HELIXOR Literature. (update: 2010/09/14)

Transkript

1 (update: 2010/09/14) A. Preclinical Publications 1. Constituents Lorch E. Neue Untersuchungen über Flavonoide in Viscum album L. ssp. abietis, album und austriacum. [New Investigations on Flavonoids from Viscum album L. ssp. abietis, album and austriacum]. Zeitschrift für Naturforschung 1993;48c(14): Lorch E, Tröger W. Pharmaceutical Quality Control of Mistletoe Preparations.In: Büssing A, editor. Mistletoe - The Genus Viscum. Amsterdam: Harwood Academic Publishers; S Pfüller U. Chemical constituents of European Mistletoe (Viscum album L.).In: Büssing A, editor. Mistletoe - The Genus Viscum. Amsterdam: Harwood Academic Publishers; S Schink M. Analyse des Proteinmusters von Extrakten verschiedener Viscum album - Varietäten mit Hilfe der zweidimensionalen Polyacrylamid-Gel-Elektrophorese [Analysis of protein patterns in extracts of different varieties of Viscum album L. by 2-dimensional Polyacryl amide gel electrophoresis]. Diplomarbeit. Stuttgart: Fachbereich Biologie, Universität Hohenheim; Schink M. Vergleichende Untersuchungen über das Proteinmuster der Europäischen Mistel (Viscum album L.) mit Hilfe der zweidimensionalen Polyacrylamid-Gel-Elektrophorese [Comparative investigations on the protein pattern of european mistletoe (Viscum album L.) by twodimensional Polyacryl amide gel electrophoresis]. Dissertation. Stuttgart: Fachbereich Biologie d. Universität Hohenheim; Pharmacokinetics No studies available (not feasible from methodological and technical reasons) 3. Phamacodynamics Büssing A. Biological and Pharmacological Properties of Viscum album L.In: Büssing A, editor. Mistletoe - The Genus Viscum. Amsterdam: Harwood Academic Publishers; , S

2 page 2 of 31 Kienle GS, Kiene H. Die Mistel in der Onkologie. Fakten und konzeptionelle Grundlagen. [Mistletoe in oncology. Facts and basic principles]. Stuttgart New York: Schattauer; Anti-Tumoural Effects a) in vitro Brust I. Mikrokalorimetrische Untersuchungen während des Wachstums behandelter und unbehandelter in vitro-kulturen einer menschlichen Leukämie-Zellinie [Microcalorimetric Investigation on the growth of treated and untreated in vitro cultures of a human leukaemia cell line]. Diplomarbeit. Stuttgart: Universität Hohenheim; Büssing A, Ostendorp H, Azhari T, Lehnert A, Mertens R, Schweizer K. In vitro effects of Viscum album L. preparations on cultured leukemic blast cells in a case of childhood T-ALL and on PBMC of healthy individuals. European Journal of Clinical Chemistry and Clinical Biochemistry 1995;33(3): A4. Büssing A, Ostendorp H, Schweizer K. In-vitro-Effekte von Viscum album (L.)-Präparationen auf kultivierte Leukämie-Zellen und mononukleäre Zellen des peripheren Blutes. [In vitro effects of Viscum album (L.) preparations on cultured leukemia cells and mononuclear cells of the peripheral blood]. Tumor Diagnostik & Therapie 1995;16(2): Büssing A, Schietzel M, Regnery A, Schweizer K. The dual role of Viscum album L. effects: cytostatic and dna stabilizing properties. XVI European Congress of Allergology and Clinical Immunology ECACI ' ; Büssing A, Koloch E, Schietzel M. Induction of Apoptosis and DNA-Stabilisation by Viscum Album L. Phytomedicine 1996;3(Suppl. I): 24. Büssing A, Suzart K, Bergmann J, Pfüller U, Schietzel M, Schweizer K. Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins. Cancer Letters 1996;99: Büssing A, Suzart K, Schweizer K. Differences in the apoptosis-inducing properties of Viscum album L. extracts. Anti-Cancer Drugs 1997;8(Suppl. 1): S9-S14.

3 page 3 of 31 Büssing A, Stein GM, Stumpf C, Schietzel M. Release of interleukin-6 in cultured B-chronic lymphocytic leukaemia cells is associated with both activation and cell death via apoptosis. Anticancer Research 1999;19(5B): Büssing A, Schietzel M. Apoptosis-Inducing Properties of Viscum album L. Extracts from Different Host Trees, Correlate with their Content of Toxic Mistletoe Lectins. Anticancer Research 1999;19(1A): Büssing A. DNA Stabilisierung und Apoptose-Induktion durch Viscum album L. [DNA stabilization and induction of apoptosis by Viscum album L. - postdoctoral thesis, University of Witten/Herdecke]. Habilitationsschrift. Witten/Herdecke: Fakultät für Medizin, Universität Witten/Herdecke; Büssing A, Kochskämper H, Rieger S, Schierholz JM, Schlodder D. 46. Decrease of in vitro susceptibility of B-CLL cells of patients treated with Viscum album extract towards the applied extract. Phytomedicine 2007;14(Suppl VII): 51. Büssing A, Kochskämper H, Rieger S, Schierholz JM, Schlodder D, Schietzel M. In vitro response of stimulated B-CLL lymphocytes of patients treated with Viscum album L. extracts. Anticancer Res 2007;27(6 B): Büssing A, Kochskämper H, Rieger S, Schlodder D, Schietzel M. Abnahme der in vitro- Empfindlichkeit leukämischer B-Zellen von Patienten mit B-CLL gegenüber dem applizierten Viscum album-extrakt. [Decreased in vitro susceptibility of patients' B-CLL cells towards the applied Viscum album extract]. In: Scheer R et al., editors. Die Mistel in der Tumortherapie 2. Essen: KVC Verlag; S Doser C. Einfluss eines Gesamtextraktes und eines Lektins aus Viscum album L. auf menschliche transformierte Zellen des hämatopoietischen Systems in vitro [Influence of a Viscum album L. extract and of mistletoe lectins on human transformed cells of the haematopoetic system in vitro]. Inaugural-Dissertation. Stuttgart: Universität Hohenheim; Doser C, Doser M, Hülsen H, Mechelke F. Influence of carbohydrates on the cytotoxicity of an aqueous mistletoe drug and of purified mistletoe lectins tested on human T-leukemia cells. Arzneimittel-Forschung/Drug Research 1989;39(6): Doser M. Charakterisierung von Zellkulturen aus menschlichem Melanom-Biopsiematerial und deren Reaktion auf Applikation eines Mistelpräparates [Characterisation of cell cultures from human melanoma biopsy material and their reaction to application of a mistletoe preparation]. Diplomarbeit. Stuttgart: Fachbereich Biologie, Universität Hohenheim; 1981.

4 page 4 of 31 Doser M. Ermittlung zellbiologischer Wirkungen verschiedener Fraktionen aus Extrakten von Viscum album L. [Cell biological effects of different fractions from Viscum album L. extracts]. Dissertation. Stuttgart: Universität Hohenheim; Fritz B. Zellbiologische und zytofluorometrische Untersuchungen von HeLa Massen- und Klonkulturen bei Applikation eines Präparates aus Viscum album L. [Cell biological and cytofluorometric investigations of the effects of a Viscum album L. preparation on HeLa mass and clonal cell cultures]. Diplomarbeit. Hohenheim: Universität Hohenheim; Fritz B, Ulrich W. Flow Cytometric Analysis of Human Cell Lines after Exposure to Preparations from Viscum album. Planta Medica 1989;55: Hahn P. Durchflusscytometrische und cytogenetische Untersuchungen zur Wirkung von Mistelextrakten auf menschliche Zellkulturen [Flow cytometric and cytogenetic analysis of human cell cultures after exposure to mistletoe extracts]. Diplomarbeit. Kaiserslautern: Fachbereich Biologie, Universität Kaiserslautern; Hahn P. Apoptoseinduzierende und antimutagene Wirkung von Viscum album L. auf humane Zellkulturen [Induction of apoptosis and anti-mutagenic effects of Viscum album L. in human cell cultures]. Dissertation. Kaiserslautern: Fachbereich Biologie der Universität Kaiserslautern; Heine H. Mistelpräparate (Viscum album L.) - Wirkungen auf menschliches Tumorgewebe in vitro. [Mistletoe products (Viscum album L.) - in vitro effects on human tumour tissue]. Zeitschrift für Phytotherapie 1985;6(3): Hülsen H, Mechelke F. The Influence of a Mistletoe Preparation on Suspension Cell Cultures of Human Leukemia and Human Myeloma Cells. Arzneimittel-Forschung/Drug Research 1982;32(9): Hülsen H. Einfluss eines Präparats aus Viscum album L. auf in vitro Suspensions- Zellkulturen von normalen und transformierten hämatopoietischen Zellen [Effect of a preparation from Viscum album L. on in vitro cell suspension cultures of normal and transformed haematopoietic cells]. Dissertation. Stuttgart: Fachbereich Biologie, Universität Hohenheim; Hülsen H, Doser C, Mechelke F. Differences in the in vitro Effectiveness of Preparations Produced from Mistletoes of Various Host Trees. Arzneimittel-Forschung/Drug Research 1986;36(3):

5 page 5 of 31 Hülsen H, Mechelke F. In Vitro Effectiveness of a Mistletoe Preparation on Cytostatic-Drug- Resistant Human Leukemia Cells. Naturwissenschaften 1987;(74): 144. Kelter G. In vitro evaluation of mistletoe extracts from Helixor in a panel of human tumor cell lines in a monolayer proliferation assay Report. Freiburg: Institute for Experimental Oncology, Oncotest GmbH; Report No.: P79E1A. Kelter G. Effect of HELIXOR M on Proliferation of the Colon Carcinoma Cell Line HCC2998 as Determined in Various Proliferation Assays Final Report. Freiburg: Institute for Experimental Oncology, Oncotest GmbH; Report No.: P79F. Kelter G. In vitro evaluation of mistletoe extracts from Helixor in a panel of human tumor cell lines in a monolayer proliferation assay Study Report. Freiburg: Institute for Experimental Oncology, Oncotest GmbH; Report No.: P79E1B. Kelter G, Fischer IU, Fiebig HH. 19. Absence of tumour growth stimulation and cytotoxic activity of standardized mistletoe extracts in human tumour cell lines in vitro. Phytomedicine 2007;14(Suppl VII): 23. Kelter G, Schierholz JM, Fischer IU, Fiebig HH. Cytotoxic activity and absence of tumor growth stimulation of standardized mistletoe extracts in human tumor models in vitro. Anticancer Res 2007;27(1A): Kelter G, Fischer IU, Fiebig HH. Antitumorale Aktivität von Mistelpräparaten und Ausschluss einer Tumorstimulation in vitro. [Antitumor activity of mistletoe products and absence of tumor growth stimulation in human tumor cell lines in vitro]. In: Scheer R et al., editors. Die Mistel in der Tumortherapie 2. Essen: KVC Verlag; S Le Trong I. Einfluss eines Präparats aus Viscum album L. auf klonale Subpopulationen einer menschlichen Leukämie-Zellinie [Influence of a Viscum album L. preparation on clonal subpopulations of a human leukaemia cell line]. Diplomarbeit. Stuttgart: Universität Hohenheim; Proft D. Einfluss eines Gesamtextrakts aus Viscum album L. auf den Kollagenstoffwechsel von peritumorösem, menschlichem Bindegewebe in Gewebekultur [Influence of a total extract of Viscum album L. on the collagen metabolism of cultured peritumoural human connective tissue]. Inaugural-Dissertation. Witten/Herdecke: Universität Witten/Herdecke; Schink M. Einfluss von HELIXOR -Mistelextrakten auf das Wachstum menschlicher und muriner Leukämie-Zellinien in vitro. [Influence of HELIXOR mistletoe products on the growth of human and murine leukaemia cell lines in vitro, study report]

6 page 6 of 31 Schlegel U. Einfluss eines Mistelpräparates auf eine menschliche Fibrosarkom- und eine menschliche Nasalkarzinom-Zellinie [Influence of a mistletoe preparation on human fibrosarcoma and nasopharyngeal carcinoma cell lines]. Diplomarbeit. Stuttgart: Universität Hohenheim; Schröder G. Einfluss eines Extraktes aus Viscum album L. auf Induktion, Wachstum, DNSund Histongehalt von Crown-Gall-Tumoren [Influence of a Viscum album L. extract on induction, growth, DNA and histone content of crown gall tumours]. Dissertation. Stuttgart: Universität Hohenheim; Schuler W. Stabilitätsuntersuchungen an standardisierten Mistelextrakten (HELIXOR) durch verschiedene Elektrophoresetechniken u. in vitro-zellkultur (HeLa-Zellen) [Stability tests on standardized mistletoe extracts (HELIXOR) by different electrophoresis techniques and HeLa cell cultures in vitro]. Diplomarbeit. Reutlingen: Fachhochschule Reutlingen; Seifert G, Jesse P, Prokop A, Reindl T, Lobitz S, Laengler A, et al. Effective induction of apoptosis by mistletoe plant extracts in an acute lymphoblastic leukemia model. Blood 2006;108(11, Part 1): 533A. Seifert G, Jesse P, Laengler A, Reindl T, Lüth M, Lobitz S, et al. Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro. Cancer letters 2008;264(2): Seifert G, Jesse P, Längler A, Henze G, Prokop A. Experimental therapeutic efficacy of mistletoe plant extracts in acute lymphoblastic leukemia. 28. Deutscher Krebskongress. Onkologie 31[Suppl. 1], Ulrich W, Mechelke F. Reaktion der In-vitro-Kulturen von menschlichen Fibroblasten, HeLa- Zellen und von murinen L-Zellen bei Applikation eines Präparates aus Viscum album L. [Reaction of in vitro cultures of human fibroblasts, HeLa cells and murine L. cells on exposure to a Viscum album L. preparation]. Arzneimittel-Forschung/Drug Research 1980;30(10): Ulrich W. Reaktionen von normalen und transformierten Zellen in vitro bei der Applikation von Extrakten aus Viscum album L. [In vitro reaction of normal and transformed cells to the application of extracts from Viscum album L.]. Dissertation. Stuttgart: Universität Hohenheim; 1982.

7 page 7 of 31 b) in vivo Beuth J, Ko HL, Schneider H, Tawadros S, Kasper HU, Zimst H, et al. Intratumoral application of standardized mistletoe extracts down regulates tumor weight via decreased cell proliferation, increased apoptosis and necrosis in a murine model. Anticancer Res 2006;26(6B): Braun JM, Ko HL, Schierholz JM, Weir D, Blackwell CC, Beuth J. Application of standardized mistletoe extracts augments immune response and down regulates metastastic organ colonization in murine models. Cancer Letters 2001;170(1): Klett C. Charakterisierung dialysierbarer Komponenten eines Viscum album-extrakts mit immunmodulatorischer Wirkung auf die natürliche Antitumor-Zytotoxizität beim Menschen [Characteristics of dialysable components of a Viscum album extract showing immunomodulatory effects on the natural anti-tumour cytotoxicity in humans]. Dissertation. Tübingen: Eberhard-Karls-Universität; Klett CY, Anderer FA. Activation of natural killer cell cytotoxicity of human blood monocytes by a low molecular weight component. Arzneimittelforschung / Drug Research 1989;39(12): Klopp R, Niemer W, Goedings P, Schmidt W, Beuth J. Änderungen der Mikrozirkulation im Tumor und umgebenden Gewebe nach Anwendung von standardisiertem Mistelextrakt. [Microcirculatory changes in the tumour and surrounding tissue following administration of standardised mistletoe extract]. DZO 2003;35(1): Rehder D. Test on the influence of a mistletoe preparation on host resistance in C57BI/6 mice Report No.: Study Report H Seifert G, Jesse P, Prokop A, Reindl T, Lobitz S, Laengler A, et al. Effective induction of apoptosis by mistletoe plant extracts in an acute lymphoblastic leukemia model. Blood 2006;108(11, Part 1): 533A. Seifert G, Jesse P, Längler A, Henze G, Prokop A. Experimental therapeutic efficacy of mistletoe plant extracts in acute lymphoblastic leukemia. 28. Deutscher Krebskongress. Onkologie 31[Suppl. 1],

8 page 8 of 31 Seifert G, Jesse P, Laengler A, Reindl T, Lüth M, Lobitz S, et al. Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro. Cancer letters 2008;264(2): Steinberg F, Fuhrmann C, Schietzel M, Streffer C. Immunmodulatory Effect of ß- Galactoside-Specific Lectin (ML l) from Mistletoe Extract in Immunodeficient Nude Mice Bearing a Human Sarcoma. Contributions to Oncology 1992;42: Immunomodulation Berg PA, Stein GM. Beeinflusst die Misteltherapie die Abwehr epithelialer Tumoren? Eine kritische immunologische Analyse. [Does mistletoe therapy influence the defence against epithelial tumours? A critical immunological analysis]. Deutsche Medizinische Wochenschrift 2001;126(12): Uhlenbruck G. Interview: Mistelgesamtextrakt Helixor - Was ist immunologisch gesichert? [Aqueous mistletoe extract Helixor - What is immunologically proven?]. Praxis Magazin 2007;(10). a) in vitro Büssing A, Schietzel M. Viscum album L.: Individuelle Immunreaktionen und spezifische zytostatische Effekte - Konsequenzen für die konventionelle zytostatische Therapie? [Viscum album L. - Individual Immune Reactions and Specific Cytostatic Effects - Consequences for Conventional Cytostatic Treatment?]. DZO 1995;27(2): Elsässer-Beile U, Lusebrink S, Grussenmeyer T, Wetterauer U, Schultze-Seemann W. Comparison of the effects of various clinically applied mistletoe preparations on peripheral blood leukocytes. Arzneimittel-Forschung / Drug Research 1998;48(12): Hamprecht K, Anderer FA. Autolytic generation of dialysable components in extracts of viscum album exhibited different mechanisms of enhancement of human NK-cytotoxicity against tumor cells. International Journal of immunopathology and pharmacology 1990;3(2):

9 page 9 of 31 Heine H. Effects of Extracts from Mistletoe (Viscum album L.) on Tumor Mastcells. Referat: International Meeting on Viscum album, Heidelberg Heine H. Immunmodulation durch Leukozytolyse. Zur Bedeutung von Lektin-Polysaccharid- Komplexen. [Immunomodulation as a result of leucocytolysis. On the importance of lectinpolysaccharide complexes]. Beilage zur Zeitschrift Onkologie 1989;12(3): 5-8. Hülsen H, Kron R, Mechelke F. Influence of Viscum album Preparations on the Natural Killer Cell-Mediated Cytotoxicity of Peripheral Blood. Naturwissenschaften 1989;76: Klett C. Charakterisierung dialysierbarer Komponenten eines Viscum album-extrakts mit immunmodulatorischer Wirkung auf die natürliche Antitumor-Zytotoxizität beim Menschen [Characteristics of dialysable components of a Viscum album extract showing immunomodulatory effects on the natural anti-tumour cytotoxicity in humans]. Dissertation. Tübingen: Eberhard-Karls-Universität; Klett CY, Anderer FA. Activation of natural killer cell cytotoxicity of human blood monocytes by a low molecular weight component. Arzneimittelforschung / Drug Research 1989;39(12): Mueller EA, Anderer FA. A Viscum album oligosaccharide activating human natural cytotoxixity is an interferon-gamma-inducer. Cancer Immunology and Immunotherapy 1990;32: Pfüller G. Untersuchungen der Lektinbindung an immunakzessorische Zellen des humanen Lymphknotens - Ein Beitrag zur Frage der biologischen Wirksamkeit von Mistellektinen [Investigation of lectin binding to accessory immune cells of human lymph nodes - Contribution to the question of biological activity of mistletoe lectins]. Inaugural-Dissertation. Berlin: Fachbereich Humanmedizin, Freie Universität; Pfüller G, Niedobitek F, Pfüller U. Darstellung von Strukturen des humanen Lymphknotens durch lektinhaltige Mistelpräparate. [Staining of human lymph node by lectins, lectin subunits and commercial preparations of mistletoe]. In: Scheer R et al., editors. Die Mistel in der Tumortherapie - Grundlagenforschung und Klinik. Essen: KVC Verlag; S Schad-Wampula I. Einfluss eines Präparates aus Viscum album L. auf Interleukin 2- abhängige in vitro Langzeitkulturen von Mitogen-stimulierten normalen menschlichen peripheren Blutlymphozyten [Influence of a Viscum album L. preparation on interleukin-2- dependant in vitro long time cell cultures of normal human peripheral blood mononuclear cells stimulated by mitogen]. Diplomarbeit. Stuttgart: Fachbereich Biologie, Universität Hohenheim; 1986.

10 page 10 of 31 Schink M. Mistletoe therapy for human cancer: the role of the natural killer cells. Anti-Cancer Drugs 1997;8(Suppl. 1): S47-S51. Schink M, Borowski M. Zytotoxische Effekte von Mistellektinen und einem Mistelpräparat auf menschliche natürliche Killerzellen in vitro. [Cytotoxic effects of mistletoe lectins and of a mistletoe product on natural killer cells in vitro]. In: Scheer R et al., editors. Die Mistel in der Tumortherapie. Grundlagenforschung und Klinik. Essen: KVC Verlag; S Schmidt KH. Untersuchungen zur Wirkung von Mistelextrakt auf Chemotaxis und Chemolumineszenz polymorphkerniger Granulozyten in vitro. [Studies on the effect of mistletoe extract on the chemotactic activity and on chemiluminescence of polymorphonuclear leucocytes in vitro]. Planta Medica 1989;55(5): Stein GM, Pfüller U, Schietzel M. Viscotoxin-free aqueous extracts from European mistletoe (Viscum album L.) stimulate activity of human granulocytes. Anticancer Research 1999;19: Stein GM, Büssing A, Schietzel M. Activation of Dendritic Cells by an Aqueous Mistletoe Extract and Mistletoe Lectin-3 In Vitro. Anticancer Research 2002;22: b) in vivo Braun JM, Ko HL, Schierholz JM, Weir D, Blackwell CC, Beuth J. Application of standardized mistletoe extracts augments immune response and down regulates metastastic organ colonization in murine models. Cancer Letters 2001;170(1): Michel C. Test on the immunotoxicity of a mistletoe preparation - subcutaneous test (28 days) in BALB/c mice. Gronau: Vivo Science GmbH; Report No.: H Rehder D. Test on the immunotoxicity of a mistletoe preparation in BALB/c mice Report No.: Study Report H Rehder D. Test on the immunotoxicity of a mistletoe preparation - Subcutaneous test (28 days) in BALB/c mice Report No.: Study Report H Schink M. Mistletoe therapy for human cancer: the role of the natural killer cells. Anti-Cancer Drugs 1997;8(Suppl. 1): S47-S51.

11 page 11 of 31 Steinberg F, Fuhrmann C, Schietzel M, Streffer C. Immunmodulatory Effect of ß-Galactoside- Specific Lectin (ML l) from Mistletoe Extract in Immunodeficient Nude Mice Bearing a Human Sarcoma. Contributions to Oncology 1992;42: DNA-Protective Effects a) in vitro Büssing A, Azhari T, Ostendorp H, Lehnert A, Schweizer K. Viscum album L. Extracts Reduce Sister Chromatid Exchanges in Cultured Peripheral Blood Mononuclear Cells. European Journal of Cancer 1994;30a(12): Büssing A, Regnery A, Schweizer K. Effects of Viscum album L. on cyclophosphamidetreated peripheral blood mononuclear cells in vitro: sister chromatid exchanges and activation/proliferation marker expression. Cancer Letters 1995;94: Büssing A, Regnery A, Pfüller U, Schweizer K. The Antimutagenic Properties of Viscum Album (L.): What's up in Mistletoes? Journal of Cancer Research and Clinical Oncology 1995;121(Suppl. 2): A. Büssing A, Schietzel M, Regnery A, Schweizer K. The dual role of Viscum album L. effects: cytostatic and dna stabilizing properties. XVI European Congress of Allergology and Clinical Immunology ECACI ' ; Büssing A, Jurin M, Zarkovic N, Azhari T, Schweizer K. DNA-stabilisierende Wirkungen von Viscum album L. - Sind Mistelextrakte als Adjuvans während der konventionellen Chemotherapie indiziert? [DNA-stabilising effects of Viscum album L. - Are mistletoe extracts indicated as adjuvant treatment during conventional chemotherapy?]. Forsch Komplementärmed Klass Naturheilkd 1996;3(5): Büssing A, Koloch E, Schietzel M. Induction of Apoptosis and DNA-Stabilisation by Viscum Album L. Phytomedicine 1996;3(Suppl. I): 24. Büssing A, Jungmann H, Suzart K, Schweizer K. Suppression of Sister Chromatid Exchange-Inducing DNA Lesions in Cultured Pheripheral Blood Mononuclear Cells by Viscum Album L. Journal of experimental & clinical cancer research 1996;15(2):

12 page 12 of 31 Büssing A. DNA Stabilisierung und Apoptose-Induktion durch Viscum album L. [DNA stabilization and induction of apoptosis by Viscum album L. - postdoctoral thesis, University of Witten/Herdecke]. Habilitationsschrift. Witten/Herdecke: Fakultät für Medizin, Universität Witten/Herdecke; Hahn P. Durchflusscytometrische und cytogenetische Untersuchungen zur Wirkung von Mistelextrakten auf menschliche Zellkulturen [Flow cytometric and cytogenetic analysis of human cell cultures after exposure to mistletoe extracts]. Diplomarbeit. Kaiserslautern: Fachbereich Biologie, Universität Kaiserslautern; Hahn P. Apoptoseinduzierende und antimutagene Wirkung von Viscum album L. auf humane Zellkulturen [Induction of apoptosis and anti-mutagenic effects of Viscum album L. in human cell cultures]. Dissertation. Kaiserslautern: Fachbereich Biologie der Universität Kaiserslautern; Regnery A. Effekte von Viscum album L. -Extrakten auf Cyclophosphamid-behandelte mononukleäre Zellen des peripheren Blutes [Effects of Viscum album L. extracts on peripheral blood mononuclear cells treated with cyclophosphamide]. Dissertation. Aachen: Technische Hochschule; b) in vivo Auerbach L, Dostal V, Vaclavik-Fleck I, Kubista E, Rosenberger A, Rieger S, et al. Signifikant höherer Anteil aktivierter NK-Zellen durch additive Misteltherapie bei chemotherapierten Mamma-Ca-Patientinnen in einer prospektiv-randomisierten doppelblinden Studie. [Significantly higher levels of activated NK cells with supplemental mistletoe therapy in patients with breast cancer and chemotherapy in a prospective randomised, double-blind clinical study]. In: Scheer R et al., editors. Fortschritte in der Misteltherapie. Aktueller Stand der Forschung und klinische Anwendung. Essen: KVC-Verlag; S Anti-Angiogenesis a) in vitro Hong S, Chang S-Y, Yeom D-H, Kang J-H, Hong K-J. Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and Helixor A. Anticancer Drugs 2007;18(9):

13 page 13 of 31 Moon JM. Effect of mistletoe on vascular endothelial growth factor expression in endometrial stroma cells in patients with endometriosis Dissertation/Thesis. Seoul, Korea: Seoul National University; b) in vivo Klopp R, Niemer W, Goedings P, Schmidt W, Beuth J. Änderungen der Mikrozirkulation im Tumor und umgebenden Gewebe nach Anwendung von standardisiertem Mistelextrakt. [Microcirculatory changes in the tumour and surrounding tissue following administration of standardised mistletoe extract]. DZO 2003;35(1): Klopp R. Periodic alteration of characteristics in the microciculation of a tumor and surrounding tissue (results of an experimental study) Internationale Konferenz "Krebserkrankung und biologischer Rhythmus", , Leitung: Prof. Dr. Maximilian Moser, Graz. Referateband der Internationalen Konferenz "Krebserkrankung und biologischer Rhythmus" other a) in vitro Proft D, Bartholmes P. Biosynthesis of collagen in cultured human tumor tissue under the influence of Viscum album-extract (Abstract). Journal of Cancer Research and Clinical Oncology 1989;115(Suppl.): 36. Proft D. Einfluss eines Gesamtextrakts aus Viscum album L. auf den Kollagenstoffwechsel von peritumorösem, menschlichem Bindegewebe in Gewebekultur [Influence of a total extract of Viscum album L. on the collagen metabolism of cultured peritumoural human connective tissue]. Inaugural-Dissertation. Witten/Herdecke: Universität Witten/Herdecke; b) in vivo Aydogdu S, Kumbaraci M, Doganavsargil B, Can C, Sarsik B. Helixor versus Ilomedine in the treatment of osteonecrosis of femoral head. Experimental study in rabbits. The Journal of bone and joint surgery, 9th EFORT Congress Nice, France, Kumbaraci M. Femur Basi Avasküler Nekroz Tedavisinde Ilomedin Ve HELIXOR Etkinliklerinin Karsilastirilmasi (Deneysel Çalisma) [Treatment of aseptic necrosis of the femur head with Ilomedine versus HELIXOR in rabbits]. Dissertation. Izmir: T.C Ege Üniversitesi Tip Fakültesi Ortopedi ve Travmatoloji Anabilim Dalý;

14 page 14 of Toxicology a) in vitro Bernhardt A, Scheuenpflug J. HELIXOR A, HELIXOR M and HELIXOR P: Inhibitory effect on cytochrome P450 marker reactions. Martinsried: GenPharmTox Bio Tech AG; Report No.: Gritzko K. HELIXOR A, M and P: MTT Cytotoxicity Testing with Human Hepatocytes. Planegg: GenPharmTox BioTech AG; Report No.: Gritzko K, Krätzer F. HELIXOR A, M and P: In vitro mammalian Chromosome Aberration Test. Martinsried: GenPharmTox Bio Tech AG; Report No.: Grötsch W, Leimbeck R. Mutagenitätsprüfung von HELIXOR P im Ames Salmonella/Mikrosomen Platteninkorporationstest. [Mutagenicity Test of HELIXOR P in the Ames Salmonella/Microsome Plate Incorporation Test]. Bad Bocklet 1988: L+S GmbH; Report No.: Grötsch W, Leimbeck R. Mutagenitätsprüfung von HELIXOR M im Ames Salmonella/Mikrosomen Platteninkorporationstest. [Mutagenicity Test of HELIXOR M in the Ames Salmonella/Microsome Plate Incorporation Test]. Bad Bocklet: L+S GmbH; Report No.: Grötsch W, Leimbeck R. Mutagenitätsprüfung von HELIXOR A im Ames Salmonella/Mikrosomen Platteninkorporationstest. [Mutagenicity Test of HELIXOR A in the Ames Salmonella/Microsome Plate Incorporation Test]. Bad Bocklet: L+S GmbH; Report No.: Guenard J, Schneider H. Salmonella/Mammalian-Microsome Mutagenicity Test with HELIXOR P. Itingen: RCC AG (Research and Consulting Company AG); Report No.: Guenard J, Schneider K. Salmonella/Mammalian-Microsome Mutagenicity Test with HELIXOR M. Itingen: RCC AG (Research and Consulting Company AG); Report No.: Guenard J, Schneider K. Salmonella/Mammalian-Microsome Mutagenicity Test with HELIXOR A. Itingen: RCC AG (Research and Consulting Company AG); Report No.:

15 page 15 of 31 Tewes B. HELIXOR A, M and P: Measurement of Cytochrome P450 Induction on Enzyme Activity Level in Freshly Isolated Pre-plated Human Hepatocytes. Planegg: GenPharmTox Bio Tech AG; Report No.: b) in vivo Albrecht A, Haist I. Test for Sensitisation (Guinea-Pig Maximisation Test) with HELIXOR A. Planegg: BSL Bioservice; Report No.: Bomblies L, Oberstadt B. Intracutaneous Test with HELIXOR A According to ISO :2002 (E). Bad Bocklet: L+S AG; Report No.: Haist I, Albrecht A. Single Dose Local Tolerance Study in Rabbits with HELIXOR A (SC) Report, 1 st Amendment, Final Histopathology Report. Planegg: BSL Bioservice; Report No.: A. Haist I, Albrecht A. Single Dose Local Tolerance Study in Rabbits with HELIXOR A (IM) Report, Final Histopathology Report. Planegg: BSL Bioservice; Report No.: B. Michel C. Test on the immunotoxicity of a mistletoe preparation - subcutaneous test (28 days) in BALB/c mice. Gronau: Vivo Science GmbH; Report No.: H Micksche M. Toxizitätsstudie - HELIXOR. [Toxicity Study - HELIXOR ]. Wien: Institut für Krebsforschung [Institute for Cancer Research]; Report No.: no study no. Rehder D. Test on the immunotoxicity of a mistletoe preparation in BALB/c mice Report No.: Study Report H Rehder D. Test on the immunotoxicity of a mistletoe preparation - Subcutaneous test (28 days) in BALB/c mice Report No.: Study Report H Rehder D. Test on the influence of a mistletoe preparation on host resistance in C57BI/6 mice Report No.: Study Report H Sebestyén I, Hirka G. 90-Day Repeated Dose Subcutaneous Toxicity Study of Test Item HELIXOR A in Rats. Veszprém (Hungary): Toxicological Research Centre Ltd; Report No.: 03/ P.

16 page 16 of 31 Sterner W, Chibanguza G. Akute subcutane Toxizität an Ratten mit HELIXOR P 50 mg - Limit Test -. [Acute Subcutaneous Toxicity in Rats with HELIXOR P 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute subcutane Toxizität an Ratten mit HELIXOR A 50 mg - Limit Test -. [Acute Subcutaneous Toxicity in Rats with HELIXOR A 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute subcutane Toxizität an Ratten mit HELIXOR M 50 mg - Limit Test -. [Acute Subcutaneous Toxicity in Rats with HELIXOR M 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research]; Report No.: Sterner W, Chibanguza G. Akute intravenöse Toxizität an Ratten mit HELIXOR A 50 mg - Limit Test -. [Acute Subcutaneous Toxicity in Rats with HELIXOR A 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute intravenöse Toxizität an Mäusen mit HELIXOR A 50 mg - Limit Test -. [Acute Intravenous Toxicity in Mice with HELIXOR A 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute subcutane Toxizität an Mäusen mit HELIXOR A 50 mg - Limit Test -. [Acute Subcutaneous Toxicity in Mice with HELIXOR A 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute intravenöse Toxizität an Ratten mit HELIXOR M 50 mg - Limit Test -. [Acute Intravenous Toxicity in Rats with HELIXOR M 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute subcutane Toxizität an Mäusen mit HELIXOR P 50 mg - Limit Test -. [Acute Subcutaneous Toxicity in Mice with HELIXOR P 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute intravenöse Toxizität an Ratten mit HELIXOR P 50 mg - Limit Test -. [Acute Intravenous Toxicity in Rats with HELIXOR P 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute intravenöse Toxizität an Mäusen mit HELIXOR P 50 mg - Limit Test -. [Acute Intravenous Toxicity in Mice with HELIXOR P 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: Sterner W, Chibanguza G. Akute subcutane Toxizität an Mäusen mit HELIXOR M 50 mg - Limit Test -. [Acute Subcutaneous Toxicity in Mice with HELIXOR M 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.:

17 page 17 of 31 Sterner W, Chibanguza G. Akute intravenöse Toxizität an Mäusen mit HELIXOR M - Limit Test -. [Acute Intravenous Toxicity in Mice with HELIXOR M 50 mg - Limit Test -]. Walsrode: IBR (International Bio Research); Report No.: B. Clinical Publications 5. Clinical Pharmacology Studies Bartzsch OM. Verhalten zellulärer Immunparameter bei Patienten mit metastasierten und nicht-metastasierten Tumoren unter Viscum album Therapie mit definiertem Lektingehalt - Eine Pilotstudie [Behaviour of cellular immune parameters in patients with metastasised and nonmetastasised tumours receiving Viscum album therapy with a defined lectin content. Summary of a MD dissertation]. Inaugural-Dissertation. Witten/Herdecke: Universität Witten/Herdecke; Berg PA, Stein GM. Beeinflusst die Misteltherapie die Abwehr epithelialer Tumoren? Eine kritische immunologische Analyse. [Does mistletoe therapy influence the defence against epithelial tumours? A critical immunological analysis]. Deutsche Medizinische Wochenschrift 2001;126(12): Büssing A, Stumpf C, Stumpf RT, Wutte H, Schietzel M. Therapiebegleitende Untersuchung immunologischer Parameter bei Tumor-Patienten nach hochdosierter intravenöser Applikation von Viscum album L.-Extrakten. [On-treatment study of immunological variables in cancer patients following high-dose intravenous administration of Viscum album L. extracts]. Zeitschrift für Onkologie 1996;28(2): Büssing A, Rosenberger A, Stumpf C, Schietzel M. Entwicklung lymphozytärer Subpopulationen bei Tumorpatienten nach subkutaner Applikation von Mistelextrakten. [Development of lymphocyte subsets in tumour patients after subcutaneous administration of mistletoe extracts]. Forsch Komplementärmed Klass Naturheilkd 1999;6(4): Mansky P, Wallerstedt D, Monahan B, Lee C, Sannes T, Stagl J, et al. Phase I study of Mistletoe extract/gemcitabine combination treatment in patients with advanced solid tumors. 28. Deutscher Krebskongress. Onkologie 31[Suppl. 1], Mansky P, Wallerstedt DB, Sannes T, Johnson L, Blackman MR, Grem JL, et al. NCCAM/NCI phase I study of mistletoe extract and gemcitabine in patients with advanced solid tumors. J Clin Oncol 2010;28(15 suppl): 2559.

18 page 18 of 31 Mansky PJ, Grem J, Wallerstedt DB, Monahan BP, Blackman MR. Mistletoe and Gemcitabine in Patients with Advanced Cancer: A Model for the Phase I Study of Botanicals and Botanical-Drug Interactions in Cancer Therapy. Integrative Cancer Therapies 2003;2(4): Mansky PJ, Wallerstedt DB, Monahan BP, Lee C, Swain SM, Evande R, et al. Mistletoe extract/gemcitabine combination treatment: An interim report from the NCCAM/NCI phase I study in patients with advanced solid tumors. Journal of Clinical Oncology 2005;23(16S (June 1 Supplement), ASCO Annual Meeting Proceedings): No Paulsen-Preisfeld A. Die Wirkung von Extrakten der Mistel (Viscum album L.) auf die cytotoxische Aktivität des Komplementsystems beim Menschen [Effects of mistletoe extracts (Viscum album L.) on the cytotoxic complement activity in humans]. Diplomarbeit. Bielefeld: Fachbereich Biologie, Universität Bielefeld; Preisfeld A. Influence of aqueous mistletoe preparations on humoral immune parameters with emphasis on the cytotoxicity of human complement in breast cancer patients. Forsch Komplementärmed Klass Naturheilkd 1997;4: Schink M, Tröger W, Goyert A, Scheuerecker H, Selbmann HK, Glaser F. Zusammenhang der NK-Zellaktivität gegen autologe Tumor- und K562-Zellen mit dem klinischen Verlauf unter Misteltherapie. [Correlation of natural killer cell activity against autologous tumour cells and K562 cells with the clinical outcome of cancer patients during therapy with mistletoe extracts]. Forsch Komplementärmed Klass Naturheilkd 2006;13(3): Schultze J. Zelluläre Immunreaktionen bei mit einem Mistelextrakt therapierten Patienten [Cellular immune reactions in a patient treated with mistletoe extract]. Inaugural-Dissertation. Tübingen: Eberhard-Karls-Universität; Schultze JL, Stettin A, Berg PA. Demonstration of Specifically Sensitized Lymphocytes in Patients treated with an Aqueous Mistletoe Extract (Viscum Album L.). Klinische Wochenschrift 1991;69(9): Son GS, Ryu WS, Kim HY, Woo SU, Park KH, Bae JW. Immunologic response to mistletoe extract (Viscum album L.) after conventional treatment in patients with operable breast cancer. Journal of Breast Cancer 2010;13(1): Stein G. Untersuchungen zur Interaktion von Mistelantigenen mit dem Immunsystem - Analyse an gesunden Probanden und mit Mistelextrakten behandelten Patienten [Studies of the interaction of mistletoe antigens with the immune system - Analysis in healthy test persons and in patients treated with mistletoe extracts]. Dissertation. Tübingen: Eberhard-Karls-Universität; 1995.

19 page 19 of 31 Stein GM, Stettin A, Schultze J, Berg PA. Induction of anti-mistletoe lectin antibodies in relation to different mistletoe extracts. Anti-Cancer Drugs 1997;8(Suppl. 1): S57-S59. Stein GM, Berg PA. Modulation of Cellular and Humoral Immune Responses During Exposure of Healthy Individuals to an Aqueous Mistletoe Extract. European Journal of Medical Research 1998;3(6): Stein GM, Berg PA. Characterisation of immunological reactivity of patients with adverse effects during therapy with an aqueous mistletoe extract. European Journal of Medical Research 1999;4(5): Stein GM, Pfüller U, Berg PA. Recognition of different antigens of mistletoe extracts by antimistletoe lectin antibodies. Cancer Letters 1999;135(2): Stettin A, Schultze JL, Stechemesser E, Berg PA. Anti-Mistletoe Lectin Antibodies Are Produced in Patients During Therapy with Aqueous Mistletoe Extract Derived from Viscum album L. and Neutralize Lectin-Induced Cytotoxicity in Vitro. Klinische Wochenschrift 1990;68: Stettin A. Induktion spezifischer Immunreaktionen während der Behandlung mit wässrigem Mistelextrakt [Induction of specific immune reactions during treatment with aqueous mistletoe extract]. Inaugural-Dissertation. Tübingen: Eberhard-Karls-Universität; Stumpf C, Büssing A. Stimulation of antitumour immunity by intrapleural instillation of a Viscum album L. extract. Anti-Cancer Drugs 1997;8(Supplement 1): S23-S Clinical Efficacy Studies Auerbach L, Vaclavik-Fleck I, Dostal V, Kubista E. Significant higher level of activated NK-cells in patients with breast cancer receiving a Viscum album (mistletoe) extract during chemotherapy. 11th Annual Symposium on Complementary Health Care, , Exeter (UK). Focus on Alternative and Complementary Therapies 9[03-4]

20 page 20 of 31 Auerbach L, Dostal V, Vaclavik-Fleck I, Kubista E, Rosenberger A, Rieger S, et al. Signifikant höherer Anteil aktivierter NK-Zellen durch additive Misteltherapie bei chemotherapierten Mamma-Ca-Patientinnen in einer prospektiv-randomisierten doppelblinden Studie. [Significantly higher levels of activated NK cells with supplemental mistletoe therapy in patients with breast cancer and chemotherapy in a prospective randomised, double-blind clinical study]. In: Scheer R et al., editors. Fortschritte in der Misteltherapie. Aktueller Stand der Forschung und klinische Anwendung. Essen: KVC-Verlag; S Beuth J, Schierholz J, Schneider B. 34. Safety and efficacy of treatment of breast cancer patients with standardized mistletoe extract: A controlled multicenter comparative cohort study. Phytomedicine 2007;14(Suppl VII): 39. Beuth J, Schierholz J, Schneider B. Mistelextrakt in der Nachsorge von Mammakarzinompatientinnen. Erfahrungsheilkunde 2008;57: Beuth J, Schneider B, Schierholz JM. Impact of complementary treatment of breast cancer patients with standardized mistletoe extract during aftercare: a controlled multicenter comparative epidemiological cohort study. Anticancer Res 2008;28(1B): Beuth J, Schierholz JM, Schneider B. Unbedenklichkeit und Wirksamkeit der Behandlung mit einem standardisierten Mistelextrakt in der Nachsorge von Mammakarzinom- Patientinnen - Eine retrospektive, kontrollierte, epidemiologische Kohortenstudie. [Safety and efficacy of complementary treatment of breast cancer patients with standardized mistletoe extract in the aftercare period - a retrospective, controlled epidemiological cohort study]. In: Scheer R et al., editors. Die Mistel in der Tumortherapie 2. Essen: KVC Verlag; S Boie D, Gutsch J. Helixor bei Kolon- und Rektumkarzinom. [Helixor in the treatment of cancers of the colon and rectum]. In: Denck H et al., editors. Kolo-rektale Tumoren. Heidelberg: Verlag für Medizin Dr. Ewald Fischer; S Boie D, Gutsch J, Burkhardt R. Die Behandlung von Lebermetastasen verschiedener Primärtumoren mit Helixor. [Treatment of liver metastases from various primary tumours with Helixor]. Therapiewoche 1981;31: Douwes FR, Wolfrum DI, Migeod F. Ergebnisse einer prospektiv randomisierten Studie: Chemotherapie versus Chemotherapie plus "Biological Response Modifier" bei metastasierendem kolorektalem Karzinom. [Results of a prospective randomised study on chemotherapy versus chemotherapy plus "biological response modifiers" in metastatic colorectal carcinoma]. Krebsgeschehen 1986;18(6):

21 page 21 of 31 Douwes FR, Kalden M, Frank G, Holzhauer P. Behandlung des fortgeschrittenen kolorektalen Karzinoms. [Treatment of the advanced colorectal carcinoma]. DZO 1988;20(3): Gutsch J. Zum Stand der Therapie der chronisch myeloischen Leukämie Erwachsener mit dem Mistelpräparat HELIXOR. [On the state of therapy for chronic myeloid leukaemia in adults with the mistletoe preparation HELIXOR ]. Ärztezeitschrift für Naturheilverfahren 1982;23(9): Gutsch J, Berger H, Scholz G, Denck H. Prospektive Studie beim radikal operierten Mammakarzinom mit Polychemotherapie, HELIXOR und unbehandelter Kontrolle. [Prospective study on radically operated breast cancer with polychemotherapy, HELIXOR and untreated control]. DZO 1988;20(4): Hellan J, Salzer G, Wutzlhofer F. Das operierte Mammakarzinom - Retrospektive Auswertung. [The operated breast cancer - retrospective evaluation]. In: Jungi WF et al., editors. Krebs und Alternativmedizin II. Berlin: Springer; S Hellan J, Danmayr E, Hellan M. Stellenwert der Komplementärmedizin in der Behandlung onkologischer Patienten - dargestellt anhand des kolo-rektalen Karzinoms. [Status of complementary medicine in the treatment of oncology patients - illustrated on the basis of the colorectal carcinoma]. DZO 1995;27(4): Hollinsky C, Danmayr E. Prognose des kleinen Mammakarzinoms (T1 N0) - Retrospektive Analyse anhand von 516 Fällen. [Prognosis of small breast cancer (T1 N0). Retrospective analysis of 516 cases]. DZO 1987;19(3): Kim MH, Park YK, Lee SH, Kim SC, Lee SY, Kim CH, et al. Comparative Study on the Effects of a Viscum album (L.) Extract (Mistletoe) and Doxycycline for Pleurodesis in Patients with Malignant Pleural Effusion. Korean Journal of Medicine 1999;57(Suppl. II): S121. Klose C, Jensen K, Herzig M, Mansmann U. Multicentric, randomized, open, prospective clinical trial for the investigation of efficacy and tolerance and adverse drug reactins of HELIXOR A in comparison to LENTINAN in patients with non small cell lung cancer, breast cancer or ovarian cancer. Forschungsberichte der Abteilung medizinische Biometrie, Universität Heidelberg, Institut für medizinische Biometrie und Informatik der Medizinischen Fakultät der Ruprecht-Karls-Universität Heidelberg; Report No.: 45.

22 page 22 of 31 Lange O, Scholz G, Gutsch J. Modulation der subjektiven und objektiven Toxizität einer aggressiven Chemo/Radiotherapie mit HELIXOR. [Modulation of the subjective and objective toxicity of aggressive chemo-/radiotherapy with HELIXOR ]. Studienbericht 1985; 1-8. Matthes H, Piao BK, Wang YX, Xie GR, Mansmann U, Beuth J, et al. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and nonsmall cell lung cancer patients. A prospective randomized controlled clinical trial. Journal of Cancer Research and Clinical Oncology 2004;130(Supplement 1): AS919. Piao BK, Wang YX, Xie GR. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Alternative Medicine Review 2004;9(2): 219. Piao BK, Wang YX, Xie GR, Mansmann U, Matthes H, Beuth JL. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Research 2004;24(1): Salzer G, Frey S, Danmayr E. Die Behandlung des operierten Magenkarzinoms am Ludwig Boltzmann Institut für Klinische Onkologie. [Treatment of the operated stomach carcinoma at the Ludwig Boltzmann Institute for Clinical Oncology, Vienna]. DZO 1990;22(1): Salzer G, Hellan J, Danmayr E, Wutzlhofer F, Arbeiter K. Das operierte kolorektale Karzinom - Eine retrospektive Therapieanalyse. [The operated colorectal cancer - a retrospective therapy analysis]. DZO 1992;24(4): Stumpf C, Schietzel M. Intrapleurale Instillation eines Extraktes aus Viscum album (L.) zur Behandlung maligner Pleuraergüsse. [Intrapleural instillation of a Viscum album (L.) extract (mistletoe) for the treatment of malignant pleural effusions]. Tumordiagnostik und Therapie 1994;15(2): Stumpf C, Rosenberger A, Rieger S, Tröger W, Schietzel M. Therapie mit Mistelextrakten bei malignen hämatologischen und lymphatischen Erkrankungen - eine monozentrische retrospektive Analyse über 16 Jahre. [Therapy with mistletoe in malignant haematological and lymphatic diseases - a single-centre retrospective analysis over 16 years]. Forsch Komplementärmed Klass Naturheilkd 2000;7(3): Stumpf C, Rosenberger A, Rieger S, Tröger W, Schietzel M, Stein GM. Retrospektive Untersuchung von Patienten mit malignem Melanom unter einer Misteltherapie. [Retrospective study of malignant melanoma patients treated with mistletoe products]. Forsch Komplementärmed Klass Naturheilkd 2003;10(5):

23 page 23 of 31 Stumpf C, Rieger S, Schietzel M. Retrospektive Untersuchung zur Therapie mit Mistelextrakten bei Mammakarzinom. [Retrospective study of breast cancer patients treated with mistletoe extracts]. DZO 2005;37(3): Stumpf C, Rieger S, Fischer IU, Schietzel M. Retrospektive Untersuchung zur Therapie mit Mistelextrakten bei Patienten mit kolorektalem Karzinom. [Retrospective study of treatment with mistletoe extracts in patients with colorectal cancer]. DZO 2007;39(1): Stumpf C, Rieger S, Fischer IU, Schierholz J, Schietzel M. 37. Comparison of survival time in patients with different tumour entities: Retrospective efficacy investigations of mistletoe therapy vs. data of a tumour registry. Phytomedicine 2007;14(Suppl VII): 42. Stumpf C, Rieger S, Fischer IU, Schierholz JM, Schietzel M. Vergleich der Überlebenszeit bei Patienten mit verschiedenen Tumorentitäten - Retrospektive Untersuchung zur Wirksamkeit von Misteltherapie vs. Daten eines Tumorregisters.In: Scheer R et al., editors. Die Mistel in der Tumortherapie 2. Essen: KVC Verlag; S Stumpf MC. Intrapleurale Instillation eines Extraktes aus Viscum album L. (HELIXOR) zur Behandlung maligner Pleuraergüsse. Eine prospektive Untersuchung [Intrapleural instillation of a Viscum album L. extract (HELIXOR) for treatment of malignant pleural effusions. A prospective study]. Inaugural-Dissertation. Witten/Herdecke: Universität Witten/Herdecke; Tröger W. 32. Additional therapy with mistletoe extracts in breast cancer patients receiving chemotherapy. A prospective randomized open label pilot study. Phytomedicine 2007;14(Suppl VII): 36. Tröger W, Matijasevic M, Zdrale Z, Tisma N, Jezdic S. Additional therapy with mistletoe extracts in breast cancer patients receiving chemotherapy a prospective randomized open label pilot study.in: Scheer R et al., editors. Die Mistel in der Tumortherapie 2. Essen: KVC Verlag; S Tröger W. Helixor - Therapy during chemotherapy. Results of a randomized clinical trial. Onkologie 2010;33(suppl. 2): 34.