Max-Planck-Institut für Stoffwechselforschung

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1 Max-Planck-Institut für Stoffwechselforschung Address Gleueler Straße Köln Deutschland Telephone Fax Website Homepage Projects

2 Research Grants Molecular imaging of neural stem cell differentiation - a novel quantitative and noninvasive approach using imaging reporters (Applicant Aswendt, Markus ) Netzwerk-abhängige Ausbreitung der Tau-Pathologie bei der Alzheimer Erkrankung (Applicant Drzezga, Alexander ) Completed projects Analyse der Rolle von Tyrosinkinasen der Insulinrezeptorfamilie in Lymphozytendifferenzierung und -funktion (Applicant Brüning, Jens Claus ) Bildgesteuerte Behandlung rezidivierender maligner Gliome: Prospektive klinische Phase I/II Studie zur intratumoralen Infusion (Convection Enhanced Delivery) von Gemcitabin (Applicant Voges, Jürgen ) Mechanisms of insulin signal transduction in macrophages in the development of diabetic neovasculatization of the retina (Applicant Brüning, Jens Claus ) Rolle des Insulin/IGF-1-regulierten forkhead Transkriptionsfaktors (FOXO)-1 bei der Kontrolle der Barriere-Funktion der Haut und bei der Entwicklung Diabetes-assoziierter Hauterkrankungen (Applicant Brüning, Jens Claus ) Synthese und Radiopharmakologie von Substraten der HSV-1 Thymidinkinase für den nicht-invasiven in vivo Nachweis von Genexpression (Applicant Jacobs, Andreas H. ) Zerebrale Acetylcholinesterase-Verteilung (AChE) bei Patienten mit posttraumatischer Belastungsstörung (PTSD) (Applicant Herholz, Karl ) Independent Junior Research Groups Non-Coding RNAs and Brown Adipose Tissue (BAT) (Applicant Kornfeld, Jan-Wilhelm ) Collaborative Research Centres

3 Metabolic control of skin morphogenesis, barrier function and development of diabetes associated skin complications (Project leaders Brüning, Jens Claus ; Niessen, Carien ) Role of mitochondrial dynamics and substrate utilisation in anorexigenic POMC-neurons (Project leaders Brüning, Jens Claus ; Horvath, Tamas L. ) SFB 829: Molecular Mechanisms Regulating Skin Homeostasis (Spokespersons Krieg, Thomas ; Niessen, Carien ) SFB 1218: Mitochondrial regulation of cellular function (Spokesperson Langer, Thomas )

4 Completed projects Central cell culture and transgenic mouse facility (Project leaders Brüning, Jens Claus ; Haase, Ingo ; Pasparakis, Ph.D., Manolis ) Core facility mouse (Project leaders Brüning, Jens Claus ; Tüting, Thomas ) IL-6 type cytokines originated from the tumor microenvironment affecting NK-T cells in the development of hepatocellular carcinoma in vivo (Project leader Wunderlich, Ph.D., Frank Thomas ) Molecular imaging of interactions between the tumor environment and tumor growth (Project leaders Neumaier, Bernd ; Persigehl, Thorsten ; Ullrich, Ph.D., Roland Tillmann ) Posttranslationale Modifikation des Insulin-Signaltransduktionsweges in vivo Rezirkulationsstörungen nach fokaler zerebraler Ischämie (Project leaders Hoehn, Mathias ; Hossmann, Konstantin-Alexander ) Role of BAX-inhibitors (BI-1) in the pathogenesis of atherosclerosis Role of insulin signal transduction in the regulation of innate immune response SFB 832: Molecular Basis and Modulation of Cellular Interactions in the Tumour Microenvironment (Spokesperson Hallek, Michael ) Validating therapeutic anti-angiogenic targets by a combined chemical genetics and imaging approach (Project leaders Thomas, Roman ; Ullrich, Ph.D., Roland Tillmann ; Wolf, Jürgen )

5 CRC/Transregios Brain systems involved in food intake - a neuroimaging approach (Project leaders Münte, Thomas F. ; Schweiger, Ulrich ; Tittgemeyer, Marc ) Defining insulin targets in control of feeding-associated reward behaviour Generation of a reference cohort with extreme eating behaviour (Project leaders Brabant, Georg ; Brüning, Jens Claus ; Kasten, Meike ; Klein, Christine ; Krämer, Ulrike M. ) Inflammatory signalling in the hedonic regulation of feeding (Project leaders Schwaninger, Markus ; Wunderlich, Ph.D., Frank Thomas ) Role of orexin signalling in energy homeostasis and reward processing (Project leaders Hausen, Anne Christine ; Jöhren, Olaf ) TRR 134: Ingestive Behaviour: Homeostasis and Reward (Spokesperson Lehnert, Hendrik ) Untersuchungen zur hormonellen Modulation dopaminerger Mechanismen von impulsivem Verhalten (Project leaders Stephan, Ph.D., Klaas Enno ; Tittgemeyer, Marc ) Clinical Research Units Elucidation of the PI3K/AKT pathway in the transformation and progression of CLL (Applicants Pallasch, Christian Philipp ; Wunderlich, Ph.D., Frank Thomas ) KFO 286: Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia (Spokesperson Hallek, Michael ) Completed projects Kernspintomographische und modell-basierte Differenzierung von Subtypen des Morbus Parkinson unter besonderer Brücksichtigung der Basalganglien-Konnektivität (Applicant Tittgemeyer, Marc )

6 Major Equipment Action Completed projects Hochauflösende bildgebende Massenspektrometrie von Neuropeptiden in dynamischen Systemen (Applicant Predel, Reinhard ) Research Training Groups GRK 1960: Neural Circuit Analysis on the Cellular and Subcellular Level (Spokesperson Büschges, Ansgar ) Clusters of Excellence EXC 229: Cellular Stress Responses in Aging-Associated Diseases (Spokesperson Brüning, Jens Claus ) Subinstitutions Abteilung für Neurologie GEPRIS is a project of the Deutsche Forschungsgemeinschaft (DFG) Contact GEPRIS at (c) Deutsche Forschungsgemeinschaft (