Ansgar Klimke, Prof. Dr. med.

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1 VITOS Klinikum Hochtaunus, Psychiatry and Psychotherapy Emil-Sioli-Weg Friedrichsdorf Germany Website: Ansgar Klimke, Prof. Dr. med. Research Experience Apr 2012 present Jan 2005 Mar 2012 Jan 1997 Dec 2004 Medical Director Vitos Klinikum Hochtaunus, Psychiatry and Psychotherapy, Head of Department Klinikum Offenbach GmbH, Psychiatry and Psychotherapy Offenbach, Germany Senior House Officer Universitätsklinikum Düsseldorf, Klinik und Poliklinik für Psychiatrie und Psychotherapie der HHU, Rheinische Kliniken Düsseldorf Düsseldorf, Germany Statistics RG Score Publications 150 Reads 4,577 Citations 1634 Awards & Grants Skills & Activities Skills Serotonin, Psychiatry, Neuropsychopharmacology, Neuroscience, Biological Psychology, Dopamine, Neurobiology, PFC, Functional Neuroscience, Behavioural Science, Psychopathology, Cognitive Psychology, Cognitive Neuroscience, Psychotherapy, Bipolar Disorder, Schizophrenia, Mental Illness, Clinical Psychiatry, Psychopharmacology, Psychotherapeutic Processes, Biological Psychiatry, Psychiatric Epidemiology, Antidepressive Agents, Treatment, Psychiatric Genetics, Clinical Assessment, Forensic Psychology,

2 Cognitive Science, Antidepressants, Neuropsychiatry, Imaging Genetics, Psychological Assessment Languages English, German Books Wolfgang Gaebel, Ansgar Klimke: Neuroleptika bei nichtpsychotischen Störungen: Grundlagen und Indikationen. 01/1999;, ISBN: , DOI: / Book Chapters A. Klimke, M. v. Wilmsdorff: Medikamentöse Behandlung psychotrope Nebenwirkungen von Nichtpsychopharmaka. Psychiatrie in der klinischen Medizin, 01/2004: pages ;, DOI: / _8 A. Klimke, S. Löffler, K. Fehsel, U. Henning: Neue Forschungsergebnisse zur Clozapin-induzierten Agranulozytose. Leponex, 01/2001: pages 21-29;, ISBN: , DOI: / _3 A. Klimke, Wolfgang Gaebel: Der Einsatz von Neuroleptika bei nicht schizophrenen Erkrankungen. Neuroleptika bei nichtpsychotischen Störungen, 01/1999: pages 1-14;, ISBN: , DOI: / _1 A. Klimke: Anwendung von neuen Neuroleptika bei nicht schizophrenen Erkrankungen. Neuroleptika bei nichtpsychotischen Störungen, 01/1999: pages 43-62;, ISBN: , DOI: / _4 K. Heininger, W. Gaebel, A. Klimke, J. Fritze: Pharmakologie. Neuro-Psychopharmaka Ein Therapie- Handbuch, 01/1998: pages ;, ISBN: , DOI: / _3 K. Heininger, A. Klimke, W. Gaebel, B. Bandelow, E. Rüther, E. Klieser, W. Lemmer: Butyrophenone und strukturanaloge Verbindungen. Neuro-Psychopharmaka Ein Therapie-Handbuch, 01/1998: pages ;, ISBN: , DOI: / _7 A. Klimke, W. Lemmer, E. Klieser: Clozapin in der Rezidivprophylaxe schizophrener Psychosen. Aktuelle Perspektiven der Biologischen Psychiatrie, 01/1996: pages ;, ISBN: , DOI: / _79 W. Mess, A. Klimke, N. Saimeh, E. Klieser: Fallbericht: Paradoxe Hirnembolie als Komplikation der Elektrokrampfbehandlung. Aktuelle Perspektiven der Biologischen Psychiatrie, 01/1996: pages ;, ISBN: , DOI: / _54 C. Boy, A. Klimke, W. Gaebel, H. W. Müller-Gärtner: In-vivo-Charakterisierung des zentralen dopaminergen Systems bei Schizophrenie mit Hilfe der Positronen-Emissionstomographie (PET). Aktuelle Perspektiven

3 der Biologischen Psychiatrie, 01/1996: pages ;, ISBN: , DOI: / _62 A. Klimke: Dopaminerges System und Verhalten: Zur psychopathologischen Relevanz cortico-striato-thalamocorticaler Circuits. Aktuelle Perspektiven der Biologischen Psychiatrie, 01/1996: pages ;, ISBN: , DOI: / _60 W. Mess, A. Klimke, E. Klieser: Untersuchungen mit der transkraniellen Dopplersonografie bei Elektrokrampfbehandlung. Aktuelle Perspektiven der Biologischen Psychiatrie, 01/1996: pages ;, ISBN: , DOI: / _46 A. Klimke, E. Klieser: Differentielle Psychopharmakotherapie bei stationären suizidalen Patienten. Suizidalität, 01/1996: pages ;, ISBN: , DOI: / _10 A. Klimke, E. Klieser, W. Lemmer: Clozapin in der Rezidivprophylaxe. Clozapin Pharmakologie und Klinik eines atypischen Neuroleptikums, 01/1995: pages 81-92;, ISBN: , DOI: / _7 Priv.-Doz. Dr.med. E. Klieser, A. Klimke: Zur Wirksamkeit der substituierten Diphenylbutylpiperidine auf schizophrene Negativsymptomatik. Fortschritte in der Diagnostik und Therapie schizophrener Minussymptomatik, 01/1994: pages ;, DOI: / _20 W. Gaebel, A. Klimke, E. Klieser: Kombination von Clozapin mit anderen Psychopharmaka. Clozapin Pharmakologie und Klinik eines atypischen Neuroleptikums, 01/1994: pages 43-58;, ISBN: , DOI: / _6 Dr. B. Schmitz, W. Lemmer, A. Klimke, E. Klieser: Zur Wirksamkeit von Roxindol bei gehemmt depressiven Patienten. Biologische Psychiatrie der Gegenwart, 01/1993: pages ;, ISBN: , DOI: / _80 Dr. A. Klimke, E. Klieser, B. Schmitz: Zur Behandlung schizophrener Negativsymptome mit neuen Dopaminagonisten. Biologische Psychiatrie der Gegenwart, 01/1993: pages ;, ISBN: , DOI: / _27 Dr. A. Klimke, E. Klieser: Der Einfluß von Narkosemittel und Benzodiazepin-Begleitmedikation auf die Wirksamkeit der Neuroelektrischen Therapie (NET). Biologische Psychiatrie der Gegenwart, 01/1993: pages ;, ISBN: , DOI: / _160 PD Dr. E. Klieser, E. Lehmann, W. Lemmer, W. H. Strauß, A. Klimke: Experimenteller Wirkungs- und Verträglichkeitsvergleich von Zotepin und Haloperidol bei akuter Schizophrenie. Biologische Psychiatrie der Gegenwart, 01/1993: pages ;, ISBN: , DOI: / _29 A. Klimke, E. Klieser, M. Klimke: Zur Wirksamkeit der neuroelektrischen Therapie bei therapieresistenten schizophrenen Psychosen. Therapieresistenz unter Neuroleptikabehandlung, 01/1993: pages ;, ISBN: , DOI: / _15 A. Klimke, E. Klieser: Dopaminagonisten zur Schizophrenie-Behandlung: Ein neues therapeutisches Wirkprinzip?. Biologische Psychiatrie, 01/1992: pages ;, ISBN: , DOI: / _48

4 A. Klimke, E. Klieser: Zur Wirksamkeit der neuroelektrischen Therapie bei Therapieresistenz. Biologische Psychiatrie, 01/1992: pages ;, ISBN: , DOI: / _17 A. Klimke, E. Klieser: The Treatment of Positive and Negative Schizophrenic Symptoms with Dopamine Agonists. Negative Versus Positive Schizophrenia, 01/1991: pages ;, ISBN: , DOI: / _23 Eckhard Klieser, Ansgar Klimke: Neue Substanzen mit Wirkung auf Serotoninrezeptoren. Serotonin ein funktioneller Ansatz für die psychiatrische Diagnose und Therapie?, 01/1991: pages ;, ISBN: , DOI: / _14 Journal Publications Gudrun Hefner, Martina Hahn, Matthias Hohner, Sybille C. Roll, Ansgar Klimke, Christoph Hiemke: QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients. Pharmacopsychiatry 02/2018;, DOI: /s Gudrun Hefner, Martina Hahn, Sibylle C. Roll, Christoph Hiemke, Ansgar Klimke: Application of the GerontoNet ADR Risk Score in a Psychiatric Setting (in press). Judith Koppehele-Gossel, Karin Schermelleh-Engel, Ansgar Klimke, Ursula Voss: A template model of embodiment while dreaming: Proposal of a mini-me. Consciousness and Cognition 11/2016; 46: , DOI: /j.concog Ansgar Klimke, Michael A. Nitsche, Konrad Maurer, Ursula Voss: Case Report: Successful Treatment of Therapy-Resistant OCD With Application of Transcranial Alternating Current Stimulation (tacs). Brain Stimulation 03/2016; 9(3)., DOI: /j.brs Wolfgang Gaebel, Mathias Riesbeck, Wolfgang Wölwer, Ansgar Klimke, Matthias Eickhoff, Martina von Wilmsdorff, Walter de Millas, Wolfgang Maier, Stephan Ruhrmann, Peter Falkai, Heinrich Sauer, Andrea Schmitt, Michael Riedel, Stefan Klingberg, Hans-Jürgen Möller: Predictors for symptom reexacerbation after targeted stepwise drug discontinuation in first-episode schizophrenia. Schizophrenia Research 11/2015; 170(1)., DOI: /j.schres J Wolff, M Berger, C Normann, F Godemann, I Hauth, A Klimke, M Löhr: [Where is convergence of psychiatry budgets leading to? A comparison of staffing regulations and actual personnel resources]. Der Nervenarzt 04/2015; 86(7)., DOI: /s z A Klimke, F Godemann, I Hauth, A Deister: Strukturqualität in psychiatrischen und psychotherapeutischen Kliniken. Der Nervenarzt 04/2015; 86(5)., DOI: /s M Berger, J Wolff, C Normann, F Godemann, E Schramm, A Klimke, A Heinz, S C Herpertz: [Guidelineadherent psychiatric-psychotherapeutic hospital care: Normative definition of staff required using the example of depression]. Der Nervenarzt 04/2015; 86(5)., DOI: /s Frank Godemann, Ansgar Klimke: TEPPkonkret. Psych Pflege Heute 05/2014; 20(03): , DOI: /s Ursula Voss, Romain Holzmann, Allan Hobson, Walter Paulus, Judith Koppehele-Gossel, Ansgar Klimke, Michael A Nitsche: Induction of self awareness in dreams through frontal low current stimulation of gamma activity. Nature Neuroscience 05/2014; 17(6)., DOI: /nn.3719

5 U Voss, S Bischofberger, A Klimke: Nightmares in PTSD. Klinische Neurophysiologie 03/2014; 45(01)., DOI: /s A. Klimke, R. Bader, R. Berton, M. Borrmann-Hassenbach, T. Brobeil, R. Nitschke, G. Reitel, M. Schillinger, F. Godemann: Vergütungssystem für Psychiatrie und Psychosomatik: Studie zur Machbarkeit eines tageskostenbasierten Entgeltsystems. Der Nervenarzt 01/2014; 85(1)., DOI: /s Anja Cerovecki, Richard Musil, Ansgar Klimke, Florian Seemüller, Ekkehard Haen, Rebecca Schennach, Kai-Uwe Kühn, Hans-Peter Volz, Michael Riedel: Withdrawal Symptoms and Rebound Syndromes Associated with Switching and Discontinuing Atypical Antipsychotics: Theoretical Background and Practical Recommendations. CNS Drugs 07/2013; 27(7)., DOI: /s Wolfgang Gaebel, Mathias Riesbeck, Wolfgang Wölwer, Ansgar Klimke, Matthias Eickhoff, Martina von Wilmsdorff, Isabella Heuser, Wolfgang Maier, Joachim Klosterkötter, Peter Falkai, Ralf Schlösser, Andrea Schmitt, Michael Riedel, Stefan Klingberg, Wolfgang Köpcke, Christian Ohmann, Hans- Jürgen Möller: Rates and predictors of remission in first-episode schizophrenia within 1year of antipsychotic maintenance treatment. Results of a randomized controlled trial within the German Research Network on Schizophrenia. Schizophrenia Research 05/2013; 152(2-3)., DOI: /j.schres Joachim Cordes, Johanna Th Nker, Gunnar Regenbrecht, J Rgen Zielasek, Christoph U Correll, Christian Schmidt-Kraepelin, Christian Lange-Asschenfeldt, Marcus W Agelink, Kai G Kahl, Wolfgang Gaebel, Ansgar Klimke, Hans Hauner: Can an early weight management program (WMP) prevent olanzapine (OLZ)-induced disturbances in body weight, blood glucose and lipid metabolism? Twenty-fourand 48-week results from a 6-month randomized trial. The World Journal of Biological Psychiatry 07/2011; 15(3)., DOI: / Jaroslav Malevani, Thomas Schillen, Rolf Speier, Dyrk Zedlick, Christian Kieser, Ansgar Klimke: Do the New German OPS Codes Map the Relevant Therapeutic Activities in Psychiatric Clinics?. Psychiatrische Praxis 05/2011; 38(4):e1-9., DOI: /s Joachim Cordes, Kai G Kahl, Christian Werner, Uwe Henning, Gunnar Regenbrecht, Rolf Larisch, Christian Schmidt-Kraepelin, Johanna Thünker, Marcus W Agelink, Stefan Löffler, Thomas Hohlfeld, Wolfgang Gaebel, Ansgar Klimke: Clomipramine-induced serum prolactin as a marker for serotonin and dopamine turnover: Results of an open label study. European Archives of Psychiatry and Clinical Neuroscience 03/2011; 261(8): , DOI: /s y Wolfgang Gaebel, Mathias Riesbeck, Wolfgang Wölwer, Ansgar Klimke, Matthias Eickhoff, Martina von Wilmsdorff, Matthias Lemke, Isabella Heuser, Wolfgang Maier, Wolfgang Huff, Andrea Schmitt, Heinrich Sauer, Michael Riedel, Stefan Klingberg, Wolfgang Köpcke, Christian Ohmann, Hans- Jürgen Möller: Relapse Prevention in First-Episode Schizophrenia Maintenance vs Intermittent Drug Treatment With Prodrome-Based Early Intervention. The Journal of Clinical Psychiatry 02/2011; 72(2): , DOI: /JCP.09m05459yel Stefan Löffler, Ansgar Klimke, Ralf Kronenwett, Guido Kobbe, Rainer Haas, Karin Fehsel: Clozapine Mobilizes CD34(+) Hematopoietic Stem and Progenitor Cells and Increases Plasma Concentration of Interleukin 6 in Patients With Schizophrenia. Journal of clinical psychopharmacology 10/2010; 30(5):591-5., DOI: /JCP.0b013e3181eeb7f7

6 Ansgar Klimke, Renate Engfer, Manfred Bauer: [A new reimbursement system for psychiatry and psychosomatic medicine--a chance for a more equitable remuneration or beginning of the end of regional full coverage?]. Psychiatrische Praxis 03/2010; 37(2):92., DOI: /s Stefan Löffler, Mignon Löffler-Ensgraber, Karin Fehsel, Ansgar Klimke: Clozapine therapy raises serum concentrations of high sensitive C-reactive protein in schizophrenic patients. International clinical psychopharmacology 03/2010; 25(2):101-6., DOI: /YIC.0b013e fd Joachim Cordes, Rolf Larisch, Uwe Henning, Johanna Thünker, Christian Werner, Guillermo Orozco, Fermín Mayoral, Fabio Rivas, Georg Auburger, Marco Tosch, Marcella Rietschel, Wolfgang Gaebel, Hans-Wilhelm Müller, Ansgar Klimke: Abnormal neuroendocrine response to clomipramine in hereditary affective psychosis. Depression and Anxiety 08/2009; 26(8):E111-9., DOI: /da J. Cordes, A. Sinha-Röder, K. Kahl, J. Malevani, J. Thuenker, C. Lange-Asschenfeldt, H. Hauner, M. Agelink, A. Klimke: Möglichkeiten des Gewichtsmanagements in der Behandlung schizophrener Psychosen mit atypischen Antipsychotika. Fortschritte der Neurologie Psychiatrie 12/2008; 76(12): , DOI: /s Stefan Löffler, Joachim Cordes, Peter Danos, Ansgar Klimke: Letter to the Editor Ziprasidone Might Prevent Life-Threatening Hypo and Hyperthermia Induced by Antipsychotics. Wolfgang Wölwer, Jürgen Brinkmeyer, Mathias Riesbeck, Lena Freimüller, Ansgar Klimke, Michael Wagner, Hans-Jürgen Möller, Stefan Klingberg, Wolfgang Gaebel: German Study Group on First Episode Schizophrenia. Neuropsychological impairments predict the clinical course in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 11/2008; 258 Suppl 5(S5):28-34., DOI: /s J Cordes, A Sinha-Röder, K G Kahl, J Malevani, J Thuenker, C Lange-Asschenfeldt, H Hauner, M W Agelink, A Klimke: [Therapeutic options for weight management in schizophrenic patients treated with atypical antipsychotics].. Fortschritte der Neurologie Psychiatrie 11/2008; 76(12): Stefan Löffler, Peter Danos, Thomas B Schillen, Ansgar Klimke: [Recurrent dysregulation of body temperature during antipsychotic pharmacotherapy].. Psychiatrische Praxis 04/2008; 35(2):91-3. Stefan Löffler, Peter Danos, Thomas Schillen, Ansgar Klimke: Rezidivierende Temperaturregulationsstörung unter Therapie mit Neuroleptika. Psychiatrische Praxis 03/2008; 35(2):91-93., DOI: /s Wolfgang Gaebel, Mathias Riesbeck, Wolfgang Wölwer, Ansgar Klimke, Matthias Eickhoff, Martina von Wilmsdorff, Maria C Jockers-Scherübl, Kai-Uwe Kühn, Matthias Lemke, Andreas Bechdolf, Stefan Bender, Detlef Degner, Ralf Schlösser, Lutz G Schmidt, Andrea Schmitt, Markus Jäger, Gerd Buchkremer, Peter Falkai, Stefan Klingberg, Wolfgang Köpcke, Wolfgang Maier, Heinz Häfner, Christian Ohmann, Hans J Salize, Frank Schneider, Hans-Jürgen Möller: Maintenance Treatment With Risperidone or Low-Dose Haloperidol in First-Episode Schizophrenia: 1Year Results of a Randomized Controlled Trial Within the German Research Network on Schizophrenia. The Journal of Clinical Psychiatry 12/2007; 68(11): , DOI: /JCP.v68n1116 Johanna Thuenker, P. Messinger, A. Klimke, C. Kirschbaum, J. Cordes: Changing psychological stress responsibility for depressive patients?. Der Nervenarzt 11/2007; 78:

7 J. Cordes, J. Thünker, S. J. Kim, D. Geßner-Ozokyay, A. Klimke, H. Hauner: The efficacy of weight management training in patients with schizophrenia. European Psychiatry 03/2007; 22(1)., DOI: /j.eurpsy M.W. Agelink, J. Kornischka, J. Cordes, A. Klimke, H. Hauner, D. Ziegler: A generalist perspective on second generation antipsychotics. Stefan Bender, Alexandra Dittmann-Balcar, Ulrich Schall, Jörg Wolstein, Ansgar Klimke, Michael Riedel, Ernst-Ulrich Vorbach, Kai-Uwe Kühn, Martin Lambert, Ralf W Dittmann, Dieter Naber: Influence of atypical neuroleptics on executive functioning in patients with schizophrenia: A randomized, double-blind comparison of olanzapine vs. clozapine. The International Journal of Neuropsychopharmacology 05/2006; 9(2): , DOI: /S Joachim Cordes, M Arends, A Mobascher, J Brinkmeyer, J Kornischka, P Eichhammer, A Klimke, G Winterer, M.W. Agelink: Potential Clinical Targets of Repetitive Transcranial Magnetic Stimulation Treatment in Schizophrenia. Neuropsychobiology 02/2006; 54(2):87-99., DOI: / Bender S, Dittmann-Balcar A, Schall U, Wolstein J, Klimke A, Riedel M, Vor-bauch E-U, Kühn K-U, Lambert M, Dittmann RW, Naber D: Does atypical antipsychotic medication improve executive functioning in schizophrenia?. The International Journal of Neuropsychopharmacology 01/2006; 6:1-2. Andrea Schmitt, Thomas Bertsch, Uwe Henning, Heike Tost, Ansgar Klimke, Fritz A Henn, Peter Falkai: Increased serum S100B in elderly, chronic schizophrenic patients: Negative correlation with deficit symptoms. Schizophrenia Research 01/2006; 80(2-3): , DOI: /j.schres Johannes Schumacher, Radka Kaneva, Rami Abou Jamra, Guillermo Orozco Diaz, Stephanie Ohlraun, Vihra Milanova, Young-Ae Lee, Fabio Rivas, Fermin Mayoral, Robert Fuerst, Antonia Flaquer, Christine Windemuth, Eudoxia Gay, Sebastian Sanz, Maria José González, Susana Gil, Francisco Cabaleiro, Francisco del Rio, Fermin Perez, Jesus Haro, Christian Kostov, Vesselin Chorbov, Amelia Nikolova-Hill, Vessela Stoyanova, George Onchev, Ivo Kremensky, Konstantin Strauch, Thomas G Schulze, Peter Nürnberg, Wolfgang Gaebel, Ansgar Klimke, Georg Auburger, Thomas F Wienker, Luba Kalaydjieva, Peter Propping, Sven Cichon, Assen Jablensky, Marcella Rietschel, Markus M Nöthen: Genomewide Scan and Fine-Mapping Linkage Studies in Four European Samples with Bipolar Affective Disorder Suggest a New Susceptibility Locus on Chromosome 1p35-p36 and Provides Further Evidence of Loci on Chromosome 4q31 and 6q24. The American Journal of Human Genetics 01/2006; 77(6): , DOI: / Karin Fehsel, Stefan Loeffler, Klaus Krieger, Uwe Henning, Markus Agelink, Victoria Kolb-Bachofen, Ansgar Klimke: Clozapine Induces Oxidative Stress and Proapoptotic Gene Expression in Neutrophils of Schizophrenic Patients. Journal of Clinical Psychopharmacology 11/2005; 25(5): , DOI: /01.jcp fe Robert D Oades, Bernd Röpcke, Uwe Henning, Ansgard Klimke: Neuropsychological measures of attention and memory function in schizophrenia: Relationships with symptom dimensions and serum monoamine activity. Behavioral and Brain Functions 09/2005; 1(1):14., DOI: / Andrea Schmitt, Thomas Bertsch, Heike Tost, Andrea Bergmann, Uwe Henning, Ansgar Klimke, Peter Falkai: Increased serum interleukin-i? and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medication. Neuropsychiatric Disease and Treatment 07/2005; 1(2):171-7., DOI: /nedt

8 Uwe Henning, Klaus Krieger, Stefan Loeffler, Fabio Rivas, Guillermo Orozco, Manuel G de Castro, Marcella Rietschel, Markus M Noethen, Ansgar Klimke: Increased levels of glucocorticoid receptors and enhanced glucocorticoid receptor auto-regulation after hydrocortisone challenge in B-lymphoblastoids from patients with affective disorders. Psychoneuroendocrinology 06/2005; 30(4): , DOI: /j.psyneuen J Cordes, A Mobascher, M Arends, M W Agelink, A Klimke: [A new method for the treatment of depression: repetitive transcranial magnetic stimulation].. DMW - Deutsche Medizinische Wochenschrift 05/2005; 130(14): J Cordes, A Mobascher, M Arends, M W Agelink, A Klimke: Ein neues Behandlungsverfahren der Depression: Die repetitive transkranielle Magnetstimulation (rtms). DMW - Deutsche Medizinische Wochenschrift 04/2005; 130(14): , DOI: /s D Naber, M Riedel, A Klimke, E-U Vorbach, M Lambert, K-U Kühn, S Bender, B Bandelow, W Lemmer, S Moritz, R W Dittmann: Randomized double blind comparison of olanzapine vs. Clozapine on subjective well-being and clinical outcome in patients with schizophrenia. Acta Psychiatrica Scandinavica 03/2005; 111(2): , DOI: /j x Arian Mobascher, Jana Boecker, Jaroslav Malevani, Mareke Arends, Ansgar Klimke, Joachim Cordes: Repetitive transcranial magnetic stimulation as an antidepressant monotherapy in a patient with major depression, leucocytopenia and rhabdomyolysis. The International Journal of Neuropsychopharmacology 01/2005; 7(4):527-9., DOI: /S Oliver Neuhaus, Bernd C Kieseier, Ansgar Klimke, Wolfgang Gaebel, Reinhard Hohlfeld, Hans-Peter Hartung: Cannabinoids in multiple sclerosis. Opportunity or threat?. Der Nervenarzt 11/2004; 75(10): , DOI: /s z Joachim Cordes, Marcus Streit, Stefan Loeffler, Martina von Wilmsdorff, Marcus Agelink, Ansgar Klimke: Reversible Neutropenia during Treatment with Olanzapine: Three Case Reports. The World Journal of Biological Psychiatry 11/2004; 5(4):230-4., DOI: / K Krieger, U Henning, A Klimke: Proteomics reveals differential protein regulation in human glioma cells by imipramine. Pharmacopsychiatry 10/2004; 36(05)., DOI: /s S Loeffler, K Fehsel, K Krieger, U Henning, A Klimke: In vitro, inhibition of oxidative stress prevents clozapineinduced apoptosis in neutrophils. Pharmacopsychiatry 10/2004; 36(05)., DOI: /s K Krieger, A Klimke, U Henning: In vitro autoregulation of glucocorticoid receptors is dependent on the medium and serum batch used. Pharmacopsychiatry 10/2004; 36(05)., DOI: /s U Henning, K Krieger, A Klimke: Metabolism of clozapine-n-oxid in disrupted cells of neuronal and blood cell origin. Pharmacopsychiatry 10/2004; 36(05)., DOI: /s Oliver Neuhaus, Bernd C. Kieseier, Ansgar Klimke, Wolfgang Gaebel, Reinhard Hohlfeld, Hans-Peter Hartung: Cannabinoide bei multipler Sklerose: Chance oder Risiko?. Der Nervenarzt 10/2004; 75(10)., DOI: /s z K Fehsel, S Loeffler, U Henning, R Kronenwett, K Krieger, A Klimke: Increased sensitivity of isolated CD34+ cells towards clozapine-treatment. Pharmacopsychiatry 06/2004; 36(05)., DOI: /s

9 U Henning, K Krieger, A Mobascher, A Klimke: Clozapine transport into human glioblastoma cells is increased after prolonged incubation with neuroleptic drugs. Pharmacopsychiatry 06/2004; 36(05)., DOI: /s J Cordes, L Kostorz, U Henning, T Schillen, W Burtscheidt, C Kirschbaum, A Klimke: Electronic monitoring of the cortisol daytime profiles during the process of alcohol withdrawal. Pharmacopsychiatry 06/2004; 36(05)., DOI: /s U Henning, K Krieger, S Loeffler, A Klimke: Transport of clozapine and its major metabolites into human cells of glial and neuronal origin. Pharmacopsychiatry 06/2004; 36(05)., DOI: /s Klaus Krieger, Ansgar Klimke, Uwe Henning: Antipsychotic drugs influence transport of the beta-adrenergic antagonist [3H]-dihydroalprenolol into neuronal and blood cells.. The World Journal of Biological Psychiatry 04/2004; 5(2):100-6., DOI: / Marcus W Agelink, A Klimke, J Cordes, D Sanner, I Kavuk, R Malessa, E Klieser, B Baumann: A functionalstructural model to understand cardiac autonomic nervous system (ANS) dysregulation in affective illness and to elucidate the ANS effects of antidepressive treatment. European journal of medical research 02/2004; 9(1): Stefan Loeffler, Karin Fehsel, Klaus Krieger, Uwe Henning, Ansgar Klimke: Inhibition of p38-mitogenactivated protein kinase may protect from clozapine-induced agranulocytosis. The World Journal of Biological Psychiatry 02/2004; 5(1):54-5., DOI: / A. Dittmann-Balcar, S. Bender, U. Schall, A. Klimke, N. Mueller, U. Vorbach, K. U. Kuehn, R. W. Dittmann, D. Naber: Effects of olanzapine versus clozapine on executive functions in schizophrenia. Schizophrenia Research 03/2003; 60(1): , DOI: /S (03) Rolf Larisch, Ansgar Klimke, Kurt Hamacher, Uwe Henning, Sorour Estalji, Thomas Hohlfeld, Henning Vosberg, Marco Tosch, Wolfgang Gaebel, Heinz H Coenen, Hans Wilhelm Müller-Gärtner: Influence of synaptic serotonin level on [18F]altanserin binding to 5HT2 receptors in man. Behavioural Brain Research 03/2003; 139(1-2):21-9., DOI: /S (01) S Loeffler, K Fehsel, U Henning, J Fischer, M Agelink, V Kolb-Bachofen, A Klimke: Increased Apoptosis of Neutrophils in a Case of Clozapine-induced Agranulocytosis. Pharmacopsychiatry 02/2003; 36(1):37-41., DOI: /s U Henning, S Löffler, K Krieger, A Klimke: Uptake of Clozapine into HL-60 Promyelocytic Leukaemia Cells. Pharmacopsychiatry 06/2002; 35(3):90-5., DOI: /s RD Oades, U Henning, A Klimke, ML Rao: Dimensions of schizophrenia; Antipsychotic medication and serum monoamine activity. Schizophrenia Research 01/2002; 53(3): Robert D Oades, Ansgard Klimke, Uwe Henning, Marie Luise Rao: Relations of clinical features, subgroups and medication to serum monoamines in schizophrenia. Human Psychopharmacology Clinical and Experimental 01/2002; 17(1):15-27., DOI: /hup.368 R Larisch, A Klimke, F Mayoral, K Hamacher, HR Herzog, H Vosberg, M Tosch, W Gaebel, F Rivas, HH Coenen, HW Muller-Gartner: Disturbance of serotonin 5HT(2) receptors in remitted patients suffering from hereditary depressive disorder. Nuklearmedizin 08/2001; 40(4): , DOI: /s

10 R Larisch, A Klimke, F Mayoral, K Hamacher, H R Herzog, H Vosberg, M Tosch, W Gaebel, F Rivas, H H Coenen, H W Müller-Gärtner: Disturbance of serotonin 5HT2 receptors in remitted patients suffering from hereditary depressive disorder [Veränderungen der serotonin-5ht2-rezeptoren bei remittierten patienten mit hereditärer depression]. Nuklearmedizin 08/2001; 40(4): D. Naber, B. Bandelow, S. Bender, A. Klimke, K. Kuhn, M. Lambert, W. Lemmer, M. Riedel, E. Vorbach, R. W. Dittmann: Subjective well-being under neuroleptic treatment with olanzapine versus clozapine: First results from a double-blind clinical trial using the SWN self-rating scale. Schizophrenia Research 01/2001; 49(1-2): U. Henning, A. Klimke: Clozapine is transported into artificial leukocytes and glial cells, but not into neuroblastoma cells. Schizophrenia Research 01/2000; 41(1): , DOI: /S (00)90906-X A. Klimke, S. Löffler, U. Henning, V. Kolb-Bachofen, K. Fehsel: The atypical antipsychotic clozapine sensitizes for granulocyte apoptosis. Schizophrenia Research 01/2000; 41(1): , DOI: /S (00) B. W. Müller, G. Sartory, S. Bender, A. Klimke, U. Henning: High dopamine impairs neuropsychological dysfunction in schizophrenia. Schizophrenia Research 01/2000; 41(1): , DOI: /S (00) Ansgar Klimke, Rolf Larisch, Astrid Janz, Henning Vosberg, H.W. Müller-Gärtner, Wolfgang Gaebel: Dopamine D2 receptor binding before and after treatment of major depression measured by [123I]IBZM SPECT. Psychiatry Research 05/1999; 90(2): , DOI: /S (99) Uwe Henning, Klaus Krieger, Ansgar Klimke: Specific binding of 3H-spiperone to peripheral blood cells: Relevance for the interpretation of binding studies in psychiatric disorders. Progress in Neuro- Psychopharmacology and Biological Psychiatry 03/1999; 23(2): , DOI: /S (98) K. Krieger, A. Klimke, U. Henning: Wed-P41. Active 3H-dopamine uptake occurs in platelets and in artificial neuronal cell lines of human origin but not in lymphocytes. European Psychiatry 12/1998; 13(4)., DOI: /S (99) S. Löffler, K. Fehsel, U. Henning, A. Klimke: Wed-P111. Lithium evoked DNA strand breaks and apoptosis in IMR-32 cells are independent of P53 and inos. European Psychiatry 12/1998; 13(4)., DOI: /S (99) A. Klimke, C. Boy, M. Eickhoff, H. Herzog, M. Holschbach, H. Mühlensiepen, M. Weckessec, E. Rota- Kops, F. Sonnenberg, W. Gaebel, R. Markstein, G. Stöcklin: FC65-6. Dopamine D1 and D4-like receptors in untreated schizophrenic patients and healthy controls. European Psychiatry 12/1998; 13(4)., DOI: /S (99) Christian Boy, Ansgar Klimke, Marcus Holschbach, Hans Herzog, H Mühlensiepen, Elena Rota Kops, Frank Sonnenberg, Wolfgang Gaebel, Gerhard Stöcklin, Rudolf Markstein, H W Müller-Gärtner: Imaging dopamine D4 receptors in the living primate brain: A positron emission tomography study using the novel D1/ D4 antagonist [11C]SDZ GLC 756. Synapse 12/1998; 30(4): , DOI: /(SICI) (199812)30:4<341::AID-SYN1>3.0.CO;2-6

11 G. Orozco, F. Rivas, M.I. Gomez, A. Bordallo, M.V. Ortega, J. Requena, A. Klimke, W. Gaebel, R. Larisch, H.-W. Müller-Gärtner, G. Auburger, P. Propping, M. Rietschel, M.M. Nöthen: Establishment of an Andalusian family collection for bipolar affective disorder. A. Klimke, C. Boy, M. Eickhoff, H. Herzog, M. Holschbach, H. Mühlensiepen, M. Weckesser, E. Rota Kops, F. Sonnenberg, W. Gaebel, R. Markstein, G. Stöcklin, H.H. Coenen, H.W Müller-Gärtner: Dopamine D4-like receptors in untreated schizophrenic patients demonstrated with PET and 11C-SDZ GLC 756. European Neuropsychopharmacology 11/1998; 8:S235., DOI: /S X(98) U. Henning, K. Krieger, A. Klimke: Wed-P75. 3H-spiperone binds with high affinity to a nondompaminergic site on human B-lymphocytes, EBV-transformed lymphoblasts and macrophages. European Psychiatry 11/1998; 13(4)., DOI: /S (99) A. Klimke, C. Boy, M. Eickhoff, H. Herzog, M. Holschbach, H. Miihlensiepen, M. Weckesser, E. Rota Kops, F. Sonnenberg, W. Gaebel, R. Markstein, G. Stocklin: Dopamine D4 like receptors in untreated schizophrenic patients demonstrated with PET and C-11-SDZ GLC 756. Schizophrenia Research 11/1998; 29(1): , DOI: /S (97) K Krieger, A Klimke, U Henning: Active [ 3 H]-Dopamine Uptake Displayed by Native Lymphocyte Suspensions is Mainly Due to Contaminating Platelets. Pharmacopsychiatry 10/1998; 31(5):193-8., DOI: /s R Larisch, W Meyer, A Klimke, F Kehren, H Vosberg, H W Müller-Gärtner: Left-right asymmetry of striatal dopamine D2 receptors. Nuclear Medicine Communications 09/1998; 19(8):781-7., DOI: / R Larisch, A Klimke: [Clinical impact of cerebral dopamine-d2 receptor scintigraphy]. Nuklearmedizin 02/1998; 37(7): U. Müller, A. Klimke, M. Jänner, W. Gaebel: Die Elektrokrampftherapie in psychiatrischen Kliniken der Bundesrepublik Deutschland Der Nervenarzt 01/1998; 69(1):15-26., DOI: /s R. Larisch, A. Klimke: Zur klinischen Wertigkeit der zerebralen Dopamin-D2-Rezeptorszintigraphie. Nuklearmedizin 01/1998; 37(07): , DOI: /s U Müller, A Klimke, M Jänner, W Gaebel: Electroconvulsive therapy in psychiatric clinics in Germany in Der Nervenarzt 01/1998; 69(1): R Larisch, A Klimke, H Vosberg, W Gaebel, H W Mueller-Gaertner: Cingulate function in depression. Neuroreport 11/1997; 8(15):i-ii. S. Löffler, U. Henning, A. Klimke: Clozapine associated agranulocytosis: Putative involvement of nitric oxide and apoptosis. Biological Psychiatry 07/1997; 42(1)., DOI: /S (97)87076-X A. Klimke, R. Larisch, S. Löffler, H. Vosberg, H. W. Müller-Gärtner, W. Gaebel: Striatal and extrastriatal binding of 123I-iodobenzamide (IBZM) during treatment of major depression. Biological Psychiatry 07/1997; 42(1)., DOI: /S (97)86917-X A. Klimke, C. Boy, H. Herzog, M. Holschbach, H. Mühlensiepen, M. Weckesser, E. Rota Kops, F. Sonnenberg, W. Gaebel, R. Markstein, G. Stöcklin, H. H. Coenen: Density and distribution of dopamine D4 receptors in primate and human brain demonstrated with 11C-SDZ GLC 756, a new PET ligand. Biological Psychiatry 07/1997; 42(1)., DOI: /S (97)

12 S. Löffler, U. Henning, A. Klimke: Differential sensitivity of IMR 32 cells towards haloperidol, clozapine and lithium. Biological Psychiatry 07/1997; 42(1)., DOI: /S (97) R Larisch, A Klimke, H Vosberg, S Löffler, W Gaebel, H W Müller-Gärtner: In VivoEvidence for the Involvement of Dopamine-D2Receptors in Striatum and Anterior Cingulate Gyrus in Major Depression. NeuroImage 05/1997; 5(4 Pt 1): , DOI: /nimg A. Klimke, R. Larisch, A. Janz, H. Vosberg, H.-W. Müller-Gärtner, W. Gaebel: Modulation of striatal dopamine-d2 receptor binding in major depression by selective serotonin re-uptake inhibitors. Psychiatry Research: Neuroimaging 02/1997; 68(2): , DOI: /S (97)81548-X A. Klimke, S. Löffler, E. Klieser: Long-term relapse prevention with clozapine in schizophrenia. European Psychiatry 12/1996; 11(4):278s., DOI: / (96) U. Henning, S. Löffler, B. Schmitz, A. Klimke: Plasma levels and metabolism of clozapine in relapse prevention of schizophrenia. European Psychiatry 12/1996; 11., DOI: / (96) A. Klimke, R. Larisch, S. Löffler, H. Vosberg, H. W. Müller-Gärtner, W. Gaebel: D2 dopamine receptor binding before and after treatment of major depression measured by single photon emission computed tomography. European Psychiatry 12/1996; 11(4)., DOI: / (96) N. Saimeh, M. Schwarz, A. Klimke: Atypical treatment of neuroleptic induced catatonia in acute psychosis. European Psychiatry 12/1996; 11(4)., DOI: / (96) A. Klimke, R. Larisch, S. Löffler, H. Vosberg, H. W. Müller-Gärtner, W. Gaebel: Increased D2/D3 dopamine receptor binding associated with pharmacotherapy response before and after treatment of major depression measured by single photon emission computed tomography (SPECT). European Neuropsychopharmacology 09/1996; 6., DOI: / X(96) W Gaebel, A Klimke: [Psychiatric emergencies and crises in gynecology]. Der Gynäkologe 01/1996; 28(6): A. Klimke, U. Henning: P-4-52 Relapse prevention with clozapine in schizophrenic outpatients: Plasma level, metabolism and compliance. European Neuropsychopharmacology 09/1995; 5(3): , DOI: / X(95)90572-U Klimke A, Boy C, Müller-Gärtner, H.W, Gaebel W: P-3-6 Investigating dopamine receptor binding with PET and SPECT ligands in schizophrenia: Clinical and methodological considerations. European Neuropsychopharmacology 09/1995; 5(3): , DOI: / X(95)90496-Z Ansgar Klimke, Eckhard Klieser: P-4-51 Prevention of relapse in schizophrenia with clozapine: An open mirrorimage study of 53 outpatients treated up to 8 years. European Neuropsychopharmacology 09/1995; 5(3): , DOI: / X(95)90571-T A Klimke, E Klieser: Das atypische Neuroleptikum Clozapin (Leponex ) - aktueller Kenntnisstand und neuere klinische Aspekte. Fortschritte der Neurologie Psychiatrie 06/1995; 63(5): , DOI: /s Ansgar Klimke, Eckhard Klieser: Catatonia: Current Therapeutic Recommendations. CNS Drugs 10/1994; 2(4): , DOI: /

13 A Klimke, E Lehmann, E Klieser: [Therapy of depression].. Versicherungsmedizin / herausgegeben von Verband der Lebensversicherungs-Unternehmen e.v. und Verband der Privaten Krankenversicherung e.v 07/1994; 46(3): A Klimke, E Klieser: Sudden death after intravenous application of lorazepam in a patient treated with clozapine [3]. American Journal of Psychiatry 06/1994; 151(5):780. A Klimke, E Klieser, E Lehmann, L Miele: Initial Improvement as a Criterion for Drug Choice in Acute Schizophrenia. Pharmacopsychiatry 02/1993; 26(1):25-9., DOI: /s A Klimke, S Knecht: Abnormalities of the Left Temporal Lobe in Schizophrenia. New England Journal of Medicine 01/1993; 327(23):1689; author reply 1690., DOI: /NEJM A Klimke: Side-effects and efficacy of clozapine in the treatment of acute schizophrenia. DOI: / X(92)90198-H A Klimke: Is the initial improvement a valid criterion for drug choice in acute schizophrenia?. European Neuropsychopharmacology 09/1992; 2(3): , DOI: / X(92) A Klimke: Dopamine autoreceptor agonists are not clinically effective in acute schizophrenia. Implications for the dopamine hypothesis. Schizophrenia Research 01/1992; 6(2)., DOI: / (92)90140-Z A Klimke, E Klieser: Antipsychotic Efficacy of the Dopaminergic Autoreceptor Agonist EMD (Roxindol). Pharmacopsychiatry 08/1991; 24(4): , DOI: /s A Klimke, E Klieser: [Effectiveness of neuro-electric therapy in drug resistant endogenous psychoses].. Fortschritte der Neurologie Psychiatrie 03/1991; 59(2):53-9. A. Klimke, E. Klieser: Zur Wirksamkeit der neuroelektrischen Therapie (NET) bei pharmakotherapeutisch resistenten endogenen Psychosen. Fortschritte der Neurologie Psychiatrie 02/1991; 59(02):53-59., DOI: /s K Heinrich, A Klimke: [Suicide in psychiatric clinic patients]. Zeitschrift für klinische Psychologie, Psychopathologie und Psychotherapie / im Auftrag der Görres-Gesellschaft 02/1990; 38(2): E Lehmann, E Klieser, A Klimke, H Krach, R Spatz: The Efficacy of Cavain in Patients Suffering from Anxiety. Pharmacopsychiatry 12/1989; 22(6): , DOI: /s