Prof. Dr. med. habil. Stephan Hellmig FACP, FEBG Humanmedizin Medizinische Universität zu Lübeck

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1 Curriculum vitae Name Prof. Dr. med. habil. Stephan Hellmig FACP, FEBG Geburtsdatum Geburtsort Hamburg-Barmbek Studium Beruflicher Werdegang Wissenschaftlicher Werdegang Humanmedizin Medizinische Universität zu Lübeck 1999 Klinik für Allgemeine Innere Medizin, UK-SH, Campus Kiel, 2005 Oberarzt und Leiter der Endoskopie 2005 Leiter des Labors für Klinische Gastroenterologie 2009 Chefarzt Klinik für Innere Medizin II. - HELIOS-Klinikum Schleswig 2013 Chefarzt Klinik für Gastroenterologie, Onkologie und Allgemeine Innere Medizin imland Kliniken Rendsburg und Eckernförde 2000 Promotion Therapie des Gallensteinleidens Therapeutisches Splitting in der Klinik für Chirurgie der Medizinischen Universität zu Lübeck, Direktor: Prof. Dr. med. H.-P. Bruch 2006 Habilitation Untersuchungen zur genetischen Prädisposition Helicobacter pylori infizierter Patienten mit Ulcus ventriculi und MALT-Lymphom, Veni legendi für das Fach Innere Medizin 2011 Ernennung zum außerplanmäßigen Professor an der Christian-Albrechts- Universität zu Kiel Auszeichnungen Qualifikationen Mitgliedschaften 2014 Fellow of the European Board of Gastroenterology (FEBG) 2014 Fellow of the American College of Physicians (FACP) Facharzt für Innere Medizin, Schwerpunktanerkennung Gastroenterologie Fachkunde Strahlenschutz und Rettungsdienst Zertifikate Ernährungsmedizin und Diabetologie ESD Training, Okayama University Hospital, Japan Deutsche Gesellschaft für Innere Medizin (DGIM) Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) Deutsche Gesellschaft für Endoskopie und bildgebende Verfahren (DGEBV) Royal Society of Medicine (London)

2 Publikationsverzeichnis Stand Hellmig S, Stuber E, Schulte C, Katsoulis S,, Folsch UR. Recurrent sanguineous and mucous diarrhea and spasms in a 46-year-old woman -- manifestation of endometriosis in the colon sigmoideum Z Gastroenterol May;40(5): Hellmig S, Folsch UR. 5-aminolevulinic acid induced fluorescence for the detection of oesophageal lesions Z Gastroenterol May;40(5): Hellmig S, Stuber E, Katsoulis S, Folsch UR. Bismuth subsalicylate in the cecum. Gastrointest Endosc Oct;56(4): Hellmig S, Stuber E, Kiehne K, Folsch UR. Unusual course of colonic tattooing with India ink. Surg Endosc Mar;17(3): Hellmig S, Katsoulis S, Fölsch U Symptomatic cholecystolithiasis after laparoscopic cholecystectectomy - A case report Surg Endosc Feb;18(2): Hellmig S, Hampe J, Helicobacter pylori infection in Africa and Europe enigma of host genetics Gut Dec;52(12): Hellmig S, Stüber E, Fölsch UR Complications of an Addisonian crisis. Gut Sep;53(9):1219, Hellmig S, Vollenberg S, Goebeler-Kolve ME, Fischbach W, Hampe J, Fölsch UR, Schreiber S IL-1 gene cluster polymorphisms and development of gastric MALT lymphoma in H.pylori infection Blood Nov 1;104(9): Hellmig S, Stuber E, Kiehne K, Kosmahl M, Folsch U. Related Articles, Links What do we really know about the long-term safety of colonic tattooing? Gastrointest Endosc Jan;61(1): Hellmig S, Mascheretti S, Fölsch U, A functional promotor polymorphism in RANTES gene does not influence the clinical course of H.pylori infection J Gastroenterol Hepatol Mar;20(3): Hellmig S, Mascheretti S, Jelschen F, Rehbein JK, Renz J, Frenzel H, Fölsch UR, Hampe J, Haplotype analysis of the CD11 gene cluster in patients with chronic H.pylori infection and ulcer disease Tissue Antigens Mar;65(3): Hellmig S, Titz A, Steinel S, Ott S, Hampe J, Fölsch U, Influence of IL-1 gene cluster polymorphisms on the development of H.pylori associated gastric ulcer

3 Immunol Lett Sep 15;100(2): Hellmig S, Hampe J, Fölsch UR, Role of IL-10 promotor haplotypes in Helicobacter pylori associated gastric inflammation Gut Jun;54(6): Hellmig S, Seeger M, Stuber E, Kiehne K,, Folsch UR. Endoscopic guided capsule endoscopy in a patient with small bowel varices after Whipple s operation Gastrointest Endosc Jul;62(1): Hellmig S, Fischbach W, Goebeler-Kolve ME, Fölsch UR,, Hampe J Association study of a functional Toll-like receptor 4 polymorphism with susceptibility to gastric MALT lymphoma Leuk Lymphoma Jun;46(6): Hellmig S, Ott S, Musfeldt M, Kosmahl M, Rosenstiel P, Stuber E, Hampe J, Folsch UR, Life-Threatening Chronic Enteritis Due to Colonization of the Small Bowel With Stenotrophomonas maltophilia. Gastroenterology Aug;129(2): Hellmig S, Gieseler F, Ott S, Rosenstiel P, Fischbach W, Fölsch U, Hampe J, Genetic variants in the topoisomerase IIα gene in patients with primary gastric B-cell lymphoma Cancer Lett Jul 18;238(2): Hellmig S, Fischbach W, Goebeler-Kolve ME, Fölsch UR, Hampe J, A functional promotor polymorphism of TNF-α is associated with primary gastric B-cell lymphoma Am J Gastroenterol Dec;100(12): Hellmig S, Ott S, Rosenstiel P, Fölsch UR, Hampe J, Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H.pylori infection Am J Gastroenterol Jan;101(1): Ott S, El Mokhtari NE, Hellmig S, Smalla K, Blaut M, Hampe J, Fölsch UR, Simon R, High bacterial diversity in atherosclerotic plaques of patients with coronary heart disease Circulation Feb 21;113(7): Rosenstiel P, Hellmig S, Hampe J,Ott J, Fischbach W, Sahly H, Lucius R, Fölsch UR, Philpott D, Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of H.pylori infection Cell Microbiol Jul;8(7): Rosenstiel P, Huse K, Till A, Hampe J, Braeutigam K, Hellmig S, Sina C, Waetzig G, Platzer M, Seegert D, A short isoform of NOD2/CARD15 (NOD-S) is an endogenous inhibitor of NOD2/RIP2- induced signalling pathways Proc Natl Acad Sci U S A Feb 28;103(9): Hellmig S, von Schöning F, Gadow C, Katsoulis S, Hedderich J, Fölsch UR, Stüber E Gastric emptying time of fluids and solids in healthy volunteers determined by C13- breath tests: influence of age, gender and body mass index J Gastroenterol Hepatol Dec;21(12):

4 24 Hellmig S, Fölsch UR Pharmacological prevention of post-ercp pancreatitis- an everlasting dream? Dig Liver Dis Aug;38(8): Madisch A, Hellmig S,,Bethke B, Stolte M, Miehlke S NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis Int J Colorectal Dis Apr;22(4): Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Folsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J,. Regulation of DMBT1 via NOD2 and TLR4 in Intestinal Epithelial Cells Modulates Bacterial Recognition and Invasion J Immunol Jun 15;178(12): Hellmig S Influence of the ethnic background on genetic susceptibilty to H.pylori infection Eur J Gastroenterol Hepatol Aug;19(8): Hellmig S, Fölsch UR Gastroesophageal reflux: diagnostic and therapy of a widespread disease Med Klin (Munich) May 15;102(5): Ott SJ, El Mokhtari NE, Rehman A, Rosenstiel P, Hellmig S, Kühbacher T, Lins M, Simon R, Fungal rdna signatures in coronary atherosclerotic plaques Environ Microbiol Dec;9(12): Hellmig S, Bartscht T, Fischbach W, Fölsch UR,. Interleukin-10 (-819 C/T) and TNF-A (-308 G/A) as risk factors for H. pylori-associated gastric MALT-lymphoma. Dig Dis Sci Jul;53(7): Ott SJ, Kühbacher T, Musfeldt M, Rosenstiel P, Hellmig S, Rehman A, Drews O, Weichert W, Timmis KN,. Fungi and inflammatory bowel diseases: Alterations of composition and diversity. Scand J Gastroenterol. 2008;43(7): Hellmig S, Troch K, Ott SJ, Schwarz T, Fölsch UR Role of H.pylori Infection in the treatment and outcome of chronic urticaria Helicobacter 2008; 13: Schafmayer C, Buch S, Völzke H, von Schönfels W, Egberts JE, Schniewind B, Brosch M, Ruether A, Franke A, Mathiak M, Sipos B, Henopp T, Catalcali J, Hellmig S, ElSharawy A, Katalinic A, Lerch MM, John U, Fölsch UR, Fändrich F, Kalthoff H,, Krawczak M, Tepel J, Hampe J Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample Int J Cancer Oct 6;124(1): Hellmig S, Troch K, Ott SJ, Fölsch UR, Schwarz T Yersinia enterocolitica another factor in the pathogenesis of chronic urticaria? Clin Exp Dermatol May Kuehbacher T, Rehman A, Lepage P, Hellmig S, Fölsch UR,, Ott SJ Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease. J Med Microbiol Dec;57:

5 36. Hellmig S, Bartscht T, Fischbach W, Ott SJ, Rosenstiel P, Klapper W, Fölsch UR, Schreiber S. Germline variations of the MALT1 gene as risk factors in the development of primary gastric B-cell lymphoma. Eur J Cancer Jul;45(10): Epub 2009 Apr Rehman A, Lepage P, Nolte A, Hellmig S,, Ott SJ. Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients. J Med Microbiol Sep;59(Pt 9): Jacobs G, Hellmig S, Huse K, Titz A, Valentonyte R, Ott S, Kosmahl M, Fischbach W, Lucius R, Klapper W, Fölsch UR, Hampe J,, Rosenstiel P Polymorphisms in the 3 UTR of the CDH1 gene are a risk factor for gastric high-grade lymphoma Haematologica Jul;96(7): Madisch A, Hellmig S,, Bethke B, Stolte M, Miehlke M Allelic Variation of the Matrix Metalloproteinase-9 gene is associated with collagenous colitis Inflamm Bowel Dis Nov;17(11): Rehman A, Heinsen FA, Koenen ME, Venema K, Knecht H, Hellmig S,, Ott SJ. Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine. BMC Microbiol Mar 27;12: Yang CA, Scheibenbogen C, Bauer S, Kleinle C, Wex T, Bornschein J, Malfertheiner P, Hellmig S, Schumann RR, Hamann L. A Frequent Toll-Like Receptor 1 Gene Polymorphism Affects NK- and T-cell IFN-γ Production and is Associated with Helicobacter pylori-induced Gastric Disease. Helicobacter Aug 28

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