Center for Reproductive Medicine Munich

Transkript

1 Center for Reproductive Medicine Munich Ambulatory Healthcare Center Dr. Walter Bollmann Dr. Thomas Brückner Dr. Ulrich Noss Dr. Daniel Noss PD Dr. Robert Ochsenkühn Dr. Barbara Wiedemann Laboratory Medicine Dr. Gerhard Noss Risto Gjavotchanoff Annual Report 2013

2 Annual report 2013 Our annual report 2013 gives an overview of all important current information concerning our Center for Reproductive Medicine, Munich. Transparency is of paramount importance for our institute. The Center for Reproductive Medicine Munich was founded in 1987 as one of the first IVF Centers in Germany and is currently one of the IVF Centers performing the most treatment cycles in Germany. We offer all current techniques in ART: IVF, ICSI, cryopreservation of pronuclei-oocytes, vitrification of blastocysts, vitrification of unfertlized eggs ( social freezing ). In 2011 we started preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD). We perform trophectoderm biopsy for CGH-array analysis. In this regard we work in close cooperation with Dr. C. Nevinny-Stickel, Institute for Human Genetics in Munich. In 2013 we became member of the ESHRE PGD Consortium Centre, as the only PGD Center in Germany. Since December 2013 our App München IVF is online. It gives general informations concerning our infertility treatments and allows a comfortable online access to our internet patient portal (at the moment in german language only).

3 Physicians and staff members 2013 Head of Department Dr. Walter Bollmann Dr. Thomas Brückner Dr. Ulrich Noss Physicians Dr. Isabelle Anders Dr. Andrea Arzberger Dr. Anna Bauer Dr. Titania Eberle Dr. Daniel Noss PD Dr. Robert Ochsenkühn Dr. Barbara Wiedemann Anaesthesiologists Dr. Karola Faist Dr. Ruth Schmid-Tannwald Dr. Gabriele Pflanz in cooperation with Professor Dr. Frank-Michael Köhn (Andrologie) Dr. Rebekka Leist (Chinesische Medizin) Dr. Dr. Claudia Nevinny-Stickel (Humangenetik) Dr. Ulrich Pickl, Dr. Ulf Salzmann (Urologie, Andrologie) Front desk Heidrun Tinnes Dembemo Anaw Osumbu Katharina Blankenburg Fadime Cetin Shirin Eckelt Julia Karbownik Petra Kahle Christiane Kirsch Franziska Köhler Michelle Preller Sabine Ranz Zeynep Sare Nadine Schug Lisa Stippl Melanie Tonhauser Sabine Wendt Manuela Wildmann Vahide Yildiz Wochenende und Aushilfe: Christian Besel Lion Leuker Michl Manuela Yvonne Trautmann Sevgi Uzun

4 Hormone laboratory Heidrun Tinnes Brigitte Flemmig Annette Greger Michaela Hartl Operating room nurses Karin Spengler Gabriele Beinert Mojgan Ensafi Vera Fiola-Kruth Ingrid Steger Monika Toth Heidi Welzenbach Wochenende und Aushilfe: Wilma Heiss, Petra Leonhard Billing department Johanna Miller Hülya Dora Annette Greger Marion Hartl Rosi Lang Gynecological cytology Ursula Totzauer Cornelia Neubert IVF secretary Petra Jaksch Denise Finzel Julia Hinz Sadiye Keskin Wochenende und Aushilfe: Jutta Neff-Ambrosio IT department Gabriele Blinzler IVF laboratory Dipl.-Biol. Edmund Kreuzer Dipl.-Biol. Birgit Groß Annemarie Groß Cornelia Hillenbrand Vanessa Hölzl Veronika Huber Sabrina Zech Andrology laboratory Ingrid Hütter Uschi Best Angela Bethäuser Agnes Gerisch-Busch Daniela Cejnar Brigitte Flemmig Beate Hefner Brigitte Matz Ilona Moser Stephanie Trenkle Serology laboratory Margret Hermanns Brigitte Flemmig Annette Greger Microbiology laboratory Tatjana Schneider Annette Greger Brigitte Recknagel Secretary s office Petra Maser Ingrid Hütter Quality assurance and statistics Dr. A. Arzberger Ilona Baumann Kerstin Walter Quality management Heidrun Tinnes Ingrid Steger Office management Heidrun Tinnes Sabine Ranz Housekeeping Premalatha Adler Fa. Globus Fa. Njoroge

5 Activity report 2013 No. of new couples with unwanted childlessness 1681 No. of hystero contrast salpingographies 317 No. of PAP tests 7057 No. of oocyte retrievals 1802 No. of embryo transfers 2142 No. of sperm analysis 3693 No. of intrauterine inseminations 577 No. of cycles with cryopreservation (2-PN oocytes) 760 No. of thawing cycles (IVF, ICSI) 983 No. of cryopreservations (spermatozoa, testicular tissue) 132 No. of hormone tests No. of serological tests No. of bacteriological tests 3490

6 Chronology 2013 January Workshop für Med. Fachangestellte zuweisender Ärzte Neue ISO 15224:2012 (Krauss-Akademie): H. Tinnes Sicherheitsaspekte mit Flüssigstickstoff (Kliem-Kuster): Dipl. Biol. E. Kreuzer February IVF naturelle (Landesverband Bayern): Dr. W. Bollmann Sicherer Umgang mit tiefkalten Gasen (Cryo-Shop): Dipl. Biol. E. Kreuzer Betriebliches Konfliktmanagement und Prävention (BGW, Heidenheim): I. Steger Hospitanz FCH Fischer (Hamburg): G. Beinert Interne Fortbildung: Abschätzung der Fertilitätsreserve (Dr. R. Ochsenkühn) Interne Fortbildung: Hormone Teil I: Dr. Th. Brückner March Word/Excel Schulung (München): G. Blinzler, B. Flemmig New Horizons in IVF Genetic Diagnostics II (Alicante): Dr. W. Bollmann 25. AGRBM Regionaltreffen (München): Dipl. Biol. E. Kreuzer Datenschutz (Landesdatenschutzamt Ansbach): Dr. A. Arzberger Excel-Schulung (München): I. Baumann, K. Walter Interne Fortbildung: Hormone Teil II: Dr. W. Bollmann April Workshop für Med. Fachangestellte zuweisender Ärzte AGRBM Jahrestagung (Leipzig): Dipl. Biol. B. Groß, Dipl. Biol. E. Kreuzer Bundesverband der Reproduktionsmediziner Bayerns (BRB): Dr. U. Noss Evakuierungs- und Brandschutzhelfer Seminar (München): P. Jaksch, I. Steger 5th International IVI Congress (Sevilla): Dr. D. Noss Vortrag intern über Hospitanz FCH Fischer Hamburg: Dr. D. Noss May Dipl. Biol. B. Groß erhält das ESHRE Zertifikat»Clinical Embryologist«Time Lapse System (Istanbul): Dipl. Biol. B. Groß Mitgliedschaft im ESHRE PGD Consortium June Sachkunde Lehrgang Sterilgutversorgung (DGSV, München): H. Welzenbach DNRa (Dortmund): V. Huber, S. Zech BRB Symposium (München): Dr. U. Noss Interne Fortbildung: Zusammenfassung international IVI Congress: Dr. W. Bollmann, Dr. D. Noss July Forum Fertilität (München, MSD): Dr. U. Noss Intensiv Seminar Endokrinologie (München): Dr. U. Noss

7 ESHRE (London): Dr. W. Bollmann, Dr. R. Ochsenkühn, Dr. B. Wiedemann, Dipl. Biol. B. Groß Stressmanagement (Dresden): I. Steger Reprofacts ESHRE: Dipl. Biol. E. Kreuzer Hospitanz FCH Dr. Fischer (Hamburg): Dipl. Biol. B. Groß Interne Fortbildung: Unterweisung Arbeitssicherheit (H. Spönla) September Workshop Excel 2010 (München): G. Blinzler, P. Maser BG Schulung (Dresden): P. Kahle, Z. Sare Praxisorganisation und Praxismanagement (München): H. Tinnes, S. Ranz October AGRBM Regionaltreffen (München): Dipl. Biol. E. Kreuzer Workshop für Med. Fachangestellte zuweisender Ärzte Moderne Hepatitis Diagnostik (München, Fa. Roche): B. Flemmig, H. Tinnes Einkaufsgemeinschaft Veranstaltung (Regensburg): G. Beinert ASRM Boston: Dr. U. Noss Interne Fortbildung: Hygieneschulung Modul 1: Ch. Hirt November Ovarian Club III (Paris): Dr. D. Noss Mitarbeiter Schulung Anmeldung Qualifizierung und Validierung (Gynemed, München): Dipl. Biol. E. Kreuzer Datenschutz KVB (München): Dr. A. Arzberger Habilitation : PD Dr. R. Ochsenkühn:»Klinische und experimentelle Studien zur Diagnostik und Therapie bei unerfülltem Kinderwunsch«PD Dr. R. Ochsenkühn: Zusatzbezeichnung»Ärztliches Qualitätsmanagement«December Aufbauseminar Stressmanagement (Dresden): I. Steger Interne Fortbildung: Arbeitssicherheitsunterweisung: (Hr. Spönla) Weihnachtsfeier der gesamten Praxis im»weinhaus Neuner«Talks:»Die Behandlung des unerfüllten Kinderwunsches durch Insemination, IVF, ICSI«(Intensiv - seminar Klinische Endokrinologie, Reproduktionsmedizin-und Labormedizin für Frauen - ärzte. München ): Dr. U. Noss, Dr. A. Arzberger»Social Freezing«(9. Münchner IVF-Symposium, , München): Dr. R. Ochsenkühn»PID bei Aneuploidie und chromosomaler Imbalance, juristische, reproduktionsmedizinische und genetische Aspekte (Forum Fertilität 2013, , München): Dr. C. Nevinny, Dr. S. Bug, Dr. U. Noss, Dipl. biol. B. Groß

8 Results 2013 Definition of terms: In vitro fertilisation (IVF): Test tube fertili - sation : fertilisation outside of the body Intracytoplasmatic sperm injection (ICSI): the injection of a sperm into a mature egg. IVF/ICSI combination of IVF and ICSI: one half of the eggs is treated with IVF, the other half with ICSI Cryo embryo transfer: transfer of thawed pronuclear oocytes and transferred as day 5 embryos Trophectoderm biopsy: extraction of cells (trophectoderm cells) from the blastocyst for PGS or PGD Vitrification: ultrafast cryopreservation, even useful for unfertilized eggs and blastocysts (high survival rate) n Oocyte retrieval cycles for IVF and ICSI, Oocyte retrieval cycles divided in IVF, ICSI and IVF/ICSI, n IVF [ ], ICSI [ ] und IVF/ICSI [ ]

9 Mean age (female patient per cycle) Age distribution, all embryo transfer cycles (IVF, ICSI, cryo-embryo transfer), 2013 age Percentage of cycles with 1, 2 or three embryos per transfer, Percentage of twins depending on the number of transferred embryos, embryo [1 ET = ], 2 embryos [2 ET = ], 3 embryos [3 ET = ]

10 Cycles with cryopreservation of pronuclear oocytes, Number of embryo transfer cycles of thawed cryopreserved pronucleus oocytes, No No Pregnancy rate depending on fresh embryo transfer with 2 embryos, age related, 2013 Pregnancy rate depending on the cryo-embryo transfer of 2 blastocysts age related, 2013 Pregnancy rate depending on the cryo-embryo transfer of 2 embryos age related, 2013 Pregnancy rate depending on the cryo-embryo transfer of 2 blastocysts age related, 2013

11 Pregnancy rate depending on all transfers (1, 2 or 3 embryos) after IVF, ICSI, age related, 2013 Pregnancy rate dending on all cryo embryo transfers (1, 2 or 3 embryos), age related, 2013 Cumulative pregnancy rate* age related, , per patient * cumulative pregnancy rate means all clinical pregnancies after IVF and ICSI in addition to the pregnancies resulting of the cryo-embryo transfers, where 2PN-oocytes could have been cryopreserved, per patient. Results after trophectoderm biopsy (PGD/PGS), 2013 Pat No. BC euploid BC % pat with ET ET BC/ET Preg Preg/ET% Preg/pat with ET% , , ,9 Results cryopreservation of blastocysts, 2013 Pat No. BC Deg. Deg. % ET BC/ET Preg Preg/ET% Preg/pat with ET% ,3% 110 1, ,6 47,1 Pat BC euploid ET patient blastocyt normal chromosome set embryo transfer BC/ET mean number of blastocysts per embryo transfer Preg/ET% clinical pregnancy per embryo transfer in % No. BC number of blastocyts Deg. degenerated blastocysts after thawing

12 Consulting hours Monday Tuesday Wednesday 9 16 Thursday 9 16 Friday 9 14 by appointment only Tal München Tel. (089) Fax (089) info@ivf-bbn.de Internet Certified to DIN EN ISO 9001:2008