Synthesis of 5'-C- and 2'-O-substituted oligoribonucleotide analogues and evaluation of their pairing properties
|
|
- Kathrin Biermann
- vor 5 Jahren
- Abrufe
Transkript
1 Research Collection Doctoral Thesis Synthesis of 5'-C- and 2'-O-substituted oligoribonucleotide analogues and evaluation of their pairing properties Author(s): Wu, Xiaolin Publication Date: 2000 Permanent Link: Rights / License: In Copyright - Non-Commercial Use Permitted This page was generated automatically upon download from the ETH Zurich Research Collection. For more information please consult the Terms of use. ETH Library
2 Diss. ETH No Synthesis of 5' C and 2' () Substituted Oligoribonucleotide Analogues and Evaluation of their Pairing Properties Submitted to the SWISS FEDERAL INSTITUTE OF TECHNOLOGY (ETH) Zürich for the degree of Doctor of Nature Sciences by XIA()LIN WlJ M.Sc from Zhongshan University Born on April 17, 1970 from Zhejiang, P.R. China Accepted on the Recommendation of Prof. Dr. A. Vasella, examiner Dr. S. Pitsch, supervisor, co-examiner Prof. Dr. B. Jaun, co-exarniner Zürich, Feb. 2000
3 I Summary A method for the preparation of oligoribonucleotide analogues containing hexofuranosyl nucleosides with additional functional groups tethered to the 6'-0-position was developed. Two additional metal-binding sites (an Laza 18-crown-6 and a triethyleneglycol moiety) were introduced into such nucleotides at the late stage of the phosphoramidite synthesis. By automated synthesis, these nucleoside analogues were efficiently incorporated into RNA sequences. The thermodynamic data of the duplex formation revealed that the presence of these two functional groups led to a significant stabilization of RNA duplexes presumably by a specific metal ion-mediated interaction. A solid-phase strategy for introduction of functional groups into oligoribonucleotides was realized by incorporating 6'-0-bromopentyl substituted allofuranosyl nucleosides into RNA sequences. This method allowed tbe efficient introduction of a variety of functional groups into RNAs by nucleophilic substitution. Four hammerhead ribozyme analogues carrying additional metal-binding sites were prepared by this method and their cleavaze activities were investiuated. Functionalization resulted in an ~ ~ enhancement of the RNA cleavage activity at low metal-ion concentrations (as compared to tbe parent ribozyme). A similar solid support functionalization of the 2'-0-position was achieved by incorporating 2'-0 bromopropyloxymethyl substituted or (2,3--expoxypropyloxy)methyl substituted nucleosides.
4 II Oligonucleotides carrymg additional (polar) 2'-0- [(2,3-dihydroxypropyloxy)methyl] substituents were prepared. The syntheses of the corresponding phosphoramidites were carried out by two routes: either by dihydroxylation of 2 1-O-allyloxymethyl substituted nucleosides or by alkylation of dimethoxytritylated, base-protected nucleosides. The thermodynamic studies of duplexes derived from these analogues in the presence of organic solvents was investigated. A significant increase of the duplex stabilities of these analogues in the presence of 40% dimethoxy ethane (DME) was observed. In the course of this project it was found that RNA-based pairing systems are much more tolerant towards the presence of certain organic solvents, than DNA-based pairing systems. Furthermore, it could be demonstrated that in the presence of 40% DME, base pairing is more selective than in aqueous solution.
5 Zusammenfassung Eine Methode für den Aufbau von Oligoribonukleotid-Analogen, die 6'-0 funktionalisierte Hexofuranosyl-Nukleoside enthalten, wurde entwickelt. Zwei zusätzliche Metallbindungsstellen (eine l-aza-iß-krone-ö- und eine 'I'riethylcnglykol-Einhcit) wurden in einem sehr späten Schritt der Synthese in solche Nukleosid-Analoge eingeführt. Diese konnten maschinell mit guter Ausbeute in RNA-Sequenzen eingebaut werden. Die Bestimmung der thermodynamischen Kenngrössen von entsprechenden Duplexen ergab eine signifikante Duplex-Stabilisierung durch die Anwesenheit der zusätzlichen Metallbindungsstellen, welche vermutlich aus einer spezifischen Metallinduzierten Wechselwirkung (zwischen den beiden Strängen) resultiert. Eine Festphasen-Methode für die Einführung von funktionellen Gruppen in Oligoribonukleotide wurde entwickelt; sie basiert auf dem Einbau von (unspezifisch vorfunktionalisierten) 6'-0-bromopentylsubstituierten Allofuranosyl-Nukleosiden in RNA Sequenzen. Diese Methode erlaubte eine ergiebige Funktionalisierung von Oligoribonukleotiden mit emer Vielzahl von Gruppen durch nukleophile Substitution. Vier "Hammerhead"-Ribozymanaloge mit zusätzlichen Metallbindungsstellen wurden mittels dieser Methode hergestellt und daraufhin bezüglich ihrer Spaltungsaktivität untersucht. Die eingeführten Funktionalisierungen führten zu einer Erhöhung der RNA-Spaltungsgeschwindigkeit (relativ.. zum natürlichen Ribozym), insbesondere bei emer genngen Metallionenkonzentration. Eine vergleichbare Festphase.n Funktonalisierung der 2 1-O-Position wurde durch die Entwicklung und den
6 II Einbau von 2'-0-Bromopropyloxymethyl- oder (2,3-Epoxypropyloxy) methyl-substituierten Nukleosiden erzielt. Oligonukleotide mit zusätzlichen (polaren) 2'-0 - [( 2,3 dihydroxypropyloxy)]methyl]-substituenten wurden hergestellt. Deren Synthese wurde entweder durch Dihydroxylierung von 2'-0 Allyloxymethyl-substituierten Nukleosiden oder durch Alkylierung von dimethoxytrityliertcn, basengeschützten Nukleosiden bewerkstelligt. Das Paarungsverhalten von solchen Analogen in Gegenwart von organischen Lösungsmitteln wurde untersucht. Eine deutliche Erhöhung der Duplexstabilitäten dieser Analogen in Gegenwart von 40% Dimethoxyethan (DME) wurde beobachtet. Im Rahmen dieses Projekts wurde gefunden, dass auf RNA basierende Paarungssysteme sich viel toleranter gegenüber gewissen Lösungsmitteln verhalten, als auf DNA basierende Paarungssysteme. Zusätzlich konnte gezeigt werden, dass die Selektivität der Paarung in Gegenwart von 40 % DME wesentlich grösser als in Wasser ist.
The theory and practice of a multi-enzyme process a novel approach for the synthesis of fructose from starch
Research Collection Doctoral Thesis The theory and practice of a multi-enzyme process a novel approach for the synthesis of fructose from starch Author(s): Moradian, Aydin Publication Date: 1990 Permanent
MehrResearch Collection. Human Cu,Zn-superoxide dismutase preparation of the apo-protein. Calorimetriy and pulse radiolysis. Doctoral Thesis.
Research Collection Doctoral Thesis Human Cu,Zn-superoxide dismutase preparation of the apo-protein. Calorimetriy and pulse radiolysis Author(s): Sutter, Barbara Publication Date: 2000 Permanent Link:
MehrResearch Collection. Isolation of low molecular weight taste peptides from Vacherin Mont d'or cheese. Doctoral Thesis. ETH Library
Research Collection Doctoral Thesis Isolation of low molecular weight taste peptides from Vacherin Mont d'or cheese Author(s): Mojarro de Guerra, Sandra H. Publication Date: 1989 Permanent Link: https://doi.org/10.3929/ethz-a-000600332
MehrGroup signature schemes and payment systems based on the discrete logarithm problem
Research Collection Doctoral Thesis Group signature schemes and payment systems based on the discrete logarithm problem Author(s): Camenisch, Jan Publication Date: 1998 Permanent Link: https://doi.org/10.3929/ethz-a-001923735
MehrResearch Collection. Backward stochastic differential equations with super-quadratic growth. Doctoral Thesis. ETH Library. Author(s): Bao, Xiaobo
Research Collection Doctoral Thesis Backward stochastic differential equations with super-quadratic growth Author(s): Bao, Xiaobo Publication Date: 2009 Permanent Link: https://doi.org/10.3929/ethz-a-005955736
MehrFmoc-kompatible Festphasensynthese von C-terminalen Peptid- Thioestern
Research Collection Doctoral Thesis Fmoc-kompatible Festphasensynthese von C-terminalen Peptid- Thioestern Author(s): Sewing, Axel Publication Date: 2001 Permanent Link: https://doi.org/10.3929/ethz-a-004227778
MehrTopologies on the set of Banach space representations
Research Collection Doctoral Thesis Topologies on the set of Banach space representations Author(s): Koller, Michael Dominik Fabian Publication Date: 1993 Permanent Link: https://doi.org/10.3929/ethz-a-000888466
MehrResearch Collection. Optisch aktive Polyvinylketone Beziehungen zwischen optischer Aktivität und Stereoregularität. Doctoral Thesis.
Research Collection Doctoral Thesis Optisch aktive Polyvinylketone Beziehungen zwischen optischer Aktivität und Stereoregularität Author(s): Allio, Angelo Publication Date: 1979 Permanent Link: https://doi.org/10.3929/ethz-a-000173135
MehrVergleichende lichtmikroskopische Untersuchungen von Banding und Schraubenstruktur in Chromosomen von Erythronium revolutum Smith
Research Collection Doctoral Thesis Vergleichende lichtmikroskopische Untersuchungen von Banding und Schraubenstruktur in Chromosomen von Erythronium revolutum Smith Author(s): Ballmer, Stephan Publication
MehrInteractive centerline finding in complex tubular structures
Research Collection Doctoral Thesis Interactive centerline finding in complex tubular structures Author(s): Spuhler, Christoph Publication Date: 2006 Permanent Link: https://doi.org/10.3929/ethz-a-005267157
MehrContribution to the development of optical sensors for anions
Research Collection Doctoral Thesis Contribution to the development of optical sensors for anions Author(s): Tan, Susie Sok Si Publication Date: 1991 Permanent Link: https://doi.org/10.3929/ethz-a-000617811
MehrAsymptotic properties of diffusions in random environment
Research Collection Doctoral Thesis Asymptotic properties of diffusions in random environment Author(s): Del Tenno, Ivan Publication Date: 2008 Permanent Link: https://doi.org/10.3929/ethz-a-005649048
MehrResearch Collection. Doctoral Thesis. ETH Library. Author(s): Tschudi-Rein, Kathrin Ruth. Publication Date: 1988
Research Collection Doctoral Thesis Aspects of the reproductive biology of Pieris brassicae (Lepidoptera, Pieridae) with special reference to eupyrene and apyrene spermatozoa Author(s): Tschudi-Rein, Kathrin
MehrResearch Collection. Security econometrics The dynamics of (in)security. Doctoral Thesis. ETH Library. Author(s): Frei, Stefan. Publication Date: 2009
Research Collection Doctoral Thesis Security econometrics The dynamics of (in)security Author(s): Frei, Stefan Publication Date: 2009 Permanent Link: https://doi.org/10.3929/ethz-a-005887804 Rights / License:
MehrResearch Collection. Magnetism in 30 picoseconds and more. Doctoral Thesis. ETH Library. Author(s): Vaterlaus, Andreas. Publication Date: 1991
Research Collection Doctoral Thesis Magnetism in 30 picoseconds and more Author(s): Vaterlaus, Andreas Publication Date: 1991 Permanent Link: https://doi.org/10.3929/ethz-a-000614775 Rights / License:
MehrApplication-specific processor for MIMO-OFDM software-defined radio
Research Collection Doctoral Thesis Application-specific processor for MIMO-OFDM software-defined radio Author(s): Eberli, Stefan Publication Date: 2009 Permanent Link: https://doi.org/10.3929/ethz-a-005925607
MehrAlgorithms for analyzing signals in DNA Applications to transcription and translation
Research Collection Doctoral Thesis Algorithms for analyzing signals in DNA Applications to transcription and translation Author(s): Friberg, Markus Publication Date: 2007 Permanent Link: https://doi.org/10.3929/ethz-a-005378601
MehrResearch Collection. Offset gate field effect transistors with high drain breakdown potential and low Miller feedback capacitance.
Research Collection Doctoral Thesis Offset gate field effect transistors with high drain breakdown potential and low Miller feedback capacitance Author(s): Dill, Hans G. Publication Date: 1967 Permanent
MehrWind Tunnel Investigation of Turbulent Flow in Urban Configurations A Time-Resolved PIV Analysis
Research Collection Doctoral Thesis Wind Tunnel Investigation of Turbulent Flow in Urban Configurations A Time-Resolved PIV Analysis Author(s): Paterna, Enrico Publication Date: 2015 Permanent Link: https://doi.org/10.3929/ethz-a-010550189
MehrResearch Collection. Synthesis and study of biological activity of procaine and acetylcholine analogues with relatively rigid intermediate chain
Research Collection Doctoral Thesis Synthesis and study of biological activity of procaine and acetylcholine analogues with relatively rigid intermediate chain Author(s): Malik, Mohinder Singh Publication
MehrResearch Collection. Digital estimation of continuous-time signals using factor graphs. Doctoral Thesis. ETH Library. Author(s): Bolliger, Lukas
Research Collection Doctoral Thesis Digital estimation of continuous-time signals using factor graphs Author(s): Bolliger, Lukas Publication Date: 2012 Permanent Link: https://doi.org/10.3929/ethz-a-007342807
MehrStress-related problems in process simulation
Research Collection Doctoral Thesis Stress-related problems in process simulation Author(s): Zelenka, Stefan Publication Date: 2001 Permanent Link: https://doi.org/10.3929/ethz-a-004183494 Rights / License:
MehrCationic Cell Penetrating Oligoprolines and the Effect of Preorganized Charge Display
Research Collection Doctoral Thesis Cationic Cell Penetrating Oligoprolines and the Effect of Preorganized Charge Display Author(s): Raschle, Philipp Stephan Publication Date: 2016 Permanent Link: https://doi.org/10.3929/ethz-a-010813602
MehrA Computational Appearance Fabrication Framework and Derived Applications
Research Collection Doctoral Thesis A Computational Appearance Fabrication Framework and Derived Applications Author(s): Papas, Marios Publication Date: 2016 Permanent Link: https://doi.org/10.3929/ethz-a-010710961
MehrDevelopment of amine-functionalized adsorbent for carbon dioxide capture from atmospheric air
Research Collection Doctoral Thesis Development of amine-functionalized adsorbent for carbon dioxide capture from atmospheric air Author(s): Gebald, Christoph Publication Date: 2014 Permanent Link: https://doi.org/10.3929/ethz-a-010171623
MehrSimulation approaches for nano-scale semiconductor devices
Research Collection Doctoral Thesis Simulation approaches for nano-scale semiconductor devices Author(s): Heinz, Frederik Ole Publication Date: 2004 Permanent Link: https://doi.org/10.3929/ethz-a-004680334
MehrResearch Collection. Zur Chemie der α-aminonitrile: γ,{delta}-dehydroleucin-nitril. Doctoral Thesis. ETH Library. Author(s): Buser, Hans-Peter
Research Collection Doctoral Thesis Zur Chemie der αaminonitrile: γ,{delta}dehydroleucinnitril Author(s): Buser, HansPeter Publication Date: 1985 Permanent Link: https://doi.org/10.3929/ethza000347283
MehrBinding to heparin and contactin/f11 of alternatively spliced fibronectin type III homology region of chicken tenascin-c
Research Collection Doctoral Thesis Binding to heparin and contactin/f11 of alternatively spliced fibronectin type III homology region of chicken tenascin-c Author(s): Weber, Peter Publication Date: 1995
MehrComputer-gestützter Entwurf von absatzweise arbeitenden chemischen Mehrproduktanlagen
Research Collection Doctoral Thesis Computer-gestützter Entwurf von absatzweise arbeitenden chemischen Mehrproduktanlagen Author(s): Klossner, Jürg Publication Date: 1985 Permanent Link: https://doi.org/10.3929/ethz-a-000342601
MehrQuantitative IR-Laserchemie mono- und bichromophorer Fluorbutane Geschwindigkeitskonstanten, Isotopen-Trennung und Modenselektivität
Research Collection Doctoral Thesis Quantitative IR-Laserchemie mono- und bichromophorer Fluorbutane Geschwindigkeitskonstanten, Isotopen-Trennung und Modenselektivität Author(s): Thöne, Hermann Josef
MehrGuidance and control for aerobatic maneuvers of an unmanned airplaine
Research Collection Doctoral Thesis Guidance and control for aerobatic maneuvers of an unmanned airplaine Author(s): Möckli, Markus Reinhard Publication Date: 2006 Permanent Link: https://doi.org/10.3929/ethz-a-005204888
MehrNichtlineare und adaptive Filter für die Flugzeugverfolgung
Research Collection Doctoral Thesis Nichtlineare und adaptive Filter für die Flugzeugverfolgung Author(s): Früh, Peter T. Publication Date: 1984 Permanent Link: https://doi.org/10.3929/ethz-a-000311033
MehrResearch Collection. Characterisation of erythromycin and tetracycline resistance in oral streptococci. Doctoral Thesis.
Research Collection Doctoral Thesis Characterisation of erythromycin and tetracycline resistance in oral streptococci Author(s): Stadler, Christina Raphaela Publication Date: 2002 Permanent Link: https://doi.org/10.3929/ethz-a-004443983
MehrOn Lagrangian quantum homology and Lagrangian cobordisms
Research Collection Doctoral Thesis On Lagrangian quantum homology and Lagrangian cobordisms Author(s): Haug, Luis Publication Date: 2014 Permanent Link: https://doi.org/10.3929/ethz-a-010160067 Rights
MehrReduction ofindigo: Kinetics andmechanism
Diss. ETB No. 15268 Reduction ofindigo: Kinetics andmechanism A dissertation submitted to the Swiss Federal Institute oftechnology (ETH), Zurich for the degree of Doctor oftechnical Seiences presented
MehrResearch Collection. Real-time multi-object tracking. Doctoral Thesis. ETH Library. Author(s): Roth, Daniel Eugen. Publication Date: 2010
Research Collection Doctoral Thesis Real-time multi-object tracking Author(s): Roth, Daniel Eugen Publication Date: 2010 Permanent Link: https://doi.org/10.3929/ethz-a-006016818 Rights / License: In Copyright
MehrSimulation of Power System Dynamics using Dynamic Phasor Models
Research Collection Doctoral Thesis Simulation of Power System Dynamics using Dynamic Phasor Models Author(s): Demiray, Turhan Publication Date: 2008 Permanent Link: https://doi.org/10.3929/ethz-a-005566449
MehrTest automation for database management systems and database applications
Research Collection Doctoral Thesis Test automation for database management systems and database applications Author(s): Lo, Chi Lik Eric Publication Date: 2007 Permanent Link: https://doi.org/10.3929/ethz-a-005512389
MehrBinary adder architectures for cell-based VLSI and their synthesis
Research Collection Doctoral Thesis Binary adder architectures for cell-based VLSI and their synthesis Author(s): Zimmermann, Reto Publication Date: 1997 Permanent Link: https://doi.org/10.3929/ethz-a-001912749
MehrThe isogenes ARO3 and ARO4 of Saccharomyces cerevisiae
Research Collection Doctoral Thesis The isogenes ARO3 and ARO4 of Saccharomyces cerevisiae Author(s): Paravicini, Gerhard Publication Date: 1989 Permanent Link: https://doi.org/10.3929/ethz-a-000507917
MehrDynamic Robot Architecture for Robust Realtime Computer Vision
Research Collection Doctoral Thesis Dynamic Robot Architecture for Robust Realtime Computer Vision Author(s): Meier, Lorenz Publication Date: 2017 Permanent Link: https://doi.org/10.3929/ethz-a-010874068
MehrMethods to assess and manage security in interconnected electrical power systems
Research Collection Doctoral Thesis Methods to assess and manage security in interconnected electrical power systems Author(s): Mäkelä, Olli Publication Date: 2013 Permanent Link: https://doi.org/10.3929/ethz-a-010087017
MehrCauchy-Riemann distributions and boundary values of analytic functions
Research Collection Doctoral Thesis Cauchy-Riemann distributions and boundary values of analytic functions Author(s): Straube Emil J. Publication Date: 1983 Permanent Link: https://doi.org/10.3929/ethz-a-000301590
MehrControl for knowledge-based information retrieval
Research Collection Doctoral Thesis Control for knowledge-based information retrieval Author(s): Ultsch, Alfred G.H. Publication Date: 1987 Permanent Link: https://doi.org/10.3929/ethz-a-000410196 Rights
MehrDopant clustering and diffusion in silicon
Research Collection Doctoral Thesis Dopant clustering and diffusion in silicon Author(s): Vollenweider, Kilian Publication Date: 2010 Permanent Link: https://doi.org/10.3929/ethz-a-006192842 Rights / License:
MehrResearch Collection. Chirale Enolate. Doctoral Thesis. ETH Library. Author(s): Naef, Reto. Publication Date: 1983
Research Collection Doctoral Thesis Chirale Enolate Author(s): Naef, Reto Publication Date: 1983 Permanent Link: https://doi.org/10.3929/ethz-a-000300141 Rights / License: In Copyright - Non-Commercial
MehrSterilisation von stückigen Lebensmitteln mit Mikrowellen
Research Collection Doctoral Thesis Sterilisation von stückigen Lebensmitteln mit Mikrowellen Author(s): Spreng, Hans Publication Date: 1975 Permanent Link: https://doi.org/10.3929/ethza000119193 Rights
MehrResearch Collection. Porous support structures and sintered thin film electrolytes for solid oxide fuel cells. Doctoral Thesis.
Research Collection Doctoral Thesis Porous support structures and sintered thin film electrolytes for solid oxide fuel cells Author(s): Will, Julia Publication Date: 1998 Permanent Link: https://doi.org/10.3929/ethz-a-001984890
MehrKey indicators in organizational health development individual and organizational variables for health-promoting change
Research Collection Doctoral Thesis Key indicators in organizational health development individual and organizational variables for health-promoting change Author(s): Müller, Frithjof Publication Date:
MehrExit of simian virus 40 from the endoplasmic reticulum
Research Collection Doctoral Thesis Exit of simian virus 40 from the endoplasmic reticulum Author(s): Geiger, Roger Publication Date: 2011 Permanent Link: https://doi.org/10.3929/ethz-a-006409952 Rights
MehrResearch Collection. Novel modes of protein-rna recognition in post-transcriptional gene regulation studied by NMR spectroscopy.
Research Collection Doctoral Thesis Novel modes of protein-rna recognition in post-transcriptional gene regulation studied by NMR spectroscopy Author(s): Oberstrass, Florian C. Publication Date: 2007 Permanent
MehrResearch Collection. Doctoral Thesis. ETH Library. Author(s): Bruderer Enzler, Heidi. Publication Date: 2015
Research Collection Doctoral Thesis Studies on Pro-Environmental Behavior Future Orientation as a Predictor of Pro-Environmental Behavior and the Assessment of Ecological Impact Author(s): Bruderer Enzler,
MehrZeitschriften in der Krise Entwicklung und Zukunft elektronischer Zeitschriften
Research Collection Doctoral Thesis Zeitschriften in der Krise Entwicklung und Zukunft elektronischer Zeitschriften Author(s): Keller, Alice Publication Date: 2001 Permanent Link: https://doi.org/10.3929/ethz-a-004074869
MehrFast and slow charge trapping and transport in organic semicondutors
Research Collection Doctoral Thesis Fast and slow charge trapping and transport in organic semicondutors Author(s): Häusermann, Roger Publication Date: 2013 Permanent Link: https://doi.org/10.3929/ethz-a-010103856
MehrVerallgemeinerungen des Herbrand'schen Satzes und Anwendungen im Gebiet der Entscheidbarkeit von Formelklassen
Research Collection Doctoral Thesis Verallgemeinerungen des Herbrand'schen Satzes und Anwendungen im Gebiet der Entscheidbarkeit von Formelklassen Author(s): Barro, François Marc Publication Date: 1977
MehrThe Navier-Stokes equations on polygonal domains with mixed boundary conditions theory and approximation
Research Collection Doctoral Thesis The Navier-Stokes equations on polygonal domains with mixed boundary conditions theory and approximation Author(s): Brun, Markus Publication Date: 2002 Permanent Link:
MehrResearch Collection. Doctoral Thesis. ETH Library. Author(s): Tschirky, Hugo. Publication Date: 1979
Research Collection Doctoral Thesis Zur Festlegung von Führungsrichtlinien Buchausgabe unter dem Titel: Führungsrichtlinien; eine Grundlage zur Gliederung und inhaltlichen Gestaltung von Führungsrichtlinien
MehrGlobale Symmetrie von stochastischen Teilchenbewegungen mit lokal symmetrischer Interaktion
Research Collection Doctoral Thesis Globale Symmetrie von stochastischen Teilchenbewegungen mit lokal symmetrischer Interaktion Author(s): Barner, Andreas Publication Date: 1983 Permanent Link: https://doi.org/10.3929/ethz-a-000294972
MehrResearch Collection. Crystal structures and crystal chemistry of ternary LnT₂X type intermetallics. Doctoral Thesis. ETH Library
Research Collection Doctoral Thesis Crystal structures and crystal chemistry of ternary LnT₂X type intermetallics Author(s): Xue, Bingzhang Publication Date: 1994 Permanent Link: https://doi.org/10.3929/ethz-a-000961977
MehrDesign, characterization and simulation of avalanche photodiodes
Research Collection Doctoral Thesis Design, characterization and simulation of avalanche photodiodes Author(s): Meier, Hektor Taavi Josef Publication Date: 2011 Permanent Link: https://doi.org/10.3929/ethz-a-006445001
MehrDevelopment of a linguistic-based approach to design foodrelated emotional evaluation lists (FEE-lists) and first applications
Research Collection Doctoral Thesis Development of a linguistic-based approach to design foodrelated emotional evaluation lists (FEE-lists) and first applications Author(s): Gmür, Angelina Susanne Publication
MehrOn the List Update Problem
DISS. ETH No. 14529, 2002 On the List Update Problem A dissertation submitted to the Swiss Federal Institute of Technology, ETH Zürich for the degree of Doctor of Technical Sciences presented by Christoph
MehrResearch Collection. Aerobic ethanol production with a flocculent yeast in a biomass recycling system. Doctoral Thesis.
Research Collection Doctoral Thesis Aerobic ethanol production with a flocculent yeast in a biomass recycling system Author(s): Lorencez Gonzales, Isaac Publication Date: 1985 Permanent Link: https://doi.org/10.3929/ethz-a-000339159
MehrResearch Collection. Skript zur Vorlesung Allgemeine Chemie I. Educational Material. ETH Library. Author(s): Nesper, Reinhard Friedrich
Research Collection Educational Material Skript zur Vorlesung Allgemeine Chemie I Author(s): Nesper, Reinhard Friedrich Publication Date: 2001 Permanent Link: https://doi.org/10.3929/ethz-a-004324518 Rights
MehrStudies of W and Z Bosons with the CMS Experiment at the LHC
Research Collection Doctoral Thesis Studies of W and Z Bosons with the CMS Experiment at the LHC Author(s): Sanchez, Ann-Karin Publication Date: 2012 Permanent Link: https://doi.org/10.3929/ethz-a-007571447
MehrAn analysis of three variants of forward guidance contracts
Research Collection Doctoral Thesis An analysis of three variants of forward guidance contracts Author(s): Liu, Yulin Publication Date: 2016 Permanent Link: https://doi.org/10.3929/ethz-a-010648109 Rights
MehrResearch Collection. Doctoral Thesis. ETH Library. Author(s): Greber, Basil Johannes. Publication Date: 2013
Research Collection Doctoral Thesis Cryo-electron microscopy structures of large ribosomal subunit complexes insights into biogenesis, evolution, and regulation of the ribosome Author(s): Greber, Basil
MehrHydrodynamics and mass transfer in a reciprocating plate extraction column
Research Collection Doctoral Thesis Hydrodynamics and mass transfer in a reciprocating plate extraction column Author(s): Bensalem, Abdel-Kader Publication Date: 1985 Permanent Link: https://doi.org/10.3929/ethz-a-000342723
MehrResearch Collection. On Successive Cancellation Decoding of Polar Codes and Related Codes. Doctoral Thesis. ETH Library. Author(s): Schürch, Christian
Research Collection Doctoral Thesis On Successive Cancellation Decoding of Polar Codes and Related Codes Author(s): Schürch, Christian Publication Date: 2016 Permanent Link: https://doi.org/10.3929/ethz-a-010811963
MehrOn the cohomology of finite groups with simple coefficients
Research Collection Doctoral Thesis On the cohomology of finite groups with simple coefficients Author(s): Stricker, Markus Andreas Publication Date: 1989 Permanent Link: https://doi.org/10.3929/ethz-a-000518488
MehrBiochemistry of nitrilotriacetate degradation in obligately aerobic, Gram-negative bacteria
Research Collection Doctoral Thesis Biochemistry of nitrilotriacetate degradation in obligately aerobic, Gram-negative bacteria Author(s): Uetz, Thomas Alfred Publication Date: 1992 Permanent Link: https://doi.org/10.3929/ethz-a-000640058
MehrStructure and function of PTB and Fox, two regulators of alternative splicing
Research Collection Doctoral Thesis Structure and function of PTB and Fox, two regulators of alternative splicing Author(s): Auweter, Sigrid D. Publication Date: 2007 Permanent Link: https://doi.org/10.3929/ethz-a-005353468
MehrBiometric authentication system using human gait
Research Collection Doctoral Thesis Biometric authentication system using human gait Author(s): Cattin, Philippe Publication Date: 2002 Permanent Link: https://doi.org/10.3929/ethz-a-004407948 Rights /
MehrResearch Collection. Structure-function relationships in the purified Ca-2+-pumping ATPase of plasma membranes. Doctoral Thesis.
Research Collection Doctoral Thesis Structure-function relationships in the purified Ca--pumping ATPase of plasma membranes Author(s): Zurini, Mauro Publication Date: 1983 Permanent Link: https://doi.org/10.3929/ethz-a-000311555
MehrStudien über die Bestimmung des ätherischen Oeles in Arzneidrogen und Gewürzen
Research Collection Doctoral Thesis Studien über die Bestimmung des ätherischen Oeles in Arzneidrogen und Gewürzen Author(s): Schenker, Ernst Publication Date: 1933 Permanent Link: https://doi.org/10.3929/ethz-a-000110642
MehrResearch Collection. Skript zur Vorlesung Allgemeine Chemie I. Educational Material. ETH Library. Author(s): Nesper, Reinhard Friedrich
Research Collection Educational Material Skript zur Vorlesung Allgemeine Chemie I Author(s): Nesper, Reinhard Friedrich Publication Date: 2001 Permanent Link: https://doi.org/10.3929/ethz-a-004324518 Rights
MehrMikrobiologische Herstellung von optisch aktiven β-hydroxy- Carbonsäureestern im präparativen Massstab
Research Collection Doctoral Thesis Mikrobiologische Herstellung von optisch aktiven βhydroxy Carbonsäureestern im präparativen Massstab Author(s): Züger, Max F. Publication Date: 1984 Permanent Link:
MehrEngineering of synthetic circuits for biomedical applications
Research Collection Doctoral Thesis Engineering of synthetic circuits for biomedical applications Author(s): Ye, Haifeng Publication Date: 2012 Permanent Link: https://doi.org/10.3929/ethz-a-007563440
MehrMultiscale modeling and simulation of fullerenes in liquids
Research Collection Doctoral Thesis Multiscale modeling and simulation of fullerenes in liquids Author(s): Kotsalis, Evangelos M. Publication Date: 2008 Permanent Link: https://doi.org/10.3929/ethz-a-005772771
MehrCharacterization of the Endosomal Protein Vps13 as a suppressor of the ER-Mitochondria Encounter Structure
Research Collection Doctoral Thesis Characterization of the Endosomal Protein Vps13 as a suppressor of the ER-Mitochondria Encounter Structure Author(s): Lang, Alexander Publication Date: 2015 Permanent
MehrHestellung enantiomerenreiner α-verzweigter β-aminösäuren und Synthese stickstoffhaltiger Bausteine für chirale Dendrimere
Research Collection Doctoral Thesis Hestellung enantiomerenreiner α-verzweigter β-aminösäuren und Synthese stickstoffhaltiger Bausteine für chirale Dendrimere Author(s): Boog, Alois Publication Date: 1998
MehrIdentification of VNTR-probes in cattle with plasmid-derived iteron repeat sequences
Research Collection Doctoral Thesis Identification of VNTR-probes in cattle with plasmid-derived iteron repeat sequences Author(s): Huebscher, Karen Jane Publication Date: 1993 Permanent Link: https://doi.org/10.3929/ethz-a-000904761
MehrA modular approach to functional self-assembled monolayers
Research Collection Doctoral Thesis A modular approach to functional self-assembled monolayers Author(s): Durmaz, Firat Publication Date: 2006 Permanent Link: https://doi.org/10.3929/ethz-a-005387433 Rights
MehrResearch Collection. A novel biofuel cell harvesting electrical energy from activated human macrophages. Doctoral Thesis.
Research Collection Doctoral Thesis A novel biofuel cell harvesting electrical energy from activated human macrophages Author(s): Sakai Stalder, Miho Publication Date: 2009 Permanent Link: https://doi.org/10.3929/ethz-a-006020938
MehrCharacterization of potential neuroactive substances released from rat brain in vitro
Research Collection Doctoral Thesis Characterization of potential neuroactive substances released from rat brain in vitro Author(s): Keller, Hans Jörg Publication Date: 1988 Permanent Link: https://doi.org/10.3929/ethz-a-000480944
MehrFunctional characterization of novel human Cul3 E3 ubiquitin ligases in cell cycle regulation
Research Collection Doctoral Thesis Functional characterization of novel human Cul3 E3 ubiquitin ligases in cell cycle regulation Author(s): Märki, Sarah A. Publication Date: 2010 Permanent Link: https://doi.org/10.3929/ethz-a-006080805
MehrResearch Collection. REM-Schlafregulation der Ratte Experimente und Simulationen. Doctoral Thesis. ETH Library. Author(s): Schuller, Jan C.
Research Collection Doctoral Thesis REM-Schlafregulation der Ratte Experimente und Simulationen Author(s): Schuller, Jan C. Publication Date: 2001 Permanent Link: https://doi.org/10.3929/ethz-a-004227727
MehrA Methodology for Supporting Design Grammar Development and Application in Computational Design Synthesis
Research Collection Doctoral Thesis A Methodology for Supporting Design Grammar Development and Application in Computational Design Synthesis Author(s): Königseder, Corinna Publication Date: 2015 Permanent
MehrMetabolic engineering of Vitamin B1 and Vitamin B6 in staple crops
Research Collection Doctoral Thesis Metabolic engineering of Vitamin B1 and Vitamin B6 in staple crops Author(s): Li, Kuan-Te Publication Date: 2014 Permanent Link: https://doi.org/10.3929/ethz-a-010192503
MehrResearch Collection. Control strategies for balancing of series and parallel connected IGBT/diode modules. Doctoral Thesis.
Research Collection Doctoral Thesis Control strategies for balancing of series and parallel connected IGBT/diode modules Author(s): Thalheim, Jan Publication Date: 2003 Permanent Link: https://doi.org/10.3929/ethz-a-004718457
MehrResearch Collection. Identification of imprinted genes and their functional roles in Arabidopsis thaliana. Doctoral Thesis.
Research Collection Doctoral Thesis Identification of imprinted genes and their functional roles in Arabidopsis thaliana Author(s): Wolff, Philip Publication Date: 2015 Permanent Link: https://doi.org/10.3929/ethz-a-010482475
MehrOperation and performance limits of MOS controlled semiconductor power devices
Research Collection Doctoral Thesis Operation and performance limits of MOS controlled semiconductor power devices Author(s): Lendenmann, Heinz Publication Date: 1995 Permanent Link: https://doi.org/10.3929/ethz-a-001410927
MehrUeber die Zusammensetzung, das Alterungsverhalten und die Inhibierung von Isolierölen
Research Collection Doctoral Thesis Ueber die Zusammensetzung, das Alterungsverhalten und die Inhibierung von Isolierölen Author(s): Künzli, Max Publication Date: 1967 Permanent Link: https://doi.org/10.3929/ethz-a-000087846
MehrResearch Collection. Chirale Synthesebausteine durch enantioselektive Reduktion mit mesophilen und thermophilen Mikroorganismen.
esearch Collection Doctoral Thesis Chirale Synthesebausteine durch enantioselektive eduktion mit mesophilen und thermophilen Mikroorganismen Author(s): Giovannini, Fabio Publication Date: 1986 Permanent
MehrResearch Collection. Morphing wing based on compliant elements. Doctoral Thesis. ETH Library. Author(s): Previtali, Francesco. Publication Date: 2015
Research Collection Doctoral Thesis Morphing wing based on compliant elements Author(s): Previtali, Francesco Publication Date: 2015 Permanent Link: https://doi.org/10.3929/ethz-a-010546627 Rights / License:
MehrImproving inter-organizational knowledge transfer to gain development project success
Research Collection Doctoral Thesis Improving inter-organizational knowledge transfer to gain development project success Author(s): Brojerdi-Heyn, Gundula Janin Christina Publication Date: 2011 Permanent
Mehr