemistry and Biochemistry. 5 th April 2005"

Transkript

1 Universität Bielefeld Graduate School of Chemistry and Biochemistry 7 th Workshop University of Bielefeld aculty of Chemistry 5 th April 2005 Programme The workshop will begin on Tuesday, April 5 th at 09:00 h. All lectures will take place in lecture hall H2. The evening dinner will be at Internationales Begegnungszentrum (IBZ). University of Bielefeld: Directions: Organization: Prof. Dr. Thomas Koop, University of Bielefeld, aculty of Chemistry, Universitätsstr. 25, D Bielefeld Tel.: We look forward to meeting you. inancial support by the Westfälisch-Lippische Universitätsgesellschaft is gratefully acknowledged.

2 Directions: Campus Map: IBZ Lecture Hall H2 Tram Station

3 7 th Workshop Lectures Session I 09:00 09:05 Prof. Dr. Thomas Koop Welcome and Opening Remarks Chairperson: Thomas Koop 09:05 10:00 Prof. Dr. Rolf W. Saalfrank riedrich-alexander-universität Erlangen-ürnberg Metalla-topomers of supramolecular host-guest compounds Main Lecture M1 10:00 10:20 Soumyajit Roy, AC I L2 Giant polyoxomolybdates: Syntheses, structure and stability studies 10:20 10:40 Janine eldmann, PC I L3 Charakterisierung von durch CVD hergestellten Zn x Co 3-x O 4 -Schichten 10:40 11:10 Coffee Break Session II Chairperson: Soumyajit Roy 11:10 11:30 ina Stemmer, BC II und Universität Hamburg L4 Amyloid precursor protein processing and binding partners 11:30 11:50 Imme Domke, AC II L5 Electrochemical Investigations of Various Diazaborole Systems 11:50 12:10 Stefan Eißler, OC III L6 Synthese von epi-d-ent-cryptophycin-52 12:10 12:30 Sonja Krahn, DC I L7 Untersuchung zum intuitiven naturwissenschaftlichen Wissen 2-6Jähriger 12:30 12:50 Daniel oveski, AC III L8 C--Aktivierung und Derivatisierung fluorierter Olefine und Pyridine am Rhodium 12:50 14:15 Lunch Break

4 7 th Workshop Lectures Session III 14:15 15:10 Dr. Rolf Postina Johannes Gutenberg-Universität Mainz Chairperson: Simon Mügge Main Lecture M9 The α-secretase ADAM10, a promising target in the treatment of Alzheimer disease: Identification and functional characterization 15:10 15:30 Henning Sielemann, AC III L10 Methyl- or Ethyl- makes the difference: Solid-state structures of 9,10-Dialkyl-9,10-dihydro-9,10-digallaanthracens 15:30 15:50 Thomas Haase, PC I L11 Investigations in Chemical Vapor Deposition Systems of Silver 15:50 16:10 Philipp Bayer, AC II L12 Invers-polarisierte Arsaalkene als Quelle hochreaktiver Arsinidene 16:10 16:40 Coffee Break Session IV 16:40 17:35 Doz. Dr. Régis Réau CRS-Université de Rennes Chairperson: Patrice okou Main Lecture M13 Organophosphorus π-conjugated systems: rom model molecules to functional materials 17:35 17:55 Sven Weigelt, OC III L14 Synthesis of Efrapeptin Analogues for Conformational Studies 17:55 18:15 Jens Krümberg, AC II L15 Kupferkomplexe von invers polarisierten Phosphaalkenen 18:45 Dinner at Internationales Begegnungszentrum (IBZ)

5 Metalla-topomers of supramolecular host-guest compounds R. W. Saalfrank, I. Bernt, B. Demleitner, H. Glaser, S. Kareth, J. Köhler, V. Seitz and E. Uller Institut für Organische Chemie der Universität Erlangen ürnberg, Henkestraße 42, D Erlangen; AX: M1 The impact of the discovery of crown ethers (mono-, bi-, tricyclic) on the development of different disciplines in chemistry is manifold. Main feature of some of these compounds is that they show properties of biomolecules. We developed a general method for the synthesis of the corresponding metalla-topomers 1-6, using programmed precursors. [1] The products are formed via spontaneous self assembly in a one pot reaction in high yield. Preliminary results of the electronic and magnetic properties of 1-6 are presented. [1] R. W. Saalfrank, A. Stark, K. Peters, H. G. von Schnering, Angew. Chem. Int. Ed. Engl. 1988, 27, 851; R. W. Saalfrank, A. Stark, M. Bremer, H.-U. Hummel, Angew. Chem. Int. Ed. Engl. 1990, 29, 311; R. W. Saalfrank, R. Burak, A. Breit, D. Stalke, R. Herbst-Irmer, J. Daub, M. Porsch, E. Bill, M. Müther, A. X. Trautwein, Angew. Chem. Int. Ed. Engl. 1994, 33, 1621; R. W. Saalfrank, R. Burak, S. Reihs,. Löw,. Hampel, H.-D. Stachel, J. Lentmaier, K. Peters, E.-M. Peters, H. G. von Schnering, Angew. Chem. Int. Ed. Engl. 1995, 34, or recent reviews see: S. Leininger, B. Olenyuk, P. J. Stang, Chem. Rev. 2000, 100, 853; J. L. Atwood, L. R. MacGillivray, Angew. Chem. Int. Ed. Engl. 1999, 38, 1018; D. L. Caulder, K.. Raymond, J. Chem. Soc. Dalton Trans, 1999, 1185; Ligand and Metal Control of Self-Assembly in Supramolecular Chemistry, R. W. Saalfrank, B. Demleitner, in Perspectives in Supramolecular Chemistry, Vol. 5 Transition Metals in Supramolecular Chemistry (Ed.: J. P. Sauvage), Wiley-VCH, Weinheim, 1999, pp. 1; Synergistic Effect of Serendipity and Rational Design in Supramolecular Chemistry, E. Uller, B. Demleitner, I. Bernt, R. W. Saalfrank, in Structure and Bonding Vol. 96 (Ed.: M. ujita), Springer, Berlin, 2000, pp. 149.

6 Giant polyoxomolybdates: Syntheses, structure and stability studies L2 Achim Müller*, Soumyajit Roy, Hartmut Bögge, Alice Merca and Marc Schmidtmann Department of Inorganic Chemistry I, University of Bielefeld, D-33615, Bielefeld, Germany. * In this presentation the story of investigation of one of the existing ring-shaped polyoxomolybdates [1] that led to the formation of extended structures [2] and alluded to their potential host-functionalities [3] will be discussed. The structure of water inside the related spherical capsules; [4] the stability of some selected spherical polyoxomolybdates in aqueous solution together with the sites vulnerable to 'attack' by degrading agents and hence responsible for their decomposition will be further proposed (see also igure 1). The presentation will conclude with a perspective for some open questions regarding the generation of these giant polyoxomolybdates from an ionic soup. [5] igure 1. An O 372 framework of an [Mo 132 ] cluster type. The [Mo 132 ] type spherical clusters' decomposition is detected by the change in their Raman spectra induced by the change of the normal coordinates of O 372 framework shown here. [1] A. Müller, S. Roy, Coord. Chem. Rev., 2003, 245, 153. [2] A. Müller, S. Roy, M. Schmidtmann, H. Bögge, Chem. Commun., 2002, [3] a) A. Müller, E. Krickemeyer, H. Bögge, M. Schmidtmann, S. Roy, A. Berkle, Angew. Chem. Int. Ed. 2002, 41, 3604; b) A. Müller, S. K. Das, S. Talismanov, S. Roy, E. Beckmann, H. Bögge, M. Schmidtmann, A. Merca, A. Berkle, L. Allouche, Y. Zhou and L. Zhang, Angew. Chem. Int. Ed. 2003, 42, [4] A. Müller, H. Bögge, E. Diemann, Inorg. Chem. Commun., 2003, 6, 52. [5] A. Müller, S. Roy, Angew. Chem. Int. Ed. (Review to be submitted).

7 Charakterisierung von durch CVD hergestellten Zn x Co 3-x O 4 -Schichten Janine eldmann, aoufal Bahlawane, Katharina Kohse-Höinghaus Universität Bielefeld, Universitätsstr. 25, Bielefeld, Deutschland L3 Mischoxide sind für den Einsatz als katalytische Materialien bei der Totaloxidation von Kohlenwasserstoffen von besonderem Interesse. Sie eignen sich potenziell zum Ersatz üblicher Edelmetallkatalysatoren, weshalb Mischoxidschichten, speziell mit Spinellstruktur, schon eingehend untersucht wurden. Über die katalytische Wirksamkeit von mittels CVD abgeschiedenen Co 3 O 4 -Schichten wurde bereits berichtet [1]. Aus der Literatur [2] geht hervor, dass die katalytische Wirksamkeit von Co 3 O 4 -Schichten bei Pulverbeschichtungen durch die Dotierung mit Zink zu ZnCo 2 O 4 erhöht werden konnte. Deshalb wurden nun dünne Zn x Co 3-x O 4 -ilme aus Co(acac) 2 und Zn(acac) 2 abgeschieden, um den Einfluss von Zink im Gitter besser zu verstehen. Zunächst wurden die Abscheidungsparameter kontrolliert variiert und die abgeschiedenen ilme anhand von XRD, EDX und Raman-Spektroskopie charakterisiert. Dabei zeigte sich, dass Precursortemperatur, Druck und Verweilzeit in diesem CVD-Prozess entscheidend sind, während die Abscheidungstemperatur keinen Einfluss auf die ilmzusammensetzung und die ilmstruktur hatte. Der Anteil an eingelagertem Zink konnte bis zu einem Wert von x = 2 variiert werden, ohne die Spinellstruktur zu verlieren. Auch die Mikrospannung und die Kristallitgröße wurden hierbei nicht signifikant verändert. Die Redox-Eigenschaften der abgeschiedenen ilme wurden mit Hilfe von H 2 -TPR (temperature programmed reduction), und die katalytische Aktivität der Schichten anhand einer katalysierten Verbrennung von Propan untersucht. [1]. Bahlawane, E. ischer Rivera, K. Kohse-Höinghaus, A. Brechling, U. Kleineberg, Appl. Catal. B: Environmental, 53 (2004), [2] G. I. Golodets, Heterogenous Catalytic Reactions Involving Molecular Oxygen, Elsevier Verlag, Amsterdam- Oxford-ew York (1983), S. 441ff.

8 Amyloid precursor protein processing and binding partners ina Stemmer Universität Hamburg, Zentrum für Molekulare eurobiologie, Institut für Biosynthese neuraler Strukturen, alkenried 94, Hamburg L4 Alzheimer s Disease (AD) is a neurodegenerative disorder characterized by the progressive and irreversible loss of neurons. Amyloid precursor protein (APP) is a type I transmembrane protein, which is cleaved by secretases. One of these secretase pathways leads to Ab production and can therefore cause plaque formation, one hallmark of AD. To inhibit this special cleavage, that leads to increased Ab amounts, it is necessary to identifiy molecules binding to the cleavage sites. ollowing the theory of complementary hydropathy we try to find possible new binding partners to the gamma-cleavage site of APP, evaluate the interaction by binding assays and characterize the binding.

9 Electrochemical Investigations of Various Diazaborole Systems Imme Domke Inorganic Chemistry II, University of Bielefeld L5 The reactivity of 1,3,2-diazaboroles towards a broad range of nucleophiles is investigated carefully and described detailed in the literature. [1] Equally the behaviour of these compounds with chemical reductiants was of interest to achieve an diazaborolide anion, which has never been observed as yet. [1] ow, the electrochemistry of 1,3,2-diazaboroles and the corresponding saturated diazaborolidines has been investigated to shed some light into the redox behaviour of such heterocycles. In addition to that, a number of diborole systems are synthesized. B e B B B This spacer molecules are studied electrochemically to get some impression on the communication between the two diazaborole-units. [1] Review: l: Weber, Coord. Chem. Rev. 2001, 215,

10 ovel routes towards the synthesis of cryptophycin analogs S. Eißler, A. Stoncius, C. A. Mast,. Sewald University of Bielefeld, Department of Chemistry; Universitaetsstr. 25, Bielefeld, Germany L6 The cryptophycins (isolated from cyanobacteria ostoc sp.) form a group of tumour-selective cytotoxic cyclic depsipeptides. The enormous activity of cryptophycin 1 against a series of multidrug resistant tumors [1] raised the significant interest in the synthesis of cryptophycins and their analogs over the past decade [2]. We have applied a new convergent synthetic approach towards the total synthesis of cryptophycin analogs. The chirality elements of epoxide fragment A were introduced relying on a single enantioselective catalytic reaction. The other chiral centres are created in a substrate controlled diastereoselective manner [3]. In my work I synthesised the enatiomer of unit A using the unit A synthesis developed by A. Stoncius and C. A. Mast and used it for the synthesis of epi-d-ent-cryptophycin-52: unit D O O O O O unit A unit C H H O O unit B Cl OMe [1] a) Shih C., Teicher B. A., Curr. Pharm. Des., 2001, 7, , b) Wagner M. M., Paul D. C., Shih C., Jordan M. A., Wilson L., Williams D. C., Cancer Chemother. Pharmacol., 1999, 43, [2] Tius M. A., Tetrahedron, 2002, 58, [3] Stoncius A., Mast C. A., Sewald., Tetrahedron: Asymmetry, 2000, 11,

11 Untersuchung zum intuitiven naturwissenschaftlichen Wissen 2-6Jähriger Sonja Krahn, Gisela Lück Universität Bielefeld, akultät für Chemie - Didaktik der Chemie I Postfach , Bielefeld L7 Kinder im Alter von 5-6 Jahren zeigen laut bisheriger Untersuchungen ein großes Interesse an Versuchen zur Physik/Chemie ihre hohe Erinnerungsfähigkeit an die Experimente und deren Deutung zeigt, dass die theoretischen Hintergründe auf einfachem iveau erfasst werden (Lück 2000). Unbestritten ist auch, dass schon sehr junge Kinder (im Alter von wenigen Monaten) über intuitives Wissen zu physikalischen Vorgängen und Eigenschaften verfügen (vgl. Spelke 1992). Studien zur intuitiven Psychologie und Biologie wurden in den letzten 20 Jahren überwiegend mit Kindern ab dem Vorschulalter durchgeführt (z. B. Inagaki & Hatano 1996). Dagegen liegen bislang kaum Untersuchungen zu Wissen über chemische Phänomene, insbesondere dieser Altersgruppe vor. Es gibt zwar Untersuchungen zum Verständnis von Zustandsänderungen und Lösungen (z. B. Osborne & Cosgrove 1983, Slone & Bockhurst 1992), aber diese und andere Untersuchungen berücksichtigen im Wesentlichen erst Kinder ab 5 Jahren. Da bei älteren Kindern die formale Instruktion eine Quelle für die Ausprägung von so genannten misconceptions sein kann, haben wir Untersuchungen mit jüngeren Kindern durchgeführt, um Erfahrungen zu den Anfängen des intuitiven Wissens über chemische Phänomenen zu sammeln. Dazu wurde eine Studie auf der Basis problemzentrierter Interviews mit über 100 Kindern im Alter von 2-7 Jahren durchgeführt. Auch entwicklungsverzögerte Kinder wurden mit einbezogen. Es wurde evaluiert ob und ab welchem Alter Kinder in der Lage sind, warmes von kaltem Wasser durch bloße Wahrnehmung der Wasserdampfbildung zu unterscheiden. Zusätzlich wurde die Einschätzung verschiedener Materialien hinsichtlich ihrer Saugfähigkeit untersucht. Im Vortrag soll die Studie von ihren Anfängen bis zu den Ergebnissen vorgestellt, Perspektiven für weitere Arbeiten aufgezeigt und Konsequenzen für die chemiedidaktische Praxis dargestellt werden. Inagaki, K.; Hatano, G. (1996): Young childrens Recognition of commonalities between animals and plants. In: Child development 67, pp Lück, G. (2000): aturwissenschaften im frühen Kindesalter Untersuchung zur Primärbegegnung von Kindern im Vorschulalter mit Phänomenen der unbelebten atur. aturwissenschaften und Technik Didaktik im Gespräch (33), LIT Verlag, Münster Slone, M.; Bockhurst,.D. (1992): Children s understanding of sugar water solutions. In: International journal of science education 14 (2), pp Spelke, E. S.; Breinlinger, K.; Macomber, J.; Jacobson, K. (1992): Origins of knowledge. In: Psychological Review 99 (4), pp Osborne, R. J. and Cosgrove, M.M (1983): Children s concepts of the changes of state of water. In: Journal of research in science teaching 20 (9), pp

12 C--Aktivierung und Derivatisierung fluorierter Olefine und Pyridine am Rhodium Thomas Braun, Daniel oveski Universität Bielefeld L8 Eine interessante Möglichkeit zur Derivatisierung perfluorierter Verbindungen besteht in deren C-- Aktivierung und einer anschließenden unktionalisierung der gebildeten fluorierten Liganden in der Koordinationssphäre eines Übergangsmetalls. [1,2] Wir konnten zeigen, dass sich Hexafluorpropen und Pentafluorpyridin mit Hilfe von Rhodiumhydrido-Komplexen aktivieren lassen. [3,4] Die Reaktivität der erhaltenen Verbindungen [Rh{C=C(C 3 )}(PEt 3 ) 3 ] und [Rh(4-C 5 4 )(PEt 3 ) 3 ] wird maßgeblich durch den fluorierten anionischen Liganden bestimmt. So reagiert der erhaltene Pyridyl-Komplex [Rh(4-C 5 4 )(PEt 3 ) 3 ] u. a. mit CO und anschließend mit MeI zu einer außergewöhnlich stabilen Acyl-Verbindung, welche sich mit weiterem CO zu einem bisher nicht zugänglichen Keton umsetzen lässt (s. Schema). [3,4] Die Umsetzung des Propen-Derivates [Rh{C=C(C 3 )}(PEt 3 ) 3 ] mit H 2 führt über einen Dihydrido-Komplex als Zwischenstufe zur Bildung von 1,1,1-Trifluorpropan und der Rhodiumfluoro-Verbindung [Rh(PEt 3 ) 3 ] (s. Schema). [3,5] H 3 C O Et 3 P Rh PEt 3 PEt 3 a) CO, -PEt 3 b) CH 3 I Et 3 P Rh PEt 3 H 3 C O I T, CO + [RhI(CO)(PEt 3 ) 2 ] Et 3 P C 3 Rh PEt 3 PEt 3 H 2 Et 3 P H Rh H C 3 PEt 3 PEt 3 2 H2 - H CH 3 CH 2 C 3 + [Rh(PEt 3 ) 3 ] [1] M. I. Sladek, T. Braun, B. eumann, H.-G. Stammler, J. Chem. Soc., Dalton Trans. 2002, 297. [2] T. Braun, R.. Perutz, Chem. Commun. 2002, [3] T. Braun, D. oveski, B. eumann, H.-G. Stammler, Angew. Chem. 2002, 15, 2870; D. oveski, T. Braun, M. Schulte, B. eumann, H.-G. Stammler, Dalton Trans. 2003, [4] D. oveski, T. Braun, B. eumann, A. Stammler, H.-G. Stammler, Dalton Trans. 2004, [5] D. oveski, T. Braun, S. Krückemeier, J. luorine Chem., 2004, 125, 959.

13 The α-secretase ADAM10, a promissing target in the treatment of Alzheimer disease: Identification and functional characterization Rolf Postina Institut für Biochemie, Johannes Gutenberg-Universität Mainz M9 Aβ peptides (Aβ) play an early and central role in Alzheimer disease (AD), the most prevalent neurodegenerative disorder. These peptides are generated in the so-called amyloidogenic pathway by sequencial proteolysis of the amyloid precursor protein (APP), an ubiquitous cell surface type I membrane protein, by β- and γ-secretases. However, the vast majority of APP is constitutively processed within the competing non-amyloidogenic pathway by α- and γ-secretase activities. Here, the α-secretase releases a soluble -terminal APP fragment (APPsα) into the extracellular matrix, which has neurotrophic and neuroprotective properties. In addition, as the α-secretase precludes formation of pathogenic Aβ peptides, this enzymatic activity may represent a protective factor against AD. The molecular origin of the α-secretase activity was elucidated by a biochemical approach (Lammich et al., 1999). Purified ADAM10 (A Disintegrin And Metalloproteinase) was identified to cleave APP-derived peptides at the main α-secretase cleavage site between position 16 and 17 of the Aβ region. urthermore, we demonstrated that ADAM10 possesses α-secretase activity in cultured cells. During our cellular studies on ADAM10 we showed that ADAM10 is synthesized as a catalytically inactive zymogen, and that the proprotein convertases PC7 and furin act as ADAM10 activators by proteolytically removing of the inhibiting ADAM10 prodomain. Moreover, we demonstrated that the ADAM10 prodomain is of essential importance for functional expression of catalytically active ADAM10 (Anders et al., 2001). To prove whether ADAM10 possesses α-secretase activity in vivo, we generated and investigated transgenic mice overexpressing either ADAM10 or the catalytically inactive ADAM10 mutant E384A. Even a moderate neuronal overexpression of ADAM10 in mice transgenic for human APP[V717I] increased the production of secreted neurotrophic APPsα, reduced the formation of Aβ peptides and prevented their deposition in plaques. unctionally, impaired long-term potentiation and cognitive deficits were alleviated. Expression of mutant catalytically inactive ADAM10 led to an enhancement of the number and size of amyloid plaques in the brains of double-transgenic mice. Our results provided the first in vivo evidence for a proteinase of the ADAM family as an α-secretase of APP, thus supporting the hypothesis that a decrease in α-secretase activity contributes to the development of AD (Postina et al., 2004). Our current studies aim to identify cellular pathways leading to an induction of ADAM10 expression and activity. Anders A., Gilbert S., Garten W., Postina R. & ahrenholz. (2001) Regulation of the α-secretase ADAM10 by its prodomain and proprotein convertases. ASEB J. 15: Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., Haass C. & ahrenholz. (1999) Constitutive and regulated α-secretase cleavage of Alzheimer s amyloid precursor protein by a disintegrin metalloprotease. Proc. atl. Acad. Sci. USA 96: Postina R., Schroeder A., Dewachter I., Bohl J., Schmitt U., Kojro E., Prinzen C., Endres K., Hiemke C., Blessing M., lamez P., Dequenne A., Godaux E., van Leuven. & ahrenholz. (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J. Clin. Invest. 113:

14 Methyl- or Ethyl- makes the difference: Solid-state structures of 9,10-Dialkyl-9,10-dihydro-9,10-digallaanthracenss Henning Sielemann Inorganic Chmeistry III, University of Bielefeld L10 The donor-free 9,10-dialkyl-9,10-dihydro-9,10-digallaanthracenes 1(alkyl: methyl) and 2 (alkyl: ethyl) were prepared by reaction of 1,2-di(chloromercurio)benzene with the corresponding trialkylgallium and isolated as colourless air- and moisture sensitive crystalline compounds. In the solid-state structure of 1 two slightly different monomers 1A and 1B are found, which form a dimer 1A 1B hold together by "medium" strong gallium arene π-interactions. urther weak π-interactions between 1A and 1A and 1B and 1B constitute a one-dimensional coordination polymer containing strands of the composition [ (1A 1B) (1B 1A) ] n. In contrast, compound 2 crystallizes in form of distinct molecular units without any further intermolecular π-interactions. The molecular units possess D 2d symmetry and are built by strong π-interactions between two digallaanthracene monomers. Two symmetrical aryl group bridges between two gallium atoms are observed for the first time in the subunits of 2. By addition of a Lewis-base (TH, Pyridine) to 2 a monomeric planar digallaanthracene framework is restored, as proven by an X-ray crystal structure analysis of 2 2 Py. The different structures of 1 and 2 are explained on the basis of steric effects.

15 Investigations in Chemical Vapor Deposition Systems of Silver Thomas Haase Physikalische Chemie 1, Universität Bielefeld, Universitätsstr. 25, Bielefeld L11 Silver is a promising candidate for the replacement of copper and aluminium as interconnect material because of its thermal and electrical properties. Chemical vapor deposition is a very good method to produce thin films and layers, however only few investigations have been reported regarding thin silver films. Suitable strategies require knowledge about the interplay of gas phase chemistry and surface chemistry. In this work, the gas phase of several newly synthesised silver(i) complexes has been analysed by temperature-programmed and in-situ mass spectrometry regarding on their volatility and thermal stability. The most promising precursors have been chosen for deposition experiments in a cold-wall reactor. Smooth and conductive silver films can be grown on glass substrates.

16 Invers-polarisierte Arsaalkene als Quelle hochreaktiver Arsinidene Philipp Bayer, Lothar Weber Anorganische Chemie II, akultät für Chemie L12 Aufgrund der geschwächten As=C-Doppelbindung in invers-polarisierten Arsaalkenen können diese Verbindungen leicht den Arsinidenbaustein R-As auf geeignete Moleküle übertragen. Phosphavinylidenkomplexe sind solche geeigneten Moleküle, da das Phosphoratom positiv polarisiert ist und somit der Addition des negativ-polarisierten Arsenatoms offen steht. Je nach Art des Substituenten am Arsenatom ergeben sich vielfältige Reaktionsprodukte, bei denen jedoch stets ein oder mehrere Arsinidenbausteine auf den Vinylidenkomplex übertragen werden. Als Beispiel einer solchen Reaktion sei die Umsetzung des errioarsaalkens 2 mit den Phosphavinylidenkomplexen 1a,b genannt [1]: OC M CO M= Mo: 1a M= W: 1b P C SiMe 3 SiMe 3 + OC e CO 2 As C Me 2 Me 2 OC M CO C P As e CO CO SiMe 3 SiMe3 3a,b [1] L. Weber, P. Bayer, H.-G. Stammler, B. eumann, Chem. Commun. 2005, 1595.

17 Organophosphorus π-conjugated systems: rom model molecules to functional materials Régis Réau Institut de Chimie de Rennes, UMR 6509, CRS-Université Rennes 1, rance M13 π-conjugated systems have attracted huge interest owing to their potential applications in electronic devices (e.g. light-emitting diodes, nonlinear optical materials ). Exploiting the unique properties of phospholes (low aromatic character, σ,π-conjugation), 1 we have developed a new family of π- conjugated oligomers and polymers 1 possessing low optical band gap. 2 The P-atom of phospholes exhibits a versatile reactivity allowing direct access to a range of new π-conjugated systems. These chemical modifications of the P-atom offer a way to diversify their electronic properties and are key issues for optoelectronic applications of phosphole-based materials (organophosphorus-containing OLED materials 3 and LO-phores 2 4 ). Lastly, chemistry of derivatives 3 exhibiting unusual σ- π conjugation will be described S P Bu 2 P S P Pd S S n P P S Bu S 3 1) M. HISSLER, P. W. DYER, R. REAU, COORD. CHEM. REV., 2003, 244, 1; 2) C. HAY, C. AVE, M. HISSLER, J. RAULT-BERTHELOT, R. RÉAU ORG. LETT., 2003, 19, 3467; 3) C. AVE, T-Y. CHO, M. HISSLER, C-W. CHE, T-Y. LUH, C.-C. WU, R. RÉAU J. AM. CHEM. SOC., 2003, 125, 9254; 4) C. AVE, M. HISSLER, K. SEECHAL, I. LEDOUX, J. ZYSS, R. REAU CHEM. COMMU, 2002, 1674; 5) C. AVE, M. HISSLER, T. KARPATI, J. RAULT- BERTHELOT, V. DEBORDE, L. TOUPET, L. YULASZI, R. REAU J. AM. CHEM. SOC., 2004, 136, 6058.

18 Synthesis of Efrapeptin Analogues for Conformational Studies Sven Weigelt and orbert Sewald Department of Chemistry, Bielefeld University, Bielefeld, Germany L14 The efrapeptins are a class of sequence-homologous peptide antibiotics (efrapeptins C-G) that are produced by the fungus Tolypocladium niveum. [1] They are inhibitors of 1 -ATPase, [2] show insecticidal and antiproliferative properties [3] and are active also against the malaria pathogen Plasmodium falciparum. [2] The efrapeptins are rich in α,α-dialkylated amino acids like Aib and contain an unusual cationic head group derived from leucinol at the C-terminus, while the - terminus is acetylated. Ac-Pip-Aib-Pip-Aib-Aib-Leu-β-Ala-Gly-Aib-Aib-Pip-Aib-Gly-Leu-Aib H ig. 1. Efrapeptin C Efrapeptin C was synthesized chemically for the first time by applying a convenient method for the introduction of Aib residues. The incorporation of the Aib residues succeeds smoothly using the highly reactive α-azido isobutyryl chloride followed by reduction of the resulting azido peptidyl resin to the amino peptidyl resin. The full sequence was assembled by a combination of solutionphase and solid-phase peptide synthesis steps with segment condensations. [4] The approach allows for the synthesis of a series of analogues required for biological and conformational studies. [5] ot only the synthesis of efrapeptins, but also the three-dimensional structure of these Aib-rich peptides is of importance for structure-activity relationship studies. Information about intramolecular interactions and distances between amino acid side chains is provided by modern MR methods. However, insufficient OE data may be obtained in the case of Aib-rich peptides. or structure determination in solution, OE experiments providing information about the distances e.g. between Aib methyl groups, are of particular importance. However, problems often occur in assigning the methyl group signals of the Aib residues in Aib-rich peptides. Aib residues, which are 2 H-labelled at the methyl groups may be introduced into peptides at welldefined positions in the amino acid sequence to get more concise MR-spectra. 2 H-labelled α- azidoisobutyryl chloride is conveniently synthesized in a six step procedure starting from acetone cyanohydrin-d 6 and can be used as D 6 -Aib equivalent. The degree of deuteration can be calculated to exceed 90% according to MR and MS data. [6] [1] a) S. Gupta, S. B. Krasnoff, D. W. Roberts, J. A. A. Renwick, L. S. Brinen, J. Clardy, J. Am. Chem. Soc. 1991, 113, ; b) S. Gupta, S. B. Krasnoff, D. W. Roberts, J. A. A. Renwick, L. S. Brinen, J. Clardy, J. Org. Chem. 1992, 57, [2] G. agaraj, M. V. Uma, M. S. Shivayogi, H. Balaram, Antimicrob. Agents Chemother. 2001, 45, [3] A. E. Papathanassiu (Ergon Pharmaceuticals LLC), U. S. Patent 2003, [4] M. Jost, J.-C. Greie,. Stemmer, S. D. Wilking, K. Altendorf,. Sewald, Angew. Chem. 2002, 114, ; Angew. Chem. Int. Ed. Engl. 2002, 41, [5] M. Jost, Synthese von Efrapeptin C und Efrapeptin-Analoga, Dissertation, Bielefeld University, Bielefeld [6] S. Weigelt,. Sewald, Synlett 2004, 4,

19 Kupferkomplexe von invers polarisierten Phosphaalkenen Jens Krümberg AK Prof. Dr. L. Weber Universität Bielefeld, Universitätsstr.25, D Bielefeld L15 Die Überbrückung von späten Übergangsmetallen durch Phosphanid-Ionen ist literaturbekannt. Die Umsetzung von Trimethylsilyldialkyl- oder -diarylphosphanen mit Kupfer(I)halogeniden führt häufig zu Metallclustern, deren zentrales Motiv ein Ring aus alternierenden Phosphor- und Kupferatomen ist. Von invers polarisierten Phosphaalkenen lassen sich ebenfalls zum Phosphanid isoelektronische Grenzstrukturen formulieren (B und C). R Me 2 P Me 2 + R Me 2 - P Me 2 R Me 2 - P Me + 2 A B C Es sollte also möglich sein, mit invers polarisierten Phosphaalkenen mehrere Metallzentren zu überbrücken. Bei der Reaktion von -P=C(Me 2 ) 2 mit Kupfer(I)chlorid bildet sich ein sechsgliedriger Ring aus drei Kupfer- und drei Phosphoratomen mit der ormel [(-P=C(Me 2 ) 2 )Cu] 3 Cl 3 1 wobei die Phosphanideinheit des Phosphaalkens jeweils zwei Kupferatome überspannt [1]. Cl (Me 2 ) 2 C Cu P P Cu Cl C(Me 2 ) 2 Cl Cu P C(Me 2 ) 2 1 Bei der Umsetzung von Me 3 Si-P=C(Me 2 ) 2 mit Kupfer(I)chlorid gelangt man zu einem roten unlöslichen eststoff, der die Zusammensetzung [(P=C(Me 2 ) 2 )Cu 2 Cl 2 ] n hat. Auch hier kann man eine Phosphorverbrückung von Kupferzentren vermuten. [1] L. Weber, J. Krümberg, H.-G. Stammler, B. eumann, Z. Anorg. Allg. Chem. 2004, 630, 2478.

Algorithms for graph visualization

Algorithms for graph visualization Algorithms for graph visualization Project - Orthogonal Grid Layout with Small Area W INTER SEMESTER 2013/2014 Martin No llenburg KIT Universita t des Landes Baden-Wu rttemberg und nationales Forschungszentrum

Mehr

Exercise (Part XI) Anastasia Mochalova, Lehrstuhl für ABWL und Wirtschaftsinformatik, Kath. Universität Eichstätt-Ingolstadt 1

Exercise (Part XI) Anastasia Mochalova, Lehrstuhl für ABWL und Wirtschaftsinformatik, Kath. Universität Eichstätt-Ingolstadt 1 Exercise (Part XI) Notes: The exercise is based on Microsoft Dynamics CRM Online. For all screenshots: Copyright Microsoft Corporation. The sign ## is you personal number to be used in all exercises. All

Mehr

Accounting course program for master students. Institute of Accounting and Auditing http://www.wiwi.hu-berlin.de/rewe

Accounting course program for master students. Institute of Accounting and Auditing http://www.wiwi.hu-berlin.de/rewe Accounting course program for master students Institute of Accounting and Auditing http://www.wiwi.hu-berlin.de/rewe 2 Accounting requires institutional knowledge... 3...but it pays: Lehman Bros. Inc.,

Mehr

Group and Session Management for Collaborative Applications

Group and Session Management for Collaborative Applications Diss. ETH No. 12075 Group and Session Management for Collaborative Applications A dissertation submitted to the SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZÜRICH for the degree of Doctor of Technical Seiences

Mehr

Extended Ordered Paired Comparison Models An Application to the Data from Bundesliga Season 2013/14

Extended Ordered Paired Comparison Models An Application to the Data from Bundesliga Season 2013/14 Etended Ordered Paired Comparison Models An Application to the Data from Bundesliga Season 2013/14 Gerhard Tutz & Gunther Schauberger Ludwig-Maimilians-Universität München Akademiestraße 1, 80799 München

Mehr

Exercise (Part II) Anastasia Mochalova, Lehrstuhl für ABWL und Wirtschaftsinformatik, Kath. Universität Eichstätt-Ingolstadt 1

Exercise (Part II) Anastasia Mochalova, Lehrstuhl für ABWL und Wirtschaftsinformatik, Kath. Universität Eichstätt-Ingolstadt 1 Exercise (Part II) Notes: The exercise is based on Microsoft Dynamics CRM Online. For all screenshots: Copyright Microsoft Corporation. The sign ## is you personal number to be used in all exercises. All

Mehr

Cluster Health Care Economy has been established in 2008 Regional approach to develop health care industries Head of the cluster is Ms.

Cluster Health Care Economy has been established in 2008 Regional approach to develop health care industries Head of the cluster is Ms. How to develop health regions as driving forces for quality of life, growth and innovation? The experience of North Rhine-Westphalia Dr. rer. soc. Karin Scharfenorth WHO Collaborating Centre for Regional

Mehr

eurex rundschreiben 094/10

eurex rundschreiben 094/10 eurex rundschreiben 094/10 Datum: Frankfurt, 21. Mai 2010 Empfänger: Alle Handelsteilnehmer der Eurex Deutschland und Eurex Zürich sowie Vendoren Autorisiert von: Jürg Spillmann Weitere Informationen zur

Mehr

USBASIC SAFETY IN NUMBERS

USBASIC SAFETY IN NUMBERS USBASIC SAFETY IN NUMBERS #1.Current Normalisation Ropes Courses and Ropes Course Elements can conform to one or more of the following European Norms: -EN 362 Carabiner Norm -EN 795B Connector Norm -EN

Mehr

Field Librarianship in den USA

Field Librarianship in den USA Field Librarianship in den USA Bestandsaufnahme und Zukunftsperspektiven Vorschau subject librarians field librarians in den USA embedded librarians das amerikanische Hochschulwesen Zukunftsperspektiven

Mehr

Technical Thermodynamics

Technical Thermodynamics Technical Thermodynamics Chapter 1: Introduction, some nomenclature, table of contents Prof. Dr.-Ing. habil. Egon Hassel University of Rostock, Germany Faculty of Mechanical Engineering and Ship Building

Mehr

ReadMe zur Installation der BRICKware for Windows, Version 6.1.2. ReadMe on Installing BRICKware for Windows, Version 6.1.2

ReadMe zur Installation der BRICKware for Windows, Version 6.1.2. ReadMe on Installing BRICKware for Windows, Version 6.1.2 ReadMe zur Installation der BRICKware for Windows, Version 6.1.2 Seiten 2-4 ReadMe on Installing BRICKware for Windows, Version 6.1.2 Pages 5/6 BRICKware for Windows ReadMe 1 1 BRICKware for Windows, Version

Mehr

Role Play I: Ms Minor Role Card. Ms Minor, accountant at BIGBOSS Inc.

Role Play I: Ms Minor Role Card. Ms Minor, accountant at BIGBOSS Inc. Role Play I: Ms Minor Role Card Conversation between Ms Boss, CEO of BIGBOSS Inc. and Ms Minor, accountant at BIGBOSS Inc. Ms Boss: Guten Morgen, Frau Minor! Guten Morgen, Herr Boss! Frau Minor, bald steht

Mehr

Accreditation of Prior Learning in Austria

Accreditation of Prior Learning in Austria Accreditation of Prior Learning in Austria Birgit Lenger ibw Institut für Bildungsforschung der Wirtschaft Institute for Research on Qualifications and Training of the Austrian Economy October, 2009 TOPICS

Mehr

Prediction Market, 28th July 2012 Information and Instructions. Prognosemärkte Lehrstuhl für Betriebswirtschaftslehre insbes.

Prediction Market, 28th July 2012 Information and Instructions. Prognosemärkte Lehrstuhl für Betriebswirtschaftslehre insbes. Prediction Market, 28th July 2012 Information and Instructions S. 1 Welcome, and thanks for your participation Sensational prices are waiting for you 1000 Euro in amazon vouchers: The winner has the chance

Mehr

Customer-specific software for autonomous driving and driver assistance (ADAS)

Customer-specific software for autonomous driving and driver assistance (ADAS) This press release is approved for publication. Press Release Chemnitz, February 6 th, 2014 Customer-specific software for autonomous driving and driver assistance (ADAS) With the new product line Baselabs

Mehr

Ingenics Project Portal

Ingenics Project Portal Version: 00; Status: E Seite: 1/6 This document is drawn to show the functions of the project portal developed by Ingenics AG. To use the portal enter the following URL in your Browser: https://projectportal.ingenics.de

Mehr

An Introduction to Monetary Theory. Rudolf Peto

An Introduction to Monetary Theory. Rudolf Peto An Introduction to Monetary Theory Rudolf Peto 0 Copyright 2013 by Prof. Rudolf Peto, Bielefeld (Germany), www.peto-online.net 1 2 Preface This book is mainly a translation of the theoretical part of my

Mehr

CHAMPIONS Communication and Dissemination

CHAMPIONS Communication and Dissemination CHAMPIONS Communication and Dissemination Europa Programm Center Im Freistaat Thüringen In Trägerschaft des TIAW e. V. 1 CENTRAL EUROPE PROGRAMME CENTRAL EUROPE PROGRAMME -ist als größtes Aufbauprogramm

Mehr

ISO 15504 Reference Model

ISO 15504 Reference Model Prozess Dimension von SPICE/ISO 15504 Process flow Remarks Role Documents, data, tools input, output Start Define purpose and scope Define process overview Define process details Define roles no Define

Mehr

Evidence of strobilurine resistant isolates of A. solani and A. alternata in Germany

Evidence of strobilurine resistant isolates of A. solani and A. alternata in Germany Technische Universität München Evidence of strobilurine resistant isolates of A. solani and A. alternata in Germany H. Hausladen, B. Adolf and J. Leiminger outline introduction material and methods results

Mehr

Delivering services in a user-focussed way - The new DFN-CERT Portal -

Delivering services in a user-focussed way - The new DFN-CERT Portal - Delivering services in a user-focussed way - The new DFN-CERT Portal - 29th TF-CSIRT Meeting in Hamburg 25. January 2010 Marcus Pattloch (cert@dfn.de) How do we deal with the ever growing workload? 29th

Mehr

Introduction to the diploma and master seminar in FSS 2010. Prof. Dr. Armin Heinzl. Sven Scheibmayr

Introduction to the diploma and master seminar in FSS 2010. Prof. Dr. Armin Heinzl. Sven Scheibmayr Contemporary Aspects in Information Systems Introduction to the diploma and master seminar in FSS 2010 Chair of Business Administration and Information Systems Prof. Dr. Armin Heinzl Sven Scheibmayr Objective

Mehr

TMF projects on IT infrastructure for clinical research

TMF projects on IT infrastructure for clinical research Welcome! TMF projects on IT infrastructure for clinical research R. Speer Telematikplattform für Medizinische Forschungsnetze (TMF) e.v. Berlin Telematikplattform für Medizinische Forschungsnetze (TMF)

Mehr

Rhodium-Catalyzed Imine-Directed C-H Bond Activation. Biomimetic Synthesis of Sesquiterpenoids

Rhodium-Catalyzed Imine-Directed C-H Bond Activation. Biomimetic Synthesis of Sesquiterpenoids Diss. ETH No. 21735 Rhodium-Catalyzed Imine-Directed C-H Bond Activation And Biomimetic Synthesis of Sesquiterpenoids A dissertation submitted to ETH ZURICH For the degree of Doctor of Sciences Presented

Mehr

LIFE SCIENCES Forschung & Entwicklung

LIFE SCIENCES Forschung & Entwicklung LIFE SCIENCES Forschung & Entwicklung Vol. 9 RHOMBOS Bibliografische Information der Deutschen Nationalbibliothek Die Deutsche Nationalbibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie;

Mehr

Bayerisches Landesamt für Statistik und Datenverarbeitung Rechenzentrum Süd. z/os Requirements 95. z/os Guide in Lahnstein 13.

Bayerisches Landesamt für Statistik und Datenverarbeitung Rechenzentrum Süd. z/os Requirements 95. z/os Guide in Lahnstein 13. z/os Requirements 95. z/os Guide in Lahnstein 13. März 2009 0 1) LOGROTATE in z/os USS 2) KERBEROS (KRB5) in DFS/SMB 3) GSE Requirements System 1 Requirement Details Description Benefit Time Limit Impact

Mehr

1.9 Dynamic loading: τ ty : torsion yield stress (torsion) τ sy : shear yield stress (shear) In the last lectures only static loadings are considered

1.9 Dynamic loading: τ ty : torsion yield stress (torsion) τ sy : shear yield stress (shear) In the last lectures only static loadings are considered 1.9 Dynaic loading: In the last lectures only static loadings are considered A static loading is: or the load does not change the load change per tie N Unit is 10 /sec 2 Load case Ι: static load (case

Mehr

Extract of the Annotations used for Econ 5080 at the University of Utah, with study questions, akmk.pdf.

Extract of the Annotations used for Econ 5080 at the University of Utah, with study questions, akmk.pdf. 1 The zip archives available at http://www.econ.utah.edu/ ~ ehrbar/l2co.zip or http: //marx.econ.utah.edu/das-kapital/ec5080.zip compiled August 26, 2010 have the following content. (they differ in their

Mehr

PCIe, DDR4, VNAND Effizienz beginnt im Server

PCIe, DDR4, VNAND Effizienz beginnt im Server PCIe, DDR4, VNAND Effizienz beginnt im Server Future Thinking 2015 /, Director Marcom + SBD EMEA Legal Disclaimer This presentation is intended to provide information concerning computer and memory industries.

Mehr

oocroa OFNA1URALSCIENCES

oocroa OFNA1URALSCIENCES DISS. ETH NO.9966 CONTACTIN/Fll IS A NEURONAL RECEPTOR OF TENASCIN A DISSERTATION SUBMITTED TO THE SWISS FEDERAL INSTITUTE OF TECHNOLOGY FüR THE DEGREE OF oocroa OFNA1URALSCIENCES PRESEN1ED BY ANDREAS

Mehr

Immunregulatorische Funktionen von T-Lymphozyten

Immunregulatorische Funktionen von T-Lymphozyten Immunregulatorische Funktionen von T-Lymphozyten DISSERTATION zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Christian-Albrechts-Universität zu Kiel vorgelegt von

Mehr

1. General information... 2 2. Login... 2 3. Home... 3 4. Current applications... 3

1. General information... 2 2. Login... 2 3. Home... 3 4. Current applications... 3 User Manual for Marketing Authorisation and Lifecycle Management of Medicines Inhalt: User Manual for Marketing Authorisation and Lifecycle Management of Medicines... 1 1. General information... 2 2. Login...

Mehr

Employment and Salary Verification in the Internet (PA-PA-US)

Employment and Salary Verification in the Internet (PA-PA-US) Employment and Salary Verification in the Internet (PA-PA-US) HELP.PYUS Release 4.6C Employment and Salary Verification in the Internet (PA-PA-US SAP AG Copyright Copyright 2001 SAP AG. Alle Rechte vorbehalten.

Mehr

Controlling the Surface Properties of Nanoparticles Bioorganically modified Nanoparticles for Cell Signaling (NANOCYTES)

Controlling the Surface Properties of Nanoparticles Bioorganically modified Nanoparticles for Cell Signaling (NANOCYTES) Surfaces and Interfaces NANCYTES Engineering at the Nanoscale, DECHEMA, 9. März 2005 Controlling the Surface Properties of Nanoparticles Bioorganically modified Nanoparticles for Cell Signaling (NANCYTES)

Mehr

Labour law and Consumer protection principles usage in non-state pension system

Labour law and Consumer protection principles usage in non-state pension system Labour law and Consumer protection principles usage in non-state pension system by Prof. Dr. Heinz-Dietrich Steinmeyer General Remarks In private non state pensions systems usually three actors Employer

Mehr

Welche Rolle kann gemeinwohlorientierte Wissenschaft/Forschungspolitik für die Entwicklung und Umsetzung einer zukunftsfähigen Green Economy spielen?

Welche Rolle kann gemeinwohlorientierte Wissenschaft/Forschungspolitik für die Entwicklung und Umsetzung einer zukunftsfähigen Green Economy spielen? Welche Rolle kann gemeinwohlorientierte Wissenschaft/Forschungspolitik für die Entwicklung und Umsetzung einer zukunftsfähigen Green Economy spielen? - In welcher Verbindung stehen gemeinwohlorientierte

Mehr

SiC Processing nimmt Produktionslinien in China in Betrieb

SiC Processing nimmt Produktionslinien in China in Betrieb SiC Processing nimmt Produktionslinien in China in Betrieb Inbetriebnahme von Produktionslinie 4 am Standort Zhenjiang Darlehen von BoC in Höhe von RMB 130 Mio. ausbezahlt Inbetriebnahme von Produktionslinie

Mehr

Inequality Utilitarian and Capabilities Perspectives (and what they may imply for public health)

Inequality Utilitarian and Capabilities Perspectives (and what they may imply for public health) Inequality Utilitarian and Capabilities Perspectives (and what they may imply for public health) 1 Utilitarian Perspectives on Inequality 2 Inequalities matter most in terms of their impact onthelivesthatpeopleseektoliveandthethings,

Mehr

Fluid-Particle Multiphase Flow Simulations for the Study of Sand Infiltration into Immobile Gravel-Beds

Fluid-Particle Multiphase Flow Simulations for the Study of Sand Infiltration into Immobile Gravel-Beds 3rd JUQUEEN Porting and Tuning Workshop Jülich, 2-4 February 2015 Fluid-Particle Multiphase Flow Simulations for the Study of Sand Infiltration into Immobile Gravel-Beds Tobias Schruff, Roy M. Frings,

Mehr

Chemical heat storage using Na-leach

Chemical heat storage using Na-leach Hilfe2 Materials Science & Technology Chemical heat storage using Na-leach Robert Weber Empa, Material Science and Technology Building Technologies Laboratory CH 8600 Dübendorf Folie 1 Hilfe2 Diese Folie

Mehr

RailMaster New Version 7.00.p26.01 / 01.08.2014

RailMaster New Version 7.00.p26.01 / 01.08.2014 RailMaster New Version 7.00.p26.01 / 01.08.2014 English Version Bahnbuchungen so einfach und effizient wie noch nie! Copyright Copyright 2014 Travelport und/oder Tochtergesellschaften. Alle Rechte vorbehalten.

Mehr

The Master of Science Entrepreneurship and SME Management

The Master of Science Entrepreneurship and SME Management The Master of Science Entrepreneurship and SME Management 1 WELCOME! 2 Our Business Faculty focus on SME and Innovation. We are accredited from AQAS. Thus, our Master in SME offers a new and innovative

Mehr

PART 3: MODELLING BUSINESS PROCESSES EVENT-DRIVEN PROCESS CHAINS (EPC)

PART 3: MODELLING BUSINESS PROCESSES EVENT-DRIVEN PROCESS CHAINS (EPC) Information Management II / ERP: Microsoft Dynamics NAV 2009 Page 1 of 5 PART 3: MODELLING BUSINESS PROCESSES EVENT-DRIVEN PROCESS CHAINS (EPC) Event-driven Process Chains are, in simple terms, some kind

Mehr

August Macke 1887-1914 Abschied, 1914 Museum Ludwig, Köln

August Macke 1887-1914 Abschied, 1914 Museum Ludwig, Köln August Macke 1887-1914 Abschied, 1914 Museum Ludwig, Köln Ideas for the classroom 1. Introductory activity wer?, was?, wo?, wann?, warum? 2. Look at how people say farewell in German. 3. Look at how people

Mehr

Modellfreie numerische Prognosemethoden zur Tragwerksanalyse

Modellfreie numerische Prognosemethoden zur Tragwerksanalyse Modellfreie numerische Prognosemethoden zur Tragwerksanalyse Zur Erlangung des akademischen Grades Doktor-Ingenieur (Dr.-Ing.) an der Fakultät Bauingenieurwesen der Technischen Universität Dresden eingereichte

Mehr

Working Sets for the Principle of Least Privilege in Role Based Access Control (RBAC) and Desktop Operating Systems DISSERTATION

Working Sets for the Principle of Least Privilege in Role Based Access Control (RBAC) and Desktop Operating Systems DISSERTATION UNIVERSITÄT JOHANNES KEPLER LINZ JKU Technisch-Naturwissenschaftliche Fakultät Working Sets for the Principle of Least Privilege in Role Based Access Control (RBAC) and Desktop Operating Systems DISSERTATION

Mehr

Support Technologies based on Bi-Modal Network Analysis. H. Ulrich Hoppe. Virtuelles Arbeiten und Lernen in projektartigen Netzwerken

Support Technologies based on Bi-Modal Network Analysis. H. Ulrich Hoppe. Virtuelles Arbeiten und Lernen in projektartigen Netzwerken Support Technologies based on Bi-Modal Network Analysis H. Agenda 1. Network analysis short introduction 2. Supporting the development of virtual organizations 3. Supporting the development of compentences

Mehr

A Practical Approach for Reliable Pre-Project Effort Estimation

A Practical Approach for Reliable Pre-Project Effort Estimation A Practical Approach for Reliable Pre-Project Effort Estimation Carl Friedrich Kreß 1, Oliver Hummel 2, Mahmudul Huq 1 1 Cost Xpert AG, Augsburg, Germany {Carl.Friedrich.Kress,Mahmudul.Huq}@CostXpert.de

Mehr

Lehrstuhl für Allgemeine BWL Strategisches und Internationales Management Prof. Dr. Mike Geppert Carl-Zeiß-Str. 3 07743 Jena

Lehrstuhl für Allgemeine BWL Strategisches und Internationales Management Prof. Dr. Mike Geppert Carl-Zeiß-Str. 3 07743 Jena Lehrstuhl für Allgemeine BWL Strategisches und Internationales Management Prof. Dr. Mike Geppert Carl-Zeiß-Str. 3 07743 Jena http://www.im.uni-jena.de Contents I. Learning Objectives II. III. IV. Recap

Mehr

XV1100K(C)/XV1100SK(C)

XV1100K(C)/XV1100SK(C) Lexware Financial Office Premium Handwerk XV1100K(C)/XV1100SK(C) All rights reserverd. Any reprinting or unauthorized use wihout the written permission of Lexware Financial Office Premium Handwerk Corporation,

Mehr

Influence of dust layer thickness. on specific dust resistivity

Influence of dust layer thickness. on specific dust resistivity on specific dust resistivity D. Pieloth, M. Majid, H. Wiggers, P. Walzel Chair of Mechanical Process Engineering, TU Dortmund, Dortmund/Germany Outline 2 Motivation Measurement of specific dust resistivity

Mehr

Why you should care. by Thomas Krimmer. Thomas Krimmer @ACS Slide 1

Why you should care. by Thomas Krimmer. Thomas Krimmer @ACS Slide 1 Why you should care. by Thomas Krimmer Thomas Krimmer @ACS Slide 1 CAS Publication Record Abstracts (Millions) 1.5 papers per minute Source: CAS helpdesk, Statistical Summary 1907-2007, 02/10/2009 Thomas

Mehr

E-Discovery the EU Data Protection Authorities approach

E-Discovery the EU Data Protection Authorities approach E-Discovery the EU Data Protection Authorities approach Breakout Session Mind the Gap: Bridging U.S. Cross-border E-discovery and EU Data Protection Obligations Dr. Alexander Dix, LL.M. Berlin Commissioner

Mehr

Seminar in Requirements Engineering

Seminar in Requirements Engineering Seminar in Requirements Engineering Vorbesprechung Frühjahrssemester 2010 22. Februar 2010 Prof. Dr. Martin Glinz Dr. Samuel Fricker Eya Ben Charrada Inhalt und Lernziele Software Produktmanagement Ziele,

Mehr

History of Mobility. Sprachniveau: Ca. A2-B2. Stationen im Verkehrshaus

History of Mobility. Sprachniveau: Ca. A2-B2. Stationen im Verkehrshaus History of Mobility Kurzbeschrieb Die zweigeschossige Halle mit einer Ausstellungsfläche von rund 2000 m² beinhaltet ein Schaulager, ein interaktives Autotheater, verschiedenste individuell gestaltete

Mehr

XML Template Transfer Transfer project templates easily between systems

XML Template Transfer Transfer project templates easily between systems Transfer project templates easily between systems A PLM Consulting Solution Public The consulting solution XML Template Transfer enables you to easily reuse existing project templates in different PPM

Mehr

INVESTITIONSGÜTER KONSUMGÜTER. Schürer Design CAPITAL GOODS CONSUMER PRODUCTS. Design & Ergonomie

INVESTITIONSGÜTER KONSUMGÜTER. Schürer Design CAPITAL GOODS CONSUMER PRODUCTS. Design & Ergonomie INVESTITIONSGÜTER CAPITAL GOODS KONSUMGÜTER CONSUMER PRODUCTS Schürer Design Design & Ergonomie Die Welt mit anderen Augen sehen... Gutes Design macht Nutzen sichtbar. Schürer Design entwickelt seit 1969

Mehr

HARTNAGEL Etikettiermaschinen für Verpackungsbecher und Automation. Etikettierautomat - EMR 8-200 / EMR 8-400

HARTNAGEL Etikettiermaschinen für Verpackungsbecher und Automation. Etikettierautomat - EMR 8-200 / EMR 8-400 Etikettierautomat - EMR 8-200 / EMR 8-400 Die Firma Hartnagel, begann vor über 15 Jahren den ersten Etikettierautomaten zu entwickeln und zu bauen. Geleitet von der Idee, das hinsichtlich der Produktführung

Mehr

GIPS 2010 Gesamtüberblick. Dr. Stefan J. Illmer Credit Suisse. Seminar der SBVg "GIPS Aperitif" 15. April 2010 Referat von Stefan Illmer

GIPS 2010 Gesamtüberblick. Dr. Stefan J. Illmer Credit Suisse. Seminar der SBVg GIPS Aperitif 15. April 2010 Referat von Stefan Illmer GIPS 2010 Gesamtüberblick Dr. Stefan J. Illmer Credit Suisse Agenda Ein bisschen Historie - GIPS 2010 Fundamentals of Compliance Compliance Statement Seite 3 15.04.2010 Agenda Ein bisschen Historie - GIPS

Mehr

AS Path-Prepending in the Internet And Its Impact on Routing Decisions

AS Path-Prepending in the Internet And Its Impact on Routing Decisions (SEP) Its Impact on Routing Decisions Zhi Qi ytqz@mytum.de Advisor: Wolfgang Mühlbauer Lehrstuhl für Netzwerkarchitekturen Background Motivation BGP -> core routing protocol BGP relies on policy routing

Mehr

-Which word (lines 47-52) does tell us that Renia s host brother is a pleasant person?

-Which word (lines 47-52) does tell us that Renia s host brother is a pleasant person? Reading tasks passend zu: Open World 1 Unit 4 (student s book) Through a telescope (p. 26/27): -Renia s exchange trip: richtig falsch unkar? richtig falsch unklar: Renia hat sprachliche Verständnisprobleme.

Mehr

Robotino View Kommunikation mit OPC. Communication with OPC DE/EN 04/08

Robotino View Kommunikation mit OPC. Communication with OPC DE/EN 04/08 Robotino View Kommunikation mit OPC Robotino View Communication with OPC 1 DE/EN 04/08 Stand/Status: 04/2008 Autor/Author: Markus Bellenberg Festo Didactic GmbH & Co. KG, 73770 Denkendorf, Germany, 2008

Mehr

Titelbild1 ANSYS. Customer Portal LogIn

Titelbild1 ANSYS. Customer Portal LogIn Titelbild1 ANSYS Customer Portal LogIn 1 Neuanmeldung Neuanmeldung: Bitte Not yet a member anklicken Adressen-Check Adressdaten eintragen Customer No. ist hier bereits erforderlich HERE - Button Hier nochmal

Mehr

TVHD800x0. Port-Weiterleitung. Version 1.1

TVHD800x0. Port-Weiterleitung. Version 1.1 TVHD800x0 Port-Weiterleitung Version 1.1 Inhalt: 1. Übersicht der Ports 2. Ein- / Umstellung der Ports 3. Sonstige Hinweise Haftungsausschluss Diese Bedienungsanleitung wurde mit größter Sorgfalt erstellt.

Mehr

A central repository for gridded data in the MeteoSwiss Data Warehouse

A central repository for gridded data in the MeteoSwiss Data Warehouse A central repository for gridded data in the MeteoSwiss Data Warehouse, Zürich M2: Data Rescue management, quality and homogenization September 16th, 2010 Data Coordination, MeteoSwiss 1 Agenda Short introduction

Mehr

Frequently asked Questions for Kaercher Citrix (apps.kaercher.com)

Frequently asked Questions for Kaercher Citrix (apps.kaercher.com) Frequently asked Questions for Kaercher Citrix (apps.kaercher.com) Inhalt Content Citrix-Anmeldung Login to Citrix Was bedeutet PIN und Token (bei Anmeldungen aus dem Internet)? What does PIN and Token

Mehr

Possible Solutions for Development of Multilevel Pension System in the Republic of Azerbaijan

Possible Solutions for Development of Multilevel Pension System in the Republic of Azerbaijan Possible Solutions for Development of Multilevel Pension System in the Republic of Azerbaijan by Prof. Dr. Heinz-Dietrich Steinmeyer Introduction Multi-level pension systems Different approaches Different

Mehr

If you have any issue logging in, please Contact us Haben Sie Probleme bei der Anmeldung, kontaktieren Sie uns bitte 1

If you have any issue logging in, please Contact us Haben Sie Probleme bei der Anmeldung, kontaktieren Sie uns bitte 1 Existing Members Log-in Anmeldung bestehender Mitglieder Enter Email address: E-Mail-Adresse eingeben: Submit Abschicken Enter password: Kennwort eingeben: Remember me on this computer Meine Daten auf

Mehr

University of Applied Sciences and Arts

University of Applied Sciences and Arts University of Applied Sciences and Arts Hannover is the Capital of Lower Saxony the greenest city in Germany the home of Hannover 96 and has 525.000 residents, about 35.000 students and a rich history

Mehr

How to access licensed products from providers who are already operating productively in. General Information... 2. Shibboleth login...

How to access licensed products from providers who are already operating productively in. General Information... 2. Shibboleth login... Shibboleth Tutorial How to access licensed products from providers who are already operating productively in the SWITCHaai federation. General Information... 2 Shibboleth login... 2 Separate registration

Mehr

Kybernetik Einführung

Kybernetik Einführung Kybernetik Einführung Mohamed Oubbati Institut für Neuroinformatik Tel.: (+49) 731 / 50 24153 mohamed.oubbati@uni-ulm.de 24. 04. 2012 Einführung Was ist Kybernetik? Der Begriff Kybernetik wurde im 1948

Mehr

Disclaimer & Legal Notice. Haftungsausschluss & Impressum

Disclaimer & Legal Notice. Haftungsausschluss & Impressum Disclaimer & Legal Notice Haftungsausschluss & Impressum 1. Disclaimer Limitation of liability for internal content The content of our website has been compiled with meticulous care and to the best of

Mehr

Transparenz 2.0. Passive Nachverfolgung und Filterung von WebApps auf dem Prüfstand

Transparenz 2.0. Passive Nachverfolgung und Filterung von WebApps auf dem Prüfstand Matthias Seul IBM Research & Development GmbH BSI-Sicherheitskongress 2013 Transparenz 2.0 Passive Nachverfolgung und Filterung von WebApps auf dem Prüfstand R1 Rechtliche Hinweise IBM Corporation 2013.

Mehr

p^db=`oj===pìééçêíáåñçêã~íáçå=

p^db=`oj===pìééçêíáåñçêã~íáçå= p^db=`oj===pìééçêíáåñçêã~íáçå= Error: "Could not connect to the SQL Server Instance" or "Failed to open a connection to the database." When you attempt to launch ACT! by Sage or ACT by Sage Premium for

Mehr

Capillary interactions, shear thickening and liquid migration in wet granular media

Capillary interactions, shear thickening and liquid migration in wet granular media Diss. ETH No. 21809 Capillary interactions, shear thickening and liquid migration in wet granular media A dissertation submitted to ETH Zurich for the degree of Doctor of Sciences presented by Roman Andri

Mehr

The poetry of school.

The poetry of school. International Week 2015 The poetry of school. The pedagogy of transfers and transitions at the Lower Austrian University College of Teacher Education(PH NÖ) Andreas Bieringer In M. Bernard s class, school

Mehr

Distributed testing. Demo Video

Distributed testing. Demo Video distributed testing Das intunify Team An der Entwicklung der Testsystem-Software arbeiten wir als Team von Software-Spezialisten und Designern der soft2tec GmbH in Kooperation mit der Universität Osnabrück.

Mehr

Hochschule Esslingen. Modulbeschreibung TBB Internationale Technische Betriebswirtschaft. Inhaltsverzeichnis. Kanalstr. 33 73728 Esslingen

Hochschule Esslingen. Modulbeschreibung TBB Internationale Technische Betriebswirtschaft. Inhaltsverzeichnis. Kanalstr. 33 73728 Esslingen Kanalstr. 33 73728 Esslingen Inhaltsverzeichnis Seite 1 von 6 TBB602 MD International Business 2 Int.Marketing/-Finance & Case Studies Int.Business 3 International Conmmercial Law 5 Erläuterungen 6 Modul

Mehr

Einsatz einer Dokumentenverwaltungslösung zur Optimierung der unternehmensübergreifenden Kommunikation

Einsatz einer Dokumentenverwaltungslösung zur Optimierung der unternehmensübergreifenden Kommunikation Einsatz einer Dokumentenverwaltungslösung zur Optimierung der unternehmensübergreifenden Kommunikation Eine Betrachtung im Kontext der Ausgliederung von Chrysler Daniel Rheinbay Abstract Betriebliche Informationssysteme

Mehr

Htm1p function in ER-associated protein degradation

Htm1p function in ER-associated protein degradation DISS. ETH No. 18470 Htm1p function in ER-associated protein degradation A dissertation submitted to ETH ZÜRICH for the degree of DOCTOR OF SCIENCES presented by SIMONE CHRISTINE CLERC Eidg. dipl. Apothekerin

Mehr

The Single Point Entry Computer for the Dry End

The Single Point Entry Computer for the Dry End The Single Point Entry Computer for the Dry End The master computer system was developed to optimize the production process of a corrugator. All entries are made at the master computer thus error sources

Mehr

creative Factory GmbH

creative Factory GmbH Micro compact car smart gmbh smart forfour series w454 Visualization Embeded into the design team of MCC Smart our team was responsible for Class-A surface modelling and for setup of the visible interior

Mehr

KURZANLEITUNG. Firmware-Upgrade: Wie geht das eigentlich?

KURZANLEITUNG. Firmware-Upgrade: Wie geht das eigentlich? KURZANLEITUNG Firmware-Upgrade: Wie geht das eigentlich? Die Firmware ist eine Software, die auf der IP-Kamera installiert ist und alle Funktionen des Gerätes steuert. Nach dem Firmware-Update stehen Ihnen

Mehr

Technology for you. Media Solutions

Technology for you. Media Solutions Technology for you Media Solutions Media Units / Media Units Media Units Robuste Installationstechnik für jeden Klassenund Schulungsraum Robust installation technology for each class- and conference room

Mehr

Beschwerdemanagement / Complaint Management

Beschwerdemanagement / Complaint Management Beschwerdemanagement / Complaint Management Structure: 1. Basics 2. Requirements for the implementation 3. Strategic possibilities 4. Direct Complaint Management processes 5. Indirect Complaint Management

Mehr

SAP PPM Enhanced Field and Tab Control

SAP PPM Enhanced Field and Tab Control SAP PPM Enhanced Field and Tab Control A PPM Consulting Solution Public Enhanced Field and Tab Control Enhanced Field and Tab Control gives you the opportunity to control your fields of items and decision

Mehr

SARA 1. Project Meeting

SARA 1. Project Meeting SARA 1. Project Meeting Energy Concepts, BMS and Monitoring Integration of Simulation Assisted Control Systems for Innovative Energy Devices Prof. Dr. Ursula Eicker Dr. Jürgen Schumacher Dirk Pietruschka,

Mehr

Total Security Intelligence. Die nächste Generation von Log Management and SIEM. Markus Auer Sales Director Q1 Labs.

Total Security Intelligence. Die nächste Generation von Log Management and SIEM. Markus Auer Sales Director Q1 Labs. Total Security Intelligence Die nächste Generation von Log Management and SIEM Markus Auer Sales Director Q1 Labs IBM Deutschland 1 2012 IBM Corporation Gezielte Angriffe auf Unternehmen und Regierungen

Mehr

3. BvD Transfer Pricing Day BEPS und die Auswirkungen auf das operationale Verrechnungspreis-Management

3. BvD Transfer Pricing Day BEPS und die Auswirkungen auf das operationale Verrechnungspreis-Management 3. BvD Transfer Pricing Day BEPS und die Auswirkungen auf das operationale Verrechnungspreis-Management Agenda Einführung Operationales Verrechnungspreis- Management Was bedeutet BEPS für Unternehmen?

Mehr

Software development with continuous integration

Software development with continuous integration Software development with continuous integration (FESG/MPIfR) ettl@fs.wettzell.de (FESG) neidhardt@fs.wettzell.de 1 A critical view on scientific software Tendency to become complex and unstructured Highly

Mehr

Cleanroom Fog Generators Volcano VP 12 + VP 18

Cleanroom Fog Generators Volcano VP 12 + VP 18 Cleanroom Fog Generators Volcano VP 12 + VP 18 Description & Functional Principle (Piezo Technology) Cleanrooms are dynamic systems. People and goods are constantly in motion. Further installations, production

Mehr

Wie agil kann Business Analyse sein?

Wie agil kann Business Analyse sein? Wie agil kann Business Analyse sein? Chapter Meeting Michael Leber 2012-01-24 ANECON Software Design und Beratung G.m.b.H. Alser Str. 4/Hof 1 A-1090 Wien Tel.: +43 1 409 58 90 www.anecon.com office@anecon.com

Mehr

Vocational Education and Training (VET) in Switzerland and Schaffhausen

Vocational Education and Training (VET) in Switzerland and Schaffhausen Presentation at Information Event February 18, 2015 Karin Baumer, Office for Vocational Education and Training Vocational Education and Training (VET) in Switzerland and Schaffhausen Seite 1 Commercial

Mehr

MHG - Modular Humidity Generator

MHG - Modular Humidity Generator MHG - Modular Humidity Generator Humidity Control Kontrollierte Luftfeuchtigkeit To provide reliable and reproducible results, an increasing number of analytical test methods require controlled environmental

Mehr

First Padova- Gießen Chemical Meeting

First Padova- Gießen Chemical Meeting Università degli Studi di Padova Justus-Liebig Department of Chemical Sciences First Padova- Gießen Chemical Meeting Aula I Via Marzolo 1 University of Padova 17-18 February 2014 Monday February 17 th,

Mehr

MOOCs. Campus 2.0? Massive Open Online Courses. E-Learning-Tag 22.Oktober 2013. Prof. Dr. med. Thomas Kamradt thomas.kamradt@med.uni-jena.

MOOCs. Campus 2.0? Massive Open Online Courses. E-Learning-Tag 22.Oktober 2013. Prof. Dr. med. Thomas Kamradt thomas.kamradt@med.uni-jena. E-Learning-Tag 22.Oktober 2013 MOOCs Massive Open Online Courses Campus 2.0? Prof. Dr. med. Thomas Kamradt thomas.kamradt@med.uni-jena.de MOOCs: Übersicht 1) Was sind & wie funktionieren MOOCs? 2) Wer

Mehr

INTERNATIONALISIERUNG - METROPOLREGION GOES INDIA

INTERNATIONALISIERUNG - METROPOLREGION GOES INDIA INTERNATIONALISIERUNG - METROPOLREGION GOES INDIA German-Indian Management Studies: ein deutsch-indischer Studiengang Prof. Dr. Thomas Meuche, Wissenschaftlicher Leiter des Instituts für Weiterbildung

Mehr

DIGICOMP OPEN TUESDAY AKTUELLE STANDARDS UND TRENDS IN DER AGILEN SOFTWARE ENTWICKLUNG. Michael Palotas 7. April 2015 1 GRIDFUSION

DIGICOMP OPEN TUESDAY AKTUELLE STANDARDS UND TRENDS IN DER AGILEN SOFTWARE ENTWICKLUNG. Michael Palotas 7. April 2015 1 GRIDFUSION DIGICOMP OPEN TUESDAY AKTUELLE STANDARDS UND TRENDS IN DER AGILEN SOFTWARE ENTWICKLUNG Michael Palotas 7. April 2015 1 GRIDFUSION IHR REFERENT Gridfusion Software Solutions Kontakt: Michael Palotas Gerbiweg

Mehr

In vier Schritten zum Titel. erfolgreichen Messeauftritt. Four steps to a successful trade fair. Hier beginnt Zukunft! The future starts here!

In vier Schritten zum Titel. erfolgreichen Messeauftritt. Four steps to a successful trade fair. Hier beginnt Zukunft! The future starts here! In vier Schritten zum Titel erfolgreichen Messeauftritt. Four steps to a successful trade fair. Hier beginnt Zukunft! The future starts here! Einleitung Intro Um Sie dabei zu unterstützen, Ihren Messeauftritt

Mehr